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  1. Book ; Online: The Challenges of COVID-19 with Obesity-Related Cancers

    Dalamaga, Maria / Nasiri-Ansari, Narjes / Spyrou, Nikolaos

    2023  

    Keywords Medicine ; COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a
    Language English
    Size 1 electronic resource (224 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377544
    ISBN 9783036573502 ; 303657350X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Special issue on "Excess body weight and cancer: Novel biologic insights and challenges".

    Dalamaga, Maria / Spyrou, Nikolaos

    Seminars in cancer biology

    2024  Volume 99, Page(s) 1–4

    MeSH term(s) Humans ; Obesity ; Risk Factors ; Neoplasms/genetics ; Biological Products ; Body Mass Index
    Chemical Substances Biological Products
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Editorial
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2024.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Physiological Effects of Weight-Cycling: A Review of Current Evidence.

    Sanaya, Nora / Janusaite, Monika / Dalamaga, Maria / Magkos, Faidon

    Current obesity reports

    2024  Volume 13, Issue 1, Page(s) 35–50

    Abstract: Purpose of review: There is a common perception among the public that yo-yo dieting, defined as repeated cycles of weight loss followed by weight regain, results in accumulation of fat in the body and lower metabolic rate, thus hindering subsequent ... ...

    Abstract Purpose of review: There is a common perception among the public that yo-yo dieting, defined as repeated cycles of weight loss followed by weight regain, results in accumulation of fat in the body and lower metabolic rate, thus hindering subsequent attempts to lose weight. We evaluated the effects of weight-cycling on body weight and body mass index (BMI), body composition including fat mass (FM) and lean body mass (LBM), and resting metabolic rate (RMR), by systematically reviewing existing scientific literature.
    Recent findings: Twenty-three cross-sectional and cohort studies (including subjects with a history of weight-cycling compared to those without such history) and interventional studies (evaluating physiological effects during one or more cycles of weight loss and regain) were identified, conducted in generally healthy adults across various age groups, races, and both genders, who had normal weight, overweight, or obesity. Eighteen studies investigated the association between weight-cycling and body weight or BMI, and thirteen of them found no significant association. Fifteen out of twenty studies also found no increase in FM, and none of eighteen studies found a decrease in LBM. Twelve out of fourteen studies reported no adverse changes in RMR either. The overwhelming majority of evidence suggests that weight-cycling (yo-yo effect) is not associated with any adverse effects in body weight, body composition, and metabolic rate. Accordingly, healthy individuals who struggle with overweight or obesity should not be discouraged from repeated attempts to lose the excess weight.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Overweight ; Cross-Sectional Studies ; Obesity/metabolism ; Weight Gain ; Weight Loss/physiology ; Body Mass Index ; Body Composition
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2162-4968
    ISSN (online) 2162-4968
    DOI 10.1007/s13679-023-00539-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Phase separation may drive mitochondrial nucleoid compartmentation.

    Dalamaga, Maria / Liu, Junli

    Metabolism open

    2022  Volume 15, Page(s) 100205

    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Editorial
    ISSN 2589-9368
    ISSN (online) 2589-9368
    DOI 10.1016/j.metop.2022.100205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction to: Update on the Obesity Epidemic: After the Sudden Rise, Is the Upward Trajectory Beginning to Flatten?

    Koliaki, Chrysi / Dalamaga, Maria / Liatis, Stavros

    Current obesity reports

    2023  Volume 12, Issue 4, Page(s) 528

    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Published Erratum
    ISSN 2162-4968
    ISSN (online) 2162-4968
    DOI 10.1007/s13679-023-00533-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A chromatin remodeling checkpoint of diet-induced macrophage activation in adipose tissue.

    Dalamaga, Maria / Liu, Junli

    Metabolism open

    2022  Volume 15, Page(s) 100204

    Abstract: The interplay between the environment and the immune cells is linked to metabolic homeostasis under physiologic and pathophysiologic conditions. Diabetes mellitus type 2 (T2D) is considered an immune-related inflammatory disorder, in which the adipose ... ...

    Abstract The interplay between the environment and the immune cells is linked to metabolic homeostasis under physiologic and pathophysiologic conditions. Diabetes mellitus type 2 (T2D) is considered an immune-related inflammatory disorder, in which the adipose tissue macrophages (ATMs) are key players orchestrating metabolic chronic meta-inflammation and contributing to the pathogenesis of metabolic disease. However, the molecular regulators that integrate the environmental signals to control ATM activation and adipose inflammation during obesity and T2D remain unclear. Epigenetic mechanisms constitute important parameters in metabolic homeostasis, obesity and T2D via the integration of the environmental factors to the transcriptional regulation of gene programs. In a very recent study published in Diabetes by Kong et al., BAF60a has been identified as a key chromatin remodeling checkpoint factor that associates obesity-associated stress signals with meta-inflammation and systemic homeostasis. Furthermore, this work uncovers Atf3 as an important downstream effector in BAF60a-mediated chromatin remodeling and transcriptional reprogramming of macrophage activation in adipose tissue. The findings of this research may contribute to the development of new therapeutic approaches for obesity-induced metabolic inflammation and associated metabolic disorders.
    Language English
    Publishing date 2022-07-31
    Publishing country England
    Document type Editorial
    ISSN 2589-9368
    ISSN (online) 2589-9368
    DOI 10.1016/j.metop.2022.100204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Perspectives and Challenges of COVID-19 with Obesity-Related Cancers.

    Dalamaga, Maria / Nasiri-Ansari, Narjes / Spyrou, Nikolaos

    Cancers

    2023  Volume 15, Issue 6

    Abstract: The emergence of COVID-19 has created an unprecedented threat worldwide, involving overwhelmed health-care systems in the majority of countries [ ... ]. ...

    Abstract The emergence of COVID-19 has created an unprecedented threat worldwide, involving overwhelmed health-care systems in the majority of countries [...].
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15061771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Targeting gasdermin D and neutrophil mobilization for cardioprotection.

    Dalamaga, Maria / Liu, Junli

    Metabolism open

    2021  Volume 12, Page(s) 100152

    Language English
    Publishing date 2021-11-24
    Publishing country England
    Document type Editorial
    ISSN 2589-9368
    ISSN (online) 2589-9368
    DOI 10.1016/j.metop.2021.100152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: DRAK2-SRSF6-regulated RNA alternative splicing is a promising therapeutic target in NAFLD/NASH.

    Dalamaga, Maria / Liu, Junli

    Metabolism open

    2021  Volume 13, Page(s) 100157

    Language English
    Publishing date 2021-12-08
    Publishing country England
    Document type Editorial
    ISSN 2589-9368
    ISSN (online) 2589-9368
    DOI 10.1016/j.metop.2021.100157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The role of exercise in obesity-related cancers: Current evidence and biological mechanisms.

    Larson, Elisabeth A / Dalamaga, Maria / Magkos, Faidon

    Seminars in cancer biology

    2023  Volume 91, Page(s) 16–26

    Abstract: Cancer ranks among the five leading causes of death in almost all countries and has important repercussions for individual and public health, the healthcare system, and society in general. Obesity increases the incidence of many types of cancer, but ... ...

    Abstract Cancer ranks among the five leading causes of death in almost all countries and has important repercussions for individual and public health, the healthcare system, and society in general. Obesity increases the incidence of many types of cancer, but growing evidence suggests that physical activity may decrease risk for developing a variety of obesity-related cancer types, and, in some cases, may improve cancer prognosis and mortality rates. This review summarizes recent evidence on the effect of physical activity on obesity-related cancer prevention and survival. For some cancers, including breast, colorectal, and endometrial cancer, there is strong evidence for a preventative effect of exercise, but for many others, including gallbladder and kidney cancer, and multiple myeloma, evidence is inconsistent or largely lacking. Though many potential mechanisms have been proposed to explain the onco-protective effect of exercise, including improved insulin sensitivity, alterations in sex hormone availability, improved immune function and inflammation, myokine secretion, and modulation of intracellular signaling at the level of AMP kinase, the exact mechanism(s) of action within each cancer subtype remains poorly defined. Overall, a deeper understanding of how exercise can help against cancer and of the exercise parameters that can be altered to optimize exercise prescription is necessary and should be the subject of future investigation.
    MeSH term(s) Humans ; Obesity/complications ; Neoplasms/complications ; Neoplasms/epidemiology ; Exercise ; Inflammation ; Signal Transduction
    Language English
    Publishing date 2023-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2023.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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