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  1. Book ; Online ; Thesis: Relevanz der gp130 Endozytose bei der Maturierung und Differenzierung dendritischer Zellen sowie Charakterisierung des molekularen Mechanismus der OSM-vermittelten Induktion antiviraler Gene ; Gutachter: Heike M. Hermanns, Manfred B. Lutz

    Hergovits, Sabine [Verfasser] / Hermanns, Heike M. [Gutachter] / Lutz, Manfred B. [Gutachter]

    2017  

    Author's details Sabine Hergovits [geb. Walter
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article: RelB+ Steady-State Migratory Dendritic Cells Control the Peripheral Pool of the Natural Foxp3+ Regulatory T Cells

    Reizis, Boris / Lutz, Manfred B.

    Frontiers in immunology, 8:726

    2017  

    Abstract: Thymus-derived natural Foxp3+ CD4+ regulatory T cells (nTregs) play a key role in maintaining immune tolerance and preventing autoimmune disease. Several studies indicate that dendritic cells (DCs) are critically involved in the maintenance and ... ...

    Institution Leibniz-Institut für Alternsforschung
    Abstract Thymus-derived natural Foxp3+ CD4+ regulatory T cells (nTregs) play a key role in maintaining immune tolerance and preventing autoimmune disease. Several studies indicate that dendritic cells (DCs) are critically involved in the maintenance and proliferation of nTregs. However, the mechanisms how DCs manage to keep the peripheral pool at constant levels remain poorly understood. Here, we describe that the NF-κB/Rel family transcription factor RelB controls the frequencies of steady-state migratory DCs (ssmDCs) in peripheral lymph nodes and their numbers control peripheral nTreg homeostasis. DC-specific RelB depletion was investigated in CD11c-Cre × RelBfl/fl mice (RelBDCko), which showed normal frequencies of resident DCs in lymph nodes and spleen while the subsets of CD103− Langerin− dermal DCs (dDCs) and Langerhans cells but not CD103+ Langerin+ dDC of the ssmDCs in skin-draining lymph nodes were increased. Enhanced frequencies and proliferation rates were also observed for nTregs and a small population of CD4+ CD44high CD25low memory-like T cells (Tml). Interestingly, only the Tml but not DCs showed an increase in IL-2-producing capacity in lymph nodes of RelBDCko mice. Blocking of IL-2 in vivo reduced the frequency of nTregs but increased the Tml frequencies, followed by a recovery of nTregs. Taken together, by employing RelBDCko mice with increased frequencies of ssmDCs our data indicate a critical role for specific ssmDC subsets for the peripheral nTreg and IL-2+ Tml frequencies during homeostasis.
    Keywords IL-2 ; RelB ; dendritic cells ; lymph nodes ; regulatory T cells
    Language English
    Document type Article
    Database Repository for Life Sciences

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    Inter-library loan at ZB MED

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  3. Book: Zur Geschichte der Ultraschalldiagnostik

    Frentzel-Beyme, Bernd / Jakobeit, Christian / Lutz, Harald / Nürnberg, Dieter / Salaschek, Manfred

    die Entwicklung des medizinischen Ultraschalls aus deutscher Sicht

    2020  

    Author's details Herausgeber: Vorstand Ultraschallmuseum e.V.: B. Frentzel-Beyme, C. Jakobeit, H. Lutz, D. Nürnberg, M. Salaschek
    Language German
    Size 267 Seiten, Illustrationen, 23 cm
    Edition 1. Auflage
    Publisher Ultraschallmuseum e.V
    Publishing place Lennep
    Publishing country Germany
    Document type Book
    HBZ-ID HT021119834
    ISBN 978-3-00-064418-4 ; 3-00-064418-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 1468 on loan 1 Vormerkungen

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  4. Book ; Collection: Handbook of dendritic cells

    Lutz, Manfred B.

    biology, diseases and therapies

    2006  

    Author's details ed. by Manfred B.Lutz
    Language English
    Dates of publication 2006-9999
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book ; Collection (display volumes)
    HBZ-ID HT014563806
    ISBN 978-3-527-31109-5 ; 3-527-31109-2
    Database Catalogue ZB MED Medicine, Health

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  5. Book: Handbook of dendritic cells / 1

    Lutz, Manfred B.

    biology, diseases and therapies

    2006  

    Author's details ed. by Manfred B.Lutz
    Collection Handbook of dendritic cells
    Language English
    Size LXXIII, 383 S. : Ill., graph. Darst.
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT014651212
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 917 order for loan Magazin

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  6. Book: Handbook of dendritic cells / 2

    Lutz, Manfred B.

    biology, diseases and therapies

    2006  

    Author's details ed. by Manfred B.Lutz
    Collection Handbook of dendritic cells
    Language English
    Size LXXII, S. 385 - 771 : Ill.
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT014651216
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 918 order for loan Magazin

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  7. Book: Handbook of dendritic cells / 3

    Lutz, Manfred B.

    biology, diseases and therapies

    2006  

    Author's details ed. by Manfred B.Lutz
    Collection Handbook of dendritic cells
    Language English
    Size LXVI, S. 773 - 1226 : Ill., graph. Darst.
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT014651218
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 919 order for loan Magazin

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  8. Article ; Online: M-MDSC

    Aintablian, Arpa / Strozniak, Sandra / Heuer, Marion / Lutz, Manfred B

    Frontiers in immunology

    2023  Volume 14, Page(s) 1130600

    Abstract: Myeloid-derived suppressor cells (MDSC) represent major regulators of immune responses, which can control T ... ...

    Abstract Myeloid-derived suppressor cells (MDSC) represent major regulators of immune responses, which can control T cells
    MeSH term(s) Mice ; Animals ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Myeloid-Derived Suppressor Cells ; Interleukin-3/pharmacology ; Arginase/metabolism ; Bone Marrow/metabolism ; Integrin alpha1
    Chemical Substances Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Interleukin-3 ; Arginase (EC 3.5.3.1) ; Integrin alpha1
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1130600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comments on the ambiguity of selected surface markers, signaling pathways and omics profiles hampering the identification of myeloid-derived suppressor cells.

    Lutz, Manfred B / Eckert, Ina N

    Cellular immunology

    2021  Volume 364, Page(s) 104347

    Abstract: Myeloid-derived suppressor cells (MDSC) are important immune-regulatory cells but their identification remains difficult. Here, we provide a critical view on selected surface markers, transcriptional and translational pathways commonly used to identify ... ...

    Abstract Myeloid-derived suppressor cells (MDSC) are important immune-regulatory cells but their identification remains difficult. Here, we provide a critical view on selected surface markers, transcriptional and translational pathways commonly used to identify MDSC by specific, their developmental origin and new possibilities by transcriptional or proteomic profiling. Discrimination of MDSC from their non-suppressive counterparts is a prerequisite for the development of successful therapies. Understanding the switch mechanisms that direct granulocytic and monocytic development into a pro-inflammatory or anti-inflammatory direction will be crucial for therapeutic strategies. Manipulation of these myeloid checkpoints are exploited by tumors and pathogens, such as M. tuberculosis (Mtb), HIV or SARS-CoV-2, that induce MDSC for immune evasion. Thus, specific markers for MDSC identification may reveal also novel molecular candidates for therapeutic intervention at the level of MDSC.
    MeSH term(s) Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Biomarkers/metabolism ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; Cells, Cultured ; Gene Expression Profiling/methods ; Humans ; Mice ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Proteomics/methods ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Signal Transduction/genetics ; Signal Transduction/immunology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances B7-H1 Antigen ; Biomarkers ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2021-03-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2021.104347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Fully functional monocytic MDSC generation from the murine HoxB8 cell line.

    Alattar, Haisam / Xu, Huaming / Zenke, Martin / Lutz, Manfred B

    European journal of immunology

    2023  Volume 53, Issue 9, Page(s) e2350466

    Abstract: Myeloid-derived suppressor cells (MDSC) play a crucial role in controlling T-cell responses, but their development and suppressor mechanisms are not fully understood. To study the molecular functions of MDSC, a large number of standardized cells are ... ...

    Abstract Myeloid-derived suppressor cells (MDSC) play a crucial role in controlling T-cell responses, but their development and suppressor mechanisms are not fully understood. To study the molecular functions of MDSC, a large number of standardized cells are required. Traditionally, bone marrow (BM) has been used to generate myeloid cell types, including MDSC. In this study, we demonstrate that a previously described protocol for generating monocytic MDSC (M-MDSC) from murine BM with GM-CSF can be fully transferred to BM cells that are conditionally transformed with HoxB8 gene (HoxB8 cells). HoxB8 cells have an extended lifespan and efficiently differentiate into MDSC that are quantitatively and qualitatively comparable to M-MDSC from BM cells. Flow cytometric analyses of LPS/IFN-γ activated cultures revealed the same iNOS
    MeSH term(s) Animals ; Mice ; Myeloid-Derived Suppressor Cells ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Cell Line ; Myeloid Cells/metabolism ; CD8-Positive T-Lymphocytes
    Chemical Substances Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language English
    Publishing date 2023-06-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202350466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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