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Article ; Online: Reduction in Average Length-of-Stay in Emergency Department of a Low-Income Country's Cancer Hospital.

Shakoor, Qurratulain / Hafeez, Haroon / Saleem, Atif / Khanzada, Zubair Shabbir / Safir, Hira / Ajmal, Zainab / Sajjad, Kashif

Journal of cancer & allied specialties

2024 Volume 10, Issue 1, Page(s) 537

Abstract: Introduction: Prolonged length of stay (LOS) in emergency departments (ED) is a widespread problem in every hospital around the globe. Multiple factors cause it and can have a negative impact on the quality of care provided to the patients and the ... ...

Abstract	Introduction: Prolonged length of stay (LOS) in emergency departments (ED) is a widespread problem in every hospital around the globe. Multiple factors cause it and can have a negative impact on the quality of care provided to the patients and the patient satisfaction rates. This project aimed to ensure that the average LOS of patients in a tertiary care cancer hospital stays below 3 hours. Materials and methods: The Six Sigma DMAIC (Define, Measure, Analyze, Improve, Control) approach was followed. Results: The average LOS was 166 minutes before implementing interventions. The two primary reasons for the increased length of stay were delays secondary to physician assessment and diagnostic lab reports. Strategies were defined to control these factors, which helped reduce the average length of stay to 142 minutes, a 30% reduction. Conclusion: A process improvement model similar to this project is recommended to enhance the quality of hospital services. It will provide valuable insights into the process flow and assist in gathering precise data on the various steps involved. The data collected can then be analyzed to identify potential causes and make informed decisions that can significantly improve hospital processes.
Language	English
Publishing date	2024-01-22
Publishing country	Pakistan
Document type	Journal Article
ISSN	2411-989X
ISSN (online)	2411-989X
DOI	10.37029/jcas.v10i1.537
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Successful radio-frequency catheter ablation of two cases of supraventricular tachycardia via a left-sided inferior vena cava.

Awan, Romana Asad / Khanzada, Muhammad Faisal / Mumtaz, Zubair / Qadir, Faisal

Pakistan journal of medical sciences

2020 Volume 36, Issue 6, Page(s) 1402–1404

Abstract: Congenital venous anomalies are uncommon, incidental findings encountered during adult interventional electrophysiology procedures. Femoral venous access is conventionally used during cardiac electrophysiology studies to gain access to the heart. The ... ...

Abstract	Congenital venous anomalies are uncommon, incidental findings encountered during adult interventional electrophysiology procedures. Femoral venous access is conventionally used during cardiac electrophysiology studies to gain access to the heart. The chance finding of an inferior vena cava anomaly may preclude the performance of these procedures from the femoral approach. We describe two cases in which we were able to successfully perform different radiofrequency catheter ablation procedures in the presence of an unusual venous anomaly, the left-sided IVC.
Language	English
Publishing date	2020-09-19
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.36.6.2947
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Zs.A 3948: Show issues

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Article: Diagnostic Performance of Artificial Intelligence-Based Models for the Detection of Early Esophageal Cancers in Barret's Esophagus: A Meta-Analysis of Patient-Based Studies.

Bhatti, Khalid M / Khanzada, Zubair S / Kuzman, Matta / Ali, Syed M / Iftikhar, Syed Y / Small, Peter

Cureus

2021 Volume 13, Issue 6, Page(s) e15447

Abstract: Introduction Barret's esophagus (BE) is a precursor of adenocarcinoma of the esophagus. The detection of high-grade dysplasia and adenocarcinoma at an early stage can improve survival but is very challenging. Artificial intelligence (AI)-based models ... ...

Abstract	Introduction Barret's esophagus (BE) is a precursor of adenocarcinoma of the esophagus. The detection of high-grade dysplasia and adenocarcinoma at an early stage can improve survival but is very challenging. Artificial intelligence (AI)-based models have been claimed to improve diagnostic accuracy. The aim of the current study was to carry out a meta-analysis of papers reporting the results of artificial intelligence-based models used in real-time white light endoscopy of patients with BE to detect early esophageal adenocarcinoma (EEAC). Methods This meta-analysis was registered with the International Prospective Register of Systematic Reviews (PROSPERO; Reg No. CRD42021246148) and its conduction and reporting followed the Preferred Reporting Items for Systematic Review and Meta-Analysis of Diagnostic Test Accuracy (PRISMA-DTA) statement guidelines. All peer-reviewed and preprint original articles that reported the sensitivity and specificity of AI-based models on white light endoscopic imaging as an index test against the standard criterion of histologically proven early oesophageal cancer on the background of Barret's esophagus reported as per-patient analysis were considered for inclusion. There was no restriction on type and year of publication, however, articles published in the English language were searched. The search engines used included Medline, PubMed, EMBASE, EMCARE, AMED, BNI, and HMIC. The search strategy included the following keywords for all search engines: ("Esophageal Cancer" OR "Esophageal Neoplasms" OR " Oesophageal Cancer" OR "Oesophageal Neoplasms" OR "Barrett's Esophagus" OR "Barrett's Oesophagus") And ("Artificial Intelligence" OR "Deep Learning" OR "Machine Learning" OR "Convolutional Network"). This search was conducted on November 30, 2020. Duplicate studies were excluded. Studies that reported more than one dataset per patient for the diagnostic accuracy of the AI-based model were included twice. Quantitative and qualitative data, including first author, year of publication, true positives (TP), false negatives (FN), false positives (FP), true negatives (TN), the threshold of the index test, and country where the study was conducted, were extracted using a data extraction sheet. The Quality Appraisal for Diverse Studies 2 (QUADS-2) tool was used to assess the quality of each study. Data were analyzed using MetaDTA, interactive online software for meta-analysis of diagnostic studies. The diagnostic performance of the meta-analysis was assessed by a summary receiver operating characteristics (sROC) plot. A meta-analysis tree was constructed using MetaDTA software to determine the effect of cumulative sensitivity and specificity on surveillance of patients with BE in terms of miss rate and overdiagnosis. Results The literature search revealed 171 relevant records. After removing duplicates, 117 records were screened. Full-text articles of 28 studies were assessed for eligibility. Only three studies reporting four datasets met the inclusion criteria. The summary sensitivity and specificity of AI-based models were 0.90 (95% CI, 0.83- 0.944) and 0.86 (95% CI, 0.781-0.91), respectively. The area under the curve for all the available evidence was 0.88. Conclusion Collective evidence for the routine usage of AI-based models in the detection of EEAC is encouraging but is limited by the low number of studies. Further prospective studies reporting the patient-based diagnostic accuracy of such models are required.
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.15447
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Article ; Online: Retro Aortic Left Renal Vein in Open Abdominal Aortic Aneurysm Surgery.

Khanzada, Zubair / Saggu, Greta / Whitaker, Simon / Kuhan, Ganesh

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2016 Volume 26, Issue 10, Page(s) 874

MeSH term(s)	Aged ; Aortic Aneurysm, Abdominal/complications ; Aortic Aneurysm, Abdominal/diagnosis ; Aortic Aneurysm, Abdominal/surgery ; Coronary Artery Disease/surgery ; Humans ; Male ; Renal Veins/abnormalities ; Renal Veins/injuries ; Renal Veins/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2016-10
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	2466
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Zs.A 6532: Show issues

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Article ; Online: Comment on: The use of pre-operative computed tomography in the assessment of the acute abdomen.

Khanzada, Zubair / Lagatolla, Nick

Annals of the Royal College of Surgeons of England

2012 Volume 94, Issue 6, Page(s) 449–50; author reply 450

MeSH term(s)	Abdomen, Acute/diagnostic imaging ; Female ; Humans ; Male ; Preoperative Care/methods ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2012-09-03
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/003588412X13373405386132
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Article ; Online: A laparoscopic approach to CBD stones.

Khanzada, Zubair / Morgan, Richard

Surgical laparoscopy, endoscopy & percutaneous techniques

2013 Volume 23, Issue 6, Page(s) 502–506

Abstract: Aim: : This study aimed to evaluate single-stage surgical (laparoscopic or open) approach to the management of common bile duct (CBD) stones, as treatment of choice.: Methods: Prospectively collected data to assess outcomes of CBD clearance, ... ...

Abstract	Aim: : This study aimed to evaluate single-stage surgical (laparoscopic or open) approach to the management of common bile duct (CBD) stones, as treatment of choice. Methods: Prospectively collected data to assess outcomes of CBD clearance, morbidity, mortality, and hospital stay, and compared with published data. Results: Successful clearance of CBD stones was achieved in 96% cases, laparoscopic exploration successful in 83%. Retained stones were found in 4% cases and another 5% developed postoperative complications. Common length of stay in hospital was 2 days, although mean stay was 4 days. Seventy-three percent of cases were elective, 27% were emergencies. Conversion rate to open surgery was 14%, which was mainly in emergency cases. Postoperative mortality was 1.2%, not directly related to the procedure. Conclusions: Good outcomes can be achieved, comparing favorably with those of other modalities, when laparoscopic bile duct exploration is chosen as treatment for CBD stones; the best results can be anticipated in elective patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Conversion to Open Surgery/statistics & numerical data ; Elective Surgical Procedures ; Emergencies ; Female ; Gallstones/mortality ; Gallstones/surgery ; Humans ; Laparoscopy ; Length of Stay ; Male ; Middle Aged ; Postoperative Complications ; Prospective Studies ; Treatment Outcome
Language	English
Publishing date	2013-12
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0b013e318290144b
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Zs.A 3200: Show issues

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Article ; Online: Bilateral spontaneous non-traumatic rupture of the Achilles tendon: a case report.

Khanzada, Zubair / Rethnam, Ulfin / Widdowson, David / Mirza, Ahmed

Journal of medical case reports

2011 Volume 5, Page(s) 263

Abstract: Introduction: We present an interesting case of spontaneous non-traumatic bilateral rupture of the Achilles tendons, which is a rare condition. Delayed or missed diagnosis of Achilles tendon ruptures by primary treating physicians is relatively common.!# ...

Abstract	Introduction: We present an interesting case of spontaneous non-traumatic bilateral rupture of the Achilles tendons, which is a rare condition. Delayed or missed diagnosis of Achilles tendon ruptures by primary treating physicians is relatively common. Case report: A 78-year-old Caucasian woman presented with spontaneous non-traumatic bilateral rupture of the Achilles tendons. Her symptoms started two days after she took ciprofloxacin 500 mg twice daily for a urinary tract infection and prednisolone 30 mg once daily for chronic obstructive airway disease. Conclusion: This case report aims to increase the awareness of this rare condition, which should be borne in mind with regard to patients who are on steroid therapy and are concurrently started on fluoroquinolones.
Language	English
Publishing date	2011-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/1752-1947-5-263
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Article ; Online: The interaction between DAP1 and autophagy in the context of human carcinogenesis.

Wazir, Umar / Khanzada, Zubair S / Jiang, Wen G / Sharma, Anup K / Kasem, Abdul / Mokbel, Kefah

Anticancer research

2014 Volume 34, Issue 1, Page(s) 1–8

Abstract: Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is ... ...

Abstract	Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is recognised as a subset of programmed cell death, with features more typical of autophagy rather than classical apoptosis. The mechanisms preventing autophagy from unravelling into autophagic cell death are still the subject of much controversy. We discuss the current understanding of these mechanisms, including recent research regarding the role of death-associated protein-1 in autophagy and apoptosis.
MeSH term(s)	Apoptosis Regulatory Proteins/metabolism ; Autophagy ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Humans
Chemical Substances	Apoptosis Regulatory Proteins ; DAP protein, human
Language	English
Publishing date	2014-01
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
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Article ; Online: Bilateral spontaneous non-traumatic rupture of the Achilles tendon

Widdowson David / Rethnam Ulfin / Khanzada Zubair / Mirza Ahmed

Journal of Medical Case Reports, Vol 5, Iss 1, p

a case report

2011 Volume 263

Abstract: Abstract Introduction We present an interesting case of spontaneous non-traumatic bilateral rupture of the Achilles tendons, which is a rare condition. Delayed or missed diagnosis of Achilles tendon ruptures by primary treating physicians is relatively ... ...

Abstract	Abstract Introduction We present an interesting case of spontaneous non-traumatic bilateral rupture of the Achilles tendons, which is a rare condition. Delayed or missed diagnosis of Achilles tendon ruptures by primary treating physicians is relatively common. Case report A 78-year-old Caucasian woman presented with spontaneous non-traumatic bilateral rupture of the Achilles tendons. Her symptoms started two days after she took ciprofloxacin 500 mg twice daily for a urinary tract infection and prednisolone 30 mg once daily for chronic obstructive airway disease. Conclusion This case report aims to increase the awareness of this rare condition, which should be borne in mind with regard to patients who are on steroid therapy and are concurrently started on fluoroquinolones.
Keywords	Medicine ; R
Language	English
Publishing date	2011-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Current state of mTOR targeting in human breast cancer.

Wazir, Umar / Wazir, Ali / Khanzada, Zubair S / Jiang, Wen G / Sharma, Anup K / Mokbel, Kefah

Cancer genomics & proteomics

2014 Volume 11, Issue 4, Page(s) 167–174

Abstract: Background/aim: The mammalian, or mechanistic, target of rapamycin (mTOR) pathway has been implicated in several models of human oncogenesis. Research in the role of mTOR in human oncogenesis remains a field of intense activity. In this mini-review, we ... ...

Abstract	Background/aim: The mammalian, or mechanistic, target of rapamycin (mTOR) pathway has been implicated in several models of human oncogenesis. Research in the role of mTOR in human oncogenesis remains a field of intense activity. In this mini-review, we intend to recount our current understanding of the mTOR pathway, its interactions, and its role in human carcinogenesis in general, and breast cancer in particular. Materials and methods: We herein outline the discrete components of the two complexes of mTOR, and attempt to define their distinct roles and interactions. Furthermore, we review current developments in the therapeutic targeting of mTOR in human breast cancer. Results: Our understanding of the organisation and interactions of the mTOR pathway continues to evolve. There has been significant incremental, albeit slow, progress in the therapeutic targeting of the mTOR pathway in human breast cancer. Conclusion: Continued progress in the field would require a better understanding of the role of the mTOR pathway in human breast cancer. By summarizing the current literature, this review will provide useful information on the topic.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Carrier Proteins/metabolism ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Molecular Targeted Therapy ; Multiprotein Complexes/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/chemistry ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Antineoplastic Agents ; Carrier Proteins ; Intracellular Signaling Peptides and Proteins ; Multiprotein Complexes ; Protein Kinase Inhibitors ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
Language	English
Publishing date	2014-07
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2144517-5
ISSN	1790-6245 ; 1109-6535
ISSN (online)	1790-6245
ISSN	1109-6535
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