Article ; Online: Making COVID-19 mRNA vaccines accessible: challenges resolved.
2022 Volume 21, Issue 9, Page(s) 1163–1176
Abstract: Introduction: The rapid spread of SARS-CoV2 infection allowed testing of mRNA vaccines ...
Abstract | Introduction: The rapid spread of SARS-CoV2 infection allowed testing of mRNA vaccines that translate the target antigen, unlike introducing antigens in traditional vaccines. It proved safer and more effective and, as a chemical vaccine, much easier to develop and manufacture. Areas covered: The science and technology behind the mRNA vaccines are pertinent to establishing low-cost manufacturing of reverse-engineered mRNA vaccines, as suggested by the WHO. A stepwise approach to establishing a compliant manufacturing facility, testing, supply chain, regulatory submissions, and intellectual property handling is presented. Expert opinion: mRNA technology is more straightforward, and the cost of establishing a manufacturing facility is affordable, even in developing countries. The technology and supplies are widely available; however, based on experience, several misconceptions and misunderstandings about mRNA vaccines need to be removed, such as the regulatory and intellectual property issues that are resolved in this paper. |
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MeSH term(s) | COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; RNA, Viral ; SARS-CoV-2/genetics ; Vaccines ; Vaccines, Synthetic ; mRNA Vaccines |
Chemical Substances | COVID-19 Vaccines ; RNA, Viral ; Vaccines ; Vaccines, Synthetic ; mRNA Vaccines |
Language | English |
Publishing date | 2022-06-17 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2181284-6 |
ISSN | 1744-8395 ; 1476-0584 |
ISSN (online) | 1744-8395 |
ISSN | 1476-0584 |
DOI | 10.1080/14760584.2022.2089121 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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