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  1. Article ; Online: MACC1 and Gasdermin-E (GSDME) regulate the resistance of colorectal cancer cells to irinotecan.

    Cheng, Ming-Zhen / Yang, Bo-Bo / Zhan, Ze-Tao / Lin, Si-Min / Fang, Zhe-Ping / Gao, Yi / Zhou, Wei-Jie

    Biochemical and biophysical research communications

    2023  Volume 671, Page(s) 236–245

    Abstract: ... The cleavage of Gasdermin-E (GSDME) is the main executors of activated pyroptosis. We found that GSDME enhanced ...

    Abstract Metastasis-associated in colon cancer 1 (MACC1) is an oncogene associated with the progression and metastasis of many solid cancer entities. High expression of MACC1 is found in colorectal cancer (CRC) tissues. So far, the role of MACC1 in CRC cell pyroptosis and resistance to irinotecan is unclear. The cleavage of Gasdermin-E (GSDME) is the main executors of activated pyroptosis. We found that GSDME enhanced CRC cell pyroptosis and reduced their resistance to irinotecan, while MACC1 inhibited the cleavage of GSDME and CRC cell pyroptosis, promoted CRC cell proliferation, and enhanced the resistance of CRC cells to irinotecan. Therefore, CRC cells with high MACC1 expression and low GSDME expression had higher resistance to irinotecan, while CRC cells with low MACC1 expression and high GSDME expression had lower resistance to irinotecan. Consistently, by analyzing CRC patients who received FOLFIRI (Fluorouracil + Irinotecan + Leucovorin) in combination with chemotherapy in the GEO database, we found that CRC patients with low MACC1 expression and high GSDME expression had higher survival rate. Our study suggests that the expression of MACC1 and GSDME can be used as detection markers to divide CRC patients into irinotecan resistant and sensitive groups, helping to determine the treatment strategy of patients.
    MeSH term(s) Humans ; Irinotecan/pharmacology ; Gasdermins ; Pyroptosis ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism
    Chemical Substances Irinotecan (7673326042) ; Gasdermins ; MACC1 protein, human ; Trans-Activators
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.06.002
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    Zs.A 116: Show issues Location:
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  2. Article ; Online: MACC1 and Gasdermin-E (GSDME) regulate the resistance of colorectal cancer cells to irinotecan

    Cheng, Ming-Zhen / Yang, Bo-Bo / Zhan, Ze-Tao / Lin, Si-Min / Fang, Zhe-Ping / Gao, Yi / Zhou, Wei-Jie

    Biochemical and Biophysical Research Communications. 2023 Sept., v. 671 p.236-245

    2023  

    Abstract: ... The cleavage of Gasdermin-E (GSDME) is the main executors of activated pyroptosis. We found that GSDME enhanced ...

    Abstract Metastasis-associated in colon cancer 1 (MACC1) is an oncogene associated with the progression and metastasis of many solid cancer entities. High expression of MACC1 is found in colorectal cancer (CRC) tissues. So far, the role of MACC1 in CRC cell pyroptosis and resistance to irinotecan is unclear. The cleavage of Gasdermin-E (GSDME) is the main executors of activated pyroptosis. We found that GSDME enhanced CRC cell pyroptosis and reduced their resistance to irinotecan, while MACC1 inhibited the cleavage of GSDME and CRC cell pyroptosis, promoted CRC cell proliferation, and enhanced the resistance of CRC cells to irinotecan. Therefore, CRC cells with high MACC1 expression and low GSDME expression had higher resistance to irinotecan, while CRC cells with low MACC1 expression and high GSDME expression had lower resistance to irinotecan. Consistently, by analyzing CRC patients who received FOLFIRI (Fluorouracil + Irinotecan + Leucovorin) in combination with chemotherapy in the GEO database, we found that CRC patients with low MACC1 expression and high GSDME expression had higher survival rate. Our study suggests that the expression of MACC1 and GSDME can be used as detection markers to divide CRC patients into irinotecan resistant and sensitive groups, helping to determine the treatment strategy of patients.
    Keywords cell proliferation ; colorectal neoplasms ; databases ; drug therapy ; fluorouracil ; metastasis ; oncogenes ; pyroptosis ; research ; survival rate ; MACC1 ; GSDME ; Irinotecan ; Colorectal cancer
    Language English
    Dates of publication 2023-09
    Size p. 236-245.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.06.002
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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies.

    Zhang, Rongjun / Wang, Xiaofeng / Tang, Zongchun / Liu, Jianxin / Yang, Shuzhen / Zhang, Youbing / Wei, Yijun / Luo, Wenyin / Wang, Jun / Li, Jialong / Chen, Bobo / Zhang, Kunhu

    Lipids in health and disease

    2014  Volume 13, Page(s) 47

    Abstract: Background: Studies investigating the association between the apolipoprotein E (APOE) gene ...

    Abstract Background: Studies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship.
    Methods: Published literature from the National Library of Medline and Embase databases were retrieved. Odds ratio (OR) and 95% confidence interval (CI) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race.
    Results: This meta-analysis included 11 case-control studies, which included 1,238 ICH cases and 3,575 controls. The combined results based on all studies showed that ICH cases had a significantly higher frequency of APOE ϵ4 allele (OR= 1.42, 95% CI= 1.21,1.67, P<0.001). In the subgroup analysis by race, we also found that ICH cases had a significantly higher frequency of APOE ϵ4 allele in Asians (OR= 1.52, 95% CI= 1.20,1.93, P<0.001) and in Caucasians (OR= 1.34, 95% CI= 1.07,1.66, P=0.009). There was no significant relationship between APOE ϵ2 allele and the risk of ICH.
    Conclusion: Our meta-analysis suggested that APOE ϵ4 allele was associated with a higher risk of ICH.
    MeSH term(s) Apolipoproteins E/genetics ; Case-Control Studies ; Cerebral Hemorrhage/genetics ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Genetic ; Protein Isoforms/genetics ; Risk Factors
    Chemical Substances Apolipoproteins E ; Protein Isoforms
    Language English
    Publishing date 2014-03-12
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ISSN 1476-511X
    ISSN (online) 1476-511X
    DOI 10.1186/1476-511X-13-47
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  4. Article ; Online: Trends in social determinants of inequality in child undernutrition from the Ethiopian Demographic and Health Surveys, 2005-2016.

    Birhanu, Frehiwot / Yitbarek, Kiddus / Atlantis, Evan / Woldie, Mirkuzie / Bobo, Firew

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0295810

    Abstract: Background: While child undernutrition has been eliminated in some middle-income countries, it remains highly prevalent in sub-Sahara African (SSA) and South Asian regions, and is disproportionately concentrated among the poor. In this study, we ... ...

    Abstract Background: While child undernutrition has been eliminated in some middle-income countries, it remains highly prevalent in sub-Sahara African (SSA) and South Asian regions, and is disproportionately concentrated among the poor. In this study, we estimated trends in child undernutrition by social determinants and related risks from wealth inequality in Ethiopia, from 2005 to 2016.
    Method: We analyzed data from three consecutive surveys (2005, 2011, and 2016) from the Ethiopian Demographic and Health Survey. First, we estimated trends in the prevalence of childhood undernutrition variables (stunting, underweight, and wasting) and social determinants (household wealth status, education level, place of residence, and administrative regions). Then we assessed evidence of undernutrition by wealth-related inequality with concentration curves (visual) and concentration indeces (quantitative). A multilevel mixed-effect Poisson regression model was used to identify predictors of undernutrition variables expressed as covariate-adjusted rate ratios, with 95% confidence intervals (RRs, 95%CI).
    Result: A total of 23,934 mother-child pairs were obtained from the three surveys. The average prevalence decreased by 12.4 percentage points for stunting (from 50.8 to 38.4%, P<0.01), 9.5 percentage points for underweight (33.2% to23.7%, P<0.01), and 2.1 percentage points for wasting (12.2% to10.1%, P<0.01). There was persistent and statistically evidence of wealth inequality in stunting, underweight, and wasting (concentration indeces of -0.2 to -0.04, all P values <0.05). Stunting, underweight, and wasting variables were associated with male sex of the child (RR 0.94, 0.95, 0.85, all P-values <0.01) recent diarrhea (RR 1.18, 1.27, 1.37, all P-values <0.01), secondary education status of the mother (RR 0.66, 0.57, 0.61, all P-values < 0.057), increasing wealth index (richest) (RR 0.73, 0.70, 0.50, all P-values < 0.05), and having no toilet facility (RR 1.16, 1.22, 1.18, all P-values < 0.05).
    Conclusion: Despite the decreased burden of stunting and underweight, the prevalence of wasting remained relatively unchanged in Ethiopia from 2005 to 2016. Moreover, wealth-related inequality in child undernutrition increased for most of the child undernutrition indicators during this period. Social determinants of child undernutrition warrant urgent implementation of strategies to reduce their health impacts in SSA.
    MeSH term(s) Female ; Humans ; Male ; Infant ; Thinness/epidemiology ; Social Determinants of Health ; Wasting Syndrome/epidemiology ; Malnutrition/epidemiology ; Child Nutrition Disorders/epidemiology ; Cachexia ; Growth Disorders/epidemiology ; Prevalence ; Health Surveys
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0295810
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  5. Article ; Online: Dolutegravir-induced severe sideroblastic anemia.

    Lemoine, Sandrine / Bobo, Maxime / Hocqueloux, Laurent / Legac, Eric / Prazuck, Thierry

    AIDS (London, England)

    2024  Volume 38, Issue 7, Page(s) 1095–1097

    MeSH term(s) Humans ; Oxazines ; Pyridones/adverse effects ; Heterocyclic Compounds, 3-Ring/adverse effects ; Piperazines/adverse effects ; Anemia, Sideroblastic/chemically induced ; Anemia, Sideroblastic/drug therapy ; HIV Infections/drug therapy ; HIV Infections/complications ; Male ; HIV Integrase Inhibitors/adverse effects ; HIV Integrase Inhibitors/therapeutic use ; Middle Aged
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Oxazines ; Pyridones ; Heterocyclic Compounds, 3-Ring ; Piperazines ; HIV Integrase Inhibitors
    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Case Reports ; Letter ; Journal Article
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003855
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2228: Show issues Location:
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  6. Article ; Online: Designing School Health Services to Provide Multi-Tiered Systems of Support (MTSS) for All Students.

    Bobo, Nichole / Clark, Elizabeth / Griffin, Renee

    NASN school nurse (Print)

    2023  Volume 38, Issue 6, Page(s) 328–336

    Abstract: A system-level health equity lens is needed to meet the needs of today's students. School nurses stand at the intersection of health and education, poised to improve the health and academic outcomes for all children in collaboration with school health ... ...

    Abstract A system-level health equity lens is needed to meet the needs of today's students. School nurses stand at the intersection of health and education, poised to improve the health and academic outcomes for all children in collaboration with school health and education colleagues with a focus to reframe "learning and health losses" to "learning and health recovery." The Multi-Tiered System of Support is a familiar approach used in schools to address education equity for students. Working alongside educators, school nurses can demonstrate how including health in this framework augments reaching the goal of supporting student academic success.
    MeSH term(s) Child ; Humans ; School Nursing ; Students ; Schools ; School Health Services
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2445634-2
    ISSN 1942-6038 ; 1942-602X
    ISSN (online) 1942-6038
    ISSN 1942-602X
    DOI 10.1177/1942602X231187069
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  7. Article ; Online: Positive Urine Drug Screens and External Mortality in Teenagers Who Present for Medical Care.

    Markota, Matej / Croarkin, Paul E / Bobo, William V

    The Journal of clinical psychiatry

    2022  Volume 83, Issue 1

    Abstract: Objective:: Methods:: Results:: Conclusions: ...

    Abstract Objective:
    Methods:
    Results:
    Conclusions:
    MeSH term(s) Adolescent ; Cohort Studies ; Drug Overdose/mortality ; Female ; Humans ; Male ; Minnesota/epidemiology ; Mortality, Premature ; Retrospective Studies ; Substance Abuse Detection/statistics & numerical data ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/mortality ; Suicide/statistics & numerical data
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.20m13729
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  8. Article ; Online: Reemergence of Blenderized Tube Feedings: Exploring the Evidence.

    Bobo, Elizabeth

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2016  Volume 31, Issue 6, Page(s) 730–735

    Abstract: A blenderized tube feeding (BTF) is a mixture of food and liquid that is pureed and administered through a feeding tube. This method of providing nourishment has been used for millenniums. In fact, it could be viewed as the original form of nutrition ... ...

    Abstract A blenderized tube feeding (BTF) is a mixture of food and liquid that is pureed and administered through a feeding tube. This method of providing nourishment has been used for millenniums. In fact, it could be viewed as the original form of nutrition support. However, over time, the role of BTF has changed. Initially, it was the only method of nourishing a patient who could not sustain himself or herself on oral feeds. With the development of commercial formulas in the mid-20th century, the usage of this feeding modality declined drastically due to the nutrition precision, ease, and sterility of commercial formulas. Recently, there has been a reemergence in blenderized tube feeds, largely due to patient/family request. The modern perception is that BTF is more natural because the nutrition is coming from whole foods and is able to be varied, as it would be in an oral diet. There are also reports of improved feeding tolerance, such as a reduction in constipation and gagging/retching. However, concerns also exist, such as contamination of the blend with microorganisms and increased viscosity causing feeding tube occlusion. This review summarizes key historical points of the diet, discusses the rationale for use, describes points to consider when using a blenderized diet, and reviews the evidence in practice.
    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1177/0884533616669703
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    Zs.A 2451: Show issues Location:
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  9. Article ; Online: Design of simple nonovershooting controllers for linear high order systems with or without time delay

    Huanchao Du / Bobo Feng / Jieshi Shen / Dan Li

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 12

    Abstract: ... dominant pole control structure having three dominant poles, i.e., one real pole and a pair of complex ...

    Abstract Abstract In this paper, we mainly considered the problem of nonovershooting control of high order systems with or without time delay by simple controllers. As basic principles for nonovershooting control systems, three propositions are offered and proved. Under direction of these principles, a nonovershooting dominant pole control structure having three dominant poles, i.e., one real pole and a pair of complex conjugate poles on its left, is proposed. While its zeroes and nondominant poles are on the left side of these three dominant poles with sufficient distance. The controllers adopted are composed by first order filter and PD-PID controller. Dominance of the three dominant poles can be checked and ensured through the computational method we offered. Two illustrating examples are given to show the effectiveness of our method.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Undernutrition in children under five associated with wealth-related inequality in 24 low- and middle-income countries from 2017 to 2022.

    Birhanu, Frehiwot / Yitbarek, Kiddus / Bobo, Firew Tekle / Atlantis, Evan / Woldie, Mirkuzie

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3326

    Abstract: Undernourishment is a persistent public health problem contributing to increased mortality in children under five in low-income countries, likely exacerbated by socio-economic disparities within communities. This paper aimed to examine the effect of ... ...

    Abstract Undernourishment is a persistent public health problem contributing to increased mortality in children under five in low-income countries, likely exacerbated by socio-economic disparities within communities. This paper aimed to examine the effect of wealth-related inequality on undernutrition in children under five in low, lower-middle, and upper-middle-income countries (LMICs). We analyzed cross-sectional data from the demographic and health survey program collected between 2017 and 2022 from 24 LMICs. Children born within 5 years preceding the survey were included in the analysis. Child undernutrition was the dependent variable (measured by stunting, wasting, and underweight) and country-level wealth-based inequality was the independent variable assessed by concentration index values stratified by the World Bank's income categories. Within country inequality of child undernutrition was determined by concentration index (C) values with 95% confidence intervals (95% CI) and sub-group analysis by place of residence and sex of the child. We then fit bootstrapped meta-regression to check the variation in inequality of child undernutrition across different income category countries. The analysis was controlled by potential confounding variables. From the total sample size of 334,502 children included in the study, 35% were undernourished. Wealth-related inequality in child undernutrition was observed in 11 countries, consistently across income categories. Child undernutrition was highly concentrated among the poor households of Türkiye [C: - 0.26, 95% CI - 0.31 to - 0.20], and Cameroon [C: - 0.19, 95% CI - 0.22 to - 0.17], and relatively it was less concentrated among the poor in Liberia [C: - 0.07, 95% CI - 0.11 to - 0.04], and Gambia [C: - 0.07, 95% CI - 0.11 to - 0.04]. There is no difference in undernutrition associated with inequality between the three broad LMIC categories. The wealth-related inequality in child undernutrition within many of the included countries is still very significant. However, the economic category of countries made no difference in explaining wealth-related inequality in child undernutrition. Inter-sectoral collaboration to fight poverty and render special attention to the disadvantaged population segments would potentially help to address the observed inequity.
    MeSH term(s) Child ; Humans ; Infant ; Developing Countries ; Cross-Sectional Studies ; Malnutrition/epidemiology ; Income ; Thinness/epidemiology ; Child Nutrition Disorders/epidemiology ; Socioeconomic Factors
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53280-0
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