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  1. Article ; Online: Anthropometric and lipid parameters are inversely associated with mortality in chronic kidney disease patients: a meta-analysis.

    He, Yapeng / Zhao, Qian / Yang, Yutong / Zhu, Dongge / Wu, Hongxia

    Journal of nephrology

    2024  

    Language English
    Publishing date 2024-01-02
    Publishing country Italy
    Document type Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01806-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Impact of Low Fertility Rates on Labor Demand and Socioeconomic Development in China.

    Wu, Yutong / Su, Binbin / Li, Jun

    China CDC weekly

    2023  Volume 5, Issue 27, Page(s) 599–604

    Language English
    Publishing date 2023-07-12
    Publishing country China
    Document type Journal Article
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2023.115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spatiotemporal variation analysis of global XCO

    Gao, Zekun / Jiang, Yutong / He, Junyu / Wu, Jiaping

    The Science of the total environment

    2023  Volume 892, Page(s) 164750

    Abstract: Combining with Carbon dioxide column concentration ( ... ...

    Abstract Combining with Carbon dioxide column concentration (XCO
    MeSH term(s) Spatio-Temporal Analysis ; Seasons
    Language English
    Publishing date 2023-06-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.164750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  4. Article ; Online: Leveraging Unlabeled Clinical Data to Boost Performance of Risk Stratification Models for Suspected Acute Coronary Syndrome.

    Wu, Yutong / Conlan, David / Perez, Siegfried / Nguyen, Anthony

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2024  Volume 2023, Page(s) 744–753

    Abstract: The performance of deep learning models in the health domain is desperately limited by the scarcity of labeled data, especially for specific clinical-domain tasks. Conversely, there are vastly available clinical unlabeled data waiting to be exploited to ... ...

    Abstract The performance of deep learning models in the health domain is desperately limited by the scarcity of labeled data, especially for specific clinical-domain tasks. Conversely, there are vastly available clinical unlabeled data waiting to be exploited to improve deep learning models where their training labeled data are limited. This paper investigates the use of task-specific unlabeled data to boost the performance of classification models for the risk stratification of suspected acute coronary syndrome. By leveraging large numbers of unlabeled clinical notes in task-adaptive language model pretraining, valuable prior task-specific knowledge can be attained. Based on such pretrained models, task-specific fine-tuning with limited labeled data produces better performances. Extensive experiments demonstrate that the pretrained task-specific language models using task-specific unlabeled data can significantly improve the performance of the downstream models for specific classification tasks.
    MeSH term(s) Humans ; Acute Coronary Syndrome/diagnosis ; Knowledge ; Language ; Risk Assessment
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 1942-597X
    ISSN (online) 1942-597X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: HER2-positive is an independent indicator for predicting pathological complete response to neoadjuvant therapy and Ki67-changed after neoadjuvant chemotherapy predicts favorable prognosis in Chinese women with locally advanced breast cancer.

    Fang, Yutong / Zhang, Qunchen / Wu, Yuan / Wu, Jundong

    Medicine

    2024  Volume 103, Issue 6, Page(s) e37170

    Abstract: The growing body of evidence suggests that breast cancer (BC) who achieve pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) may experience a more favorable prognosis. The objective of this study is to investigate the correlation ... ...

    Abstract The growing body of evidence suggests that breast cancer (BC) who achieve pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) may experience a more favorable prognosis. The objective of this study is to investigate the correlation between clinicopathologic parameters of locally advanced breast cancer (LABC) patients and the outcomes of NAC, with the aim of identifying predictive indicators for pCR. Additionally, we seek to examine the conversion of IHC markers in pCR patients following NAC and its impact on the prognosis of BC patients. We conducted a study involving 126 patients with LABC. Clinicopathological parameters associated with pCR were subjected to univariate and multivariate analysis. Kaplan-Meier (KM) curves and the log-rank test were used to compare the statistical difference in prognosis in different groups of patients. Additionally, we used difference and consistency tests to examine the conversion of immunohistochemistry (IHC) markers following NAC. The status of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and molecular subtypes of BC were associated with pCR in the univariate analysis (all P < .05), which may be potential markers to predict pCR. HER2 was identified as an independent factor for predicting pCR in the multivariate analysis. The pCR rate of HER2-positive patients who received NAC combined targeted therapy was higher than that of patients who only received NAC (P = .003). The disease-free survival (DFS) rate of TNBC patients who achieved pCR was significantly higher than that of non-pCR TNBC patients (P = .026). The IHC marker conversion after NAC mainly existed in PR (P = .041). Ki67 expression decreased in the luminal B subtype and increased in the HER2 enriched subtype after NAC (all P < .001). Patients with Ki67 expression change after NAC had longer overall survival (OS) and DFS than unchanged patients (all P < .05). HER2-positive is an independent indicator for predicting pCR, and HE2-positive patients who received NAC combined targeted therapy were favorable to achieving pCR. IHC markers of BC patients exhibit varying degrees of alterations after NAC, and changes in Ki67 expression after NAC could serve as a marker to predict a better prognosis.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Ki-67 Antigen/metabolism ; Neoadjuvant Therapy/adverse effects ; Triple Negative Breast Neoplasms/pathology ; Prognosis ; Receptor, ErbB-2/metabolism ; China ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Ki-67 Antigen ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Impact of policy measures on smallholders’ livelihood resilience

    Yutong Wang / Jianzhong Yan / Ya Wu

    Ecological Indicators, Vol 158, Iss , Pp 111351- (2024)

    Evidence from Hehuang Valley, Tibetan Plateau

    1481  

    Abstract: Enhancing livelihood resilience is an effective approach for smallholders to cope with climate change in which governments play an important role. Nevertheless, few studies have investigated the impact of policy measures on smallholders’ livelihood ... ...

    Abstract Enhancing livelihood resilience is an effective approach for smallholders to cope with climate change in which governments play an important role. Nevertheless, few studies have investigated the impact of policy measures on smallholders’ livelihood resilience (SLR), especially for the case of vulnerable Tibetan Plateau. Based on a longitudinal survey of 321 households in the semiagricultural and semipastoral region of Hehuang Valley during 2017–2022, this study assesses the changes in SLR. By adopting the multinomial logistic model, the impact of policy measures on SLR was been further explored. The results show that SLR in the focal area increased from 0.100 in 2017 to 0.122 in 2022. Policy measures of low-interest loans, irrigation facilities, improved seed and information sharing play a significant positive role in enhancing SLR, whereas training on skills and subsidies have no significant influence on SLR. In addition, the coverage of irrigation facilities and the promotion of training on skills need to be improved. The results not only help local government understand the effectiveness of existing policy measures on SLR but also provide recommendations for improving SLR.
    Keywords Small-scale farming ; Resilience ; Government support ; Multinomial logistic regression ; Ecology ; QH540-549.5
    Subject code 910
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Design and Simulation of Au/SiO

    Sun, Meng / Song, Yutong / Wu, Haoyu / Wang, Qi

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 6

    Abstract: In this paper, three different structures of surface plasmon resonance (SPR) sensors based on the Kretschmann configuration: Au/ ... ...

    Abstract In this paper, three different structures of surface plasmon resonance (SPR) sensors based on the Kretschmann configuration: Au/SiO
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23063163
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  8. Article ; Online: Decorating of 2D indium oxide onto 2D bismuth oxybromide to enhance internal electric field and stimulate artificial photosynthesis.

    Liu, Jingjing / Wang, Ruonan / Shang, Yutong / Zou, Xinyu / Wu, Shanwen / Zhong, Qin

    Journal of colloid and interface science

    2024  Volume 663, Page(s) 21–30

    Abstract: ... ...

    Abstract CO
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.01.172
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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  9. Article ; Online: Gut-tropic T cells and extra-intestinal autoimmune diseases.

    Wu, Yutong / Wang, Qiaolin / Jia, Sujie / Lu, Qianjin / Zhao, Ming

    Autoimmunity reviews

    2024  , Page(s) 103544

    Abstract: Gut-tropic T cells primarily originate from gut-associated lymphoid tissue (GALT), and gut-tropic integrins mediate the trafficking of the T cells to the gastrointestinal tract, where their interplay with local hormones dictates the residence of the ... ...

    Abstract Gut-tropic T cells primarily originate from gut-associated lymphoid tissue (GALT), and gut-tropic integrins mediate the trafficking of the T cells to the gastrointestinal tract, where their interplay with local hormones dictates the residence of the immune cells in both normal and compromised gastrointestinal tissues. Targeting gut-tropic integrins is an effective therapy for inflammatory bowel disease (IBD). Gut-tropic T cells are further capable of entering the peripheral circulatory system and relocating to multiple organs. There is mounting evidence indicating a correlation between gut-tropic T cells and extra-intestinal autoimmune disorders. This review aims to systematically discuss the origin, migration, and residence of gut-tropic T cells and their association with extra-intestinal autoimmune-related diseases. These discoveries are expected to offer new understandings into the development of a range of autoimmune disorders, as well as innovative approaches for preventing and treating the diseases.
    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2024.103544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5913: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Activation of CHPF by transcription factor NFIC promotes NLRP3 activation during the progression of colorectal cancer.

    Wu, Jiamei / Wang, Miao / Zhang, Yuechuan / Liu, Guohong / Xing, Yutong

    Functional & integrative genomics

    2024  Volume 24, Issue 1, Page(s) 20

    Abstract: Given the role of chondroitin polymerizing factor (CHPF) in several cancers, we investigated its role in the progression of colorectal cancer (CRC) and its association with NLRP3 inflammasome activation. High expression of CHPF in CRC predicted poor ... ...

    Abstract Given the role of chondroitin polymerizing factor (CHPF) in several cancers, we investigated its role in the progression of colorectal cancer (CRC) and its association with NLRP3 inflammasome activation. High expression of CHPF in CRC predicted poor patient prognosis. Using colony formation, EdU staining, wound healing, Transwell invasion, and flow cytometry assays, we revealed that the downregulation of CHPF inhibited the malignant behavior of CRC cells. CHPF promoted NLRP3 inflammasome activation by inducing the MAPK signaling pathway, as evidenced by enhanced expression of Phos-ERK1/2, Phos-MEK1, Phos-MEK2, and NLRP3. Additionally, nuclear factor 1 C-type (NFIC) was revealed as a potential upstream transcription factor of CHPF in the modulation of CRC, and the anti-tumor effects elicited through its knockdown were compromised by CHPF in vitro and in vivo. In summary, we demonstrated that NFIC promoted NLRP3 activation to support CRC development via the CHPF-mediated MAPK signaling.
    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Down-Regulation ; Inflammasomes ; MAP Kinase Signaling System ; NFI Transcription Factors ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics
    Chemical Substances Inflammasomes ; NFI Transcription Factors ; NFIC protein, human ; NLR Family, Pyrin Domain-Containing 3 Protein ; chondroitin synthase (EC 2.4.1.175) ; NLRP3 protein, human
    Language English
    Publishing date 2024-01-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2014670-X
    ISSN 1438-7948 ; 1438-793X
    ISSN (online) 1438-7948
    ISSN 1438-793X
    DOI 10.1007/s10142-024-01299-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5230: Show issues Location:
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