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  1. Article ; Online: Abnormal acinar-β-cell crosstalk in type 2 diabetes.

    Geravandi, Shirin / Ardestani, Amin

    Trends in endocrinology and metabolism: TEM

    2023  Volume 34, Issue 11, Page(s) 685–687

    Abstract: Cellular crosstalk plays a vital role in maintaining pancreas homeostasis. Recently, in Cell Metabolism, Basile et al. demonstrated that aberrant upregulation of acinar-cell-specific pancreatic elastase CELA3B within endocrine islets reduces β-cell ... ...

    Abstract Cellular crosstalk plays a vital role in maintaining pancreas homeostasis. Recently, in Cell Metabolism, Basile et al. demonstrated that aberrant upregulation of acinar-cell-specific pancreatic elastase CELA3B within endocrine islets reduces β-cell viability in type 2 diabetes (T2D). This identifies detrimental acinar-β-cell crosstalk as a novel pathogenic mechanism in diabetes.
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2023.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2999: Show issues Location:
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  2. Article ; Online: How β cells can smell insulin fragments.

    Ardestani, Amin / Maedler, Kathrin

    Cell metabolism

    2022  Volume 34, Issue 2, Page(s) 189–191

    Abstract: In this issue of Cell Metabolism, Cheng et al. identify olfactory receptor Olfr109 in β cells with increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes. Binding of a small insulin fragment to Olfr109 fosters islet ... ...

    Abstract In this issue of Cell Metabolism, Cheng et al. identify olfactory receptor Olfr109 in β cells with increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes. Binding of a small insulin fragment to Olfr109 fosters islet inflammation, β cell failure, and diabetes progression.
    MeSH term(s) Animals ; Diabetes Mellitus, Type 2 ; Insulin ; Insulin-Secreting Cells ; Islets of Langerhans ; Mice ; Smell
    Chemical Substances Insulin
    Language English
    Publishing date 2022-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hippo STK kinases drive metabolic derangement.

    Maedler, Kathrin / Ardestani, Amin

    Nature metabolism

    2021  Volume 3, Issue 3, Page(s) 295–296

    Language English
    Publishing date 2021-03-24
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-021-00370-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MST1 deletion protects β-cells in a mouse model of diabetes.

    Ardestani, Amin / Maedler, Kathrin

    Nutrition & diabetes

    2022  Volume 12, Issue 1, Page(s) 7

    Abstract: The pro-apoptotic kinase Mammalian Sterile 20-like kinase 1 (MST1), an integral component of the Hippo pathway, is a key regulator of organ size, stress response, and tissue homeostasis; its aberrant hyperactivation is linked to multiple pathological ... ...

    Abstract The pro-apoptotic kinase Mammalian Sterile 20-like kinase 1 (MST1), an integral component of the Hippo pathway, is a key regulator of organ size, stress response, and tissue homeostasis; its aberrant hyperactivation is linked to multiple pathological disorders including diabetes. Here we show that MST1 deletion in mice resulted in improved glucose tolerance and insulin secretion, and restored pancreatic β-cell mass as a result of improved β-cell survival and proliferation in the combined high fat/high sucrose and streptozotocin (HFS/STZ) model of β-cell destruction and diabetes. Importantly, the glucose-lowering effects in the MST1-knockout (KO) mice could be accounted to the enhanced β-cell mass and improved insulin secretion without changes in insulin sensitivity. Metabolic and morphological data suggest that normalization of blood glucose and insulin secretion, islet architecture, and β-cell mass by MST1 deletion in response to diabetes-induced injury occurs as a result of improved β-cell survival and proliferation establishing MST1 as potent regulator of physiological β-cell turnover.
    MeSH term(s) Animals ; Diabetes Mellitus/metabolism ; Insulin ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Mammals/metabolism ; Mice ; Mice, Knockout ; Streptozocin/metabolism
    Chemical Substances Insulin ; Streptozocin (5W494URQ81)
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2609314-5
    ISSN 2044-4052 ; 2044-4052
    ISSN (online) 2044-4052
    ISSN 2044-4052
    DOI 10.1038/s41387-022-00186-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting glucose metabolism for treatment of COVID-19.

    Ardestani, Amin / Azizi, Zahra

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 112

    MeSH term(s) Blood Glucose ; COVID-19 ; Glycolysis ; Humans ; Monocytes ; SARS-CoV-2
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2021-03-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00532-4
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  6. Article: PHLPP1 deletion restores pancreatic β-cell survival and normoglycemia in the db/db mouse model of obesity-associated diabetes.

    Lupse, Blaz / Heise, Nick / Maedler, Kathrin / Ardestani, Amin

    Cell death discovery

    2022  Volume 8, Issue 1, Page(s) 57

    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-00853-5
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  7. Article ; Online: Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy.

    Ardestani, Amin / Maedler, Kathrin

    Autophagy

    2021  Volume 17, Issue 12, Page(s) 4494–4496

    Abstract: A progressive decline in the macroautophagic/autophagic flux is a hallmark of pancreatic β-cell failure in type 2 diabetes (T2D) but the responsible intrinsic factors and underlying molecular mechanisms are incompletely understood. A stress-sensitive ... ...

    Abstract A progressive decline in the macroautophagic/autophagic flux is a hallmark of pancreatic β-cell failure in type 2 diabetes (T2D) but the responsible intrinsic factors and underlying molecular mechanisms are incompletely understood. A stress-sensitive multicomponent cellular loop of the Hippo pathway kinase LATS2 (large tumor suppressor 2), MTOR (mechanistic target of rapamycin kinase) complex 1 (MTORC1) and autophagy regulates β-cell survival and metabolic adaptation. Chronic metabolic stress leads to LATS2 hyperactivation which then induces MTORC1, subsequently impairing the cellular autophagic flux and consequently triggering β-cell death. Reciprocally, under physiological conditions, autophagy controls β-cell survival by lysosomal degradation of LATS2. These signaling cross-talks and the interaction between autophagy and LATS2 are important for the regulation of β-cell turnover and functional compensation under metabolic stress.
    MeSH term(s) Autophagy/physiology ; Diabetes Mellitus, Type 2/metabolism ; Hippo Signaling Pathway ; Humans ; Insulin-Secreting Cells/pathology ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Protein Serine-Threonine Kinases ; Tumor Suppressor Proteins/metabolism
    Chemical Substances Tumor Suppressor Proteins ; LATS2 protein, human (EC 2.7.1.11) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2021.1972404
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    Zs.A 6741: Show issues Location:
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  8. Article ; Online: Targeting glucose metabolism for treatment of COVID-19

    Amin Ardestani / Zahra Azizi

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    2021  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Managing the Dual Diagnosis Dilemma of Bipolar Disorder and Substance Abuse in Clinical Settings.

    Samimi Ardestani, Seyed Mehdi / Amin-Esmaeili, Masoumeh / Seif, Pegah / Gudarzi, Shahrokh S / Rafiefarahzadi, Maliheh / Semnani, Yousef

    Journal of dual diagnosis

    2024  Volume 20, Issue 2, Page(s) 178–187

    Abstract: Objective: Drug addiction is a chronic mental disorder that significantly impacts all aspects of an individual's life, and substance use disorder in patients with bipolar disorder. The objective of this study is to assess the frequency of substance ... ...

    Abstract Objective: Drug addiction is a chronic mental disorder that significantly impacts all aspects of an individual's life, and substance use disorder in patients with bipolar disorder. The objective of this study is to assess the frequency of substance abuse among patients with bipolar spectrum disorder.
    Method: This cross-sectional study evaluated the frequency of bipolar spectrum disorder in patients taking methadone through various screening measures, including Mini Mental State Examination (MMSE), DSM IV criteria, Mood Disorders Questionnaire (MDQ), Goodwin and Ghaemi's criteria, and Akiskal classification for bipolar disorders.
    Results: Out of the total 197 participants in the study, 77 were identified as individuals engaging in poly-substance abuse. The investigation assessed the frequency of bipolar spectrum disorder based on various diagnostic criteria: 24% according to DSM-IV criteria, 29.9% using MDQ, 29.9% based on Ghaemi and Goodwin's criteria, and the highest rate at 48.2% when applying Akiskal's classification.
    Conclusions: This study highlights the high frequency of bipolar disorder among individuals with substance use disorder, especially those with concomitant depression. Therefore, it is crucial to pay special attention to individuals with substance use disorder with co-existing bipolar disorder.
    MeSH term(s) Humans ; Bipolar Disorder/complications ; Bipolar Disorder/diagnosis ; Bipolar Disorder/epidemiology ; Diagnosis, Dual (Psychiatry) ; Cross-Sectional Studies ; Substance-Related Disorders/complications ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2179549-6
    ISSN 1550-4271 ; 1550-4263
    ISSN (online) 1550-4271
    ISSN 1550-4263
    DOI 10.1080/15504263.2024.2328600
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    Zs.A 6004: Show issues Location:
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  10. Article: Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.

    Ardestani, Amin / Maedler, Kathrin

    Frontiers in endocrinology

    2020  Volume 11, Page(s) 585922

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Organoids ; Pandemics ; Pluripotent Stem Cells ; Pneumonia, Viral ; SARS-CoV-2 ; Tropism
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2020.585922
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