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Article ; Online: Vasospastic angina in a boy with hereditary hemorrhagic telangiectasia due to heterogenous large deletion around ENG.

Narazaki, Kentaro / Nagatomo, Yusaku / Uike, Kiyoshi / Sonoda, Motoshi / Nagata, Hazumu / Yamamura, Kenichiro / Ohga, Shouichi

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15500

MeSH term(s)	Humans ; Male ; Coronary Vasospasm/diagnosis ; Coronary Vasospasm/genetics ; Endoglin/genetics ; Mutation ; Telangiectasia, Hereditary Hemorrhagic/complications ; Telangiectasia, Hereditary Hemorrhagic/diagnosis ; Child ; Sequence Deletion
Chemical Substances	Endoglin ; ENG protein, human
Language	English
Publishing date	2023-02-10
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15500
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Zs.A 848: Show issues

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Article ; Online: [Clinical Functionality of Dispersive OVDs: Improvement of One of the Properties of 3% Hyaluronic Acid and 4% Chondroitin Sulfate Combination].

Watanabe, Ippei / Suzuki, Kiyoshi / Nagata, Mayumi / Matsushima, Hiroyuki

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2022 Volume 142, Issue 4, Page(s) 401–411

Abstract: Ophthalmic viscosurgical devices (OVDs) are mainly divided into two general categories: cohesive and dispersive. Dispersive OVDs such as the 3% hyaluronic acid and 4% chondroitin sulfate (HA/CS) combination have excellent adhesion to ocular tissues and ... ...

Abstract	Ophthalmic viscosurgical devices (OVDs) are mainly divided into two general categories: cohesive and dispersive. Dispersive OVDs such as the 3% hyaluronic acid and 4% chondroitin sulfate (HA/CS) combination have excellent adhesion to ocular tissues and protect the corneal endothelium to a greater extent than cohesive OVDs. Herein, we summarize our recent findings regarding one of the properties of the HA/CS combination related to clinical performance. (i) The room temperature stability of OVDs and needle clogging by OVDs remain clinical issues. We demonstrated that adding d-sorbitol to the HA/CS combination preserved its viscosity, which was equivalent after 2 year-storage at room temperature to the viscosity of HA/CS combination stored under refrigeration for 2 years without d-sorbitol. Besides, the HA/CS combination with d-sorbitol could be used repeatedly without cleaning or replacing the needle, suggesting that the addition of d-sorbitol prevents drying and solidification of the OVD on the needle. (ii) Although it can be inferred from numerous studies that the tissue adhesion of OVDs influences their retention by the eye, little is known about the physical properties of OVDs that contribute to intraocular retention. To address this issue, we compared two types of adhesive forces, detachment force and repulsive force, for each OVD. Compared with other dispersive OVDs, the HA/CS combination showed higher values for both adhesive forces. These results suggest that adhesive forces may be used as an index of dispersive OVD retention in the eye.
MeSH term(s)	Adhesives ; Chondroitin Sulfates ; Hyaluronic Acid ; Phacoemulsification ; Viscosity
Chemical Substances	Adhesives ; Hyaluronic Acid (9004-61-9) ; Chondroitin Sulfates (9007-28-7)
Language	Japanese
Publishing date	2022-03-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.21-00208
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Zs.A 643: Show issues

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Article: Mechanism Underlying Conflicting Drug-Drug Interaction Between Aprepitant and Voriconazole via Cytochrome P450 3A4-Mediated Metabolism.

Ishida, Masako / Kumagai, Takeshi / Yamamoto, Tatsuro / Suzuki, Hiroyuki / Moriki, Kuniaki / Fujiyoshi, Masachika / Nagata, Kiyoshi / Shimada, Miki

Yonago acta medica

2024 Volume 67, Issue 1, Page(s) 31–40

Abstract: Background: Voriconazole is an antifungal drug for which therapeutic monitoring is recommended to prevent side effects. Temporary administration of the antiemetic drug fosaprepitant remarkably decreases the plasma concentration of voriconazole from the ... ...

Abstract	Background: Voriconazole is an antifungal drug for which therapeutic monitoring is recommended to prevent side effects. Temporary administration of the antiemetic drug fosaprepitant remarkably decreases the plasma concentration of voriconazole from the therapeutic range. The ratio of the major metabolite voriconazole Methods: Concentrations of voriconazole and voriconazole Results: Cytochrome P450 3A4 and 2C9 mRNA levels increased ~4- and 2-fold, respectively, over time. Cytochrome P450 3A4 induction was confirmed using reporter assays. We also assessed L-755446, a major metabolite of aprepitant that lacks a triazole ring. Both compounds dose-dependently increased reporter activity; however, induction by L-755446 was stronger than that by aprepitant. Conclusion: These results indicate that aprepitant initially inhibited voriconazole metabolism via its triazole ring and increased cytochrome P450 3A4 induction following L-755446 formation. The decrease in plasma voriconazole concentration 7 days after fosaprepitant administration was mainly attributed to cytochrome P450 3A4 induction by L-755446.
Language	English
Publishing date	2024-01-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	840719-8
ISSN	1346-8049 ; 0513-5710
ISSN (online)	1346-8049
ISSN	0513-5710
DOI	10.33160/yam.2024.02.004
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Zs.A 268: Show issues

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Article ; Online: Cardiac sarcoidosis accompanied by a tumor-like blush on coronary angiography.

Asakura, Kiyoshi / Minami, Yoshiyasu / Nagata, Takako / Koitabashi, Toshimi / Ako, Junya

Journal of cardiology cases

2022 Volume 26, Issue 1, Page(s) 21–23

Abstract: A 71-year-old female was diagnosed with cardiac sarcoidosis by a history of complete atrioventricular block requiring pacemaker implantation and a focal thinning of basal interventricular septum (IVS) on echocardiography. Coronary angiography showed a ... ...

Abstract	A 71-year-old female was diagnosed with cardiac sarcoidosis by a history of complete atrioventricular block requiring pacemaker implantation and a focal thinning of basal interventricular septum (IVS) on echocardiography. Coronary angiography showed a tumor-like blush fed by septal branch of left anterior descending artery and right coronary artery concomitant with a coronary-to-right ventricle shunt. Echocardiography showed a low echoic mass at mid-IVS with an abnormal shunt flow into right ventricle. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) showed an uptake at the corresponding site of mid-IVS. Eight months after the initiation of steroid therapy, FDG-PET showed no abnormal uptake at mid-IVS, suggesting decreased activity of cardiac sarcoidosis. We experienced a case of cardiac sarcoidosis with FDG uptake accompanied by a tumor-like blush at mid-IVS. The present case suggests the involvement of microvascular accumulation in the activity of cardiac sarcoidosis. <
Language	English
Publishing date	2022-02-21
Publishing country	Japan
Document type	Case Reports
ISSN	1878-5409
ISSN (online)	1878-5409
DOI	10.1016/j.jccase.2022.01.011
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Article ; Online: Author Correction: Development of postoperative delirium prediction models in patients undergoing cardiovascular surgery using machine learning algorithms.

Nagata, Chie / Hata, Masahiro / Miyazaki, Yuki / Masuda, Hirotada / Wada, Tamiki / Kimura, Tasuku / Fujii, Makoto / Sakurai, Yasushi / Matsubara, Yasuko / Yoshida, Kiyoshi / Miyagawa, Shigeru / Ikeda, Manabu / Ueno, Takayoshi

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4396

Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51975-y
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Article ; Online: Higher triglyceride levels are associated with the higher prevalence of layered plaques in non-culprit coronary plaques.

Asakura, Kiyoshi / Minami, Yoshiyasu / Nagata, Takako / Katamine, Masahiro / Muramatsu, Yusuke / Kinoshita, Daisuke / Ako, Junya

Journal of thrombosis and thrombolysis

2023 Volume 57, Issue 1, Page(s) 58–66

Abstract: High triglyceride (TG) levels have been recognized as a risk factor for cardiovascular events in patients with coronary artery disease (CAD). This study aimed to clarify the association between TG levels and characteristics of non-culprit coronary ... ...

Abstract	High triglyceride (TG) levels have been recognized as a risk factor for cardiovascular events in patients with coronary artery disease (CAD). This study aimed to clarify the association between TG levels and characteristics of non-culprit coronary plaques in patients with CAD. A total of 531 consecutive patients with stable CAD who underwent percutaneous coronary intervention for culprit lesions and optical coherence tomography (OCT) assessment of non-culprit plaques in the culprit vessel were included in this study. The morphology of the non-culprit plaques assessed by OCT imaging were compared between the higher TG (TG ≥ 150 mg/dL, n = 197) and lower TG (TG < 150 mg/dL, n = 334) groups. The prevalence of layered plaques (40.1 vs. 27.5%, p = 0.004) was significantly higher in the higher TG group than in the lower TG group, although the prevalence of other plaque components was comparable between the two groups. High TG levels were an independent factor for the presence of layered plaques (odds ratio 1.761, 95% confidence interval 1.213-2.558, p = 0.003) whereas high low-density lipoprotein cholesterol levels (≥ 140 mg/dL) and low eicosapentaenoic acid/arachidonic acid ratios (< 0.4) were independently associated with a higher prevalence of thin-cap fibroatheroma and macrophages. Higher TG levels were associated with a higher prevalence of layered plaques in non-culprit plaques among patients with stable CAD. These results may partly explain the effect of TG on the progression of coronary plaques and the increased incidence of recurrent events in patients with CAD.
MeSH term(s)	Humans ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/epidemiology ; Plaque, Atherosclerotic/pathology ; Prevalence ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/pathology ; Risk Factors ; Triglycerides ; Tomography, Optical Coherence/methods ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/pathology ; Coronary Angiography/methods
Chemical Substances	Triglycerides
Language	English
Publishing date	2023-09-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-023-02888-6
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Zs.A 4352: Show issues

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Article ; Online: A synthesized gamma distribution-based patient-specific VMAT QA using a generative adversarial network.

Matsuura, Takaaki / Kawahara, Daisuke / Saito, Akito / Yamada, Kiyoshi / Ozawa, Shuichi / Nagata, Yasushi

Medical physics

2023 Volume 50, Issue 4, Page(s) 2488–2498

Abstract: Background: Artificial intelligence (AI)-based gamma passing rate (GPR) prediction has been proposed as a time-efficient virtual patient-specific QA method for the delivery of volumetric modulation arc therapy (VMAT). However, there is a limitation that ...

Abstract	Background: Artificial intelligence (AI)-based gamma passing rate (GPR) prediction has been proposed as a time-efficient virtual patient-specific QA method for the delivery of volumetric modulation arc therapy (VMAT). However, there is a limitation that the GPR value loses the locational information of dose accuracy. Purpose: The objective was to predict the failing points in the gamma distribution and the GPR using a synthesized gamma distribution of VMAT QA with a deep convolutional generative adversarial network (GAN). Methods: The fluence maps of 270 VMAT beams for prostate cancer were measured using an electronic portal imaging device and analyzed using gamma evaluation with 3%/2-mm, 2%/1-mm, 1%/1-mm, and 1%/0.5-mm tolerances. The 270 gamma distributions were divided into two datasets: 240 training datasets for creating a model and 30 test datasets for evaluation. The image prediction network for the fluence maps calculated by the treatment planning system (TPS) to the gamma distributions was created using a GAN. The sensitivity, specificity, and accuracy of detecting failing points were evaluated using measured and synthesized gamma distributions. In addition, the difference between measured GPR (mGPR) and predicted GPR (pGPR) values calculated from the synthesized gamma distributions was evaluated. Results: The root mean squared errors between mGPR and pGPR were 1.0%, 2.1%, 3.5%, and 3.6% for the 3%/2-mm, 2%/1-mm, 1%/1-mm, and 1%/0.5-mm tolerances, respectively. The accuracies for detecting failing points were 98.9%, 96.9%, 94.7%, and 93.7% for 3%/2-mm, 2%/1-mm, 1%/1-mm, and 1%/0.5-mm tolerances, respectively. The sensitivity and specificity were the highest for 1%/0.5-mm and 3%/2-mm tolerances, which were 82.7% and 99.6%, respectively. Conclusions: We developed a novel system using a GAN to generate a synthesized gamma distribution-based patient-specific VMAT QA. The system is promising from the point of view of quality assurance in radiotherapy because it shows high performance and can detect failing points.
MeSH term(s)	Male ; Humans ; Radiotherapy, Intensity-Modulated/methods ; Artificial Intelligence ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy Dosage ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Quality Assurance, Health Care
Language	English
Publishing date	2023-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.16210
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Zs.A 1210: Show issues

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Article ; Online: Body mass index and characteristics of coronary plaque in younger patients with type 2 diabetes.

Katamine, Masahiro / Minami, Yoshiyasu / Asakura, Kiyoshi / Nagata, Takako / Katsura, Aritomo / Muramatsu, Yusuke / Hashimoto, Takuya / Kinoshita, Daisuke / Ako, Junya

Nutrition, metabolism, and cardiovascular diseases : NMCD

2023 Volume 34, Issue 3, Page(s) 792–798

Abstract: Background and aims: The association between the body mass index (BMI) and the characteristics of coronary plaque in younger type 2 diabetes (T2D) patients with coronary artery disease (CAD) remains to be elucidated.: Methods and results: A total of ... ...

Abstract	Background and aims: The association between the body mass index (BMI) and the characteristics of coronary plaque in younger type 2 diabetes (T2D) patients with coronary artery disease (CAD) remains to be elucidated. Methods and results: A total of 138 consecutive younger (<65 years) T2D patients with CAD, who underwent optical coherence tomography imaging of the culprit lesion were included. The patients were classified into either the higher BMI group (n = 68) or the lower BMI group (n = 70) according to the median of BMI (25.9 kg/m Conclusion: Higher BMI was associated with a higher prevalence of TCFA in younger T2D patients with CAD, particularly in patients with HbA1c ≥ 7.0 %.
MeSH term(s)	Humans ; Plaque, Atherosclerotic ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/complications ; Body Mass Index ; Glycated Hemoglobin ; Predictive Value of Tests ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2023-12-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2023.12.009
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Zs.A 3149: Show issues

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Article ; Online: Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system.

Yamazoe, Yasushi / Yamada, Takashi / Nagata, Kiyoshi

Food safety (Tokyo, Japan)

2020 Volume 8, Issue 2, Page(s) 34–51

Abstract: Human CYP3A4 is involved in metabolisms of diverse hydrophobic chemicals. Using the data of therapeutic azole fungicides known to interact with CYP3A4, applicability of CYP3A4 Template system was first confirmed to reconstitute faithfully the interaction ...

Abstract	Human CYP3A4 is involved in metabolisms of diverse hydrophobic chemicals. Using the data of therapeutic azole fungicides known to interact with CYP3A4, applicability of CYP3A4 Template system was first confirmed to reconstitute faithfully the interaction on Template. More than twenty numbers of pesticide azoles were then applied to the Template system. All the azole stereo-isomers applied, except for talarozole, interacted through nitrogen atoms of triazole or imidazole parts and sat stably for inhibitions through fulfilling three-essential interactions. For their CYP3A4-mediated oxidations, clear distinctions were suggested among the enantiomers and diastereomers of azole pesticides on Templates. Thus, the stereoisomers would have their-own regio- and stereo-selective profiles of the metabolisms. A combined metabolic profile of each azole obtained with CYP3A4 Template system, however, resembled with the reported profile of the
Language	English
Publishing date	2020-06-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2768899-9
ISSN	2187-8404 ; 2187-8404
ISSN (online)	2187-8404
ISSN	2187-8404
DOI	10.14252/foodsafetyfscj.D-20-00010
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Book ; Online: Polarization calibration of the Tandem Etalon Magnetograph of the Solar Magnetic Activity Research Telescope at Hida Observatory

Yamasaki, Daiki / Nagata, Shin'ichi / Ichimoto, Kiyoshi

2022

Abstract: The Tandem Etalon Magnetograph (TEM) is one of the instruments of the Solar Magnetic Activity Research Telescope of Hida Observatory. The TEM is a partial disk (320" x240") filter magnetograph which scans the wavelength around a Fe I line at 6303 ... ...

Abstract	The Tandem Etalon Magnetograph (TEM) is one of the instruments of the Solar Magnetic Activity Research Telescope of Hida Observatory. The TEM is a partial disk (320" x240") filter magnetograph which scans the wavelength around a Fe I line at 6303 angstrom and achieves polarimetric sensitivity of < 5x10^-4 for each wavelength. To obtain the polarimeter response matrix of the instrument, we have carried out end-to-end polarization calibrations of the instrument. We have also measured the polarization characteristics of the polarization beam splitter (PBS), which is a crucial component of the instrument. As a result of end-to-end calibration, we found significant spatial variation in the response matrix across the field of view. From a laboratory test, we found that 1% of the magnitude of a circular diattenuation of the PBS was due to the retardation caused by the stress in the cube and the linear diattenuation of the film. Although the spatial variation across the field of view is more than ten times larger, to achieve the polarimetric sensitivity of < 5x10^-4, this can be well explained by the polarization characteristic of the PBS and corrected by using the response matrix obtained in the end-to-end calibration. In addition, we also obtained the daily variation of the polarization property of the TEM. We found that the crosstalk from Stokes Q to V changes an amount comparable to the tolerance through a day. In the present configuration, we require a pixel-by-pixel calibration every 100 minutes to meet the accuracy requirement. Comment: 19 pages, 11 figures. Accepted for the Publications of the Astronomical Society of Japan
Keywords	Astrophysics - Solar and Stellar Astrophysics ; Astrophysics - Instrumentation and Methods for Astrophysics
Subject code	621
Publishing date	2022-08-22
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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