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Article ; Online: EYSIER Charter Mark with ABCDE and Assessment for Personal and Social Learning; a Bottom-up Approach to Building Faculty of Judgement with an Open Access Knowledge Base of Science with and for Society (Swafs)

European Journal of Education; Vol 3 No; 129-150 ; 2601-8624 ; 2601-8616

2020 Volume 2, Issue : May - August 2020

Abstract: ... Young Societal Innovators for Equity and Renewal (EYSIER) Charter Mark to align commercial, humanitarian ...

Abstract	Civic society must mobilise education and training to move from Covid 19 disruption to recovery to meet the goals established by the President of the European Commission « A Union that strives for more » and promoted through the European Education Area. Using Five stages of ‘A Blueprint for Character Development for Evolution’ (ABCDE), citizens map their journey to making good decisions in a new social contract to amplify recovery. A is European Qualifications Framework (EQF) Level 1 to ask good questions to solve problems; What is social distancing? How can I optimise success in virtual-classrooms? How can I safely create a new job for myself? B is EQF Competence Level 2 and focusses to explore the best that has been thought and said from explicit Scientific/social knowledge and synthesise it with implicit personal knowledge/beliefs, to gain shared understandings of definitions of terms. C is EQF Competence Level 3 to develop robust methods for data-collection/handling to find solutions to personal and social, cultural, health, economic and political problems. D is EQF Competence Level 4 to develop theories of change from data as solutions to social and personal problems for recovery. E is EQF Competence Level 5 to develop moral and ethical principles in a new social contract. ABCDE is implemented with ‘Assessment for Personal and Social Learning’, A Massive Online Open-Access Course, and toolkit to gain the Empowering Young Societal Innovators for Equity and Renewal (EYSIER) Charter Mark to align commercial, humanitarian evolutionary and sustainable goals to propel recovery.
Keywords	covid19
Subject code	300
Language	English
Publishing date	2020-08-15
Publisher	European Center for Science Education and Research
Publishing country	eu
Document type	Article ; Online
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Article ; Online: Marked variation in out-of-pocket costs for cancer care in Western Australia.

Slavova-Azmanova, Neli S / Newton, Jade C / Saunders, Christobel M

The Medical journal of Australia

2020 Volume 212, Issue 11, Page(s) 525–526

MeSH term(s)	Adult ; Cost of Illness ; Female ; Health Expenditures/statistics & numerical data ; Healthcare Disparities/economics ; Humans ; Male ; Middle Aged ; Neoplasms/economics ; Western Australia
Language	English
Publishing date	2020-04-20
Publishing country	Australia
Document type	Letter
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.50590
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Article ; Online: Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers.

Scharpf, Robert B / Balan, Archana / Ricciuti, Biagio / Fiksel, Jacob / Cherry, Christopher / Wang, Chenguang / Lenoue-Newton, Michele L / Rizvi, Hira A / White, James R / Baras, Alexander S / Anaya, Jordan / Landon, Blair V / Majcherska-Agrawal, Marta / Ghanem, Paola / Lee, Jocelyn / Raskin, Leon / Park, Andrew S / Tu, Huakang / Hsu, Hil /

Arbour, Kathryn C / Awad, Mark M / Riely, Gregory J / Lovly, Christine M / Anagnostou, Valsamo

Cancer research

2022 Volume 82, Issue 21, Page(s) 4058–4078

Abstract: ... gene expression programs pointing to differential recruitment of cancer hallmarks as well as phenotypic ...

Abstract	The RAS family of small GTPases represents the most commonly activated oncogenes in human cancers. To better understand the prevalence of somatic RAS mutations and the compendium of genes that are coaltered in RAS-mutant tumors, we analyzed targeted next-generation sequencing data of 607,863 mutations from 66,372 tumors in 51 cancer types in the AACR Project GENIE Registry. Bayesian hierarchical models were implemented to estimate the cancer-specific prevalence of RAS and non-RAS somatic mutations, to evaluate co-occurrence and mutual exclusivity, and to model the effects of tumor mutation burden and mutational signatures on comutation patterns. These analyses revealed differential RAS prevalence and comutations with non-RAS genes in a cancer lineage-dependent and context-dependent manner, with differences across age, sex, and ethnic groups. Allele-specific RAS co-mutational patterns included an enrichment in NTRK3 and chromatin-regulating gene mutations in KRAS G12C-mutant non-small cell lung cancer. Integrated multiomic analyses of 10,217 tumors from The Cancer Genome Atlas (TCGA) revealed distinct genotype-driven gene expression programs pointing to differential recruitment of cancer hallmarks as well as phenotypic differences and immune surveillance states in the tumor microenvironment of RAS-mutant tumors. The distinct genomic tracks discovered in RAS-mutant tumors reflected differential clinical outcomes in TCGA cohort and in an independent cohort of patients with KRAS G12C-mutant non-small cell lung cancer that received immunotherapy-containing regimens. The RAS genetic architecture points to cancer lineage-specific therapeutic vulnerabilities that can be leveraged for rationally combining RAS-mutant allele-directed therapies with targeted therapies and immunotherapy. Significance: The complex genomic landscape of RAS-mutant tumors is reflective of selection processes in a cancer lineage-specific and context-dependent manner, highlighting differential therapeutic vulnerabilities that can be clinically translated.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Bayes Theorem ; Proto-Oncogene Proteins p21(ras)/genetics ; Mutation ; Genomics ; Tumor Microenvironment
Chemical Substances	Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-22-1731
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Book ; Online ; E-Book: Neurological complications of systemic cancer and antineoplastic therapy

Newton, Herbert B. / Malkin, Mark G.

2022

Author's details	edited by Herbert B. Newton, Mark G. Malkin
Keywords	Electronic books ; Central Nervous System Neoplasms / secondary ; Neoplasm Metastasis ; Antineoplastic Agents / adverse effects ; Central Nervous System / drug effects ; Central Nervous System / radiation effects ; Neoplasms / complications
Language	English
Size	1 Online-Ressource (xix, 657 Seiten), Illustrationen, Diagramme
Edition	Second edtion
Publisher	Elsevier Academic Press
Publishing place	London
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021299661
ISBN	978-0-12-821977-5 ; 9780128219768 ; 0-12-821977-7 ; 0128219769
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Epigenetic marking and neuronal plasticity.

Duman, Ronald S / Newton, Samuel S

Biological psychiatry

2007 Volume 62, Issue 1, Page(s) 1–3

MeSH term(s)	Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Central Nervous System Diseases/physiopathology ; Chromatin Assembly and Disassembly/drug effects ; Chromatin Assembly and Disassembly/physiology ; DNA Methylation ; Epigenesis, Genetic/physiology ; Gene Expression Regulation/physiology ; Humans ; Memory/physiology ; Mental Disorders/drug therapy ; Mental Disorders/physiopathology ; Neuronal Plasticity/physiology ; Neurons/physiology ; Psychotropic Drugs/pharmacology ; Psychotropic Drugs/therapeutic use ; Schizophrenia/physiopathology
Chemical Substances	Antidepressive Agents ; Psychotropic Drugs
Language	English
Publishing date	2007-07-01
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2007.04.037
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Article ; Online: Trophic assimilation efficiency markedly increases at higher trophic levels in four-level host-parasitoid food chain.

Sanders, Dirk / Moser, Andrea / Newton, Jason / van Veen, F J Frank

Proceedings. Biological sciences

2016 Volume 283, Issue 1826, Page(s) 20153043

Abstract: ... that can act at the fourth and fifth trophic levels, we show markedly increased trophic assimilation ...

Abstract	Trophic assimilation efficiency (conversion of resource biomass into consumer biomass) is thought to be a limiting factor for food chain length in natural communities. In host-parasitoid systems, which account for the majority of terrestrial consumer interactions, a high trophic assimilation efficiency may be expected at higher trophic levels because of the close match of resource composition of host tissue and the consumer's resource requirements, which would allow for longer food chains. We measured efficiency of biomass transfer along an aphid-primary-secondary-tertiary parasitoid food chain and used stable isotope analysis to confirm trophic levels. We show high efficiency in biomass transfer along the food chain. From the third to the fourth trophic level, the proportion of host biomass transferred was 45%, 65% and 73%, respectively, for three secondary parasitoid species. For two parasitoid species that can act at the fourth and fifth trophic levels, we show markedly increased trophic assimilation efficiencies at the higher trophic level, which increased from 45 to 63% and 73 to 93%, respectively. In common with other food chains, δ(15)N increased with trophic level, with trophic discrimination factors (Δ(15)N) 1.34 and 1.49‰ from primary parasitoids to endoparasitic and ectoparasitic secondary parasitoids, respectively, and 0.78‰ from secondary to tertiary parasitoids. Owing to the extraordinarily high efficiency of hyperparasitoids, cryptic higher trophic levels may exist in host-parasitoid communities, which could alter our understanding of the dynamics and drivers of community structure of these important systems.
MeSH term(s)	Animals ; Aphids/parasitology ; Biomass ; Female ; Food Chain ; Host-Parasite Interactions ; Larva/growth & development ; Larva/parasitology ; Larva/physiology ; Switzerland ; Wasps/growth & development ; Wasps/parasitology ; Wasps/physiology
Language	English
Publishing date	2016-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2015.3043
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Zs.A 1364: Show issues

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Article ; Online: Is shape in the eye of the beholder? Assessing landmarking error in geometric morphometric analyses on live fish.

Moccetti, Paolo / Rodger, Jessica R / Bolland, Jonathan D / Kaiser-Wilks, Phoebe / Smith, Rowan / Nunn, Andy D / Adams, Colin E / Bright, Jen A / Honkanen, Hannele M / Lothian, Angus J / Newton, Matthew / Joyce, Domino A

PeerJ

2023 Volume 11, Page(s) e15545

Abstract: ... four independent operators that applied an identical landmarking scheme to replicate photographs of 291 ...

Abstract	Geometric morphometrics is widely used to quantify morphological variation between biological specimens, but the fundamental influence of operator bias on data reproducibility is rarely considered, particularly in studies using photographs of live animals taken under field conditions. We examined this using four independent operators that applied an identical landmarking scheme to replicate photographs of 291 live Atlantic salmon (
MeSH term(s)	Animals ; Reproducibility of Results ; Information Dissemination ; Research Design ; Rivers ; Salmo salar
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15545
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Article ; Online: The Enigma of Methanol Synthesis by Cu/ZnO/Al

Beck, Arik / Newton, Mark A / van de Water, Leon G A / van Bokhoven, Jeroen A

Chemical reviews

2024 Volume 124, Issue 8, Page(s) 4543–4678

Abstract: The activity and durability of the Cu/ZnO/ ... ...

Abstract	The activity and durability of the Cu/ZnO/Al
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207949-5
ISSN	1520-6890 ; 0009-2665
ISSN (online)	1520-6890
ISSN	0009-2665
DOI	10.1021/acs.chemrev.3c00148
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Article ; Online: Global pediatric surgery and anesthesia inequities: how do we have a global effort?

Niconchuk, Jonathan A / Newton, Mark W

Current opinion in anaesthesiology

2022 Volume 35, Issue 3, Page(s) 351–356

Abstract: Purpose of review: The SARS-CoV-2 (COVID-19) pandemic has highlighted the inequities in access to healthcare while also revealing our global connectivity. These inequities are emblematic of decades of underinvestment in healthcare systems, education, ... ...

Abstract	Purpose of review: The SARS-CoV-2 (COVID-19) pandemic has highlighted the inequities in access to healthcare while also revealing our global connectivity. These inequities are emblematic of decades of underinvestment in healthcare systems, education, and research in low-middle income countries (LMICs), especially in surgery and anesthesiology. Five billion people remain without access to safe surgery, and we must take appropriate action now. Recent findings: The pediatric perioperative mortality in low-resourced settings may be as high as 100 times greater than in high-resourced settings, and a pediatric surgery workforce density benchmark of 4/1 million population could increase survivability to over 80%. Delay in treatment for congenital surgically correctable issues dramatically increases disability-adjusted life years. Appropriate academic partnerships which promote education are desired but the lack of authorship position priority for LMIC-based researchers must be addressed. Five perioperative benchmark indicators have been published including: geospatial access to care within 2 h of location; workforce/100,000 population; volume of surgery/100,000 population; perioperative mortality within 30 days of surgery or until discharged; and risks for catastrophic expenditure from surgical care. Summary: Research that determines ethical and acceptable partnership development between high- and low-resourced settings focusing on education and capacity building needs to be standardized and followed.
MeSH term(s)	Anesthesia/adverse effects ; Anesthesiology ; COVID-19 ; Child ; Developing Countries ; Global Health ; Humans ; SARS-CoV-2 ; Workforce
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645203-6
ISSN	1473-6500 ; 0952-7907
ISSN (online)	1473-6500
ISSN	0952-7907
DOI	10.1097/ACO.0000000000001122
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Zs.A 2564: Show issues

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Article ; Online: Is shape in the eye of the beholder? Assessing landmarking error in geometric morphometric analyses on live fish

Paolo Moccetti / Jessica R. Rodger / Jonathan D. Bolland / Phoebe Kaiser-Wilks / Rowan Smith / Andy D. Nunn / Colin E. Adams / Jen A. Bright / Hannele M. Honkanen / Angus J. Lothian / Matthew Newton / Domino A. Joyce

PeerJ, Vol 11, p e

2023 Volume 15545

Abstract: ... four independent operators that applied an identical landmarking scheme to replicate photographs of 291 ... a systematic error despite following the same landmarking scheme. No significant differences were detected ... when the landmarking process was repeated by the same operator on a random subset of photographs. Importantly, in spite ...

Abstract	Geometric morphometrics is widely used to quantify morphological variation between biological specimens, but the fundamental influence of operator bias on data reproducibility is rarely considered, particularly in studies using photographs of live animals taken under field conditions. We examined this using four independent operators that applied an identical landmarking scheme to replicate photographs of 291 live Atlantic salmon (Salmo salar L.) from two rivers. Using repeated measures tests, we found significant inter-operator differences in mean body shape, suggesting that the operators introduced a systematic error despite following the same landmarking scheme. No significant differences were detected when the landmarking process was repeated by the same operator on a random subset of photographs. Importantly, in spite of significant operator bias, small but statistically significant morphological differences between fish from the two rivers were found consistently by all operators. Pairwise tests of angles of vectors of shape change showed that these between-river differences in body shape were analogous across operator datasets, suggesting a general reproducibility of findings obtained by geometric morphometric studies. In contrast, merging landmark data when fish from each river are digitised by different operators had a significant impact on downstream analyses, highlighting an intrinsic risk of bias. Overall, we show that, even when significant inter-operator error is introduced during digitisation, following an identical landmarking scheme can identify morphological differences between populations. This study indicates that operators digitising at least a sub-set of all data groups of interest may be an effective way of mitigating inter-operator error and potentially enabling data sharing.
Keywords	Measurement error ; Bias ; Landmarks ; Morphometrics ; Replication crisis ; Reproducibility ; Medicine ; R
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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