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  1. Article ; Online: Implications of using home urine pregnancy tests versus facility-based tests for assessment of outcome following medication abortion provided via telemedicine.

    Anger, Holly A / Raymond, Elizabeth G

    Contraception

    2023  Volume 124, Page(s) 110055

    Abstract: Objectives: To assess whether planning high-sensitivity urine pregnancy tests (HSPT) rather than facility-based tests for medication abortion follow-up may increase risk of unplanned clinical visits or procedural completion of the abortion.: Study ... ...

    Abstract Objectives: To assess whether planning high-sensitivity urine pregnancy tests (HSPT) rather than facility-based tests for medication abortion follow-up may increase risk of unplanned clinical visits or procedural completion of the abortion.
    Study design: We used data from the TelAbortion Project, a 5-year study assessing the safety and feasibility of providing mifepristone and misoprostol by telemedicine and mail in the United States. We categorized participants by whether the pretreatment follow-up plan included HSPT at home 3-5 weeks after treatment or facility-based tests (ultrasound or serum human chorionic gonadotropin) within 2 weeks after treatment. We used multivariable logistic regression to compare likelihood of post-treatment unplanned, abortion-related clinical visits and procedural intervention in these groups.
    Results: Of 1324 patients who planned HSPT follow-up and 576 who planned facility-based tests, 85% and 83%, respectively, provided outcome information. Post-treatment clinical visits were less frequent in the HSPT group (19%) than in the facility-based test group (79%); most of the latter were to obtain the planned test. However, unplanned, abortion-related visits were significantly more common in the HSPT group (adjusted risk difference: 6.5%; p < 0.01). The likelihood of procedural completion did not differ by group. Planned follow-up test was not associated with delay in procedural completion or detection of ongoing pregnancy.
    Conclusions: Follow-up of medication abortion with home HSPT was associated with fewer post-treatment clinical visits, modestly more unplanned, abortion-related clinical visits, and no increase in the risk of procedural interventions or delayed identification or management of treatment failures. This option is an appropriate follow-up approach after medication abortion.
    Implications: Use of home high-sensitivity pregnancy tests rather than facility-based tests for outcome assessment after medication abortion is associated with a modest increase in unplanned clinical visits but does not lead to an increase in procedural interventions or delays identification and management of treatment failure.
    MeSH term(s) Pregnancy ; Female ; Humans ; United States ; Abortion, Induced ; Mifepristone/therapeutic use ; Misoprostol/therapeutic use ; Pregnancy Tests ; Telemedicine
    Chemical Substances Mifepristone (320T6RNW1F) ; Misoprostol (0E43V0BB57)
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2023.110055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effectiveness and safety of misoprostol-only for first-trimester medication abortion: An updated systematic review and meta-analysis.

    Raymond, Elizabeth G / Weaver, Mark A / Shochet, Tara

    Contraception

    2023  Volume 127, Page(s) 110132

    Abstract: Objectives: This study aimed to update our 2019 systematic review of data on the effectiveness and safety of misoprostol-only for first-trimester abortion.: Study design: We searched PubMed on December 18, 2022, to find published articles describing ... ...

    Abstract Objectives: This study aimed to update our 2019 systematic review of data on the effectiveness and safety of misoprostol-only for first-trimester abortion.
    Study design: We searched PubMed on December 18, 2022, to find published articles describing the outcomes of treatment with misoprostol-only for abortion of viable intrauterine pregnancy at ≤91 days of gestation. From each article identified, two authors independently abstracted relevant data about each group of patients treated with a distinct regimen. We assessed the risk of bias using four defined indicators. We estimated the proportion of patients with treatment failure using meta-analytic methods as well as the proportion hospitalized or transfused after treatment. We examined associations between treatment failure and selected characteristics of the groups.
    Results: We identified 49 papers with 66 groups that collectively included 16,354 evaluable patients, of whom 2960 (meta-analytic estimate 15%, 95% CI 12%, 19%) had treatment failures. Of 9228 patients assessed for ongoing pregnancy after treatment, 521 (meta-analytic estimate 6%, 95% CI 5%, 8%) had that condition. Failure risk was significantly associated with misoprostol dose, the total allowed number of doses, the maximum duration of dosing, and certain indicators of risk of bias. Among 11,007 patients allowed to take at least three misoprostol doses, the first consisting of misoprostol 800 mcg administered vaginally, sublingually, or buccally, the meta-analytic estimate of the failure risk was 11% (95% CI 8%, 14%). At most, 0.2% of 15,679 evaluable patients were hospitalized or received transfusions.
    Conclusions: Although some studies in this updated review were adjudicated to have a high risk of bias, the results continue to support the key conclusion of our 2019 analysis: misoprostol-only is effective and safe for the termination of first-trimester intrauterine pregnancy.
    Implications: Misoprostol-only is a safe and effective option for medication abortion in the first trimester if mifepristone is unavailable or inaccessible.
    MeSH term(s) Pregnancy ; Female ; Humans ; Misoprostol/adverse effects ; Abortifacient Agents ; Pregnancy Trimester, First ; Mifepristone ; Abortion, Induced/methods ; Abortifacient Agents, Nonsteroidal/adverse effects
    Chemical Substances Misoprostol (0E43V0BB57) ; Abortifacient Agents ; Mifepristone (320T6RNW1F) ; Abortifacient Agents, Nonsteroidal
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2023.110132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: PAPP-A as a screening tool for assessment of gestational age before medication abortion in an intended-use population.

    Frye, Laura J / Buhimschi, Irina A / Raymond, Elizabeth G / Zhao, Guomao / Winikoff, Beverly

    Biomarkers in medicine

    2023  Volume 17, Issue 2, Page(s) 73–85

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Pregnancy ; Female ; Humans ; Pregnancy Trimester, First ; Pregnancy-Associated Plasma Protein-A ; Gestational Age ; Abortion, Induced ; ROC Curve ; Biomarkers
    Chemical Substances Pregnancy-Associated Plasma Protein-A (EC 3.4.24.-) ; Biomarkers
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2022-0653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: In Reply to PAPP-A Results Cannot Be Used to Accurately Estimate Gestational Age.

    Buhimschi, Irina A / Frye, Laura J / Winikoff, Beverly / Raymond, Elizabeth G

    The journal of applied laboratory medicine

    2022  Volume 7, Issue 4, Page(s) 1002–1004

    MeSH term(s) Biomarkers ; Gestational Age ; Humans ; Pregnancy-Associated Plasma Protein-A ; Risk Factors
    Chemical Substances Biomarkers ; Pregnancy-Associated Plasma Protein-A (EC 3.4.24.-)
    Language English
    Publishing date 2022-06-02
    Publishing country England
    Document type Letter ; Comment
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfac021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cannabidiol (CBD) Use in Type 2 Diabetes: A Case Report.

    Mattes, Raymond G / Espinosa, Melchor L / Oh, Sam S / Anatrella, Elizabeth M / Urteaga, Elizabeth M

    Diabetes spectrum : a publication of the American Diabetes Association

    2021  Volume 34, Issue 2, Page(s) 198–201

    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211544-4
    ISSN 1040-9165
    ISSN 1040-9165
    DOI 10.2337/ds20-0023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A practical guide to feedback in the workplace: Transitioning from learner to independent practitioner.

    Goodlet, Kellie J / Raymond, Alexandre / Schlosser, Elizabeth G

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2020  Volume 77, Issue 15, Page(s) 1196–1199

    MeSH term(s) Formative Feedback ; Guidelines as Topic/standards ; Humans ; Pharmacists/standards ; Pharmacists/trends ; Pharmacy Residencies/standards ; Workplace/psychology ; Workplace/standards
    Language English
    Publishing date 2020-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxaa067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Surgical Management of Arteriovenous Malformation in the Foot: A Case Study.

    Bonarigo, Elizabeth M / Cavaliere, Raymond G

    The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

    2020  Volume 60, Issue 1, Page(s) 146–151

    Abstract: Arteriovenous malformations are frequently found in the head and neck, and are occasionally associated with congenital syndromes. They are rarely reported in the foot and ankle; however, when encountered in these particular locations, they may become ... ...

    Abstract Arteriovenous malformations are frequently found in the head and neck, and are occasionally associated with congenital syndromes. They are rarely reported in the foot and ankle; however, when encountered in these particular locations, they may become painful and interfere with ambulation. Because of the lack of literature on pedal arteriovenous malformations, they remain enigmatic when encountered clinically. They form as a result of atypical development of the vascular system during embryogenesis. The identification, diagnosis, and treatment of an arteriovenous malformation can be challenging, because it may present similarly to more frequent soft-tissue pathologies in podiatric practice. These include fibroma, lipoma, ganglion cyst, or proteinaceous cyst. They have unpredictable behavior and a high recurrence rate. Failure to recognize and treat an arteriovenous malformation appropriately could result in ulceration, hemorrhage, and amputation. The identification and diagnosis must be accompanied with a full vascular work-up to determine the magnitude, flow, and extent of the lesion. After vascular work up, conservative, and surgical treatment options can be explored. This is an unusual case report of an arteriovenous malformation of the plantar foot that was previously misdiagnosed, and later presented to our facility for a second opinion. The steps taken for identification, diagnosis, and treatment are discussed along with surgical technique for excision of an arteriovenous malformation with successful outcome at 1 year follow-up. This case report will provide clinicians with armamentarium for diagnosis, workup, and treatment, when considering arteriovenous malformation in the differential diagnosis.
    MeSH term(s) Amputation ; Arteriovenous Malformations/diagnostic imaging ; Arteriovenous Malformations/surgery ; Diagnosis, Differential ; Humans ; Neoplasm Recurrence, Local ; Syndrome
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1146972-9
    ISSN 1542-2224 ; 1067-2516
    ISSN (online) 1542-2224
    ISSN 1067-2516
    DOI 10.1053/j.jfas.2019.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Contraception Special Issue on the mifepristone Risk Evaluation and Mitigation Strategy (REMS).

    Cleland, Kelly / Foster, Angel M / Gómez, Anu Manchikanti / Raymond, Elizabeth G / Westhoff, Carolyn L

    Contraception

    2021  Volume 104, Issue 1, Page(s) 1–3

    MeSH term(s) Abortifacient Agents, Steroidal ; Contraception ; Humans ; Mifepristone ; Risk Assessment ; Risk Evaluation and Mitigation ; United States ; United States Food and Drug Administration
    Chemical Substances Abortifacient Agents, Steroidal ; Mifepristone (320T6RNW1F)
    Language English
    Publishing date 2021-06-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2021.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mailing abortion pills does not delay care: A cohort study comparing mailed to in-person dispensing of abortion medications in the United States.

    Koenig, Leah R / Raymond, Elizabeth G / Gold, Marji / Boraas, Christy M / Kaneshiro, Bliss / Winikoff, Beverly / Coplon, Leah / Upadhyay, Ushma D

    Contraception

    2023  Volume 121, Page(s) 109962

    Abstract: Objective: Given the substantial barriers to abortion access in the United States, many clinics now mail patients abortion medications. We examined whether dispensing the medications by mail prolonged time to medication use.: Study design: We ... ...

    Abstract Objective: Given the substantial barriers to abortion access in the United States, many clinics now mail patients abortion medications. We examined whether dispensing the medications by mail prolonged time to medication use.
    Study design: We analyzed data from no-test medication abortions with medication provided either by mail or in a clinic from 11 United States clinics from February 2020 to January 2021. We examined mean number of days from patients' first contact with the clinic to mifepristone ingestion, its two-component intervals (first contact to medication dispensing and dispensing to mifepristone ingestion), and pregnancy duration at mifepristone ingestion. We used Poisson regression to compare mean outcomes across three dispensing methods: in-person, mailed from the clinic, and mailed from a mail-order pharmacy.
    Results: Among the 2600 records, patients took mifepristone on average at 49 days of gestation (95% CI, 47-51) and 7 days (95% CI, 4-10) after first contact. Mean time from first contact to mifepristone ingestion was 6 days when medications were dispensed in-person and 9 days when mailed (p = 0.38). While time from first contact to dispensing was similar across methods (6 days in-person, 5 days mailed, p = 0.77), more time elapsed from dispensing to mifepristone ingestion when medications were mailed (4 days from clinic, 5 days from mail-order pharmacy) versus dispensed in-person (0.3 days, p < 0.001). Time to mifepristone ingestion was shorter with higher pregnancy duration. Pregnancy duration at ingestion was similar across methods (48 days in-person, 50 days mailed).
    Conclusions: Mailing medications did not significantly prolong time from patients' first contact with the clinic to mifepristone ingestion or increase pregnancy duration at mifepristone ingestion.
    Implications: Abortion providers should offer a range of medication abortion dispensing options, prioritizing patient preference.
    MeSH term(s) Pregnancy ; Female ; United States ; Humans ; Mifepristone/therapeutic use ; Cohort Studies ; Abortion, Induced/methods ; Pharmaceutical Services ; Pharmacies ; Misoprostol/therapeutic use
    Chemical Substances Mifepristone (320T6RNW1F) ; Misoprostol (0E43V0BB57)
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2023.109962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical outcomes of medication abortion using misoprostol-only: A retrospective chart review at an abortion provider organization in the United States.

    Raymond, Elizabeth G / Weaver, Mark A / Shochet, Tara / Grant, Melissa / Boyd, Kathryn / Koenig, Leah R / Upadhyay, Ushma

    Contraception

    2023  Volume 126, Page(s) 110109

    Abstract: Objectives: This study aimed to evaluate the effectiveness and safety of medication abortion with misoprostol-only among patients treated by an abortion provider organization in the United States during the COVID-19 pandemic.: Study design: We ... ...

    Abstract Objectives: This study aimed to evaluate the effectiveness and safety of medication abortion with misoprostol-only among patients treated by an abortion provider organization in the United States during the COVID-19 pandemic.
    Study design: We abstracted data from patients receiving misoprostol-only for abortion from December 2020 to December 2021. Two regimens were used, both allowing three to four doses of misoprostol 800 mcg every 3 hours but differing in the recommended administration routes (vaginal, buccal, or sublingual). We estimated the proportions of patients who had complete abortion and ongoing pregnancy in the two regimen groups in complete case analyses and after imputing missing outcomes based on pretreatment characteristics. We also estimated maximum effectiveness, assuming that all patients without known treatment failures had complete abortions. We tabulated serious adverse events.
    Results: We ascertained abortion outcomes for 476 (52%) of the total 911 treated patients. Of the 476 patients, 389 (82%) had complete abortion confirmed by test or history, and 45 (9%) had ongoing pregnancies detected after the provision of treatment. These proportions did not differ significantly between the two regimen groups in adjusted complete case analyses (p > 0.44). The results of imputed analyses were similar. Of the total 911 patients, at most 90% (95% confidence interval 88%, 92%) had complete abortion, and at least 5% (95% confidence interval 4%, 7%) had ongoing pregnancy. Serious adverse events were reported in three patients (0.6% of 487 patients with data for this outcome).
    Conclusions: Our analysis suggests that the misoprostol-only regimens studied were safe and effective for most patients. Due to high loss to follow-up, observations from patients contacted after treatment likely somewhat underestimate true effectiveness.
    Implications: Medication abortion with misoprostol-only was safe and produced complete abortion in most patients with follow-up. If loss to follow-up is high, effectiveness observed by clinics may misestimate true treatment efficacy.
    MeSH term(s) Pregnancy ; Female ; Humans ; United States ; Misoprostol/adverse effects ; Retrospective Studies ; Pandemics ; COVID-19/etiology ; Abortion, Induced/methods ; Abortion, Spontaneous/etiology ; Mifepristone/adverse effects ; Abortifacient Agents, Nonsteroidal/adverse effects
    Chemical Substances Misoprostol (0E43V0BB57) ; Mifepristone (320T6RNW1F) ; Abortifacient Agents, Nonsteroidal
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2023.110109
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