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  1. Article ; Online: Skin microbiome in atopic dermatitis: New insights from clinical trials.

    Rieder, Florian / Mukherjee, Pranab K

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 37, Issue 4, Page(s) 649–650

    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Skin ; Microbiota
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18991
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    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  2. Article ; Online: Fibrosis in IBD: from pathogenesis to therapeutic targets.

    Rieder, Florian / Mukherjee, Pranab K / Massey, William J / Wang, Yan / Fiocchi, Claudio

    Gut

    2024  Volume 73, Issue 5, Page(s) 854–866

    Abstract: Background: Intestinal fibrosis resulting in stricture formation and obstruction in Crohn's disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest unmet needs in inflammatory bowel disease (IBD). ... ...

    Abstract Background: Intestinal fibrosis resulting in stricture formation and obstruction in Crohn's disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest unmet needs in inflammatory bowel disease (IBD). Fibrosis is caused by a multifactorial and complex process involving immune and non-immune cells, their soluble mediators and exposure to luminal contents, such as microbiota and environmental factors. To date, no antifibrotic therapy is available. Some progress has been made in creating consensus definitions and measurements to quantify stricture morphology for clinical practice and trials, but approaches to determine the degree of fibrosis within a stricture are still lacking.
    Objective: We herein describe the current state of stricture pathogenesis, measuring tools and clinical trial endpoints development.
    Design: Data presented and discussed in this review derive from the past and recent literature and the authors' own research and experience.
    Results and conclusions: Significant progress has been made in better understanding the pathogenesis of fibrosis, but additional studies and preclinical developments are needed to define specific therapeutic targets.
    MeSH term(s) Humans ; Constriction, Pathologic ; Inflammatory Bowel Diseases/therapy ; Crohn Disease/pathology ; Colitis, Ulcerative/pathology ; Fibrosis
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-329963
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Edge-Based Two-Dimensional α-In

    Dutta, Debopriya / Mukherjee, Subhrajit / Uzhansky, Michael / Mohapatra, Pranab K / Ismach, Ariel / Koren, Elad

    ACS applied materials & interfaces

    2023  Volume 15, Issue 14, Page(s) 18505–18515

    Abstract: Heterostructures based on two-dimensional materials offer the possibility to achieve synergistic functionalities, which otherwise remain secluded by their individual counterparts. Herein, ferroelectric polarization switching in α- ... ...

    Abstract Heterostructures based on two-dimensional materials offer the possibility to achieve synergistic functionalities, which otherwise remain secluded by their individual counterparts. Herein, ferroelectric polarization switching in α-In
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c00590
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  4. Article ; Online: Elovanoid-N34 modulates TXNRD1 key in protection against oxidative stress-related diseases.

    Calandria, Jorgelina M / Bhattacharjee, Surjyadipta / Kala-Bhattacharjee, Sayantani / Mukherjee, Pranab K / Feng, Yuehan / Vowinckel, Jakob / Treiber, Tobias / Bazan, Nicolas G

    Cell death & disease

    2023  Volume 14, Issue 12, Page(s) 819

    Abstract: The thioredoxin (TXN) system is an NADPH + ... ...

    Abstract The thioredoxin (TXN) system is an NADPH + H
    MeSH term(s) Humans ; Thioredoxin Reductase 1/genetics ; Oxidation-Reduction ; Protein Isoforms/metabolism ; Cytosol/metabolism ; Oxidative Stress ; Lipids
    Chemical Substances Thioredoxin Reductase 1 (EC 1.8.1.9) ; Protein Isoforms ; Lipids ; TXNRD1 protein, human (EC 1.8.1.9)
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-06334-6
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  5. Article ; Online: Algorithmic augmentation in the pseudopotential-based lattice Boltzmann method for simulating the pool boiling phenomenon with high-density ratio.

    Mukherjee, Aritra / Basu, Dipankar N / Mondal, Pranab K

    Physical review. E

    2021  Volume 103, Issue 5-1, Page(s) 53302

    Abstract: The pseudopotential-based lattice Boltzmann method (LBM), despite enormous potential in facilitating natural development and migration of interfaces during multiphase simulation, remains restricted to low-density ratios, owing to inherent thermodynamic ... ...

    Abstract The pseudopotential-based lattice Boltzmann method (LBM), despite enormous potential in facilitating natural development and migration of interfaces during multiphase simulation, remains restricted to low-density ratios, owing to inherent thermodynamic inconsistency. The present paper focuses on augmenting the basic algorithm by enhancing the isotropy of the discrete equation and thermodynamic consistency of the overall formulation, to expedite simulation of pool boiling at higher-density ratios. Accordingly, modification is suggested in the discrete form of the updated interparticle interaction term, by expanding the discretization to the eighth order. The proposed amendment is successful in substantially reducing the spurious velocity in the vicinity of a static droplet, while allowing stable simulation at a much higher-density ratio under identical conditions, which is a noteworthy improvement over existing Single Relaxation Time (SRT)-LBM algorithms. Various pool boiling scenarios have been explored for a reduced temperature of 0.75, which itself is significantly lower than reported in comparable literature, in both rectangular and cylindrical domains, and also with micro- and distributed heaters. All three regimes of pool boiling have aptly been captured with both plain and structured heaters, allowing the development of the boiling curve. The predicted value of critical heat flux for the plain heater agrees with Zuber correlation within 10%, illustrating both quantitative and qualitative capability of the proposed algorithm.
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.103.053302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Integrated inflammatory signaling landscape response after delivering Elovanoid free-fatty-acid precursors leading to experimental stroke neuroprotection.

    Reid, Madigan M / Belayev, Ludmila / Khoutorova, Larissa / Mukherjee, Pranab K / Obenaus, Andre / Shelvin, Kierany / Knowles, Stacey / Hong, Sung-Ha / Bazan, Nicolas G

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15841

    Abstract: Despite efforts to identify modulatory neuroprotective mechanisms of damaging ischemic stroke cascade signaling, a void remains on an effective potential therapeutic. The present study defines neuroprotection by very long-chain polyunsaturated fatty acid ...

    Abstract Despite efforts to identify modulatory neuroprotective mechanisms of damaging ischemic stroke cascade signaling, a void remains on an effective potential therapeutic. The present study defines neuroprotection by very long-chain polyunsaturated fatty acid (VLC-PUFA) Elovanoid (ELV) precursors C-32:6 and C-34:6 delivered intranasally following experimental ischemic stroke. We demonstrate that these precursors improved neurological deficit, decreased T2WI lesion volume, and increased SMI-71 positive blood vessels and NeuN positive neurons, indicating blood-brain barrier (BBB) protection and neurogenesis modulated by the free fatty acids (FFAs) C-32:6 and C-34:6. Gene expression revealed increased anti-inflammatory and pro-homeostatic genes and decreases in expression of pro-inflammatory genes in the subcortex. Additionally, the FFAs elicit a comprehensive downregulation of inflammatory microglia/monocyte-derived macrophages and astrocyte-associated genes in the subcortical region. Functional analysis reveals inhibition of immune-related pathways and production of upstream molecules related to detrimental signaling events in post-stroke acute and subacute phases.
    MeSH term(s) Humans ; Fatty Acids, Nonesterified ; Neuroprotection ; Stroke/genetics ; Ischemic Stroke ; Astrocytes
    Chemical Substances Fatty Acids, Nonesterified
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42126-w
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  7. Article ; Online: Spin-valley Rashba monolayer laser.

    Rong, Kexiu / Duan, Xiaoyang / Wang, Bo / Reichenberg, Dror / Cohen, Assael / Liu, Chieh-Li / Mohapatra, Pranab K / Patsha, Avinash / Gorovoy, Vladi / Mukherjee, Subhrajit / Kleiner, Vladimir / Ismach, Ariel / Koren, Elad / Hasman, Erez

    Nature materials

    2023  Volume 22, Issue 9, Page(s) 1085–1093

    Abstract: Direct-bandgap transition metal dichalcogenide monolayers are appealing candidates to construct atomic-scale spin-optical light sources owing to their valley-contrasting optical selection rules. Here we report on a spin-optical monolayer laser by ... ...

    Abstract Direct-bandgap transition metal dichalcogenide monolayers are appealing candidates to construct atomic-scale spin-optical light sources owing to their valley-contrasting optical selection rules. Here we report on a spin-optical monolayer laser by incorporating a WS
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-023-01603-3
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  8. Article ; Online: Maskless Device Fabrication and Laser-Induced Doping in MoS

    Kafri, Alonit / Dutta, Debopriya / Mukherjee, Subhrajit / Mohapatra, Pranab K / Ismach, Ariel / Koren, Elad

    ACS applied materials & interfaces

    2021  Volume 13, Issue 4, Page(s) 5399–5405

    Abstract: We present a novel maskless device fabrication technique for rapid prototyping of two-dimensional (2D)-based electronic materials. The technique is based on a thermally activated and self-developed cyclic polyphthalaldehyde (c-PPA) resist using a ... ...

    Abstract We present a novel maskless device fabrication technique for rapid prototyping of two-dimensional (2D)-based electronic materials. The technique is based on a thermally activated and self-developed cyclic polyphthalaldehyde (c-PPA) resist using a commercial Raman system and 532 nm laser illumination. Following the successful customization of electrodes to form field effect transistors based on MoS
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c19194
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  9. Book ; Online: Edge-based 2D alpha-In2Se3-MoS2 ferroelectric field effect device

    Dutta, Debopriya / Mukherjee, Subhrajit / Uzhansky, Michael / Mohapatra, Pranab K. / Ismach, Ariel / Koren, Elad

    2023  

    Abstract: Heterostructures based on two dimensional (2D) materials offer the possibility to achieve synergistic functionalities which otherwise remain secluded by their individual counterparts. Herein ferroelectric polarization switching in alpha-In2Se3 has been ... ...

    Abstract Heterostructures based on two dimensional (2D) materials offer the possibility to achieve synergistic functionalities which otherwise remain secluded by their individual counterparts. Herein ferroelectric polarization switching in alpha-In2Se3 has been utilized to engineer multilevel non-volatile conduction states in partially overlapping alpha-In2Se3-MoS2 based ferroelectric semiconducting field effect device. In particular, we demonstrate how the intercoupled ferroelectric nature of alpha-In2Se3 allows to non-volatilely switch between n-i and n-i-n type junction configurations based on a novel edge state actuation mechanism, paving the way for sub-nanometric scale non-volatile device miniaturization. Furthermore the induced asymmetric polarization enables enhanced photogenerated carriers separation resulting in extremely high photoresponse of 1275 AW-1 in the visible range and strong non-volatile modulation of the bright A- and B- excitonic emission channels in the overlaying MoS2 monolayer. Our results show significant potential to harness the switchable polarization in partially overlapping alpha-In2Se3-MoS2 based FeFETs to engineer multimodal non-volatile nanoscale electronic and optoelectronic devices.
    Keywords Condensed Matter - Materials Science ; Physics - Applied Physics
    Publishing date 2023-01-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Cutaneous dysbiosis may amplify barrier dysfunction in patients with atopic dermatitis.

    Hammond, Margaret / Gamal, Ahmed / Mukherjee, Pranab K / Damiani, Giovanni / McCormick, Thomas S / Ghannoum, Mahmoud A / Nedorost, Susan

    Frontiers in microbiology

    2022  Volume 13, Page(s) 944365

    Abstract: Atopic dermatitis (AD) is associated with cutaneous dysbiosis, barrier defects, and immune dysregulation, but the interplay between these factors needs further study. Early-onset barrier dysfunction may facilitate an innate immune response to commensal ... ...

    Abstract Atopic dermatitis (AD) is associated with cutaneous dysbiosis, barrier defects, and immune dysregulation, but the interplay between these factors needs further study. Early-onset barrier dysfunction may facilitate an innate immune response to commensal organisms and, consequently, the development of allergic sensitization. We aimed to compare the cutaneous microbiome in patients with active dermatitis with and without a history of childhood flexural dermatitis (atopic dermatitis). Next-gen Ion-Torrent deep-sequencing identified AD-associated changes in the skin bacterial microbiome ("bacteriome") and fungal microbiome ("mycobiome") of affected skin in swabs from areas of skin affected by dermatitis. Data were analyzed for diversity, abundance, and inter-kingdom correlations. Microbial interactions were assessed in biofilms using metabolic activity (XTT) assay and scanning electron microscopy (SEM), while host-pathogen interactions were determined in cultured primary keratinocytes exposed to biofilms. Increased richness and abundance of
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.944365
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