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  1. Article ; Online: Unanswered questions from the IRONMAN trial.

    Ambrosi, Pierre / Habib, Gilbert

    Lancet (London, England)

    2023  Volume 401, Issue 10387, Page(s) 1494–1495

    MeSH term(s) Humans ; Anthropometry ; Swimming ; Bicycling
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00447-6
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  2. Article ; Online: Comment on "Epidemiological and clinical characteristics of heart transplant recipients during the 2019 coronavirus outbreak in Wuhan, China" by Ren et al.

    Ambrosi, Pierre

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2020  Volume 39, Issue 7, Page(s) 729

    MeSH term(s) China ; Coronavirus ; Disease Outbreaks ; Heart Transplantation ; Surveys and Questionnaires
    Keywords covid19
    Language English
    Publishing date 2020-04-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2020.04.002
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  3. Article: Comment on "Epidemiological and clinical characteristics of heart transplant recipients during the 2019 coronavirus outbreak in Wuhan, China" by Ren et al

    Ambrosi, Pierre

    J Heart Lung Transplant

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #47949
    Database COVID19

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  4. Article ; Online: High rate of seroconversion after COVID-19 vaccination during the long term follow-up of heart transplant recipients.

    Ambrosi, Pierre / Basire, Agnès / Habib, Gilbert

    Transplant infectious disease : an official journal of the Transplantation Society

    2022  , Page(s) e13945

    Language English
    Publishing date 2022-08-30
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13945
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  5. Article ; Online: Association of Plasma Creatinine Phosphokinase Elevation and a History of Idiopathic Cardiomyopathy in Recipients of Heart Transplant.

    Ambrosi, Pierre / Riberi, Alberto / Attarian, Shahram / Nguyen, Karine / Guieu, Régis / Habib, Gilbert

    The American journal of cardiology

    2023  Volume 213, Page(s) 50–54

    Abstract: Plasma creatinine phosphokinase (CPK) elevation is frequent after heart transplantation. In the present study, we tested the hypothesis that this CPK elevation is related to idiopathic cardiomyopathy as primary cardiac disease. We included 203 patients ... ...

    Abstract Plasma creatinine phosphokinase (CPK) elevation is frequent after heart transplantation. In the present study, we tested the hypothesis that this CPK elevation is related to idiopathic cardiomyopathy as primary cardiac disease. We included 203 patients who survived >1 year after heart transplantation. Plasma CPK was measured every 4 months during a 15.1 ± 7.7-year follow-up. In univariate analysis, CPK elevation was significantly associated with age at transplantation, length of follow-up, treatment with everolimus, and idiopathic cardiomyopathy as primary cardiac disease. In multivariate analysis, idiopathic cardiomyopathy and length of follow-up were the only significant predictors of CPK elevation (p = 0.002 and p = 0.0001, respectively). A subgroup of 19 patients had frequent CPK elevation (>20% of the dosages). All these patients but 1 had an idiopathic cardiomyopathy as primary disease. In 5 of these 19 patients, we identified a syndrome known to affect both cardiac and skeletal muscles. In conclusion, underlying idiopathic cardiomyopathy is a major determinant of plasma CPK elevation after heart transplantation. Our results show that besides well-described syndromes associating skeletal and cardiac muscle disease, idiopathic cardiomyopathy may be associated with subclinical skeletal muscle myopathy.
    MeSH term(s) Humans ; Creatinine ; Creatine Kinase ; Cardiomyopathies ; Heart Transplantation ; Muscular Diseases
    Chemical Substances Creatinine (AYI8EX34EU) ; Creatine Kinase (EC 2.7.3.2)
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.11.070
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  6. Article ; Online: Effets cliniques à court terme des statines initiées avant une intervention.

    Ambrosi, Pierre

    Presse medicale (Paris, France : 1983)

    2013  Volume 42, Issue 3, Page(s) 261–268

    Abstract: In high-risk patients, long-term statin therapy prevents cardiovascular events. Short-term clinical benefit of statin therapy has been recently evaluated by randomized clinical trials in the setting of vascular surgery, coronary bypass surgery and ... ...

    Title translation Short-term clinical effects of periprocedural statin therapy.
    Abstract In high-risk patients, long-term statin therapy prevents cardiovascular events. Short-term clinical benefit of statin therapy has been recently evaluated by randomized clinical trials in the setting of vascular surgery, coronary bypass surgery and percutaneous coronary interventions. According to the trial scheme, statin therapy was started either few weeks or few hours before the intervention. In the field of vascular surgery, the clinical benefit of preprocedure statin administration has been supported by DECREASE III trial. Fluvastatin significantly decreased the incidence of periprocedural myocardial ischemia as defined by ECG changes or troponin elevation. However, this study has methodological flaws, including primary endpoint modification during the trial and the lack of clinical relevance of this endpoint. The administration of statins before a coronary bypass could reduce the occurrence of postoperative atrial fibrillation, according to 4 randomized trials. This finding is discordant with the result of a recent meta-analysis of long-term published and unpublished long-term trials that showed no significant beneficial effects of statins on atrial fibrillation. Several trials have evaluated the usefulness of statin pretreatment before PCI. Most of them have found that statin pretreatment prevents periprocedural myocardial infarctions or major cardiac events. However, most of these events were isolated enzymatic elevations. Moreover, myocardial infarction definition was at odds with the recommendations in some of these trials. A recent meta-analysis of these trials has found that statin pretreatment leads to a 44% reduction in the incidence of major cardiac events at 30 days. The magnitude of this decrease is not consistent with the results of previous long-term trials evaluating statins after acute coronary syndromes. Current evidence does not strongly support short-term clinical benefit of pre-procedural statin administration.
    MeSH term(s) Angioplasty, Balloon, Coronary ; Coronary Artery Bypass ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Preoperative Care ; Time Factors ; Treatment Outcome ; Vascular Surgical Procedures
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language French
    Publishing date 2013-03
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2012.05.016
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  7. Article ; Online: Authors' Reply to the Letter by Shoar et al. on "Glycosylated Hemoglobin as a Surrogate for the Prevention of Cardiovascular Events in Cardiovascular Outcome Trials Comparing New Antidiabetic Drugs to Placebo".

    Ambrosi, Pierre / Daumas, Aurélie / Villani, Patrick / Giorgi, Roch

    Cardiology

    2020  Volume 145, Issue 6, Page(s) 387

    MeSH term(s) Cardiovascular Diseases ; Diabetes Mellitus, Type 2 ; Glycated Hemoglobin A ; Humans ; Hypoglycemic Agents ; Metformin
    Chemical Substances Glycated Hemoglobin A ; Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000507361
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  8. Article ; Online: Glycosylated Hemoglobin as a Surrogate for the Prevention of Cardiovascular Events in Cardiovascular Outcome Trials Comparing New Antidiabetic Drugs to Placebo.

    Ambrosi, Pierre / Daumas, Aurélie / Villani, Patrick / Giorgi, Roch

    Cardiology

    2020  Volume 145, Issue 6, Page(s) 370–374

    Abstract: Background and objectives: The value of glycosylated hemoglobin (HbA1c) as a surrogate marker for the prevention of cardiovascular outcomes on antidiabetic drugs is debated. The 2008 FDA guidance led to multiple large clinical trials to evaluate the ... ...

    Abstract Background and objectives: The value of glycosylated hemoglobin (HbA1c) as a surrogate marker for the prevention of cardiovascular outcomes on antidiabetic drugs is debated. The 2008 FDA guidance led to multiple large clinical trials to evaluate the effect of new antidiabetic drugs versus placebo on major adverse cardiac events (MACE). The aim of this study was to evaluate the relation between MACE and HbA1c decrease between antidiabetic drug and placebo across the spectrum of cardiovascular outcome trials (CVOT).
    Methods: In this systematic review, we included randomized controlled trials that compared an antidiabetic drug to placebo in addition to current standard of care with the primary intention of demonstrating cardiovascular safety. We investigated the relationship between MACE decrease on antidiabetic drug and HbA1c reduction on antidiabetic drug using the coefficient correlation. We also studied the effects of potential confounders on MACE decrease.
    Results: Fourteen eligible trials including 128,149 patients were included, 12,114 of whom experienced MACE. Mean achieved HbA1c absolute reductions on antidiabetic treatment versus placebo varied from 0.29 to 1%. The decrease of MACE on antidiabetic drug was significantly correlated with mean HbA1c reduction (r = 0.88, 95% CI: 0.67-0.96, p < 0.001) and weight loss (r = 0.81, 95% CI: 0.46-0.94, p < 0.001). In a bivariate model including weight loss, only HbA1c reduction remained significantly correlated with the decrease of MACE on antidiabetic drug (p = 0.019).
    Conclusion: Across CVOT, the decrease in MACE incidence on various antidiabetic drugs is significantly correlated with HbA1c reduction. This meta-analysis supports HbA1c as an appropriate surrogate endpoint for cardiovascular events. Our analysis supports that changes in HbA1c should be taken into account while interpreting effects of new antidiabetic drugs on cardiovascular outcomes.
    MeSH term(s) Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2 ; Glycated Hemoglobin A ; Humans ; Hypoglycemic Agents/therapeutic use
    Chemical Substances Glycated Hemoglobin A ; Hypoglycemic Agents
    Language English
    Publishing date 2020-02-21
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000506004
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  9. Article ; Online: Correspondance à propos de l'article: "Quel bilan lipidique et comment l'interpréter chez le patient ayant une maladie coronaire?"

    Ambrosi, Pierre

    Presse medicale (Paris, France : 1983)

    2010  Volume 39, Issue 2, Page(s) 286–287

    Title translation Letter on the article: "Which lipid profiles and how to interpret in patients with coronary heart disease?".
    MeSH term(s) Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Coronary Disease/etiology ; Coronary Disease/prevention & control ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hypercholesterolemia/blood ; Hypercholesterolemia/complications ; Hypercholesterolemia/drug therapy ; Patient Selection ; Risk Reduction Behavior
    Chemical Substances Cholesterol, HDL ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language French
    Publishing date 2010-02
    Publishing country France
    Document type Letter
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2009.11.004
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  10. Article ; Online: Intravenous Milrinone for Cerebral Vasospasm: Here Comes the Sun?

    Lakhal, Karim / Robert-Edan, Vincent / Rodie-Talbere, Pierre-André / Ambrosi, Xavier / Fresco, Marion

    Neurocritical care

    2021  Volume 36, Issue 1, Page(s) 329–330

    MeSH term(s) Administration, Intravenous ; Cerebral Angiography ; Humans ; Milrinone/therapeutic use ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/drug therapy ; Vasospasm, Intracranial/drug therapy ; Vasospasm, Intracranial/etiology
    Chemical Substances Milrinone (JU9YAX04C7)
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-021-01392-0
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