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  1. Article: Immunohistochemical study of p53 overexpression in radiation-induced colon cancers.

    Minami, K / Matsuzaki, S / Hayashi, N / Mokarim, A / Ito, M / Sekine, I

    Journal of radiation research

    1998  Volume 39, Issue 1, Page(s) 1–10

    Abstract: The expressions of p53 and proliferating cell nuclear antigen (PCNA) were studied immunohistochemically from paraffin sections of 7 cases (9 lesions) of radiation-induced colon cancer and 42 cases of spontaneous colon cancer. Age distribution of ... ...

    Abstract The expressions of p53 and proliferating cell nuclear antigen (PCNA) were studied immunohistochemically from paraffin sections of 7 cases (9 lesions) of radiation-induced colon cancer and 42 cases of spontaneous colon cancer. Age distribution of radiation-induced and spontaneous colon cancer were 68.1 years (range, 56 to 77 years) and 67.4 years (range, 31 to 85 years), respectively. Among the radiation-induced colon cancers, there were 3 lesions of mucinous carcinoma (33%), a much higher than found for spontaneous mucinous cancer. Immunohistochemically, p53 protein expression was detected in 7/9 (78%) of radiation-induced cancers and in 23/42 (55%) of spontaneous colon cancers. chi 2 analysis found no significant differences between radiation-induced and spontaneous colon cancers in age distribution or p53-positive staining for frequency, histopathology, or Dukes' classification. In radiation colitis around the cancers including aberrant crypts, spotted p53 staining and abnormal and scattered PCNA-positive staining were observed. In histologically normal cells, p53 staining was almost absent and PCNA-positive staining was regularly observed in the lower half of the crypt. In radiation colitis including aberrant glands, cellular proliferation increased and spotted p53 expression was observed. This study suggests that radiation colitis and aberrant glands might possess malignant potential and deeply associate with carcinogenesis of radiation-induced colon cancer.
    MeSH term(s) Adult ; Aged ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Female ; Gene Expression ; Genes, p53 ; Humans ; Immunohistochemistry ; Middle Aged ; Neoplasms, Radiation-Induced/genetics ; Neoplasms, Radiation-Induced/metabolism ; Neoplasms, Second Primary/genetics ; Neoplasms, Second Primary/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Uterine Cervical Neoplasms/radiotherapy
    Chemical Substances Proliferating Cell Nuclear Antigen ; Tumor Suppressor Protein p53
    Language English
    Publishing date 1998-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 603983-2
    ISSN 0449-3060
    ISSN 0449-3060
    DOI 10.1269/jrr.39.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Transarterial infusion of cisplatin and doxorubicin in bladder cancer.

    Mokarim, A / Uetani, M / Sakamoto, I / Hayashi, N / Nomata, K / Ohtani, H

    Acta oncologica (Stockholm, Sweden)

    1997  Volume 36, Issue 2, Page(s) 175–181

    Abstract: Forty-five patients (median age 63 years) with muscle invasive bladder cancer were treated with transcatheter intraarterial infusion (TAI) of cisplatin (CDDP) and doxorubicin. They received a total of 114 courses (median 3 courses per patient) of TAI. ... ...

    Abstract Forty-five patients (median age 63 years) with muscle invasive bladder cancer were treated with transcatheter intraarterial infusion (TAI) of cisplatin (CDDP) and doxorubicin. They received a total of 114 courses (median 3 courses per patient) of TAI. Complete response was obtained in 20 patients (44%), partial response in 17 (38%), stable disease in 6(13%), and progression of disease in 2 patients (5%). The overall response rate was 82% at a median follow-up of 36 months. The actuarial survival of the patient population was 72% at 5 years; 36 patients were alive and 9 had died of cancer progression. The treatment was generally extremely well tolerated without major complications. The current study also revealed the fact that papillary carcinomas were more sensitive to this therapy than were non-papillary tumors. Overall, response rate and local control were significantly higher in low-grade than in high-grade tumors. The observed high complete response and good survival rate suggest that intraarterial CDDP and doxorubicin might be highly effective for localized invasive bladder cancer.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/pathology ; Cisplatin/administration & dosage ; Disease Progression ; Doxorubicin/administration & dosage ; Female ; Humans ; Infusions, Intra-Arterial ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Doxorubicin (80168379AG) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 1997
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ISSN 0284-186X
    ISSN 0284-186X
    DOI 10.3109/02841869709109227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Combined intraarterial chemotherapy and radiotherapy in the treatment of bladder carcinoma.

    Mokarim, A / Uetani, M / Hayashi, N / Sakamoto, I / Minami, K / Ogawa, Y / Ochi, M / Matsuoka, Y / Hayashi, K / Nomata, K

    Cancer

    1997  Volume 80, Issue 9, Page(s) 1776–1785

    Abstract: Background: The combination of radiotherapy and cisplatin-based chemotherapy has proved to be an effective treatment for bladder carcinoma in many clinical studies. Intra-arterial approaches to chemotherapy have been developed to reduce systemic ... ...

    Abstract Background: The combination of radiotherapy and cisplatin-based chemotherapy has proved to be an effective treatment for bladder carcinoma in many clinical studies. Intra-arterial approaches to chemotherapy have been developed to reduce systemic toxicities and improve response rates. This study was designed to determine the effectiveness of intra-arterial chemotherapy with cisplatin and doxorubicin combined with radiotherapy in the treatment of patients with invasive bladder carcinoma. The objectives were to evaluate the response rate, bladder preservation rate, toxicity, and survival rate.
    Methods: Thirty-five patients with muscle-invasive bladder carcinoma at clinical stage T2-T4N0M0 were each treated with 2courses of intra-arterial cisplatin and doxorubicin at 3-week intervals, whereas radiotherapy was administered for 4 weeks (2 gray [Gy] given a total of 20 times, at 5 fractions per week). Patients with complete responses were given an additional course of chemotherapy (intra-arterial cisplatin and doxorubicin) and irradiation (20 Gy), and patients with residual tumor after the initial chemoradiotherapy underwent cystectomy.
    Results: A clinical complete response was observed in 26 patients (74%; 95% confidence interval, 59-89%), and an incomplete response was observed in 9 (26%; 95% confidence interval, 11-41%). The bladder was preserved in all patients with a complete response, and it was tumor free in 19 of them (54% of all patients). The actuarial survival rate was 76.6% at 5 years. After a median follow-up interval of 45 months, 28 patients (80%) were alive and 7 (20%) had died due to disease progression. The regimen was well tolerated, with no severe systemic or local toxicities.
    Conclusions: The high rates of response, survival, and bladder preservation observed indicate that this combined intra-arterial chemotherapy and radiotherapy regimen would be useful in the management of invasive bladder carcinoma. This was a small Phase II trial; the results are preliminary, and the utility of this treatment modality in patient management remains to be proven.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Combined Modality Therapy ; Doxorubicin/administration & dosage ; Doxorubicin/adverse effects ; Drug Administration Schedule ; Female ; Humans ; Injections, Intra-Arterial ; Male ; Middle Aged ; Radiotherapy Dosage ; Survival Analysis ; Treatment Outcome ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/radiotherapy
    Chemical Substances Doxorubicin (80168379AG) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 1997-11-01
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Review
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/(sici)1097-0142(19971101)80:9<1776::aid-cncr12>3.0.co;2-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.146: Show issues Location:
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