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Article: Antioxidant and cytotoxicity activity of a nanoemulsion from Satureja kermanica (Lamiaceae).

Hassanabadi, Navid / Mahdavi Meymand, Zahra / Ashrafzadeh, Anis / Sharififar, Fariba

2024

Abstract: Objective: Satureja kermanica is a native species with a relatively wide distribution in Iran, which has been studied less. Due to the low stability of the plants, in this study, the methanolic extract of S. kermanica (MSK) along with a nanoemulsion ( ... ...

Abstract	Objective: Satureja kermanica is a native species with a relatively wide distribution in Iran, which has been studied less. Due to the low stability of the plants, in this study, the methanolic extract of S. kermanica (MSK) along with a nanoemulsion (NEK) preparation was evaluated in terms of antioxidant and cytotoxic activity. Material and methods: The aerial parts of S. kermanica were collected and after studying the organoleptic characteristics and quality control parameters, were extracted with methanol. Total phenolic compounds and total flavonoids of the plant were measured. A nanoemulsion preparation was prepared using ultrasonication method from S. kermanica extract. After measuring the particle size of nanoemulsion, both MSK and NEK were evaluated for their antioxidant and cytotoxic activity using DPPH scavenging assay and MTT colorimetric method on breast cancer cell line (MCF-7) respectively. Results: Phytochemical studies exhibited the presence of secondary metabolites including flavonoids, tannins, steroids and carbohydrates in the plant. Based on the histogram of the SBL nanosizer, the average diameter of nanoemulsion was determined as 37.09nm. Both MSK and NEK showed dose-dependent antioxidant and cytotoxic activity. The IC Conclusion: MSK and NEK showed antioxidant and cytotoxic activity, but in NEK, the antioxidant and cytotoxic potential of the plant was more prominent, which may be due to the rapid release of the bioactive component from the nanoemulsion.
Language	English
Publishing date	2024-01-25
Publishing country	France
Document type	Journal Article
ZDB-ID	307-4
ISSN	0003-4509
ISSN	0003-4509
DOI	10.1016/j.pharma.2024.01.005
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Article ; Online: The Role of Pharmacotherapeutic Agents in Children with Desmoid Tumors.

Douglass, David P / Navid, Fariba / Weiss, Aaron R

Paediatric drugs

2022 Volume 24, Issue 5, Page(s) 433–445

Abstract: Desmoid tumors (DT) are rare fibroblastic, soft-tissue tumors that do not metastasize but can aggressively infiltrate tissues causing significant chronic discomfort and/or functional impairment. In the pediatric population, the incidence of DT is ... ...

Abstract	Desmoid tumors (DT) are rare fibroblastic, soft-tissue tumors that do not metastasize but can aggressively infiltrate tissues causing significant chronic discomfort and/or functional impairment. In the pediatric population, the incidence of DT is greatest during infancy and adolescence but can occur at any age. Dysregulated β-catenin, most commonly resulting from mutations in either CTNNB1 or germline APC (adenomatous polyposis coli) drives DT. Most cases are sporadic but some are associated with predisposition syndromes such as familial adenomatous polyposis (FAP). Historically, treatment has been surgery. However, the recurrence rate after surgery can be high. Various systemic cytotoxic chemotherapy regimens used in other soft-tissue sarcomas have been applied to DT with differing results. Given the chronic and rarely life-threatening nature of this disease and the potential short- and long-term toxicity of these regimens, especially in children, alternative non-cytotoxic interventions have been investigated. Molecularly targeted agents such as tyrosine kinase and gamma secretase inhibitors have shown activity against DT. Innovative local control therapies are being employed as alternatives to surgery and radiation. Periods of prolonged stability and spontaneous regression in the absence of therapy in some patients has prompted wider adoption of an upfront active surveillance approach in the appropriate setting. This review will briefly summarize the epidemiology, pathophysiology, and clinical presentation of DT in children, then focus on historical, current, and future pharmacotherapeutic management and finally, propose areas for future study.
MeSH term(s)	Adenomatous Polyposis Coli/drug therapy ; Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/pathology ; Adolescent ; Antineoplastic Agents/adverse effects ; Child ; Fibromatosis, Aggressive/drug therapy ; Fibromatosis, Aggressive/genetics ; Fibromatosis, Aggressive/pathology ; Genes, APC ; Humans ; Incidence ; Mutation
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2022-07-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1492748-2
ISSN	1179-2019 ; 1174-5878
ISSN (online)	1179-2019
ISSN	1174-5878
DOI	10.1007/s40272-022-00526-x
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Zs.A 5205: Show issues

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Article: Genetic alterations in childhood melanoma.

Navid, Fariba

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

2014 , Page(s) 589–592

Abstract: Melanoma is rare in children. However, the clinical features of the disease in this population have been well-documented through single-institution experiences and population-based analyses. Still, our understanding of the etiologic factors in children ... ...

Abstract	Melanoma is rare in children. However, the clinical features of the disease in this population have been well-documented through single-institution experiences and population-based analyses. Still, our understanding of the etiologic factors in children remains unclear and diagnosis of melanoma remains challenging in certain cases. This article reviews emerging evidence indicating that molecular characterization of these lesions in children may be of diagnostic and therapeutic value.
Language	English
Publishing date	2014-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2431126-1
ISSN	1548-8756 ; 1548-8748
ISSN (online)	1548-8756
ISSN	1548-8748
DOI	10.14694/EdBook_AM.2012.32.589
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Article ; Online: Bone marrow-derived c-kit positive stem cell administration protects against diabetes-induced nephropathy in a rat model by reversing PI3K/AKT/GSK-3β pathway and inhibiting cell apoptosis.

Ghaffari-Nasab, Arshad / Ghiasi, Fariba / Keyhanmanesh, Rana / Roshangar, Leila / Salmani Korjan, Elnaz / Nazarpoor, Navid / Mirzaei Bavil, Fariba

Molecular and cellular biochemistry

2023 Volume 479, Issue 3, Page(s) 603–615

Abstract: Stem cell-based therapy has been proposed as a novel therapeutic strategy for diabetic nephropathy. This study was designed to evaluate the effect of systemic administration of rat bone marrow-derived c-kit positive (c- ... ...

Abstract	Stem cell-based therapy has been proposed as a novel therapeutic strategy for diabetic nephropathy. This study was designed to evaluate the effect of systemic administration of rat bone marrow-derived c-kit positive (c-kit
MeSH term(s)	Animals ; Male ; Rats ; Apoptosis ; Bone Marrow/metabolism ; Diabetic Nephropathies/therapy ; Glycogen Synthase Kinase 3 beta/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction ; Stem Cells/metabolism ; Proto-Oncogene Proteins c-kit ; Diabetes Complications/metabolism ; Mesenchymal Stem Cells/metabolism ; Cell- and Tissue-Based Therapy/methods
Chemical Substances	Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2023-05-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-023-04750-y
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Zs.A 892: Show issues

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Article ; Online: A familial case of recurrent hydatidiform mole with p.Asp108Ilefs∗30 causing mutation in KHDC3L: A genetic and clinical report.

Fatemi, Nayeralsadat / Varkiani, Maryam / Ramazanali, Fariba / Almadani, Navid / Totonchi, Mehdi

Taiwanese journal of obstetrics & gynecology

2022 Volume 61, Issue 2, Page(s) 395–398

Abstract: Objective: Hydatidiform mole (HM) is defined by trophoblastic proliferation and vesicular enlargement of placental villi in which, KHDC3L gene plays a causal role.: Case report: This report presents a clinical review and genetic screening for p ... ...

Abstract	Objective: Hydatidiform mole (HM) is defined by trophoblastic proliferation and vesicular enlargement of placental villi in which, KHDC3L gene plays a causal role. Case report: This report presents a clinical review and genetic screening for p.Asp108Ilefs∗30 mutation in KHDC3L gene in an affected woman with a previous history of HM and three siblings with a history of HM. Pathological examination of molar pregnancy in proband confirmed a typical complete HM (CHM). Also, DNA extraction was done, polymerase chain reaction was carried out and then sequencing was performed by the Sanger sequencing method. The screened mutation was found in all three sisters in a homozygous state. Conclusion: Egg donation is suggested for having viable children in these patients with the lowest risk of inadvertent damage.
MeSH term(s)	Female ; Humans ; Hydatidiform Mole/genetics ; Hydatidiform Mole/pathology ; Mutation ; Neoplasm Recurrence, Local ; Placenta/pathology ; Pregnancy ; Proteins/genetics ; Uterine Neoplasms/complications ; Uterine Neoplasms/genetics
Chemical Substances	KHDC3L protein, human ; Proteins
Language	English
Publishing date	2022-03-31
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	2202946-1
ISSN	1875-6263 ; 1875-6263
ISSN (online)	1875-6263
ISSN	1875-6263
DOI	10.1016/j.tjog.2022.02.038
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Article ; Online: Survival outcomes and surgical morbidity based on surgical approach to pulmonary metastasectomy in pediatric, adolescent and young adult patients with osteosarcoma.

Kuo, Christopher / Malvar, Jemily / Chi, Yueh-Yun / Kim, Eugene S / Shah, Rachana / Navid, Fariba / Stein, James E / Mascarenhas, Leo

Cancer medicine

2023 Volume 12, Issue 20, Page(s) 20231–20241

Abstract: Background: Thoracotomy is considered the standard surgical approach for the management of pulmonary metastases in osteosarcoma (OST). Several studies have identified the advantages of a thoracoscopic approach, however, the clinical significance of ... ...

Abstract	Background: Thoracotomy is considered the standard surgical approach for the management of pulmonary metastases in osteosarcoma (OST). Several studies have identified the advantages of a thoracoscopic approach, however, the clinical significance of thoracotomy compared to thoracoscopy is yet to be evaluated in a randomized trial. Aims: The primary aim was to determine the survival outcomes in OST patients based on surgical approach for pulmonary metastasectomy (PM) and secondary aim was to assess the post-operative morbidities of OST PM through various surgical approaches. Materials and methods: We conducted a single institution retrospective study to compare survival outcomes and surgical morbidity according to the surgical approach of the management of pulmonary metastases in patients with OST. Results: Sixty-one patients with OST underwent PM. Twenty-one patients were metastatic at diagnosis and underwent PM during primary treatment; nine had thoracotomy, six thoracoscopy, and six combined thoracoscopy with thoracotomy (CTT). Forty-three patients with first pulmonary relapse or progression underwent PM; 18 had thoracotomy, 16 thoracoscopy and nine CTT. There was no difference in survival between surgical approaches. There were significantly more postoperative morbidities associated with thoracotomy for initial PM (pain and postoperative chest tube placement), and for PM at first relapse (pneumothoraces, pain, Foley catheter use and prolonged hospitalizations). Conclusion: Our study demonstrates that patients with OST pulmonary metastases have comparable poor outcomes despite varying surgical approaches for PM. There were significantly more postoperative morbidities associated with thoracotomy for PM. Surgical bias and other competing risks could not be assessed given the limitations of a retrospective study and may be addressed in a prospective trial evaluating surgical approach for PM in OST.
MeSH term(s)	Humans ; Child ; Adolescent ; Young Adult ; Metastasectomy/adverse effects ; Retrospective Studies ; Prospective Studies ; Lung Neoplasms ; Osteosarcoma/surgery ; Osteosarcoma/pathology ; Bone Neoplasms/surgery ; Bone Neoplasms/pathology ; Morbidity ; Pain ; Recurrence ; Thoracotomy/adverse effects
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6491
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Article: Selective Growth of GaP Crystals on CMOS-Compatible Si Nanotip Wafers by Gas Source Molecular Beam Epitaxy.

Kafi, Navid / Kang, Songdan / Golz, Christian / Rodrigues-Weisensee, Adriana / Persichetti, Luca / Ryzhak, Diana / Capellini, Giovanni / Spirito, Davide / Schmidbauer, Martin / Kwasniewski, Albert / Netzel, Carsten / Skibitzki, Oliver / Hatami, Fariba

Crystal growth & design

2024 Volume 24, Issue 7, Page(s) 2724–2733

Abstract: Gallium phosphide (GaP) is a III-V semiconductor with remarkable optoelectronic properties, and it has almost the same lattice constant as silicon (Si). However, to date, the monolithic and large-scale integration of GaP devices with silicon remains ... ...

Abstract	Gallium phosphide (GaP) is a III-V semiconductor with remarkable optoelectronic properties, and it has almost the same lattice constant as silicon (Si). However, to date, the monolithic and large-scale integration of GaP devices with silicon remains challenging. In this study, we present a nanoheteroepitaxy approach using gas-source molecular-beam epitaxy for selective growth of GaP islands on Si nanotips, which were fabricated using complementary metal-oxide semiconductor (CMOS) technology on a 200 mm n-type Si(001) wafer. Our results show that GaP islands with sizes on the order of hundreds of nanometers can be successfully grown on CMOS-compatible wafers. These islands exhibit a zinc-blende phase and possess optoelectronic properties similar to those of a high-quality epitaxial GaP layer. This result marks a notable advancement in the seamless integration of GaP-based devices with high scalability into Si nanotechnology and integrated optoelectronics.
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ISSN	1528-7483
ISSN	1528-7483
DOI	10.1021/acs.cgd.3c01337
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Article ; Online: Investigating the role of mobile health in epilepsy management

Atefeh Khoshkangin / Fariba Sadat Agha Seyyed Esmaeil Amiri / Kosar Ghaddaripouri / Navid Noroozi / Mohammad Reza Mazaheri Habibi

Journal of Education and Health Promotion, Vol 12, Iss 1, Pp 304-

A systematic review

2023 Volume 304

Abstract: Epilepsy is the most common chronic neurologic disease which is characterized by recurrent attacks of headache after seizure. Researches show that self-management is an important factor in improving the quality of life and quality of care of people ... ...

Abstract	Epilepsy is the most common chronic neurologic disease which is characterized by recurrent attacks of headache after seizure. Researches show that self-management is an important factor in improving the quality of life and quality of care of people affected by epilepsy. Mobile phone technologies play a potential role in patient care assistance and treatment of epilepsy. This systematic review was conducted with an aim to study the role of mobile health in the management of epilepsy. This study was conducted by searching databases such as PubMed, Scopus, Web of Science, and Google scholar search engines using the following keywords: “m-health,” “mobile health,” “Telemedicine,” “Mobile Application,” “Smartphone,” “epilepsy,” and “epilepsy management.” Articles published from January 1, 1990 to September 1, 2021 were searched. Inclusion criteria included all articles published in English with a focus on the role of mHealth in the management of epilepsy. Review articles and studies that were not about patients were omitted. In this study, of a total of 4225 retrieved articles, 10 studies met the full-text inclusion criteria. Three types of researches (30%) were done in the USA, five studies (50%) were conducted as randomized controlled trials, and eight articles (80%) had the highest quality. Among the considered articles, three articles (30%) were engaged in training users in epilepsy management. Five articles (50%) reported improvement in seizure control in patients with epilepsy and two articles (20%) did not report any significant improvement. Mobile technologies have a promising role in providing health assessment, education, and other services for patients, and they also help in controlling seizures attack and improvement of epilepsy management. These technologies enjoy great attractiveness, and utilizing them will lead to patient satisfaction.
Keywords	epilepsy ; epilepsy management ; mobile health ; seizure ; self-management ; smartphone ; smartphone application ; telemedicine ; Special aspects of education ; LC8-6691 ; Public aspects of medicine ; RA1-1270
Subject code	306
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Investigating the role of mobile health in epilepsy management: A systematic review.

Khoshkangin, Atefeh / Agha Seyyed Esmaeil Amiri, Fariba Sadat / Ghaddaripouri, Kosar / Noroozi, Navid / Mazaheri Habibi, Mohammad Reza

Journal of education and health promotion

2023 Volume 12, Page(s) 304

Abstract	Epilepsy is the most common chronic neurologic disease which is characterized by recurrent attacks of headache after seizure. Researches show that self-management is an important factor in improving the quality of life and quality of care of people affected by epilepsy. Mobile phone technologies play a potential role in patient care assistance and treatment of epilepsy. This systematic review was conducted with an aim to study the role of mobile health in the management of epilepsy. This study was conducted by searching databases such as PubMed, Scopus, Web of Science, and Google scholar search engines using the following keywords: "m-health," "mobile health," "Telemedicine," "Mobile Application," "Smartphone," "epilepsy," and "epilepsy management." Articles published from January 1, 1990 to September 1, 2021 were searched. Inclusion criteria included all articles published in English with a focus on the role of mHealth in the management of epilepsy. Review articles and studies that were not about patients were omitted. In this study, of a total of 4225 retrieved articles, 10 studies met the full-text inclusion criteria. Three types of researches (30%) were done in the USA, five studies (50%) were conducted as randomized controlled trials, and eight articles (80%) had the highest quality. Among the considered articles, three articles (30%) were engaged in training users in epilepsy management. Five articles (50%) reported improvement in seizure control in patients with epilepsy and two articles (20%) did not report any significant improvement. Mobile technologies have a promising role in providing health assessment, education, and other services for patients, and they also help in controlling seizures attack and improvement of epilepsy management. These technologies enjoy great attractiveness, and utilizing them will lead to patient satisfaction.
Language	English
Publishing date	2023-09-29
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2715449-X
ISSN	2319-6440 ; 2277-9531
ISSN (online)	2319-6440
ISSN	2277-9531
DOI	10.4103/jehp.jehp_1188_22
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Article: Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors.

Christodoulou, Eirini / Yellapantula, Venkata / O'Halloran, Katrina / Xu, Liya / Berry, Jesse L / Cotter, Jennifer A / Zdanowicz, Anya / Mascarenhas, Leo / Amatruda, James F / Ostrow, Dejerianne / Bootwalla, Moiz / Gai, Xiaowu / Navid, Fariba / Biegel, Jaclyn A

NPJ precision oncology

2023 Volume 7, Issue 1, Page(s) 21

Abstract: We designed a liquid biopsy (LB) platform employing low-pass whole genome sequencing (LP-WGS) and targeted sequencing of cell-free (cf) DNA from plasma to detect genome-wide copy number alterations (CNAs) and gene fusions in pediatric solid tumors. A ... ...

Abstract	We designed a liquid biopsy (LB) platform employing low-pass whole genome sequencing (LP-WGS) and targeted sequencing of cell-free (cf) DNA from plasma to detect genome-wide copy number alterations (CNAs) and gene fusions in pediatric solid tumors. A total of 143 plasma samples were analyzed from 19 controls and 73 patients, including 44 bone or soft-tissue sarcomas and 12 renal, 10 germ cell, five hepatic, and two thyroid tumors. cfDNA was isolated from plasma collected at diagnosis, during and after therapy, and/or at relapse. Twenty-six of 37 (70%) patients enrolled at diagnosis without prior therapy (radiation, surgery, or chemotherapy) had circulating tumor DNA (ctDNA), based on the detection of CNAs from LP-WGS, including 18 of 27 (67%) patients with localized disease and eight of 10 (80%) patients with metastatic disease. None of the controls had detectable somatic CNAs. There was a high concordance of CNAs identified by LP-WGS to CNAs detected by chromosomal microarray analysis in the matching tumors. Mutations identified in tumor samples with our next-generation sequencing (NGS) panel, OncoKids®, were also detected by LP-WGS of ctDNA in 14 of 26 plasma samples. Finally, we developed a hybridization-based capture panel to target EWSR1 and FOXO1 fusions from patients with Ewing sarcoma or alveolar rhabdomyosarcoma (ARMS), respectively. Fusions were detected in the plasma from 10 of 12 patients with Ewing sarcoma and in two of two patients with ARMS. Combined, these data demonstrate the clinical applicability of our LB platform to evaluate pediatric patients with a variety of solid tumors.
Language	English
Publishing date	2023-02-20
Publishing country	England
Document type	Journal Article
ISSN	2397-768X
ISSN	2397-768X
DOI	10.1038/s41698-023-00357-0
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