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Article ; Online: The γ-glutamyl cycle serves as an amino acids supply system in colorectal cancer organoids under chronic hypoxia.

Tabata, Sho / Endo, Hiroko / Makinoshima, Hideki / Soga, Tomoyoshi / Inoue, Masahiro

Biochemical and biophysical research communications

2024 Volume 714, Page(s) 149977

Abstract: Malignant tumors are characterized by a hypoxic microenvironment, and metabolic reprogramming is necessary to ensure energy production and oxidative stress resistance. Although the microenvironmental properties of tumors vary under acute and chronic ... ...

Abstract	Malignant tumors are characterized by a hypoxic microenvironment, and metabolic reprogramming is necessary to ensure energy production and oxidative stress resistance. Although the microenvironmental properties of tumors vary under acute and chronic hypoxia, studies on chronic hypoxia-induced metabolic changes are limited. In the present study, we performed a comprehensive metabolic analysis in a chronic hypoxia model using colorectal cancer (CRC) organoids, and identified an amino acid supply system through the γ-glutamyl cycle, a glutathione recycling pathway. We analyzed the metabolic changes caused by hypoxia over time and observed that chronic hypoxia resulted in an increase in 5-oxoproline and a decrease in oxidized glutathione (GSSG) compared to acute hypoxia. These findings suggest that chronic hypoxia induces metabolic changes in the γ-glutamyl cycle. Moreover, inhibition of the γ-glutamyl cycle via γ-glutamyl cyclotransferase (GGCT) and γ-glutamyl transferase 1 (GGT1) knockdown significantly reversed chronic hypoxia-induced upregulation of 5-oxoproline and several amino acids. Notably, GGT1 knockdown downregulated the intracellular levels of γ-glutamyl amino acids. Conclusively, these results indicate that the γ-glutamyl cycle serves as an amino acid supply system in CRC under chronic hypoxia, which provides fresh insight into cancer metabolism under chronic hypoxia.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149977
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Article ; Online: Simplified Lumboperitoneal Shunt Surgery Using 2 Small Skin Incisions: 2-Dimensional Operative Video.

Goto, Yukihiro / Inoue, Takuro / Oka, Hideki

Operative neurosurgery (Hagerstown, Md.)

2022 Volume 22, Issue 2, Page(s) e86–e87

Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1227/ONS.0000000000000056
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Article: A Type 2 Diabetes Mellitus Patient With Severe Diabetic Gastroparesis Successfully Treated With Intravenous Erythromycin.

Inoue, Saori / Yasuda, Hiroko / Takashi, Kamiya / Okamoto, Hideki

Cureus

2023 Volume 15, Issue 11, Page(s) e49075

Abstract: Gastroparesis, characterized by a decrease in gastric emptying, can lead to worsened diabetes control and a reduced quality of life. The patient was a 32-year-old male with type 2 diabetes. He was initially admitted for control of diabetes, and two ... ...

Abstract	Gastroparesis, characterized by a decrease in gastric emptying, can lead to worsened diabetes control and a reduced quality of life. The patient was a 32-year-old male with type 2 diabetes. He was initially admitted for control of diabetes, and two months later, he was readmitted due to nausea and vomiting. He showed resistance to various drugs, including antiemetics, and an upper gastrointestinal endoscopy revealed significant gastric residue, leading to a diagnosis of gastroparesis. We administered intravenous erythromycin. After three days of treatment, the vomiting resolved. Gastroparesis is challenging to manage, and there are limited effective treatment options. We experienced a case of diabetic gastroparesis with severe vomiting and loss of appetite that responded remarkably well to intravenous erythromycin treatment. Intravenous administration of erythromycin may be a potentially effective treatment for gastroparesis.
Language	English
Publishing date	2023-11-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49075
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Article ; Online: Natural radionuclides and radiological risk assessment in the stream and river sediments of a high background natural radiation area Kanyakumari, India.

Natarajan, Thennaarassan / Sahoo, Sarata Kumar / Inoue, Kazumasa / Arae, Hideki / Aono, Tatsuo / Fukushi, Masahiro

Environmental monitoring and assessment

2024 Volume 196, Issue 3, Page(s) 330

Abstract: The Kanyakumari coast is known to be a high background natural radiation area due to the placer deposits of heavy minerals such as ilmenite, monazite, and rutile. The Kanyakumari river sediments that could be the source of the elevated amounts of natural ...

Abstract	The Kanyakumari coast is known to be a high background natural radiation area due to the placer deposits of heavy minerals such as ilmenite, monazite, and rutile. The Kanyakumari river sediments that could be the source of the elevated amounts of natural radionuclides in the coastal sands have been studied in this paper. The activity concentrations of primordial radionuclides
MeSH term(s)	Rivers ; Background Radiation ; Environmental Monitoring ; Thorium/analysis ; Radioisotopes/analysis ; Soil Pollutants, Radioactive/analysis ; India ; Risk Assessment ; Radiation Monitoring/methods ; Potassium Radioisotopes/analysis
Chemical Substances	Thorium (60YU5MIG9W) ; Radioisotopes ; Soil Pollutants, Radioactive ; Potassium Radioisotopes
Language	English
Publishing date	2024-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-024-12456-x
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Article: Protein dynamics of a light-driven Na

Otomo, Akihiro / Mizuno, Misao / Inoue, Keiichi / Kandori, Hideki / Mizutani, Yasuhisa

Biophysics and physicobiology

2023 Volume 20, Issue Supplemental, Page(s) e201016

Abstract: Direct observation of protein structural changes during ion transport in ion pumps provides valuable insights into the mechanism of ion transport. In this study, we examined structural changes in the light-driven sodium ion ( ... ...

Abstract	Direct observation of protein structural changes during ion transport in ion pumps provides valuable insights into the mechanism of ion transport. In this study, we examined structural changes in the light-driven sodium ion (Na
Language	English
Publishing date	2023-02-25
Publishing country	Japan
Document type	Journal Article
ISSN	2189-4779
ISSN	2189-4779
DOI	10.2142/biophysico.bppb-v20.s016
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Article ; Online: Is High-Flow Nasal Cannula Oxygen Therapy an Aerosol-Generating Medical Procedure?

Hamada, Satoshi / Tanabe, Naoya / Inoue, Hideki / Hirai, Toyohiro

Archivos de bronconeumologia

2022 Volume 57, Issue 9, Page(s) 601–602

MeSH term(s)	Aerosols ; Cannula ; Humans ; Oxygen ; Oxygen Inhalation Therapy/methods
Chemical Substances	Aerosols ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-06-08
Publishing country	Spain
Document type	Case Reports
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbr.2021.01.008
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Zs.B 2655: Show issues

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Article ; Online: Cis

Urui, Taito / Hayashi, Kouhei / Mizuno, Misao / Inoue, Keiichi / Kandori, Hideki / Mizutani, Yasuhisa

The journal of physical chemistry. B

2024 Volume 128, Issue 3, Page(s) 744–754

Abstract: The creation of unidirectional ion transporters across membranes represents one of the greatest challenges in chemistry. Proton-pumping rhodopsins are composed of seven transmembrane helices with a retinal chromophore bound to a lysine side chain via a ... ...

Abstract	The creation of unidirectional ion transporters across membranes represents one of the greatest challenges in chemistry. Proton-pumping rhodopsins are composed of seven transmembrane helices with a retinal chromophore bound to a lysine side chain via a Schiff base linkage and provide valuable insights for designing such transporters. What makes these transporters particularly intriguing is the discovery of both outward and inward proton-pumping rhodopsins. Surprisingly, despite sharing identical overall structures and membrane topologies, these proteins facilitate proton transport in opposite directions, implying an underlying rational mechanism that can transport protons in different directions within similar protein structures. In this study, we unraveled this mechanism by examining the chromophore structures of deprotonated intermediates in schizorhodopsins, a recently discovered subfamily of inward proton-pumping rhodopsins, using time-resolved resonance Raman spectroscopy. The photocycle of schizorhodopsins revealed the
MeSH term(s)	Proton Pumps/chemistry ; Protons ; Bacteriorhodopsins/chemistry ; Schiff Bases/chemistry ; Ion Transport ; Light
Chemical Substances	Proton Pumps ; Protons ; Bacteriorhodopsins (53026-44-1) ; Schiff Bases
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c07510
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Article: Coregulation of

Kojima, Soichi / Minagawa, Haruka / Yoshida, Chika / Inoue, Eri / Takahashi, Hideki / Ishiyama, Keiki

Frontiers in plant science

2023 Volume 14, Page(s) 1127006

Abstract: Ammonium absorbed by roots is assimilated into amino acids. The glutamine synthetase/glutamate synthase (glutamine 2-oxoglutarate aminotransferase) (GS/GOGAT) cycle is essential to this biological process. ... ...

Abstract	Ammonium absorbed by roots is assimilated into amino acids. The glutamine synthetase/glutamate synthase (glutamine 2-oxoglutarate aminotransferase) (GS/GOGAT) cycle is essential to this biological process. In
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1127006
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Article ; Online: [Embolic stroke due to ascending aortic thrombus in a patient with treatment-resistant ulcerative colitis].

Inoue, Kenichi / Ogata, Toshiyasu / Mishima, Takayasu / Ishibashi, Hideki / Hirai, Fumihito / Tsuboi, Yoshio

Rinsho shinkeigaku = Clinical neurology

2024 Volume 64, Issue 2, Page(s) 93–98

Abstract: The patient was a 49-year-old man presenting with recurrent melena due to progressive ulcerative colitis. One day, he developed left lower facial weakness and dysarthria, and the next day, he was transferred to our hospital because of muscle weakness in ... ...

Abstract	The patient was a 49-year-old man presenting with recurrent melena due to progressive ulcerative colitis. One day, he developed left lower facial weakness and dysarthria, and the next day, he was transferred to our hospital because of muscle weakness in his left upper and lower extremities. On admission, neurological findings revealed left hemiplegia, including left facial palsy, dysarthria, and left hemispatial neglect. Brain MRI with diffusion-weighted image showed a fresh infarction in the right anterior and middle cerebral artery territory. Contrast-enhanced CT showed thrombus in the ascending aorta in addition to occlusion of the right internal carotid artery, suggesting the diagnosis of cerebral infarction with an embolic source in the aortic lesion. The intra-aortic thrombus disappeared after 48th day of antithrombotic therapy. Laboratory findings revealed elevated blood viscosity, proteinase-3-anti-neutrophil cytoplasmic antibody (PR3-ANCA), and β2GP1-IgG antibodies, suggesting that the cause of the aortic thrombus may be due to elevated blood viscosity and autoantibodies, as well as highly active ulcerative colitis.
MeSH term(s)	Male ; Humans ; Middle Aged ; Colitis, Ulcerative/complications ; Embolic Stroke ; Dysarthria ; Aorta ; Thrombosis/diagnostic imaging ; Thrombosis/etiology
Language	Japanese
Publishing date	2024-01-20
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001901
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Zs.MO 223: Show issues

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Article ; Online: Chromophore-Protein Interactions Affecting the Polyene Twist and π-π* Energy Gap of the Retinal Chromophore in Schizorhodopsins.

Urui, Taito / Shionoya, Tomomi / Mizuno, Misao / Inoue, Keiichi / Kandori, Hideki / Mizutani, Yasuhisa

The journal of physical chemistry. B

2024 Volume 128, Issue 10, Page(s) 2389–2397

Abstract: The properties of a prosthetic group are broadened by interactions with its neighboring residues in proteins. The retinal chromophore in rhodopsins absorbs light, undergoes structural changes, and drives functionally important structural changes in ... ...

Abstract	The properties of a prosthetic group are broadened by interactions with its neighboring residues in proteins. The retinal chromophore in rhodopsins absorbs light, undergoes structural changes, and drives functionally important structural changes in proteins during the photocycle. It is therefore crucial to understand how chromophore-protein interactions regulate the molecular structure and electronic state of chromophores in rhodopsins. Schizorhodopsin is a newly discovered subfamily of rhodopsins found in the genomes of Asgard archaea, which are extant prokaryotes closest to the last common ancestor of eukaryotes and of other microbial species. Here, we report the effects of a hydrogen bond between a retinal Schiff base and its counterion on the twist of the polyene chain and the color of the retinal chromophore. Correlations between spectral features revealed the unexpected fact that the twist of the polyene chain is reduced as the hydrogen bond becomes stronger, suggesting that the twist is caused by tight atomic contacts between the chromophore and nearby residues. In addition, the strength of the hydrogen bond is the primary factor affecting the color-tuning of the retinal chromophore in schizorhodopsins. The findings of this study are valuable for manipulating the molecular structure and electronic state of the chromophore by controlling chromophore-protein interactions.
MeSH term(s)	Retinaldehyde/chemistry ; Molecular Structure ; Rhodopsin ; Polyenes ; Schiff Bases/chemistry
Chemical Substances	Retinaldehyde (RR725D715M) ; Rhodopsin (9009-81-8) ; Polyenes ; Schiff Bases
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c08465
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