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Article ; Online: Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models.

Li, Tian / Mao, Na / Xie, Zihao / Wang, Jianing / Jin, Fuyu / Li, Yaqian / Liu, Shupeng / Cai, Wenchen / Gao, Xuemin / Wei, Zhongqiu / Yang, Fang / Xu, Hong / Liu, Heliang / Zhang, Haibo / Xu, Dingjie

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 129, Page(s) 155616

Abstract: ... to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key ...

Abstract	Background: Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue. However, the precise effects and mechanisms of TCM in treating silicosis remain uncertain and subject to debate. Objective: The study aims to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key component, paeoniflorin, in silicosis using a murine model. Methods: Silicotic mice were treated with YYQFD, pirfenidone (PFD), or paeoniflorin. RAW264.7 cells and mouse lung fibroblasts (MLF) were stimulated with silica, matrix metalloproteinase-12 (MMP-12), or TGF-β1, followed by treatment with paeoniflorin, PFD, or relevant inhibitors. YYQFD constituents were characterized using High-Performance Liquid Chromatography (HPLC). Lung fibrosis severity was assessed via histopathological examination, micro-CT imaging, lung functions, and Western blot analysis. Transcriptome sequencing and bioinformatics analysis were employed to delineate the gene expression profile and target genes modulated by YYQFD in silicosis. Results: Treatment with YYQFD ameliorated silica-induced lung fibrosis. Transcriptome sequencing identified MMP-12 as a potential common target of YYQFD and PFD. Additionally, a potential pro-inflammatory role of MMP-12, regulated by silica-induced TLR4 signaling pathways, was revealed. Paeoniflorin, one of the most distinctive compounds in YYQFD, attenuated silica-induced MMP-12 increase and its derived inflammatory factors in macrophages through a direct binding effect. Notably, paeoniflorin treatment exerted anti-fibrotic effects by inhibiting MMP-12-derived inflammatory factors and TGF-β1-induced myofibroblast differentiation in silica-exposed mice. Conclusions: This study underscores paeoniflorin as one of the most principal bioactive compounds in YYQFD, highlighting its capacity to attenuate lung inflammation driven by macrophage-derived MMP-12 and reduce lung fibrosis both in vivo and in vitro.
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155616
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Zs.A 4115: Show issues

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Article ; Online: The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification.

Peng, Xiaohuan / Zhu, Xiaofeng / Di, Tianning / Tang, Futian / Guo, Xiaojia / Liu, Yang / Bai, Jun / Li, Yanhong / Li, Lijuan / Zhang, Liansheng

Frontiers in immunology

2022 Volume 13, Page(s) 994053

Abstract: ... Yin-Yang theory" in ancient China, meaning that the opposing forces may actually be interdependent and ...

Abstract	Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid clonal diseases with diverse clinical courses, and immune dysregulation plays an important role in the pathogenesis of MDS. However, immune dysregulation is complex and heterogeneous in the development of MDS. Lower-risk MDS (LR-MDS) is mainly characterized by immune hyperfunction and increased apoptosis, and the immunosuppressive therapy shows a good response. Instead, higher-risk MDS (HR-MDS) is characterized by immune suppression and immune escape, and the immune activation therapy may improve the survival of HR-MDS. Furthermore, the immune dysregulation of some MDS changes dynamically which is characterized by the coexistence and mutual transformation of immune hyperfunction and immune suppression. Taken together, the authors think that the immune dysregulation in MDS with different risk stratification can be summarized by an advanced philosophical thought "Yin-Yang theory" in ancient China, meaning that the opposing forces may actually be interdependent and interconvertible. Clarifying the mechanism of immune dysregulation in MDS with different risk stratification can provide the new basis for diagnosis and clinical treatment. This review focuses on the manifestations and roles of immune dysregulation in the different risk MDS, and summarizes the latest progress of immunotherapy in MDS.
MeSH term(s)	Humans ; Immunosuppression Therapy ; Immunotherapy/adverse effects ; Myelodysplastic Syndromes/therapy ; Risk Assessment ; Yin-Yang
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.994053
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Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9110704

Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

Abstract	Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW. Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms. Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9110704
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Zs.A 5995: Show issues

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Article ; Online: The Yin Yang 1 of Penaeus vannamei regulates transcription of the small subunit hemocyanin gene during Vibrio parahaemolyticus infection.

Yang, Peikui / Zhao, Xianliang / Aweya, Jude Juventus / Zhang, Yueling

Developmental and comparative immunology

2023 Volume 151, Page(s) 105087

Abstract: ... the Yin Yang 1 transcription factor homolog in Penaeus vannamei (PvYY1) as a key factor that modulates ...

Abstract	Hemocyanin is a respiratory protein, it is also a multifunctional immune molecule that plays a vital role against pathogen invasion in shrimp. However, the regulation of hemocyanin gene expression in shrimp hemocytes and the mechanisms involved during pathogen infection remains unclear. Here, we used DNA pull-down followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the Yin Yang 1 transcription factor homolog in Penaeus vannamei (PvYY1) as a key factor that modulates transcription of the small subunit hemocyanin gene of P. vannamei (PvHMCs) in hemocytes during Vibrio parahaemolyticus AHPND (VP
MeSH term(s)	Animals ; Hemocyanins ; Arthropod Proteins/genetics ; Penaeidae ; Vibrio parahaemolyticus ; Chromatography, Liquid ; Yin-Yang ; Tandem Mass Spectrometry ; Immunity, Innate/genetics
Chemical Substances	Hemocyanins (9013-72-3) ; Arthropod Proteins
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2023.105087
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Zs.A 1327: Show issues

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Article ; Online: Restricted Phase Space Thermodynamics of Einstein-Power-Yang-Mills AdS Black Hole.

Du, Yun-Zhi / Li, Huai-Fan / Zhang, Yang / Zhou, Xiang-Nan / Zhao, Jun-Xin

Entropy (Basel, Switzerland)

2023 Volume 25, Issue 4

Abstract: We consider the thermodynamics of the Einstein-power-Yang-Mills AdS black holes in the context ... of the non-linear Yang-Mills parameter on these thermodynamic properties is also investigated. ...

Abstract	We consider the thermodynamics of the Einstein-power-Yang-Mills AdS black holes in the context of the gauge-gravity duality. Under this framework, Newton's gravitational constant and the cosmological constant are varied in the system. We rewrite the thermodynamic first law in a more extended form containing both the pressure and the central charge of the dual conformal field theory, i.e., the restricted phase transition formula. A novel phenomena arises: the dual quantity of pressure is the effective volume, not the geometric one. That leads to a new behavior of the Van de Waals-like phase transition for this system with the fixed central charge: the supercritical phase transition. From the Ehrenfest's scheme perspective, we check out the second-order phase transition of the EPYM AdS black hole. Furthermore the effect of the non-linear Yang-Mills parameter on these thermodynamic properties is also investigated.
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25040687
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Article ; Online: Two new species of genus Spilolonchoptera Yang, 1998 from China (Diptera, Lonchopteridae).

Gao, Shang / Zhang, Bing / Yang, Ding

Zootaxa

2021 Volume 4980, Issue 2, Page(s) 389394

Abstract: Only five species of the genus Spilolonchoptera Yang, 1998 were previously known from China. Here ...

Abstract	Only five species of the genus Spilolonchoptera Yang, 1998 were previously known from China. Here two new species, Spilolonchoptera hainanensis sp. nov. and Spilolonchoptera zhejiangensis sp. nov. are reported from China. A key to species of the genus Spilolonchoptera from China is presented.
Language	English
Publishing date	2021-06-01
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4980.2.10
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Article: Retraction: Yang, B. et al. Nitrogen Doped Intercalation TiO

Yang, Ben / She, Yin / Zhang, Changgeng / Kang, Shuai / Zhou, Jin / Hu, Wei / Nanomaterials Editorial Office

Nanomaterials (Basel, Switzerland)

2021 Volume 11, Issue 4

Abstract: This article [1] has been retracted at the request of the authors due to data errors [ ... ]. ...

Abstract	This article [1] has been retracted at the request of the authors due to data errors [...].
Language	English
Publishing date	2021-04-06
Publishing country	Switzerland
Document type	Retraction of Publication
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano11040936
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Article ; Online: The Yin and Yang of traditional Chinese and Western medicine.

Fu, Rao / Li, Jie / Yu, Huatao / Zhang, Yang / Xu, Zhihong / Martin, Cathie

Medicinal research reviews

2021 Volume 41, Issue 6, Page(s) 3182–3200

Abstract: The success of Western Scientific approaches to medicine, over the last 150 years, can be measured by substantial increases in life expectancy, reductions in infant mortality and the virtual elimination of many infectious diseases accompanied by ... ...

Abstract	The success of Western Scientific approaches to medicine, over the last 150 years, can be measured by substantial increases in life expectancy, reductions in infant mortality and the virtual elimination of many infectious diseases accompanied by development of effective management practices for noncommunicable diseases. However, major challenges remain in the form of infectious diseases that evolve resistance to pharmaceuticals rapidly, new diseases, particularly those caused by viruses and effective long-term treatments for chronic, noncommunicable diseases. Traditional Chinese Medicine (TCM) can offer complementary treatments based on personalised interventions, informed by knowledge accumulated from empirical observations gathered over centuries of practice, that address the impact of disease on the whole body. We provide examples of both infectious and noncommunicable diseases where the combination of Western Scientific Medicine (WSM) and TCM can benefit patients in terms of the speed and efficacy of recovery or disease management. TCM is a healing skill based on practice, while WSM is scientific, based on experiments. Against this background, an understanding of the mechanisms of action of traditional Chinese medicinal preparations will offer fresh routes to discovery and development of new therapeutics as well as patented medical prescriptions, which will rely heavily on modern scientific methodologies for their adoption and success, particularly those in plant genomics, plant breeding and synthetic biology.
MeSH term(s)	China ; Humans ; Medicine, Chinese Traditional
Language	English
Publishing date	2021-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603210-2
ISSN	1098-1128 ; 0198-6325
ISSN (online)	1098-1128
ISSN	0198-6325
DOI	10.1002/med.21793
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Zs.A 1764: Show issues

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Article ; Online: Understanding Yin-Yang Philosophic Concept Behind Tai Chi Practice.

Liu, Hao Howe / Nichols, Charles / Zhang, Hong

Holistic nursing practice

2023 Volume 37, Issue 5, Page(s) E75–E82

Abstract: Yin-yang theorizes that everything in the world is interoppositionally unified with 2 dynamic ... opposites (yin and yang), interrooted, interchangeable, and interconvertible. Tai chi (TC) movements and ... postures are essentially yin-yang concept-based. However, there is still a lack of understanding ...

Abstract	Yin-yang theorizes that everything in the world is interoppositionally unified with 2 dynamic opposites (yin and yang), interrooted, interchangeable, and interconvertible. Tai chi (TC) movements and postures are essentially yin-yang concept-based. However, there is still a lack of understanding of yin-yang concepts and applications among people practicing TC. So, in this concept review, we aimed to provide basic understanding of the yin-yang concept and characteristics behind TC practice. Terms derived from the yin-yang concept in TC practice may include blood/qi (energy), stability/mobility, closing/opening moves, expiration/inspiration, solid/empty stance, and defensive/offensive hand movements and postures. These yin-yang attributes are interrestricted and dependent on maintaining a dynamic mind-body harmony. With the yin-yang application, TC can be considered a self-controlled balance perturbation exercise to challenge the stability-mobility (yin-yang) to a new level of harmony. As a health promotion holistic intervention, TC can facilitate the flow in blood/qi pathways or meridians to improve medical conditions. As an integrative mind-body exercise, TC can activate different body parts and brain regions to participate in and coordinate the combined physical and mental activities.
MeSH term(s)	Humans ; Yin-Yang ; Tai Ji ; Meridians ; Exercise Therapy ; Health Promotion
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	639032-8
ISSN	1550-5138 ; 0887-9311
ISSN (online)	1550-5138
ISSN	0887-9311
DOI	10.1097/HNP.0000000000000598
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Zs.A 2212: Show issues

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Article ; Online: Lee-Yang zeros and quantum Fisher information matrix in a nonlinear system.

Tao, Hong / Su, Yuguo / Zhang, Xingyu / Liu, Jing / Wang, Xiaoguang

Physical review. E

2023 Volume 108, Issue 2-1, Page(s) 24104

Abstract: The distribution of Lee-Yang zeros not only matters in thermodynamics and quantum mechanics ... of corresponding Lee-Yang zeros. Utilizing the coupling between a probe qubit and the nonlinear system, all Lee ... Yang zeros can be detected in the dynamics of the probe qubit by tuning the coupling strength and ...

Abstract	The distribution of Lee-Yang zeros not only matters in thermodynamics and quantum mechanics, but also in mathematics. Hereby we propose a nonlinear quantum toy model and discuss the distribution of corresponding Lee-Yang zeros. Utilizing the coupling between a probe qubit and the nonlinear system, all Lee-Yang zeros can be detected in the dynamics of the probe qubit by tuning the coupling strength and linear coefficient of the nonlinear system. Moreover, the analytical expression of the quantum Fisher information matrix at the Lee-Yang zeros is provided and an interesting phenomenon is discovered. Both the coupling strength and temperature can simultaneously attain their precision limits at the Lee-Yang zeros. However, the probe qubit cannot work as a thermometer at a Lee-Yang zero if it sits on the unit circle.
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.108.024104
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