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  1. AU=Atkinson Sarah H.
  2. AU=Ma Chunlong
  3. AU="Park, Youngjin"
  4. AU="Lakbita, Omar"
  5. AU=ElGokhy Sherin M
  6. AU="Stegmaier, Sabine"
  7. AU="Simons, Gemma N"
  8. AU="Domínguez-Zorita, Sonia"
  9. AU="Nakashima, Ayaka"
  10. AU="Skorecki, Karl"
  11. AU=Ibrahim Salwa
  12. AU=Geocadin Romergryko G
  13. AU="Leroy, J"
  14. AU="Wilson, Peter H"
  15. AU="Cunha, Carla Baroni"

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  1. Artikel: Universal iron supplementation: the best strategy to tackle childhood anaemia in malaria-endemic countries?

    Karthikappallil, Roshan / Atkinson, Sarah H

    Wellcome open research

    2023  Band 8, Seite(n) 345

    Abstract: Iron deficiency presents a major public health concern in many malaria-endemic regions, and both conditions affect young children most severely. Daily iron supplementation is the standard public health intervention recommended to alleviate rates of iron ... ...

    Abstract Iron deficiency presents a major public health concern in many malaria-endemic regions, and both conditions affect young children most severely. Daily iron supplementation is the standard public health intervention recommended to alleviate rates of iron deficiency in children, but there is controversy over whether universal supplementation could increase the incidence and severity of malaria infection. Current evidence suggests that iron supplementation of deficient individuals is safe and effective in high-transmission settings when accompanied by malaria prevention strategies. However, low-resource settings often struggle to effectively control the spread of malaria, and it remains unclear whether supplementation of iron replete individuals could increase their risk of malaria and other infections. This review explores the evidence for and against universal iron supplementation programmes, and alternative strategies that could be used to alleviate iron deficiency in malaria-endemic areas, while minimising potential harm.
    Sprache Englisch
    Erscheinungsdatum 2023-08-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.19750.1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Challenges in estimating the prevalence of vitamin D deficiency in Africa - Authors' reply.

    Mogire, Reagan M / Atkinson, Sarah H

    The Lancet. Global health

    2022  Band 10, Heft 4, Seite(n) e474

    Mesh-Begriff(e) Africa/epidemiology ; Humans ; Prevalence ; Vitamin D ; Vitamin D Deficiency/epidemiology
    Chemische Substanzen Vitamin D (1406-16-2)
    Sprache Englisch
    Erscheinungsdatum 2022-03-18
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(22)00040-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch ; Online: Chapter Review of the Central and South Atlantic Shelf and Deep-Sea Benthos: Science, Policy, and Management

    Bridges, Amelia E.H / Howell, Kerry L / Amaro, Teresa / Atkinson, Lara / Barnes, David K. A / Bax, Narissa / Bell, James B / Bernardino, Angelo F / Beuck, Lydia / Braga-Henriques, Andreia / Brandt, Angelika / Bravo, María E / Brix, Saskia / Butt, Stanley / Carranza, Alvar / Doti, Brenda L / Elegbede, Isa O / Esquete, Patricia / Freiwald, André /
    Gaudron, Sylvie M / Guilhon, Maila / Hebbeln, Dierk / Horton, Tammy / Kainge, Paulus / Kaiser, Stefanie / Lauretta, Daniel / Limongi, Pablo / McQuaid, Kirsty A / Milligan, Rosanna J / Miloslavich, Patricia / Narayanaswamy, Bhavani E / Orejas, Covadonga / Paulus, Sarah / Pearman, Tabitha R. R / Angel Perez, Jose A / Ross, Rebecca E / Saeedi, Hanieh / Shimabukuro, Mauricio / Sink, Kerry / Stevenson, Angela / Taylor, Michelle / Titschack, Jürgen / Vieira, Rui P / Vinha, Beatriz / Wienberg, Claudia

    2023  

    Schlagwörter Ecological science, the Biosphere ; Evolution ; Biology, life sciences ; Atlantic deep sea ; Benthic ecology ; Marine spatial planning ; Biodiversity patterns ; Gap analysis
    Sprache Englisch
    Umfang 1 electronic resource (91 pages)
    Verlag Taylor and Francis
    Erscheinungsort Boca Raton, Abingdon
    Dokumenttyp Buch ; Online
    Anmerkung English
    HBZ-ID HT030613088
    ISBN 9781003363873 ; 1003363873
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  4. Artikel: Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections.

    Abuga, Kelvin M / Nairz, Manfred / MacLennan, Calman A / Atkinson, Sarah H

    Wellcome open research

    2023  Band 8, Seite(n) 48

    Abstract: Severe anaemia and invasive bacterial infections remain important causes of hospitalization and death among young African children. The emergence and spread of antimicrobial resistance demand better understanding of bacteraemia risk factors to inform ... ...

    Abstract Severe anaemia and invasive bacterial infections remain important causes of hospitalization and death among young African children. The emergence and spread of antimicrobial resistance demand better understanding of bacteraemia risk factors to inform prevention strategies. Epidemiological studies have reported an association between severe anaemia and bacteraemia. In this review, we explore evidence that severe anaemia is associated with increased risk of invasive bacterial infections in young children. We describe mechanisms of iron dysregulation in severe anaemia that might contribute to increased risk and pathogenesis of invasive bacteria, recent advances in knowledge of how iron deficiency and severe anaemia impair immune responses to bacterial infections and vaccines, and the gaps in our understanding of mechanisms underlying severe anaemia, iron deficiency, and the risk of invasive bacterial infections.
    Sprache Englisch
    Erscheinungsdatum 2023-02-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.18829.1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Effects of iron intake on neurobehavioural outcomes in African children: a systematic review and meta-analysis of randomised controlled trials.

    Mutua, Agnes M / Mwangi, Kelvinson / Abubakar, Amina / Atkinson, Sarah H

    Wellcome open research

    2021  Band 6, Seite(n) 181

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2021-11-24
    Erscheinungsland England
    Dokumenttyp Systematic Review
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.16931.2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Ironing out sex differences in tuberculosis prevalence.

    Yates, Tom A / Atkinson, Sarah H

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2017  Band 21, Heft 5, Seite(n) 483–484

    Sprache Englisch
    Erscheinungsdatum 2017-05-01
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.17.0194
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: How Eliminating Malaria May Also Prevent Iron Deficiency in African Children.

    Muriuki, John Muthii / Atkinson, Sarah H

    Pharmaceuticals (Basel, Switzerland)

    2018  Band 11, Heft 4

    Abstract: Malaria and iron deficiency are common among children living in sub-Saharan Africa. Several studies have linked a child's iron status to their future risk of malaria infection; however, few have examined whether malaria might be a cause of iron ... ...

    Abstract Malaria and iron deficiency are common among children living in sub-Saharan Africa. Several studies have linked a child's iron status to their future risk of malaria infection; however, few have examined whether malaria might be a cause of iron deficiency. Approximately a quarter of African children at any one time are infected by malaria and malaria increases hepcidin and tumor necrosis factor-α concentrations leading to poor iron absorption and recycling. In support of a hypothetical link between malaria and iron deficiency, studies indicate that the prevalence of iron deficiency in children increases over a malaria season and decreases when malaria transmission is interrupted. The link between malaria and iron deficiency can be tested through the use of observational studies, randomized controlled trials and genetic epidemiology studies, each of which has its own strengths and limitations. Confirming the existence of a causal link between malaria infection and iron deficiency would readjust priorities for programs to prevent and treat iron deficiency and would demonstrate a further benefit of malaria control.
    Sprache Englisch
    Erscheinungsdatum 2018-10-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph11040096
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Biology of Anemia: A Public Health Perspective.

    Brittenham, Gary M / Moir-Meyer, Gemma / Abuga, Kelvin Mokaya / Datta-Mitra, Ananya / Cerami, Carla / Green, Ralph / Pasricha, Sant-Rayn / Atkinson, Sarah H

    The Journal of nutrition

    2023  Band 153 Suppl 1, Seite(n) S7–S28

    Abstract: Our goal is to present recent progress in understanding the biological mechanisms underlying anemia from a public health perspective. We describe important advances in understanding common causes of anemia and their interactions, including iron ... ...

    Abstract Our goal is to present recent progress in understanding the biological mechanisms underlying anemia from a public health perspective. We describe important advances in understanding common causes of anemia and their interactions, including iron deficiency (ID), lack of other micronutrients, infection, inflammation, and genetic conditions. ID develops if the iron circulating in the blood cannot provide the amounts required for red blood cell production and tissue needs. ID anemia develops as iron-limited red blood cell production fails to maintain the hemoglobin concentration above the threshold used to define anemia. Globally, absolute ID (absent or reduced body iron stores that do not meet the need for iron of an individual but may respond to iron supplementation) contributes to only a limited proportion of anemia. Functional ID (adequate or increased iron stores that cannot meet the need for iron because of the effects of infection or inflammation and does not respond to iron supplementation) is frequently responsible for anemia in low- and middle-income countries. Absolute and functional ID may coexist. We highlight continued improvement in understanding the roles of infections and inflammation in causing a large proportion of anemia. Deficiencies of nutrients other than iron are less common but important in some settings. The importance of genetic conditions as causes of anemia depends upon the specific inherited red blood cell abnormalities and their prevalence in the settings examined. From a public health perspective, each setting has a distinctive composition of components underlying the common causes of anemia. We emphasize the coincidence between regions with a high prevalence of anemia attributed to ID (both absolute and functional), those with endemic infections, and those with widespread genetic conditions affecting red blood cells, especially in sub-Saharan Africa and regions in Asia and Oceania.
    Mesh-Begriff(e) Humans ; Public Health ; Anemia/epidemiology ; Anemia/etiology ; Iron ; Anemia, Iron-Deficiency ; Iron Deficiencies ; Inflammation/complications ; Biology ; Prevalence
    Chemische Substanzen Iron (E1UOL152H7)
    Sprache Englisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1016/j.tjnut.2023.07.018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  9. Artikel ; Online: Effects of iron intake on neurobehavioural outcomes in African children

    Agnes M. Mutua / Kelvinson Mwangi / Amina Abubakar / Sarah H. Atkinson

    Wellcome Open Research, Vol

    a systematic review and meta-analysis of randomised controlled trials [version 2; peer review: 2 approved]

    2021  Band 6

    Abstract: Background: Iron deficiency and developmental delay are common in African children. While experimental studies indicate an important role of iron in brain development, effects of iron on child development remain unclear. We aimed to evaluate the effects ... ...

    Abstract Background: Iron deficiency and developmental delay are common in African children. While experimental studies indicate an important role of iron in brain development, effects of iron on child development remain unclear. We aimed to evaluate the effects of iron supplementation or fortification on neurobehavioural outcomes in African children and further summarise these effects in children living in non-African countries for comparison. Methods: We searched PubMed, EMBASE, PsycINFO, Scopus and Cochrane Library for studies published up to 22nd October 2021. We included randomised controlled trials (RCTs) evaluating effects of iron supplementation or fortification on neurobehavioural outcomes in children. Due to heterogeneity in study methods, we analysed all studies qualitatively and in secondary analyses only seven RCTs with 11 arms were meta-analysed. Results: We identified 2231 studies and included 35 studies (n=9988) in the systematic review. Only five studies (n=1294) included African children while 30 (n=8694) included children living in non-African countries. Of the five African studies, two (n=647) reported beneficial effects of iron supplementation on neurobehavioural outcomes in anaemic children, while three (n=647) found no beneficial effects. Of 30 studies in children living in non-African countries, 10 (n=3105) reported beneficial effects of iron supplementation or fortification on neurobehavioural outcomes, seven (n=786) reported beneficial effects only in children who had iron deficiency, iron deficiency anaemia or anaemia while 13 (n=4803) reported no beneficial effects. Conclusions: There are few studies in African children despite the high burden of iron deficiency and developmental delay in this population. Evidence on the effects of iron supplementation on neurobehavioural outcomes remains unclear and there is need for further well-powered studies evaluating these effects in African populations. PROSPERO registration: CRD42018091278 (20/03/2018)
    Schlagwörter Iron deficiency ; iron deficiency anaemia ; African children ; cognitive ; motor ; language ; eng ; Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag Wellcome
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children.

    Abuga, Kelvin M / Muriuki, John Muthii / Williams, Thomas N / Atkinson, Sarah H

    International journal of molecular sciences

    2020  Band 21, Heft 18

    Abstract: Severe anaemia and invasive bacterial infections are common causes of childhood sickness and death in sub-Saharan Africa. Accumulating evidence suggests that severely anaemic African children may have a higher risk of invasive bacterial infections. ... ...

    Abstract Severe anaemia and invasive bacterial infections are common causes of childhood sickness and death in sub-Saharan Africa. Accumulating evidence suggests that severely anaemic African children may have a higher risk of invasive bacterial infections. However, the mechanisms underlying this association remain poorly described. Severe anaemia is characterized by increased haemolysis, erythropoietic drive, gut permeability, and disruption of immune regulatory systems. These pathways are associated with dysregulation of iron homeostasis, including the downregulation of the hepatic hormone hepcidin. Increased haemolysis and low hepcidin levels potentially increase plasma, tissue and intracellular iron levels. Pathogenic bacteria require iron and/or haem to proliferate and have evolved numerous strategies to acquire labile and protein-bound iron/haem. In this review, we discuss how severe anaemia may mediate the risk of invasive bacterial infections through dysregulation of hepcidin and/or iron homeostasis, and potential studies that could be conducted to test this hypothesis.
    Mesh-Begriff(e) Africa ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/metabolism ; Anemia, Iron-Deficiency/pathology ; Bacterial Infections/etiology ; Bacterial Infections/metabolism ; Bacterial Infections/pathology ; Child ; Female ; Hepcidins/metabolism ; Humans ; Iron/metabolism ; Male ; Risk Factors ; Severity of Illness Index
    Chemische Substanzen HAMP protein, human ; Hepcidins ; Iron (E1UOL152H7)
    Sprache Englisch
    Erscheinungsdatum 2020-09-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21186976
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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