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Book ; Online: SAI

Yao, Lei / Zhang, Yong / Yan, Zilong / Tian, Jialu

Solving AI Tasks with Systematic Artificial Intelligence in Communication Network

2023

Abstract: ... we propose Systematic Artificial Intelligence (SAI), which is a framework designed to solve AI tasks ... in the model library, SAI can complete numerous complex AI tasks in the communication network, achieving ...

Abstract	In the rapid development of artificial intelligence, solving complex AI tasks is a crucial technology in intelligent mobile networks. Despite the good performance of specialized AI models in intelligent mobile networks, they are unable to handle complicated AI tasks. To address this challenge, we propose Systematic Artificial Intelligence (SAI), which is a framework designed to solve AI tasks by leveraging Large Language Models (LLMs) and JSON-format intent-based input to connect self-designed model library and database. Specifically, we first design a multi-input component, which simultaneously integrates Large Language Models (LLMs) and JSON-format intent-based inputs to fulfill the diverse intent requirements of different users. In addition, we introduce a model library module based on model cards which employ model cards to pairwise match between different modules for model composition. Model cards contain the corresponding model's name and the required performance metrics. Then when receiving user network requirements, we execute each subtask for multiple selected model combinations and provide output based on the execution results and LLM feedback. By leveraging the language capabilities of LLMs and the abundant AI models in the model library, SAI can complete numerous complex AI tasks in the communication network, achieving impressive results in network optimization, resource allocation, and other challenging tasks.
Keywords	Computer Science - Artificial Intelligence
Subject code	004
Publishing date	2023-10-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In vitro and in vivo exploration of the anti-atopic dermatitis mechanism of action of Tibetan medicine Qi-Sai-Er-Sang-Dang-Song decoction.

Liu, Jia / Tao, Yiwen / Zou, Xuemei / Liu, Qian / Meng, Xianli / Zhang, Yi / Su, Jinsong

Journal of ethnopharmacology

2023 Volume 306, Page(s) 116155

Abstract: Ethnopharmacological relevance: Tibetan medicine Qi-Sai-Er-Sang-Dang-Song Decoction(QSD, ཆུ་སེར ...

Abstract	Ethnopharmacological relevance: Tibetan medicine Qi-Sai-Er-Sang-Dang-Song Decoction(QSD, ཆུ་སེར་སེང་ལྡེང་སུམ་ཐང་།)is a traditional Tibetan medical formulation with demonstrated clinical benefits in atopic dermatitis (AD). However, its potential mechanism and molecular targets remain to be elucidated. Aim of the study: This study aims to explore the activity and mechanism of QSD on AD in multiple dimensions by combining in vitro and in vivo experiments with network pharmacology. Materials and methods: The AD effect of QSD was investigated by evaluating the levels of nitric oxide (NO) and interleukin-6 (IL-6) in the lipopolysaccharide (LPS) stimulated RAW264.7 cells. AD-like skin lesions in female BALB/c mice were induced by 2,4-dinitrochlorobenzene (DNCB). QSD or dexamethasone (positive control) were gavagely administered daily for 15 consecutive days. The body weight and skin lesion severity were recorded throughout the study. Enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) analysis were used to illuminate the molecular targets associated with the anti-AD effects of QSD. Meanwhile, the ingredients of QSD in the blood were revealed and analyzed by Ultra performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) method. Network pharmacology was used to predict the targets and mechanism of active ingredient therapy for AD. In addition, the network pharmacology outcomes were further verified by molecular docking. Result: After treatment with QSD, the levels of NO and IL-6 were decreased in the cell supernatant. Herein, QSD markedly decreased the eosinophil and mast cells infiltration in the dorsal skin of the 2,4-dinitrochlorobenzene. Moreover, QSD reconstructed the epidermal barrier by increasing the content of collagen fibers and changing the arrangement of DNCB-treated mice. QSD not only inhibited the levels of tumor necrosis factor-α (TNF-α) and interleukin-12 (IL-12) but also inhibited phosphorylation of p38, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) proteins in the dorsal skin. Four active ingredients were identified through UPLC-Q-TOF/MS, including (-)-epicatechin, kaempferol-7-O-glucoside, cassiaside, and questin. After the network pharmacological analysis, six core targets of QSD closely related to AD were obtained, including TNF-α, IL-6, Caspase-3 (CASP3), Epidermal growth factor (EGFR), Peroxisome proliferator-activated receptor gamma (PPARG), and Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1). Meanwhile, through Gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, the Mitogen-activated protein kinase (MAPK) signaling pathway occupies an important position in the QSD treatment of AD. The molecular docking results showed that the six core targets are stable in binding to the four active ingredients as indicated by the molecular docking results. Conclusions: The anti-AD effect of QSD might be related to the reconstruction of the epidermal barrier and inhibition of inflammation, which regulated the MAPK pathway. Hence, it provided a promising idea for the study of Tibetan medicine prescriptions for the treatment of AD.
MeSH term(s)	Female ; Animals ; Mice ; Dinitrochlorobenzene ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6 ; Medicine, Tibetan Traditional ; Molecular Docking Simulation ; Qi ; Anti-Inflammatory Agents/pharmacology ; Dermatitis, Atopic/drug therapy ; Mitogen-Activated Protein Kinases/metabolism ; Skin Diseases/drug therapy ; Drugs, Chinese Herbal/pharmacology
Chemical Substances	Dinitrochlorobenzene ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Anti-Inflammatory Agents ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-01-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116155
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Article ; Online: Tibetan medicine Qi-Sai-Er-Sang-Dang-Song Decoction inhibits TNF-α-induced rheumatoid arthritis in human fibroblast-like synoviocytes via regulating NOTCH1/NF-κB/NLRP3 pathway.

Su, Jinsong / Tao, Yiwen / Liu, Jia / Sun, Jiayi / Zeng, Yong / Meng, Xianli / Fan, Gang / Zhang, Yi

Journal of ethnopharmacology

2023 Volume 310, Page(s) 116402

Abstract: Ethnopharmacological relevance: Qi-Sai-Er-Sang-Dang-Song Decoction (QSD, ཆུ་སེར་སེང་ལྡེང་སུམ་ཐང ...

Abstract	Ethnopharmacological relevance: Qi-Sai-Er-Sang-Dang-Song Decoction (QSD, ཆུ་སེར་སེང་ལྡེང་སུམ་ཐང་།), a Tibetan classical herbal formula, is commonly used in Tibetan hospital preparation for the treatment of rheumatoid arthritis (RA). Its efficacy is to relieve inflammation, dispel cold, remove dampness, and alleviate pain. However, its anti-RA mechanism is still unclear. Aim of the study: This study aimed to investigate the effect of QSD on rheumatoid arthritis and explore its anti-inflammatory mechanism against human fibroblast-like synoviocytes (HFLSs) by regulating the notch family of receptors (NOTCH1)/Nuclear factor-κB (NF-κB)/nucleotide-binding (NLRP3) pathway. Materials and methods: We used ultra-performance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC-Q-TOF-MS) to identify the chemical composition of QSD. Then, HFLSs were exposed to drug-containing serum. The effect of QSD drug-containing serum on HFLS viability was detected using the cell counting kit-8 (CCK-8) assay. Next, we explored the anti-inflammatory effect of QSD using enzyme-linked immunosorbent assay (ELISA) for inflammatory factors, such as interleukin-18 (IL-18), interleukin-1β (IL-1β), and interleukin-6 (IL-6). The expression of NOTCH-related proteins, a member of the NOTCH1, Cleaved NOTCH1, hairy and enhancer of split-1 (HES-1), NF-κB p65, NF-κB pp65, NLRP3, and delta-like 1 (DLL-1), was examined using western blotting. Furthermore, the relative mRNA expression levels of NOTCH1, NF-κB p65, NLRP3, DLL-1, and HES-1 were detected using real-time quantitative (RT-qPCR). To explore the mechanism underlying the anti-RA effect of QSD, we the used the NOTCH signaling pathway inhibitor LY411575 and transfection with a NOTCH1 siRNA. In addition, we employed immunofluorescence to determine the expression of HES-1 and NF-κB p65 in vitro. Result: Our results revealed that QSD ameliorated inflammation in HFLSs. Compared with the model group, the QSD drug-containing serum group had obviously down-regulated levels of IL-18, IL-1β, and IL-6. Consistently, the CCK-8 results showed that the QSD drug-containing serum had no obvious toxicity towards HFLSs. Moreover, both LY411575 and siNOTCH1, QSD could reduce NOTCH1, NLRP3, and HES-1 protein expression levels, and LY411575 could significantly inhibit the expression levels of NF-κB p65, NF-κB pp65, and Cleaved NOTCH1 (p < 0.05). siNOTCH1 could also suppress the expression of DLL-1. The RT-qPCR results indicated that QSD could downregulate the relative mRNA expression levels of NOTCH1, NF-κB p65, NLRP3, DLL-1, and HES-1 in HFLSs (p < 0.05). In the immunofluorescence experiment, the fluorescence intensities of HES-1 and NF-κB p65 in HFLSs were found to decrease after exposure to QSD drug-containing serum (p < 0.05). Ultimately, 44 chemical components were detected in QSD using UPLC-Q-TOF-MS. Conclusion: This study reveals that the QSD can markedly ameliorate inflammation induced by TNF-α on HFLS. The effect of QSD on HFLS may be exerted by inhibition of the NOTCH1/NF-κB/NLRP3 signaling pathway.
MeSH term(s)	Humans ; NF-kappa B/metabolism ; Synoviocytes ; Tumor Necrosis Factor-alpha/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Interleukin-18/metabolism ; Interleukin-18/pharmacology ; Interleukin-18/therapeutic use ; Interleukin-6/metabolism ; Medicine, Tibetan Traditional ; Qi ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/metabolism ; Inflammation/drug therapy ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/metabolism ; Fibroblasts/metabolism ; RNA, Messenger/metabolism
Chemical Substances	NF-kappa B ; Tumor Necrosis Factor-alpha ; NLR Family, Pyrin Domain-Containing 3 Protein ; Interleukin-18 ; Interleukin-6 ; Anti-Inflammatory Agents ; RNA, Messenger ; NOTCH1 protein, human
Language	English
Publishing date	2023-03-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116402
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Article ; Online: Reply to the comments by Venkata Siva Naga Sai Goli and Devendra Narain Singh of the paper "Incorporation of Xuan-paper waste residue in red mud/waste polyethylene composites".

Chen, Chen / Zhang, Yihe / Zhang, Na

Journal of hazardous materials

2020 Volume 404, Issue Pt A, Page(s) 124161

MeSH term(s)	Aluminum Oxide ; Industrial Waste/analysis ; Polyethylene
Chemical Substances	Industrial Waste ; Polyethylene (9002-88-4) ; Aluminum Oxide (LMI26O6933)
Language	English
Publishing date	2020-10-02
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2020.124161
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Article: Environmental changes and human activity since the Neolithic: Evidence from pollen and phytoliths in Hochung, Sai Kung area, Hong Kong

Yang, Shixiong / Edward A. Laws / Hong Wang / Huizhong Tan / Jie Li / Zhenhong Zhang / Zhuo Zheng

Elsevier B.V. Review of palaeobotany and palynology. 2018 Nov., v. 258

2018

Abstract: An excavation has revealed in Hochung, in the Sai Kung area of Hong Kong, which mainly deposited ...

Abstract	An excavation has revealed in Hochung, in the Sai Kung area of Hong Kong, which mainly deposited during the Middle to Late Neolithic period. Base on pollen and phytolith analysis, and combine with pervious published report reconstructed the paleoenvironmental changes around the archeological site. Results show that the settings around the Hochung site changed from river bank, lagoon to floodplain marsh and finally changed to cultivated land during Middle to Late Holocene. Evidence of pollen and phytoliths, coupled with the excavated relics, revealed that the Neolithic culture was characterized by fishing and hunting at ~4200–3500 yr BP, without evidence of rice cultivation or other agricultural activity in this area. Until the Tang and Song Dynasties, rice cultivation appeared based on pollen and phytolith assemblages, but the area of excavated site was not yet an in situ rice field. During the Ming and Qing dynasties, rice agriculture flourished, and the area turned into a local paddy field, lasting until 1960s. Meanwhile, the gradual reduction of evergreen broad-leaved trees and the increase of pioneer plants such as Dicranopteris and other secondary plants since the Tang and Song dynasties imply that the expansion of human agricultural activity caused serious damage to the natural evergreen broad-leaved forest. In the history period, the agriculture civilization has very closely relationship between the south area and the north area, especially from the Qin Dynasty to present.
Keywords	broadleaved trees ; Dicranopteris ; floodplains ; Holocene epoch ; humans ; marshes ; paddies ; paleoecology ; phytoliths ; pioneer species ; pollen ; rice ; China
Language	English
Dates of publication	2018-11
Size	p. 36-47.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0034-6667
DOI	10.1016/j.revpalbo.2018.07.001
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Integrating candidate metabolites and biochemical factors to elucidate the action mechanism of Xue-sai-tong injection based on (1)H NMR metabolomics.

Jiang, Miaomiao / Zhao, Xiaoping / Wang, Linli / Xu, Lei / Zhang, Yan / Li, Zheng

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2016 Volume 1026, Page(s) 87–96

Abstract: ... of Traditional Chinese Medicines (TCM). This approach was applied to Xue-Sai-Tong injection (XST) to reveal the action mechanism ...

Abstract	A strategy of integrating candidate metabolites with crucial biochemical factors was proposed in this study to discover relevant biological functions for interpreting the action mechanism of Traditional Chinese Medicines (TCM). This approach was applied to Xue-Sai-Tong injection (XST) to reveal the action mechanism based on the metabolic response in an ischemia/reperfusion (I/R) rat model by analyzing NMR profile. Partial least squares discriminate analysis (PLS-DA) was used to compare metabolic profiles of serum samples and revealed nine metabolites altered by I/R injury could be restored to normal status (sham-operated group) under the therapy of XST. The pathway enrichment analysis suggested the metabolic changes were mainly involved in pyruvate metabolism, glycolysis, and citrate cycle. The functional roles of the candidate metabolites were further identified by Pearson correlation analysis with the key biochemical factors in serum. The results indicated pyruvate, succinate, acetate and lysine showed significant associations with the oxidative stress factors. Elevated level of pyruvate was found as an essential metabolic response for the major effect of XST against I/R injury by enhancing glycolysis and overcoming the induced reactive oxygen species (ROS). This metabolomics approach provides a better understanding of the mechanisms of TCM and helps to develop a holistic view of TCM efficacy.
MeSH term(s)	Animals ; Male ; Medicine, Chinese Traditional ; Metabolomics ; Proton Magnetic Resonance Spectroscopy ; Rats ; Rats, Sprague-Dawley ; Saponins/administration & dosage
Chemical Substances	Saponins ; xuesetong
Language	English
Publishing date	2016-02-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2016.01.039
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Zs.A 813: Show issues

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Article: Integrating candidate metabolites and biochemical factors to elucidate the action mechanism of Xue-sai-tong injection based on 1H NMR metabolomics

Jiang, Miaomiao / Lei Xu / Linli Wang / Xiaoping Zhao / Yan Zhang / Zheng Li

Journal of chromatography. 2016 July 15, v. 1026

2016

Abstract: ... of Traditional Chinese Medicines (TCM). This approach was applied to Xue-Sai-Tong injection (XST) to reveal the action mechanism ...

Abstract	A strategy of integrating candidate metabolites with crucial biochemical factors was proposed in this study to discover relevant biological functions for interpreting the action mechanism of Traditional Chinese Medicines (TCM). This approach was applied to Xue-Sai-Tong injection (XST) to reveal the action mechanism based on the metabolic response in an ischemia/reperfusion (I/R) rat model by analyzing NMR profile. Partial least squares discriminate analysis (PLS-DA) was used to compare metabolic profiles of serum samples and revealed nine metabolites altered by I/R injury could be restored to normal status (sham-operated group) under the therapy of XST. The pathway enrichment analysis suggested the metabolic changes were mainly involved in pyruvate metabolism, glycolysis, and citrate cycle. The functional roles of the candidate metabolites were further identified by Pearson correlation analysis with the key biochemical factors in serum. The results indicated pyruvate, succinate, acetate and lysine showed significant associations with the oxidative stress factors. Elevated level of pyruvate was found as an essential metabolic response for the major effect of XST against I/R injury by enhancing glycolysis and overcoming the induced reactive oxygen species (ROS). This metabolomics approach provides a better understanding of the mechanisms of TCM and helps to develop a holistic view of TCM efficacy.
Keywords	acetates ; animal models ; blood serum ; chromatography ; citrates ; glycolysis ; ischemia ; least squares ; lysine ; mechanism of action ; metabolites ; metabolomics ; nuclear magnetic resonance spectroscopy ; Oriental traditional medicine ; oxidative stress ; pyruvic acid ; reactive oxygen species ; succinic acid ; therapeutics
Language	English
Dates of publication	2016-0715
Size	p. 87-96.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	1570-0232
DOI	10.1016/j.jchromb.2016.01.039
Database	NAL-Catalogue (AGRICOLA)

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Book: 2011 Quan guo xiang qi jia ji lian sai jing cai dui ju jie xi

Luan, Xiaofeng / Zhang, Xiaoping

2011

Title translation	Analyse hervorragender Partien der nationalen Xiangqi-Jiaji-Meisterschaft 2011
Title variant	2011 quanguo xiangqi jiaji liansai jingcai duiju jiexi ; 2011-ch'üan-kuo-hsiang-ch'i-chia-chi-lien-sai-ching-ts'ai-tui-chü-chieh-hsi / Luan Hsiao-Feng, Chang Hsiao-P'ing p'ien-chu
Author's details	Luan Xiaofeng, Zhang Xiaoping bianzhu
Keywords	Chinesisches Schach
Language	Chinese
Size	558 S, graph. Darst.
Publisher	Liao ning ke xue ji shu chu ban she
Publishing place	Shenyang
Document type	Book
Note	In chines. Schr.
ISBN	9787538174359 ; 7538174354
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online ; E-Book: Nucleic acid amplification strategies for biosensing, bioimaging and biomedicine

Zhang, Shusheng / Bi, Sai / Song, Xinyue

2019

Author's details	Shusheng Zhang, Sai Bi, Xinyue Song editors
Language	English
Size	1 Online-Ressource (xxi, 337 Seiten), Illustrationen, Diagramme
Publisher	Springer
Publishing place	Singapore
Publishing country	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020057405
ISBN	978-981-13-7044-1 ; 9789811370434 ; 981-13-7044-3 ; 9811370435
DOI	10.1007/978-981-13-7044-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A case report on the surgical management of a severe avulsion injury involving the trunk and perineum.

Chen, Qing-Jiang / Zhang, Sai-Qiong / Li, Wu-Quan

Asian journal of surgery

2024

Language	English
Publishing date	2024-02-19
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.02.069
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