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Article ; Online: A Single-Hydrophone Coherent-Processing Method for Line-Spectrum Enhancement

Zhenxing Zhao / Qi Li / Zhi Xia / Dajing Shang

Remote Sensing, Vol 15, Iss 659, p

2023 Volume 659

Abstract: Improving the line-spectrum detection capability of a single hydrophone is of great significance for the passive detection of small underwater platforms. In this paper, we propose a single-hydrophone cross-power spectrum (SHCS) method based on time- ... ...

Abstract	Improving the line-spectrum detection capability of a single hydrophone is of great significance for the passive detection of small underwater platforms. In this paper, we propose a single-hydrophone cross-power spectrum (SHCS) method based on time-domain coherence. This method uses the coherence of the line spectrum and the non-coherence of the continuous spectrum noise to obtain coherent gain and improve the signal-to-noise ratio (SNR) of the line spectrum. The effects of the input SNR, number of averaging operations, and overlap ratio on the performance of the SHCS method under a background of Gaussian white noise are simulated and analyzed. The results show that when the overlap ratio is 0 and the number of averaging operations reaches saturation, the SHCS method can achieve the best performance and about 15 dB coherence gain is obtained. The performance of the SHCS method was verified by sea experiments. Under the extremely low input SNR, in which the line spectrum was almost completely submerged in the marine environmental noise, the SHCS method can obtain about 10 dB coherence gain. Under the conventional input SNR, in which the line spectrum could be observed, the SHCS method can obtain about 13 dB coherence gain. The results of processing the radiated noise from an actual cargo ship also demonstrate the effectiveness of the SHCS method.
Keywords	passive detection ; line-spectrum enhancement ; single-hydrophone cross-spectrum method ; coherence gain ; sea experiment ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Divergent suicidal symptomatic activations converge on somato-cognitive action network in depression.

Li, Jiao / Wang, Dajing / Xia, Jie / Zhang, Chao / Meng, Yao / Xu, Shuo / Chen, Huafu / Liao, Wei

Molecular psychiatry

2024

Abstract: Individuals with depression have the highest lifetime prevalence of suicide attempts (SA) among mental illnesses. Numerous neuroimaging studies have developed biomarkers from task-related neural activation in depressive patients with SA, but the findings ...

Abstract	Individuals with depression have the highest lifetime prevalence of suicide attempts (SA) among mental illnesses. Numerous neuroimaging studies have developed biomarkers from task-related neural activation in depressive patients with SA, but the findings are inconsistent. Empowered by the contemporary interconnected view of depression as a neural system disorder, we sought to identify a specific brain circuit utilizing published heterogeneous neural activations. We systematically reviewed all published cognitive and emotional task-related functional MRI studies that investigated differences in the location of neural activations between depressive patients with and without SA. We subsequently mapped an underlying brain circuit functionally connecting to each experimental activation using a large normative connectome database (n = 1000). The identified SA-related functional network was compared to the network derived from the disease control group. Finally, we decoded this convergent functional connectivity network using microscale transcriptomic and chemo-architectures, and macroscale psychological processes. We enrolled 11 experimental tasks from eight studies, including depressive patients with SA (n = 147) and without SA (n = 196). The heterogeneous SA-related neural activations localized to the somato-cognitive action network (SCAN), exhibiting robustness to little perturbations and specificity for depression. Furthermore, the SA-related functional network was colocalized with brain-wide gene expression involved in inflammatory and immunity-related biological processes and aligned with the distribution of the GABA and noradrenaline neurotransmitter systems. The findings demonstrate that the SA-related functional network of depression is predominantly located at the SCAN, which is an essential implication for understanding depressive patients with SA.
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-024-02450-7
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Article ; Online: The Immunosuppression of Etoposide Deserves Attention in Chemoimmunotherapy.

Yang, Wei / Zhang, Yeke / Xia, Dajing / Xu, Xiaofeng

American journal of clinical oncology

2021 Volume 44, Issue 5, Page(s) 224–225

MeSH term(s)	Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Drug-Related Side Effects and Adverse Reactions/etiology ; Drug-Related Side Effects and Adverse Reactions/pathology ; Etoposide/administration & dosage ; Humans ; Immunosuppression/adverse effects ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Platinum/administration & dosage ; Prognosis ; Small Cell Lung Carcinoma/drug therapy ; Small Cell Lung Carcinoma/immunology ; Small Cell Lung Carcinoma/pathology ; Survival Rate
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; durvalumab (28X28X9OKV) ; Platinum (49DFR088MY) ; Etoposide (6PLQ3CP4P3) ; tremelimumab (QEN1X95CIX)
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0000000000000804
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Article: High-Performance, Degradable, Self-Healing Bio-Based Nanocomposite Coatings with Antibacterial and Antioxidant Properties.

Zhang, Qiang / Bu, Qihang / Xia, Jiangyue / Sun, Rongxue / Li, Dajing / Luo, Haibo / Jiang, Ning / Wang, Cheng

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 7

Abstract: The purpose of this study is to obtain a bio-based coating with good functional activity and self-healing ability, demonstrating its potential in food, materials, and other application fields. Plastic coatings can cause serious environmental pollution. ... ...

Abstract	The purpose of this study is to obtain a bio-based coating with good functional activity and self-healing ability, demonstrating its potential in food, materials, and other application fields. Plastic coatings can cause serious environmental pollution. It was a good solution to replace plastic coatings with degradable coatings. However, the development of degradable coatings in the fields of food and materials was limited due to their insufficient antibacterial ability and weak comprehensive properties. Therefore, chitosan nanoparticles (NPs) loaded with gallic acid (GA) were self-assembled with gelatin (GE) to prepare high-performance, degradable, self-healing bio-based nanocomposite coatings with antibacterial and antioxidant properties. The oxygen permeability of GE nanocomposite coatings decreased gradually with the addition of NPs, and the barrier properties increased significantly. At the same time, due to the excellent antioxidant and antibacterial ability of GA, the antioxidant effect of the nanocomposite coatings increased by 119%, and the antibacterial rate against
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13071220
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Article ; Online: Toxic epidermal necrolysis associated with chemoimmunotherapy for lymphoma: case report and literature review.

Yang, Wei / Xu, Xiaofeng / Xia, Dajing / Wang, Huaichong / Jiang, Jing / Yang, Guoliang

Immunotherapy

2022 Volume 14, Issue 5, Page(s) 275–282

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Disease-Free Survival ; Humans ; Immunotherapy/adverse effects ; Lymphoma, Extranodal NK-T-Cell/drug therapy ; Lymphoma, Extranodal NK-T-Cell/etiology ; Male ; Oxaliplatin/therapeutic use ; Stevens-Johnson Syndrome/diagnosis ; Stevens-Johnson Syndrome/drug therapy ; Stevens-Johnson Syndrome/etiology ; Treatment Outcome
Chemical Substances	Oxaliplatin (04ZR38536J)
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2021-0074
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Article ; Online: High-Performance, Degradable, Self-Healing Bio-Based Nanocomposite Coatings with Antibacterial and Antioxidant Properties

Qiang Zhang / Qihang Bu / Jiangyue Xia / Rongxue Sun / Dajing Li / Haibo Luo / Ning Jiang / Cheng Wang

Nanomaterials, Vol 13, Iss 1220, p

2023 Volume 1220

Abstract	The purpose of this study is to obtain a bio-based coating with good functional activity and self-healing ability, demonstrating its potential in food, materials, and other application fields. Plastic coatings can cause serious environmental pollution. It was a good solution to replace plastic coatings with degradable coatings. However, the development of degradable coatings in the fields of food and materials was limited due to their insufficient antibacterial ability and weak comprehensive properties. Therefore, chitosan nanoparticles (NPs) loaded with gallic acid (GA) were self-assembled with gelatin (GE) to prepare high-performance, degradable, self-healing bio-based nanocomposite coatings with antibacterial and antioxidant properties. The oxygen permeability of GE nanocomposite coatings decreased gradually with the addition of NPs, and the barrier properties increased significantly. At the same time, due to the excellent antioxidant and antibacterial ability of GA, the antioxidant effect of the nanocomposite coatings increased by 119%, and the antibacterial rate against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) increased by 32% and 58%, respectively, compared with the pure GE coatings. In addition, the nanocomposite coatings can be repaired within 24 h after being scratched at room temperature. Finally, GA coated with chitosan nanoparticles can significantly delay the escape of GA, and the retardation of gallic acid release exceeded 89% in simulated solutions after 24 h immersion, extending the service life of the nanocomposite coatings.
Keywords	nanocomposite coating ; self-healing ; antioxidant ; antibacterial ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19.

He, Weifeng / Gao, Yuan / Zhou, Jing / Shi, Yi / Xia, Dajing / Shen, Han-Ming

International journal of biological sciences

2022 Volume 18, Issue 12, Page(s) 4690–4703

Abstract: There is increasing amount of evidence indicating the close interplays between the replication cycle of SARS-CoV-2 and the autophagy-lysosome pathway in the host cells. While autophagy machinery is known to either assist or inhibit the viral replication ... ...

Abstract	There is increasing amount of evidence indicating the close interplays between the replication cycle of SARS-CoV-2 and the autophagy-lysosome pathway in the host cells. While autophagy machinery is known to either assist or inhibit the viral replication process, the reciprocal effects of the SARS-CoV-2 on the autophagy-lysosome pathway have also been increasingly appreciated. More importantly, despite the disappointing results from the clinical trials of chloroquine and hydroxychloroquine in treatment of COVID-19, there is still ongoing effort in discovering new therapeutics targeting the autophagy-lysosome pathway. In this review, we provide an update-to-date summary of the interplays between the autophagy-lysosome pathway in the host cells and the pathogen SARS-CoV-2 at the molecular level, to highlight the prognostic value of autophagy markers in COVID-19 patients and to discuss the potential of developing novel therapeutic strategies for COVID-19 by targeting the autophagy-lysosome pathway. Thus, understanding the nature of such interactions between SARS-CoV-2 and the autophagy-lysosome pathway in the host cells is expected to provide novel strategies in battling against this global pandemic.
MeSH term(s)	Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Autophagy ; COVID-19/drug therapy ; Humans ; Lysosomes ; Pandemics ; SARS-CoV-2
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-07-11
Publishing country	Australia
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.72544
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Article ; Online: USH2A

Yang, Dexin / Feng, Yuqin / Lu, Haohua / Chen, Kelie / Xu, Jinming / Li, Peiwei / Wang, Tianru / Xia, Dajing / Wu, Yihua

Journal of Zhejiang University. Science. B

2023 Volume 24, Issue 2, Page(s) 143–156

Abstract: This study aimed to identify subtypes of genomic variants associated with the efficacy of immune checkpoint inhibitors (ICIs) by conducting systematic literature search in electronic databases up to May 31, 2021. The main outcomes including overall ... ...

Title translation	USH2A
Abstract	This study aimed to identify subtypes of genomic variants associated with the efficacy of immune checkpoint inhibitors (ICIs) by conducting systematic literature search in electronic databases up to May 31, 2021. The main outcomes including overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and durable clinical benefit (DCB) were correlated with tumor genomic features. A total of 1546 lung cancer patients with available genomic variation data were included from 14 studies. The Kirsten rat sarcoma viral oncogene homolog
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/genetics ; Extracellular Matrix Proteins/genetics ; Immune Checkpoint Inhibitors/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins p21(ras)/genetics ; Treatment Outcome
Chemical Substances	ErbB Receptors (EC 2.7.10.1) ; Extracellular Matrix Proteins ; Immune Checkpoint Inhibitors ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; USH2A protein, human
Language	Chinese
Publishing date	2023-02-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2247290-3
ISSN	1862-1783 ; 1673-1581
ISSN (online)	1862-1783
ISSN	1673-1581
DOI	10.1631/jzus.B2200292
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Article ; Online: Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated

Ni, Heng / Tang, Song / Lu, Guang / Niu, Yuequn / Xu, Jinming / Zhang, Honghe / Hu, Jian / Shen, Han-Ming / Wu, Yihua / Xia, Dajing

Life science alliance

2024 Volume 7, Issue 6

Abstract: Since its first discovery, long noncoding RNA Linc00673 has been linked to carcinogenesis and metastasis of various human cancers. Linc00673 had five transcriptional isoforms and their biological functions remained to be explored. Here we have reported ... ...

Abstract	Since its first discovery, long noncoding RNA Linc00673 has been linked to carcinogenesis and metastasis of various human cancers. Linc00673 had five transcriptional isoforms and their biological functions remained to be explored. Here we have reported that Linc00673-V3, one of the isoforms of Linc00673, promoted non-small cell lung cancer chemoresistance, and increased Linc00673-V3 expression level was associated with enhanced autophagy. Mechanistically, we discerned the existence of a stem-loop configuration engendered by the 1-100-nt and 2200-2275-nt fragments within Linc00673-V3. This structure inherently interacted with Smad3, thereby impeding its ubiquitination and subsequent degradation orchestrated by E3 ligase STUB1. The accumulation of Smad3 contributed to autophagy via up-regulation of
MeSH term(s)	Humans ; Autophagy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Protein Isoforms ; Ubiquitin-Protein Ligases ; RNA, Long Noncoding/metabolism ; Smad3 Protein/metabolism ; Microtubule-Associated Proteins/metabolism
Chemical Substances	Protein Isoforms ; STUB1 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; long non-coding RNA SLNCR1, human ; RNA, Long Noncoding ; SMAD3 protein, human ; Smad3 Protein ; MAP1LC3B protein, human ; Microtubule-Associated Proteins
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202302408
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Article ; Online: High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer.

Shen, Yuqing / Lin, Hui / Chen, Kelie / Ge, Wanzhong / Xia, Dajing / Wu, Yihua / Lu, Weiguo

Journal of ovarian research

2022 Volume 15, Issue 1, Page(s) 48

Abstract: Background: Taxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood. Thus, we probed the mechanism of Taxol resistance in serous ovarian cancer with multiple bioinformatic ... ...

Abstract	Background: Taxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood. Thus, we probed the mechanism of Taxol resistance in serous ovarian cancer with multiple bioinformatic methods to provide novel insights into potential therapies. Methods: The differentially expressed genes (DEGs) in Taxol-sensitive and Taxol-resistant cell lines and their relationship with the overall survival (OS) and progression-free interval (PFI) of ovarian cancer patients were analyzed using gene expression datasets from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The role of receptor interacting serine/threonine kinase 2 (RIPK2) was validated via identification of its coexpressed genes, functional analysis and generation of a protein-protein interaction (PPI) network. The single sample gene set enrichment analysis (ssGSEA) was used to explore immune infiltration, and genomic alterations of RIPK2 were also analyzed via cBio Cancer Genomics Portal (cBioProtal). Results: RIPK2 was highly expressed in Taxol resistant ovarian cancer cell lines, and its high expression was also linked with shorter OS and PFI in serous ovarian cancer patients. The PPI network analysis and pathway analysis demonstrated that RIPK2 might participate in the positive regulation of NF-κB transcription factor activity. RIPK2 expression was related to tumor microenvironment alterations, which might participate in the formation of Taxol resistance. Conclusions: Our studies suggested that high expression of RIPK2 is related to Taxol resistance in serous ovarian cancer, and that RIPK2 induces Taxol resistance through NOD1/RIPK2/NF-κB inflammatory pathway activation and tumor microenvironment changes.
MeSH term(s)	Carcinoma, Ovarian Epithelial ; Cystadenocarcinoma, Serous/drug therapy ; Cystadenocarcinoma, Serous/genetics ; Cystadenocarcinoma, Serous/pathology ; Female ; Humans ; NF-kappa B/metabolism ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Receptor-Interacting Protein Serine-Threonine Kinase 2/genetics ; Receptor-Interacting Protein Serine-Threonine Kinase 2/metabolism ; Tumor Microenvironment/genetics
Chemical Substances	NF-kappa B ; RIPK2 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinase 2 (EC 2.7.11.1) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2455679-8
ISSN	1757-2215 ; 1757-2215
ISSN (online)	1757-2215
ISSN	1757-2215
DOI	10.1186/s13048-022-00986-2
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