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  1. Article ; Online: Inadvertent stem cell transfer demonstrating a way for tolerance induction.

    Pilat, Nina

    Kidney international

    2023  Volume 103, Issue 1, Page(s) 21–22

    Abstract: In this issue, Sobrino et al. present a case of hematopoietic chimerism and subsequent tolerance after isolated kidney transplantation in a pediatric patient with syndromic combined immune deficiency. This report not only highlights the chimerism ... ...

    Abstract In this issue, Sobrino et al. present a case of hematopoietic chimerism and subsequent tolerance after isolated kidney transplantation in a pediatric patient with syndromic combined immune deficiency. This report not only highlights the chimerism approach for tolerance induction in transplantation, but it is also the first evidence of hematopoietic stem cells in human kidneys. This commentary discusses the potency and risks of the chimerism approach for tolerance induction after solid organ transplantation, especially in (pediatric) patients with immune deficiencies.
    MeSH term(s) Humans ; Child ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Host Disease ; Immune Tolerance ; Organ Transplantation ; Transplantation Chimera ; Transplantation Tolerance ; Chimerism
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Case Reports ; Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The potential for Treg-enhancing therapies in transplantation.

    Steiner, Romy / Pilat, Nina

    Clinical and experimental immunology

    2022  Volume 211, Issue 2, Page(s) 122–137

    MeSH term(s) T-Lymphocytes, Regulatory ; Transplantation Tolerance ; Immune Tolerance ; Graft Rejection/prevention & control
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxac118
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 337: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Treg Therapy for the Induction of Immune Tolerance in Transplantation-Not Lost in Translation?

    Pilat, Nina / Steiner, Romy / Sprent, Jonathan

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment ... ...

    Abstract The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment increase morbidity and mortality in transplant patients. Regulatory T cells (Tregs) have proven to be efficient in the induction of allograft tolerance and prolongation of graft survival in numerous preclinical models, and treatment has now moved to the clinics. The results of the first Treg-based clinical trials seem promising, proving the feasibility and safety of Treg therapy in clinical organ transplantation. However, many questions regarding Treg phenotype, optimum dosage, antigen-specificity, adjunct immunosuppressants and efficacy remain open. This review summarizes the results of the first Treg-based clinical trials for tolerance induction in solid organ transplantation and recapitulates what we have learnt so far and which questions need to be resolved before Treg therapy can become part of daily clinical practice. In addition, we discuss new strategies being developed for induction of donor-specific tolerance in solid organ transplantation with the clinical aims of prolonged graft survival and minimization of immunosuppression.
    MeSH term(s) T-Lymphocytes, Regulatory ; Graft Rejection ; Immune Tolerance ; Organ Transplantation/adverse effects ; Immunosuppression Therapy/methods ; Transplantation Tolerance ; Immunosuppressive Agents/therapeutic use
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treg Therapies Revisited: Tolerance Beyond Deletion.

    Pilat, Nina / Sprent, Jonathan

    Frontiers in immunology

    2021  Volume 11, Page(s) 622810

    Abstract: Induction of immune tolerance is the Holy Grail in transplantation medicine and autoimmunity. Currently, patients are required to use immunosuppressive drugs for the rest of their lives, resulting in unwanted side effects and complication from global ... ...

    Abstract Induction of immune tolerance is the Holy Grail in transplantation medicine and autoimmunity. Currently, patients are required to use immunosuppressive drugs for the rest of their lives, resulting in unwanted side effects and complication from global suppression of the immune response. It is well established that regulatory T cells (Tregs) are critical for the maintenance of immune tolerance towards self-antigens by several mechanisms of immune regulation, in parallel with intrathymic deletion of self-reactive T cells during ontogeny. Therefore, approaches for increasing Treg numbers or function
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmune Diseases/therapy ; Clonal Deletion ; Graft Rejection/immunology ; Graft Rejection/pathology ; Graft Rejection/therapy ; Humans ; Immunotherapy ; T-Lymphocytes, Regulatory/transplantation ; Transplantation, Homologous
    Language English
    Publishing date 2021-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.622810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treg Therapy for the Induction of Immune Tolerance in Transplantation—Not Lost in Translation?

    Nina Pilat / Romy Steiner / Jonathan Sprent

    International Journal of Molecular Sciences, Vol 24, Iss 1752, p

    2023  Volume 1752

    Abstract: The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment ... ...

    Abstract The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment increase morbidity and mortality in transplant patients. Regulatory T cells (Tregs) have proven to be efficient in the induction of allograft tolerance and prolongation of graft survival in numerous preclinical models, and treatment has now moved to the clinics. The results of the first Treg-based clinical trials seem promising, proving the feasibility and safety of Treg therapy in clinical organ transplantation. However, many questions regarding Treg phenotype, optimum dosage, antigen-specificity, adjunct immunosuppressants and efficacy remain open. This review summarizes the results of the first Treg-based clinical trials for tolerance induction in solid organ transplantation and recapitulates what we have learnt so far and which questions need to be resolved before Treg therapy can become part of daily clinical practice. In addition, we discuss new strategies being developed for induction of donor-specific tolerance in solid organ transplantation with the clinical aims of prolonged graft survival and minimization of immunosuppression.
    Keywords transplantation ; regulatory T cells ; tolerance ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Editorial: Immunological Tolerance in Transplantation: More Than Deletion.

    Pilat, Nina / Wekerle, Thomas / Geissler, Edward K / Sprent, Jonathan

    Frontiers in immunology

    2022  Volume 13, Page(s) 959115

    MeSH term(s) Immune Tolerance ; Transplantation Tolerance
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.959115
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  7. Article ; Online: Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension.

    Fejes, Rebeka / Lutnik, Martin / Weisshaar, Stefan / Pilat, Nina / Wagner, Karl-Heinz / Stüger, Hans-Peter / Peake, Jonathan M / Woodman, Richard J / Croft, Kevin D / Bondonno, Catherine P / Hodgson, Jonathan M / Wolzt, Michael / Neubauer, Oliver

    Food & function

    2024  Volume 15, Issue 8, Page(s) 4065–4078

    Abstract: The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of ... ...

    Abstract The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate
    MeSH term(s) Humans ; Male ; Female ; Aged ; Middle Aged ; Nitrates/administration & dosage ; Nitrates/metabolism ; Beta vulgaris/chemistry ; Blood Pressure/drug effects ; Hypertension/diet therapy ; Hypertension/metabolism ; Hypertension/drug therapy ; Fruit and Vegetable Juices/analysis ; Cross-Over Studies ; Nitrites/analysis ; Saliva/chemistry ; Saliva/metabolism
    Chemical Substances Nitrates ; Nitrites
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo03749e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  8. Article ; Online: Joining Forces in Basic Science: ITS Meeting 2.0.

    Pilat, Nina / Issa, Fadi / Luo, Xunrong / Chong, Anita / Bromberg, Jonathan / Kotsch, Katja

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10843

    Abstract: The second International Transplant Science (ITS) meeting jointly organized by the European Society for Organ Transplantation (ESOT), the American Society of Transplantation (AST), and The Transplantation Society (TTS) took place in May 2022 in one of ... ...

    Abstract The second International Transplant Science (ITS) meeting jointly organized by the European Society for Organ Transplantation (ESOT), the American Society of Transplantation (AST), and The Transplantation Society (TTS) took place in May 2022 in one of Europe's most iconic cities: Berlin, Germany. The ITS meeting 2022 was designed to serve as an international platform for scientific discussions on the latest ground-breaking discoveries in the field, while providing an excellent opportunity to present cutting-edge research to the scientific community. We think this is fundamental for the exchange of new ideas and establishment of collaborative work between advanced transplant experts, young professionals and early-stage researchers and students. Scientific sessions tackled hot topics in transplantation such as mechanisms of tolerance, biomarkers, big data and artificial intelligence. Our educational pre-meeting focused on the breakthrough and challenges in single-cell multimodal omics. The program included panel discussions illuminating various topics concerning conflicts and problems related to gender, such as challenges for female scientists. Attendees returned to their institutes with not only profound knowledge of the latest discoveries, technologies, and concepts in basic and translational science, but also inspired and excited after discussions and networking sessions with fellow scientists which have been duly missed during the pandemic.
    MeSH term(s) Artificial Intelligence ; Female ; Germany ; Humans ; Immune Tolerance ; Organ Transplantation ; Transplants
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Impact of Graft-Resident Leucocytes on Treg Mediated Skin Graft Survival.

    Steiner, Romy / Weijler, Anna M / Wekerle, Thomas / Sprent, Jonathan / Pilat, Nina

    Frontiers in immunology

    2021  Volume 12, Page(s) 801595

    Abstract: The importance and exact role of graft-resident leucocytes (also referred to as passenger leucocytes) in transplantation is controversial as these cells have been reported to either initiate or retard graft rejection. T cell activation to allografts is ... ...

    Abstract The importance and exact role of graft-resident leucocytes (also referred to as passenger leucocytes) in transplantation is controversial as these cells have been reported to either initiate or retard graft rejection. T cell activation to allografts is mediated
    MeSH term(s) Allografts/immunology ; Animals ; Graft Rejection/immunology ; Graft Survival/immunology ; Immune Tolerance/immunology ; Leukocytes/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Skin Transplantation ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2021-11-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.801595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Combining Adoptive Treg Transfer with Bone Marrow Transplantation for Transplantation Tolerance.

    Pilat, Nina / Granofszky, Nicolas / Wekerle, Thomas

    Current transplantation reports

    2017  Volume 4, Issue 4, Page(s) 253–261

    Abstract: Purpose of review: The mixed chimerism approach is an exceptionally potent strategy for the induction of donor-specific tolerance in organ transplantation and so far the only one that was demonstrated to work in the clinical setting. Regulatory T cells ( ...

    Abstract Purpose of review: The mixed chimerism approach is an exceptionally potent strategy for the induction of donor-specific tolerance in organ transplantation and so far the only one that was demonstrated to work in the clinical setting. Regulatory T cells (Tregs) have been shown to improve chimerism induction in experimental animal models. This review summarizes the development of innovative BMT protocols using therapeutic Treg transfer for tolerance induction.
    Recent findings: Treg cell therapy promotes BM engraftment in reduced conditioning protocols in both, mice and non-human primates. In mice, transfer of polyclonal recipient Tregs was sufficient to substitute cytotoxic recipient conditioning. Treg therapy prevented chronic rejection of skin and heart allografts related to tissue-specific antigen disparities, in part by promoting intragraft Treg accumulation.
    Summary: Adoptive Treg transfer is remarkably effective in facilitating BM engraftment in reduced-intensity protocols in mice and non-human primates. Furthermore, it promotes regulatory mechanisms that prevent chronic rejection.
    Language English
    Publishing date 2017-11-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2196-3029
    ISSN 2196-3029
    DOI 10.1007/s40472-017-0164-7
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