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Article ; Online: 2D reproduction of the face on the Turin Shroud by infrared femtosecond pulse laser processing.

Donnet, C / Granier, J / Vergé, G / Bleu, Y / Reynaud, S / Vocanson, F

Applied optics

2019 Volume 58, Issue 9, Page(s) 2158–2165

Abstract: Femtosecond pulse laser processing concentrates a huge quantity of light energy in extremely short pulses of a few tens to hundreds of femtoseconds, enabling superficial laser machining or marking of any kind of materials, with a reduced or insignificant ...

Abstract	Femtosecond pulse laser processing concentrates a huge quantity of light energy in extremely short pulses of a few tens to hundreds of femtoseconds, enabling superficial laser machining or marking of any kind of materials, with a reduced or insignificant heat affected area. A digitized paper printed image of the face on the Turin Shroud was used to monitor a scan head intercalated between a femtosecond pulsed laser source and a linen fabric sample, enabling the direct 2D reproduction of the image of the face with a laser beam size corresponding to one pixel of the digitized image. The contrast in the marked image was controlled by adjusting the energy density, the number of superimposed pulses per pixel, and the distance between successive impacts. The visual aspect of the laser-induced image is very similar, at naked eye, to the source image. The negative photograph of the marked linen fabric reveals a face remarkably close to the well-known negative picture of the face on the Turin Shroud. Analyses by infrared spectroscopy, Raman spectroscopy, and scanning electron microscopy were performed to characterize the laser marked areas.
Language	English
Publishing date	2019-01-31
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.58.002158
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Article ; Online: Myelodysplastic syndrome following chimeric antigen receptor T-cell therapy treated with allogenic stem cell transplantation.

Saleh, Khalil / Arbab, Ahmadreza / Ghez, David / Bigenwald, Camille / Cotteret, Sophie / Marzac, Christophe / Pasquier, Florence / Pilorge, Sylvain / Saada, Véronique / Vergé, Véronique / Ribrag, Vincent / Castilla-Llorente, Cristina

Immunotherapy

2023 Volume 15, Issue 6, Page(s) 401–407

Abstract: Chimeric antigen receptor (CAR) T-cell therapy is currently approved for the treatment of B-cell non-Hodgkin lymphomas and B-cell acute lymphoblastic leukemia. Prolonged hematological toxicity is an emergent concern following CAR T cells and occurred in ... ...

Abstract	Chimeric antigen receptor (CAR) T-cell therapy is currently approved for the treatment of B-cell non-Hodgkin lymphomas and B-cell acute lymphoblastic leukemia. Prolonged hematological toxicity is an emergent concern following CAR T cells and occurred in 30% of patients with unknown mechanism. Few cases of myelodysplastic syndrome (MDS) following CAR T-cell therapy were reported and attributed to previous chemotherapies in heavily pretreated patients. The authors report the case of a patient with diffuse large B-cell lymphoma treated with axicabtagene ciloleucel who developed prolonged hematological toxicity by day 28. During the follow-up, the diagnosis of MDS was made. The patient underwent allogenic hematological stem cell transplantation. The patient remains in complete remission of his lymphoma and MDS 19 months after hematological stem cell transplantation.
MeSH term(s)	Humans ; Immunotherapy, Adoptive/adverse effects ; Receptors, Chimeric Antigen ; Lymphoma, Large B-Cell, Diffuse ; Hematopoietic Stem Cell Transplantation ; Myelodysplastic Syndromes ; Antigens, CD19/therapeutic use ; Receptors, Antigen, T-Cell
Chemical Substances	Receptors, Chimeric Antigen ; Antigens, CD19 ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2022-0205
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Article ; Online: Involvement of ST6Gal I-mediated α2,6 sialylation in myoblast proliferation and differentiation.

Vergé, Caroline / Bouchatal, Amel / Chirat, Frédéric / Guérardel, Yann / Maftah, Abderrahman / Petit, Jean-Michel

FEBS open bio

2019 Volume 10, Issue 1, Page(s) 56–69

Abstract: Myogenesis is a physiological process which involves the proliferation of myoblasts and their differentiation into multinucleated myotubes, which constitute the future muscle fibers. Commitment of myoblasts to differentiation is regulated by the balance ... ...

Abstract	Myogenesis is a physiological process which involves the proliferation of myoblasts and their differentiation into multinucleated myotubes, which constitute the future muscle fibers. Commitment of myoblasts to differentiation is regulated by the balance between the myogenic factors Pax7 and MyoD. The formation of myotubes requires the presence of glycans, especially N-glycans, on the cell surface. We examined here the involvement of α2,6 sialylation during murine myoblastic C2C12 cell differentiation by generating a st6gal1-knockdown C2C12 cell line; these cells exhibit reduced proliferative potential and precocious differentiation due to the low expression of Pax7. The earlier fusion of st6gal1-knockdown cells leads to a high fusion index and a drop in reserve cells (Pax7
MeSH term(s)	Animals ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Mice ; Myoblasts/cytology ; Myoblasts/metabolism ; PAX7 Transcription Factor/genetics ; PAX7 Transcription Factor/metabolism ; Sialyltransferases/deficiency ; Sialyltransferases/metabolism
Chemical Substances	PAX7 Transcription Factor ; Pax7 protein, mouse ; Sialyltransferases (EC 2.4.99.-) ; beta-D-galactoside alpha 2-6-sialyltransferase (EC 2.4.99.1)
Language	English
Publishing date	2019-12-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.12745
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Article ; Online: Effect of Adapted Physical Activity in Patients With Advanced Pancreatic Cancer: The APACaP GERCOR Randomized Trial.

Neuzillet, Cindy / Bouché, Olivier / Tournigand, Christophe / Chibaudel, Benoist / Bauguion, Lucile / Bengrine-Lefevre, Leïla / Lopez-Trabada Ataz, Daniel / Mabro, May / Metges, Jean-Philippe / Péré-Vergé, Denis / Conroy, Thierry / Lièvre, Astrid / Andre, Morgan / Desseigne, Françoise / Goldwasser, François / Henriques, Julie / Anota, Amélie / Hammel, Pascal

Journal of the National Comprehensive Cancer Network : JNCCN

2023 Volume 21, Issue 12, Page(s) 1234–1242.e17

Abstract: Background: The impact of adapted physical activity (APA) on health-related quality of life (HRQoL) in patients with advanced pancreatic ductal adenocarcinoma (aPDAC) is unknown. This study evaluated whether APA in addition to standard care improved ... ...

Abstract	Background: The impact of adapted physical activity (APA) on health-related quality of life (HRQoL) in patients with advanced pancreatic ductal adenocarcinoma (aPDAC) is unknown. This study evaluated whether APA in addition to standard care improved HRQoL in patients who have aPDAC who are receiving first-line chemotherapy. Patients and methods: Patients with locally advanced/metastatic PDAC and an ECOG performance status of 0 to 2 were randomized (1:1) to receive standard care (standard arm) or standard care plus a home-based 16-week APA program (APA arm). The primary objective was the effect of the APA program on 3 dimensions of the EORTC QLQ-C30: global health status, physical function, and fatigue at week 16 (W16), with a one-sided type I error of 0.017 for each dimension. The primary HRQoL analysis was performed in patients with available baseline and W16 scores for the dimensions (ie, the modified intention-to-treat population 1 [mITT1]), and secondary longitudinal HRQoL analyses using the mixed model for repeated measures (MMRM) and time until definitive deterioration (TUDD) methods were performed in the mITT1 population and in patients with baseline and at least one follow-up questionnaire (mITT2 population). A difference of ≥5 points was considered to be clinically relevant. Results: Of 326 included patients, 313 were randomized to the standard (n=157) or APA (n=156) arms. In the mITT1 population (n=172), the mean differences in global health status, physical function, and fatigue at W16 adjusted from baseline were -0.98 (SD, 23.9; P=.39), -2.08 (SD, 21.3; P=.26), and 4.16 (SD, 29.2; P=.17), respectively, showing a non-statistically significant benefit with APA. In the mITT2 population (n=259), APA was associated with statistically significant and clinically relevant improvement in 5 and 8 dimensions of the HRQoL in the longitudinal MMRM and TUDD analyses, respectively. Conclusions: APA improved several dimensions of HRQoL in patients with aPDAC receiving first-line chemotherapy and standard care.
MeSH term(s)	Humans ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Fatigue/etiology ; Health Status ; Pancreatic Neoplasms/drug therapy ; Quality of Life ; Research Design ; Exercise
Language	English
Publishing date	2023-12-09
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2250759-0
ISSN	1540-1413 ; 1540-1405
ISSN (online)	1540-1413
ISSN	1540-1405
DOI	10.6004/jnccn.2023.7065
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Article ; Online: Proopiomelanocortin deficiency diagnosed in infancy in two boys and a review of the known cases.

Graves, Lara E / Khouri, Joseph M / Kristidis, Peter / Verge, Charles F

Journal of paediatrics and child health

2021 Volume 57, Issue 4, Page(s) 484–490

Abstract: ... years (c.133-2A>C) and at age 9 months (c.64del) due to infantile hyperphagic obesity. Neither patient ... whereas the only other reported case of c.64del had significant delay. This suggests, if ACTH deficiency is treated ...

Abstract	Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder characterised by adrenocorticotropic hormone (ACTH) deficiency, red hair and hyperphagic obesity. Two unrelated cases presented with hypoglycaemia due to isolated ACTH deficiency in the neonatal period. POMC deficiency was suspected at age 2 years (c.133-2A>C) and at age 9 months (c.64del) due to infantile hyperphagic obesity. Neither patient had a convincing red hair phenotype at the time of diagnostic suspicion, illustrating the importance of suspecting POMC deficiency in isolated ACTH deficiency. Both patients have normal psychomotor development, whereas the only other reported case of c.64del had significant delay. This suggests, if ACTH deficiency is treated early in the neonatal period, that psychomotor retardation is not a part of the phenotype. We review 24 reported cases of POMC deficiency published to date. Although there is no current specific treatment for obesity in POMC deficiency, we anticipate that setmelanotide may be a useful future treatment option.
MeSH term(s)	Adrenal Insufficiency/diagnosis ; Adrenocorticotropic Hormone ; Child, Preschool ; Humans ; Infant ; Male ; Obesity ; Pro-Opiomelanocortin/deficiency ; Pro-Opiomelanocortin/genetics
Chemical Substances	Pro-Opiomelanocortin (66796-54-1) ; Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2021-03-05
Publishing country	Australia
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.15407
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Article ; Online: Acute intermittent hypoxia alters disease course and promotes CNS repair including resolution of inflammation and remyelination in the experimental autoimmune encephalomyelitis model of MS.

Tokarska, Nataliya / Naniong, Justin M A / Johnston, Jayne M / Salapa, Hannah E / Muir, Gillian D / Levin, Michael C / Popescu, Bogdan F / Verge, Valerie M K

Glia

2023 Volume 71, Issue 8, Page(s) 2045–2066

Abstract: Remyelination and neurodegeneration prevention mitigate disability in Multiple Sclerosis (MS). We have shown acute intermittent hypoxia (AIH) is a novel, non-invasive and effective therapy for peripheral nerve repair, including remyelination. Thus, we ... ...

Abstract	Remyelination and neurodegeneration prevention mitigate disability in Multiple Sclerosis (MS). We have shown acute intermittent hypoxia (AIH) is a novel, non-invasive and effective therapy for peripheral nerve repair, including remyelination. Thus, we posited AIH would improve repair following CNS demyelination and address the paucity of MS repair treatments. AIH's capacity to enhance intrinsic repair, functional recovery and alter disease course in the experimental autoimmune encephalomyelitis (EAE) model of MS was assessed. EAE was induced by MOG
MeSH term(s)	Encephalomyelitis, Autoimmune, Experimental/pathology ; Encephalomyelitis, Autoimmune, Experimental/therapy ; Multiple Sclerosis/pathology ; Multiple Sclerosis/therapy ; Remyelination ; Animals ; Mice ; Mice, Inbred C57BL ; Anaerobiosis ; Oxygen ; Female
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639414-0
ISSN	1098-1136 ; 0894-1491
ISSN (online)	1098-1136
ISSN	0894-1491
DOI	10.1002/glia.24381
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Article ; Online: Crude and acid oils from olive pomace as alternative fat sources in growing-finishing pigs.

Verge-Mèrida, G / Barroeta, A C / Guardiola, F / Verdú, M / Balart, M / Font-I-Furnols, M / Solà-Oriol, D

Animal : an international journal of animal bioscience

2021 Volume 15, Issue 12, Page(s) 100389

Abstract: The inclusion of crude and acid oils from olive pomace can lead to more unsaturated meat products and, especially in the case of olive pomace acid oil, achieve a more economically and environmentally sustainable swine production. The objective of this ... ...

Abstract	The inclusion of crude and acid oils from olive pomace can lead to more unsaturated meat products and, especially in the case of olive pomace acid oil, achieve a more economically and environmentally sustainable swine production. The objective of this trial was to study the effect of dietary supplementation with crude and acid oils from olive pomace, which are rich in monounsaturated fatty acids (FAs) and have differing free FA content, on growth performance, digestibility, carcass parameters and FA profile of Longissimus muscle (LM) and backfat in growing-finishing pigs compared to the conventional crude palm oil. A total of 224 male and female pigs [(Landrace × Large White) × Duroc] were randomly distributed into 48 pens according to initial BW (58.7 ± 9.71 kg, mean ± SD) and sex. Four experimental treatments were randomly assigned (n = 12 pens/treatment; 4-5 pigs/pen) for the growing (0-42 days) and finishing (40-62 days) phases. Treatments consisted of a basal diet supplemented with 5% (as-fed basis) palm oil (PO), olive pomace oil (O), olive pomace acid oil (OA) or a mixture (M) of PO and OA at 50/50. No differences were found in the growth performance results between PO, O or M, but animals fed OA showed a lower gain to feed ratio than M (P = 0.008). No differences were found in apparent ileal digestibility among treatments, however, animals fed O and OA showed the highest values of total FA apparent total tract digestibility, while those fed PO had the lowest values, and M had intermediate values (P < 0.001). No differences were observed in carcass composition among treatments. In relation to backfat and the LM FA profile, O and OA treatments led to a higher unsaturated FA to saturated FA ratio and a lower content in saturated FA than PO. Moreover, O showed a higher intramuscular fat (IMF) content in LM than PO (P = 0.037). It is concluded that olive pomace oil is an interesting alternative fat source that can be included at 5% in growing-finishing pig diets, leading to meat products with more IMF, rich in monounsaturated FA, reaching high FA digestibility values and good pig performance parameters. Alternatively, olive pomace acid oil blended with conventional palm oil did not negatively impact fat utilisation nor performance. Including these fat by-products reduced feeding costs and led to a more efficient and environmentally sustainable production.
MeSH term(s)	Animals ; Body Composition ; Diet/veterinary ; Fatty Acids ; Female ; Male ; Olea ; Plant Oils ; Swine
Chemical Substances	Fatty Acids ; Plant Oils
Language	English
Publishing date	2021-11-27
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial, Veterinary
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2021.100389
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Article: Olive Pomace and Soybean-Sunflower Acid Oils as Alternative Fat Sources in European Seabass (

Verge-Mèrida, Gerard / Barroeta, Ana Cristina / Ferrer, Carlos / Serrano, Tània / Guardiola, Francesc / Soler, María Dolores / Sala, Roser

Animals : an open access journal from MDPI

2022 Volume 12, Issue 9

Abstract: ... pomace acid oil); 3 blends: S-O, S-OA, SA-OA at a 1:1 ratio; and a diet containing only fish oil (F ...

Abstract	The effects of dietary inclusion of soybean-sunflower and olive pomace acid oils on growth, digestibility and flesh composition were studied in European seabass. Eight diets were fed for 100 days (101.37 ± 0.33 g initial weight, mean ± SD), differing in the added fat source (25% fish oil, 75% experimental oil): S (crude soybean oil), SA (soybean-sunflower acid oil), O (crude olive pomace oil) or OA (olive pomace acid oil); 3 blends: S-O, S-OA, SA-OA at a 1:1 ratio; and a diet containing only fish oil (F) as a control. Animals fed OA showed the worst performance among dietary treatments, with the lowest weight, specific growth ratio, average daily gain and the highest feed conversion ratio (p < 0.01). In contrast, other diets including acid oils did not impair performance. Acid oil diets did not affect the apparent digestibility of dry matter, crude protein or total fatty acids (p > 0.05), but a lower digestibility of lipids and saturated fatty acids was observed (p < 0.001). Flesh composition and fatty acid profile were not affected by the high dietary free FA content (p > 0.05). Hence the results suggest that the studied acid oils may potentially be used in fish diets although further studies are needed.
Language	English
Publishing date	2022-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12091198
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Article ; Online: Predictors of Suicide Re-Attempt in a Spanish Adolescent Population after 12 Months' Follow-Up.

Alvarez-Subiela, Xavier / Castellano-Tejedor, Carmina / Verge-Muñoz, Mireia / Esnaola-Letemendia, Kike / Palao-Vidal, Diego / Villar-Cabeza, Francisco

International journal of environmental research and public health

2022 Volume 19, Issue 13

Abstract: Background: This study aims to identify the main predictive factors that allow for the recognition of adolescents with a higher risk of re-attempting suicide. Method: A longitudinal 12-month follow-up design was carried out in a sample of 533 Spanish ... ...

Abstract	Background: This study aims to identify the main predictive factors that allow for the recognition of adolescents with a higher risk of re-attempting suicide. Method: A longitudinal 12-month follow-up design was carried out in a sample of 533 Spanish adolescents between 12 and 17 years old. The data collection period comprised September 2013 to November 2016, including a one-year follow-up after hospital discharge. Results: A statistically significant regression model was obtained to predict suicide re-attempt at 12-months’ follow-up (χ2 = 34.843; p < 0.001; Nagelkerke R2 = 0.105), including personal history of self-injury (OR = 2.721, p < 0.001, 95% CI [1.706, 4.340]) and age (OR = 0.541, p = 0.009, 95% CI [0.340, 0.860]), correctly classifying 82.6% of the sample. Our results show that having a personal history of self-injury and being younger than 14 years old were predictors of suicide re-attempt during the first year after an adolescent’s first admission to emergency services. Conclusions: Considering these factors could contribute to the design of more tailored and effective interventions to prevent suicidal behavior in adolescents at high risk of re-attempting suicide.
MeSH term(s)	Adolescent ; Child ; Follow-Up Studies ; Humans ; Risk Factors ; Self-Injurious Behavior/epidemiology ; Suicidal Ideation ; Suicide ; Suicide, Attempted
Language	English
Publishing date	2022-06-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19137566
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Article ; Online: Isolated cerebral mucormycosis associated with intravenous drug use.

Durà-Miralles, X / Escolà-Vergé, L / Moreno, D / Martínez-Ricarte, F / Lung, M / Fernández-Hidalgo, N / Auger, C / Martín-Gómez, M-T

Journal de mycologie medicale

2020 Volume 30, Issue 4, Page(s) 101046

Abstract: We present an uncommon case of isolated basal ganglia mucormycosis in a patient without any known cause of immunosuppression, but with a history of drug injection. The patient presented a good clinical and radiological response to antifungal treatment ... ...

Abstract	We present an uncommon case of isolated basal ganglia mucormycosis in a patient without any known cause of immunosuppression, but with a history of drug injection. The patient presented a good clinical and radiological response to antifungal treatment without aggressive surgical debridement (liposomal amphotericin B combined with isavuconazole for 4 weeks followed by isavuconazole as maintenance therapy for 10 months).
MeSH term(s)	Amphotericin B/administration & dosage ; Central Nervous System Fungal Infections/diagnosis ; Central Nervous System Fungal Infections/drug therapy ; Central Nervous System Fungal Infections/etiology ; Central Nervous System Fungal Infections/microbiology ; Cocaine ; Cocaine-Related Disorders/complications ; Cocaine-Related Disorders/drug therapy ; Cocaine-Related Disorders/microbiology ; Drug Therapy, Combination ; Drug Users ; Humans ; Magnetic Resonance Imaging ; Male ; Marijuana Abuse/complications ; Marijuana Abuse/drug therapy ; Marijuana Abuse/microbiology ; Middle Aged ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Mucormycosis/etiology ; Mucormycosis/microbiology ; Nitriles/administration & dosage ; Pyridines/administration & dosage ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/diagnostic imaging ; Substance Abuse, Intravenous/drug therapy ; Substance Abuse, Intravenous/microbiology ; Triazoles/administration & dosage
Chemical Substances	Nitriles ; Pyridines ; Triazoles ; liposomal amphotericin B ; isavuconazole (60UTO373KE) ; Amphotericin B (7XU7A7DROE) ; Cocaine (I5Y540LHVR)
Language	English
Publishing date	2020-10-06
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	1067006-3
ISSN	1773-0449 ; 1156-5233
ISSN (online)	1773-0449
ISSN	1156-5233
DOI	10.1016/j.mycmed.2020.101046
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