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  1. Article ; Online: Stuart Schlossman (1935-2023).

    Rudd, Christopher E

    Nature immunology

    2024  Volume 25, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01707-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  2. Article ; Online: CD8

    Rudd, Christopher E

    Nature cancer

    2023  Volume 4, Issue 9, Page(s) 1214–1216

    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Histocompatibility Antigens Class I/genetics ; Genes, MHC Class I/genetics ; Neoplasms/genetics ; Cell Death
    Chemical Substances Histocompatibility Antigens Class I
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00606-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: How the Discovery of the CD4/CD8-p56

    Rudd, Christopher E

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 626095

    Abstract: The past 25 years have seen enormous progress in uncovering the receptors and signaling mechanisms on T-cells that activate their various effecter functions. Until the late 1980s, most studies on T-cells had focused on the influx of calcium and the ... ...

    Abstract The past 25 years have seen enormous progress in uncovering the receptors and signaling mechanisms on T-cells that activate their various effecter functions. Until the late 1980s, most studies on T-cells had focused on the influx of calcium and the levels of cAMP/GMP in T-cells. My laboratory then uncovered the interaction of CD4 and CD8 co-receptors with the protein-tyrosine kinase p56
    Language English
    Publishing date 2021-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.626095
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  4. Article: Commentary: Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report.

    Rudd, Christopher E

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 613734

    Language English
    Publishing date 2020-12-16
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.613734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade.

    Rudd, Christopher E

    Science immunology

    2020  Volume 5, Issue 43

    Abstract: PD-1 mediates antitumor immunity by regulating lineage fate commitment and function of myeloid cells (see related Research Article by ... ...

    Abstract PD-1 mediates antitumor immunity by regulating lineage fate commitment and function of myeloid cells (see related Research Article by Strauss
    MeSH term(s) Humans ; Immunotherapy ; Myeloid Cells ; Neoplasms ; Programmed Cell Death 1 Receptor
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2020-01-27
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.aaz8128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response.

    Rudd, Christopher E

    Frontiers in immunology

    2020  Volume 11, Page(s) 1638

    Abstract: The SARS-CoV2 (COVID-19) pandemic and uncertainties in developing a vaccine have created an urgent need for new therapeutic approaches. A key question is whether it is possible to make rational predictions of new therapies based on the presently ... ...

    Abstract The SARS-CoV2 (COVID-19) pandemic and uncertainties in developing a vaccine have created an urgent need for new therapeutic approaches. A key question is whether it is possible to make rational predictions of new therapies based on the presently available scientific and medical information. In this regard, I have noticed an omission in the present analysis in the literature related to the exploitation of glycogen synthase kinase 3 (GSK-3) as a therapeutic approach. This is based on two key observations, that GSK-3 inhibitors can simultaneously block SARs viral replication, while boosting CD8+ adaptive T-cell and innate natural killer (NK) responses. Firstly, it is already clear that GSK-3 phosphorylation of SARs CoV1 N protein on key serine residues is needed for viral replication such that small molecule inhibitors (SMIs) of GSK-3 can inhibit viral replication. In comparing protein sequences, I show here that the key sites in the N protein of SARs CoV1 N for replication are conserved in SARs CoV2. This strongly suggests that GSK-3 SMIs will also inhibit SARs Cov2 replication. Secondly, we and others have previously documented that GSK-3 SMIs markedly enhance CD8+ cytolytic T-cell (CTL) and NK cell anti-viral effector functions leading to a reduction in both acute and chronic viral infections in mice. My hypothesis is that the repurposing of low-cost inhibitors of GSK-3 such as lithium will limit SARS-CoV2 infections by both reducing viral replication and potentiating the immune response against the virus. To date, there has been no mention of this dual connection between GSK-3 and SARs CoV2 in the literature. To my knowledge, no other drugs exist with the potential to simultaneously target both viral replication and immune response against SARs CoV2.
    MeSH term(s) Betacoronavirus/physiology ; CD8-Positive T-Lymphocytes/enzymology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/enzymology ; Coronavirus Infections/immunology ; Enzyme Inhibitors/therapeutic use ; Glycogen Synthase Kinase 3 ; Humans ; Immunity, Cellular/drug effects ; Killer Cells, Natural/enzymology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Virus Replication/drug effects
    Chemical Substances Enzyme Inhibitors ; Glycogen Synthase Kinase 3 (EC 2.7.11.26)
    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Glycogen Synthase Kinase-3 (GSK-3) Regulation of Inhibitory Coreceptor Expression in T-cell Immunity.

    Issa, Mark E / Rudd, Christopher E

    Journal of cellular immunology

    2022  Volume 3, Issue 5, Page(s) 336–342

    Abstract: The serine/threonine kinase, glycogen synthase kinase 3 (GSK-3) has been implicated in immune cell activation and function. Our recent studies have shown that the abrogation of GSK-3 activity down-regulates the expression of key inhibitory receptors PD-1 ...

    Abstract The serine/threonine kinase, glycogen synthase kinase 3 (GSK-3) has been implicated in immune cell activation and function. Our recent studies have shown that the abrogation of GSK-3 activity down-regulates the expression of key inhibitory receptors PD-1 and LAG-3. It also regulates the expression of the transcription factor NFAT which, in turn, is responsible for inhibiting PD-1/LAG-3 transcription as well as activating the expression of cytolytic effector proteins such as perforin and granzyme B. The role of components of the Wnt signaling pathway in these events remains to be fully uncovered. This mini-review discusses the recent discoveries that have elucidated the role of the GSK-3 signaling pathway in cancer immunotherapy.
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 2689-2812
    ISSN (online) 2689-2812
    DOI 10.33696/immunology.3.115
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  8. Article ; Online: Advances in T-cell co-receptor biology and cancer immunotherapy.

    Rudd, Christopher E

    Seminars in immunology

    2019  Volume 42, Page(s) 101281

    MeSH term(s) Animals ; Humans ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy ; Receptors, Antigen, T-Cell/immunology
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2019-10-11
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2019.101281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

    Christopher E. Rudd

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: The past 25 years have seen enormous progress in uncovering the receptors and signaling mechanisms on T-cells that activate their various effecter functions. Until the late 1980s, most studies on T-cells had focused on the influx of calcium and the ... ...

    Abstract The past 25 years have seen enormous progress in uncovering the receptors and signaling mechanisms on T-cells that activate their various effecter functions. Until the late 1980s, most studies on T-cells had focused on the influx of calcium and the levels of cAMP/GMP in T-cells. My laboratory then uncovered the interaction of CD4 and CD8 co-receptors with the protein-tyrosine kinase p56lck which are now widely accepted as the initiators of the tyrosine phosphorylation cascade leading to T-cell activation. The finding explained how immune recognition receptors expressed by many immune cells, which lack intrinsic catalytic activity, can transduce activation signals via non-covalent association with non-receptor tyrosine kinases. The discovery also established the concept that a protein tyrosine phosphorylation cascade operated in T-cells. In this vein, we and others then showed that the CD4- and CD8-p56lck complexes phosphorylate the TCR complexes which led to the identification of other protein-tyrosine kinases such as ZAP-70 and an array of substrates that are now central to studies in T-cell immunity. Other receptors such as B-cell receptor, Fc receptors and others were also subsequently found to use src kinases to control cell growth. In T-cells, p56lck driven phosphorylation targets include co-receptors such as CD28 and CTLA-4 and immune cell-specific adaptor proteins such as LAT and SLP-76 which act to integrate signals proximal to surface receptors. CD4/CD8-p56lck regulated events in T-cells include intracellular calcium mobilization, integrin activation and the induction of transcription factors for gene expression. Lastly, the identification of the targets of p56lck in the TCR and CD28 provided the framework for the development of chimeric antigen receptor (CAR) therapy in the treatment of cancer. In this review, I outline a history of the development of events that led to the development of the “TCR signaling paradigm” and its implications to immunology and immunotherapy.
    Keywords p56lck tyrosine kinase ; CD4 ; CD8 ; tyrosine phosphorylation ; chimeric antigen receptor ; immunotherapy ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Editorial: T-Cell Signaling Networks in Health and Disease.

    Rudd, Christopher E / Merida, Isabel / Hawse, William

    Frontiers in immunology

    2022  Volume 13, Page(s) 875580

    Language English
    Publishing date 2022-04-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.875580
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