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  1. Article ; Online: Is miR-223 Upregulation in Inflammatory Bowel Diseases a Protective Response?

    Chen, Jiezhong / Vitetta, Luis

    Frontiers in bioscience (Elite edition)

    2023  Volume 15, Issue 1, Page(s) 5

    Abstract: Inflammatory bowel diseases (IBD) are characterized by chronic inflammation and damage of colonocytes with etiology of genetic, epigenetic and environmental factors. MicroRNA-223 (miR-223) has been found to be increased in both IBD patients and animal ... ...

    Abstract Inflammatory bowel diseases (IBD) are characterized by chronic inflammation and damage of colonocytes with etiology of genetic, epigenetic and environmental factors. MicroRNA-223 (miR-223) has been found to be increased in both IBD patients and animal colitis models. However, contentious opinions relevant to the roles of miR-223 in IBD have been reported. Notwithstading that most studies have described that miR-223 has anti-inflammatory effects, several reports have progressed a pro-inflammatory view. In this review, we summarise both the anti-inflammatory and pro-inflammatory effects of miR-223 on key molecules in inflammatory responses in both animal models and in patients diagnosed with IBD and objectively discuss the possible basis for the discrepancies.
    MeSH term(s) Animals ; Colitis/genetics ; Inflammation ; Inflammatory Bowel Diseases/genetics ; MicroRNAs/genetics ; Up-Regulation ; Humans
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-03-23
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2565080-4
    ISSN 1945-0508 ; 1945-0494
    ISSN (online) 1945-0508
    ISSN 1945-0494
    DOI 10.31083/j.fbe1501005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gut-brain axis in the neurological comorbidity of COVID-19.

    Chen, Jiezhong / Vitetta, Luis

    Brain communications

    2021  Volume 3, Issue 2, Page(s) fcab118

    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcab118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gut Dysbiosis Could Be a Major Factor for the Effects of Low-Grade Endotoxemia in COVID-19 Comment on: Low-Grade Endotoxemia and Thrombosis in COVID-19.

    Chen, Jiezhong / Vitetta, Luis

    Clinical and translational gastroenterology

    2022  Volume 13, Issue 1, Page(s) e00440

    MeSH term(s) COVID-19 ; Dysbiosis ; Endotoxemia ; Humans ; SARS-CoV-2 ; Thrombosis/etiology
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cancer Metastasis-on-a-Chip for Modeling Metastatic Cascade and Drug Screening.

    Brooks, Anastasia / Zhang, Yali / Chen, Jiezhong / Zhao, Chun-Xia

    Advanced healthcare materials

    2024  , Page(s) e2302436

    Abstract: Microfluidic chips are valuable tools for studying intricate cellular and cell-microenvironment interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities of in vivo tumor microenvironment. However, cancer-metastasis-on- ... ...

    Abstract Microfluidic chips are valuable tools for studying intricate cellular and cell-microenvironment interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities of in vivo tumor microenvironment. However, cancer-metastasis-on-a-chip (CMoC) models combine the advantages of 3D cultures and microfluidic technology, serving as powerful platforms for exploring cancer mechanisms and facilitating drug screening. These chips are able to compartmentalize the metastatic cascade, deepening the understanding of its underlying mechanisms. This article provides an overview of current CMoC models, focusing on distinctive models that simulate invasion, intravasation, circulation, extravasation, and colonization, and their applications in drug screening. Furthermore, challenges faced by CMoC and microfluidic technologies are discussed, while exploring promising future directions in cancer research. The ongoing development and integration of these models into cancer studies are expected to drive transformative advancements in the field.
    Language English
    Publishing date 2024-01-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202302436
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  5. Article ; Online: The gut-liver axis in chronic liver disease associated with severe COVID-19.

    Chen, Jiezhong / Vitetta, Luis

    European journal of gastroenterology & hepatology

    2021  Volume 33, Issue 1S Suppl 1, Page(s) e1103

    MeSH term(s) COVID-19 ; Humans ; Liver ; Liver Diseases/diagnosis ; Liver Diseases/etiology ; SARS-CoV-2
    Language English
    Publishing date 2021-10-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000002290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2932: Show issues Location:
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  6. Article ; Online: Intestinal dysbiosis in celiac disease: Decreased butyrate production may facilitate the onset of the disease.

    Chen, Jiezhong / Vitetta, Luis

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 41

    MeSH term(s) Butyrates ; Celiac Disease ; Dysbiosis ; Gastrointestinal Microbiome ; Humans ; Intestinal Mucosa
    Chemical Substances Butyrates
    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2113655118
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    Zs.A 1148: Show issues Location:
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  7. Article ; Online: Commensal bacterial metabolites may strengthen the effect of anti-IL6 treatment for COVID-19.

    Chen, Jiezhong / Vitetta, Luis

    Clinical immunology (Orlando, Fla.)

    2021  Volume 232, Page(s) 108870

    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19 ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2021.108870
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    Zs.A 880: Show issues Location:
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  8. Article ; Online: Editorial: Signalling Pathways in Virus-caused Cancers.

    Chen, Jiezhong

    Current cancer drug targets

    2017  Volume 17, Issue 6, Page(s) 496–497

    MeSH term(s) Humans ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; Signal Transduction ; Virus Diseases/complications
    Language English
    Publishing date 2017-08-22
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2064824-8
    ISSN 1873-5576 ; 1568-0096
    ISSN (online) 1873-5576
    ISSN 1568-0096
    DOI 10.2174/156800961706170630192514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5589: Show issues Location:
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  9. Article ; Online: The Role of the Gut-Lung Axis in COVID-19 Infections and Its Modulation to Improve Clinical Outcomes.

    Chen, Jiezhong / Vitetta, Luis

    Frontiers in bioscience (Scholar edition)

    2022  Volume 14, Issue 3, Page(s) 23

    Abstract: The main entry point of SARS-CoV-2 is the respiratory tract and as such immune defence in this site determines if the virus will spill-over to the systemic circulation and circulate and infect other major organs. The first line of mucosal immune defence ... ...

    Abstract The main entry point of SARS-CoV-2 is the respiratory tract and as such immune defence in this site determines if the virus will spill-over to the systemic circulation and circulate and infect other major organs. The first line of mucosal immune defence is composed of mucins, an epithelial barrier, and immune cells in the nasal cavity. The lung immune defence is carried out by numerous alveoli. The lung microbiota is a key factor in determining the efficacy of lung mucosal immunity protection. The intestinal microbiota has been demonstrated to affect the severity of COVID-19. Gut dysbiosis is involved in hyperinflammation and multiple organ failure through communications with multiple organs. The gut lung axis could be the earliest axis affected in COVID-19. Through the gut-lung axis, gut dysbiosis can affect the pathogenesis of the lung in COVID-19. In this review, we summarise the effects that gut dysbiosis can progress on the lung, and the lung microbiota. The possible mechanisms and approaches for modulation are discussed.
    MeSH term(s) COVID-19 ; Dysbiosis ; Humans ; Lung ; Mucins ; SARS-CoV-2
    Chemical Substances Mucins
    Language English
    Publishing date 2022-09-06
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2565100-6
    ISSN 1945-0524 ; 1945-0516
    ISSN (online) 1945-0524
    ISSN 1945-0516
    DOI 10.31083/j.fbs1403023
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    Zs.A 7071: Show issues Location:
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  10. Article ; Online: Increased PD-L1 Expression May Be Associated With the Cytokine Storm and CD8+ T-Cell Exhaustion in Severe COVID-19.

    Chen, Jiezhong / Vitetta, Luis

    The Journal of infectious diseases

    2021  Volume 223, Issue 9, Page(s) 1659–1660

    MeSH term(s) B7-H1 Antigen ; CD8-Positive T-Lymphocytes ; COVID-19 ; Cytokine Release Syndrome ; Humans ; SARS-CoV-2
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab061
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