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Article ; Online: Anticoagulation Therapy by Age and Embolic Risk for Nonvalvular Atrial Fibrillation in Mexico, an Upper-Middle-Income Country: The CARMEN-AF Registry.

Márquez, Manlio F / Baños-González, Manuel A / Guevara-Valdivia, Milton E / Vázquez-Acosta, Jorge / de Los Ríos Ibarra, Manuel O / Aguilar-Linares, Julio A / Jiménez-Cruz, Marcelo / Matadamas-Hernández, Norberto / Camacho-Casillas, Rocío / Magaña-Magaña, Reynaldo / Rojel-Martínez, Ulises / Alcocer-Gamba, Marco A / Lara-Vaca, Susano / Rodríguez-Reyes, Humbert / Islava-Gálvez, Marco A / Betancourt-Hernández, Lidia E / Reyes-Reyes, Nicolás / Beltrán-Gámez, Miguel E / Cantú-Brito, Carlos /

Baños-Velasco, Alberto Z / Del Rivero Morfin, Pedro J / González-Hermosillo, J Antonio

Global heart

2020 Volume 15, Issue 1, Page(s) 32

Abstract: ... of OAT according to age and thromboembolic risk in patients included in CARMEN-AF, a nationwide registry ... patients ≥18 years old and with at least one thromboembolic risk factor enrolled in the CARMEN-AF Registry ... CARMEN-AF is a nationwide multi-centric registry seeking to bridge the data gap on anticoagulation ...

Abstract	Background: Documenting the patterns of oral anticoagulation therapy (OAT) is essential to prevent thromboembolic complications of nonvalvular atrial fibrillation (NVAF). Objective: To report the patterns of OAT according to age and thromboembolic risk in patients included in CARMEN-AF, a nationwide registry of NVAF in Mexico, an upper middle-income country. Material and methods: There were 1,423 consecutive patients ≥18 years old and with at least one thromboembolic risk factor enrolled in the CARMEN-AF Registry at their regular clinical visit during a three-year period. They were analyzed according to 1) age, 2) AF type, and 3) CHA Results: Overall, 16.4% of patients did not receive antithrombotic treatment, 19.4% received antiplatelet drugs (APD), 29.2% vitamin K antagonists (VKA), and 34.6% direct oral anticoagulants (DOAC). With increasing age, the proportion of subjects treated with VKA decreased significantly from 36.2% in subjects <65 years to 22.5% in those ≥75 years old ( Conclusions: VKA use for NVAF in Mexico decreased in relation to increasing age. The proportion of DOAC therapy was the same in all age groups. Nevertheless, elderly patients with high thromboembolic risk received a suboptimal thromboprophylaxis. These data could help to improve gaps in the implementation of global guidelines. Clinical trial registration: http://www.clinicaltrials.gov. Unique identifier: NCT02334852. Highlights: CARMEN-AF is a nationwide multi-centric registry seeking to bridge the data gap on anticoagulation therapy for NVAF in Mexico.Elderly patients are more prone to receive suboptimal OAT for NVAF.DOAC were less frequently used in high thromboembolic risk patients (CHA
MeSH term(s)	Age Factors ; Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Female ; Fibrinolytic Agents/therapeutic use ; Humans ; Incidence ; Male ; Mexico/epidemiology ; Registries ; Risk Factors ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Survival Rate/trends ; Thromboembolism/complications ; Thromboembolism/prevention & control
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2020-04-10
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2629633-0
ISSN	2211-8179 ; 2211-8160
ISSN (online)	2211-8179
ISSN	2211-8160
DOI	10.5334/gh.767
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Article: Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry.

Antonio González-Hermosillo, J / Baños-González, Manuel A / Guevara-Valdivia, Milton E / Vázquez-Acosta, Jorge A / de Los Ríos Ibarra, Manuel Odín / Aguilar-Linares, Kulio A / Cantú-Brito, Carlos / Leiva-Pons, José L / Pozas-Garza, Gerardo / Favela-Pérez, Eddie A / Márquez, Manlio F

International journal of cardiology. Heart & vasculature

2019 Volume 22, Page(s) 117–122

Abstract: ... in Mexico, an upper middle-income country, into the prospective national CARMEN-AF Registry.: Methods ... A total of 1423 consecutive patients, with at least one thromboembolic risk factor were enrolled in CARMEN ... of direct oral anticoagulants (DOAC) (33.8% women vs 35.4% men).: Conclusions: CARMEN-AF Registry ...

Abstract	Background: Atrial Fibrillation (AF) is associated with an increased risk of stroke and systemic embolism. Several studies have suggested that female AF patients could have a greater risk for stroke. There is scarce information about clinical characteristics and use of antithrombotic therapies in Latin American patients with nonvalvular AF. Objective: To describe the gender differences in clinical characteristics, thromboembolic risk, and antithrombotic therapy of patients with nonvalvular AF recruited in Mexico, an upper middle-income country, into the prospective national CARMEN-AF Registry. Methods: A total of 1423 consecutive patients, with at least one thromboembolic risk factor were enrolled in CARMEN-AF Registry during a three-year period (2014-2017). They were categorized according to Gender. Results: Overall, 48.6% were women, mean age 70 ± 12 years. Diabetes, smoking, alcoholism, non-ischemic cardiomyopathy, coronary artery disease, and obstructive sleep apnea were higher in men. Most women were found with paroxysmal AF (40.6%), and most men with permanent AF (44.0%). No gender differences were found in the use of vitamin K antagonists (VKA) (30.5% in women vs. 28.0% in men). No gender differences were found in the use of direct oral anticoagulants (DOAC) (33.8% women vs 35.4% men). Conclusions: CARMEN-AF Registry demonstrates that in Mexico, regardless of gender, a large proportion of patients remain undertreated. No gender differences were found in the use of VKA or DOAC.
Language	English
Publishing date	2019-01-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2018.12.017
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Article ; Online: High rates of colonization by Staphylococcus aureus in medical students before their clinical practices.

Ríos, Esther / Rodríguez-Avial, Iciar / Culebras, Esther / Rodríguez-Avial, Carmen

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 4, Page(s) 251–253

MeSH term(s)	Humans ; Staphylococcus aureus ; Students, Medical ; Staphylococcal Infections ; Methicillin-Resistant Staphylococcus aureus
Language	English
Publishing date	2023-03-02
Publishing country	Spain
Document type	Letter ; Comment
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2023.02.002
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Article ; Online: Quality of life in long-term cervical cancer survivors compared with healthy women and women with benign gynecological disorders.

Cea García, Jorge / Rodríguez Jiménez, Inmaculada / Márquez Maraver, Francisco / Ríos-Pena, Laura / Carmen Rubio Rodríguez, M

European journal of obstetrics, gynecology, and reproductive biology

2024 Volume 297, Page(s) 78–85

Abstract: Objective: The impact of cervical cancer treatment on the quality of life of long-term survivors compared with the general female population is controversial, and no studies have been conducted comparing patients with benign gynecological diseases. The ... ...

Abstract	Objective: The impact of cervical cancer treatment on the quality of life of long-term survivors compared with the general female population is controversial, and no studies have been conducted comparing patients with benign gynecological diseases. The aim of this study was to compare the quality of life of cervical cancer survivors with that of healthy controls. Study design: A case-control study was conducted to compare the quality of life of 106 cervical cancer survivors from a tertiary hospital and 185 women admitted to a gynecological outpatient clinic from the same health area for a healthy woman check-up (n 46) or for a benign gynecological disorder (symptomatic, n 113; asymptomatic, n 26). To measure quality of life, self-administered questionnaires, such as the Functional Assessment Cancer Therapy-cervix and World Health Organization quality of life-brief version, were employed. Baseline scores were collected when patients first reported, and further evaluations were completed at 0-6, 7-12, 13-24, 25-60, and more than 60 months. For the contrastive analysis hypothesis, we employed R statistical software. Results: Except for the environment domain at 0-6, 7-12, and 13-24 months (51.52 vs. 60.73, p < 0.0001; 52 vs. 60.73, p < 0.0001; 49.81 vs. 60.73, p < 0.0001, respectively), we found no statistically significant differences in the quality of life between cervical cancer survivors and controls. We did find differences in the physical health domain scores at 0-6 months (60.22 vs. 72.42, p = 0.039) and the social relationships domain scores at 13-24 months (54 vs. 71.42, p = 0.017) between cases and asymptomatic controls. Conclusion: Except for physical well-being, environment and social relationships, which were substantially better for controls, especially in the asymptomatic, long-term cervical cancer survivorśquality of life did not vary from that of controls.
Language	English
Publishing date	2024-04-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2024.03.036
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Article ; Online: Oxidative stress in the bivalve Diplodon chilensis under direct and dietary glyphosate-based formulation exposure.

Iummato, María Mercedes / Sabatini, Sebastián Eduardo / Rocchetta, Iara / Yusseppone, María Soledad / Del Carmen Ríos de Molina, María / Juárez, Ángela Beatriz

Environmental science and pollution research international

2024 Volume 31, Issue 16, Page(s) 23610–23622

Abstract: The aim of this study was to evaluate and compare the effects on biochemical parameters and organosomatic indices in the freshwater bivalve Diplodon chilensis exposed to a glyphosate-based formulation under direct and dietary exposures (4 mg a.p./L). ... ...

Abstract	The aim of this study was to evaluate and compare the effects on biochemical parameters and organosomatic indices in the freshwater bivalve Diplodon chilensis exposed to a glyphosate-based formulation under direct and dietary exposures (4 mg a.p./L). After 1, 7, and 14 days of exposure, reduced glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels and the activities of glutathione-S- transferase (GST), superoxide dismutase (SOD), and catalase (CAT) were evaluated in the gills and digestive gland. The hepatosomatic (HSI) and branchiosomatic (BSI) indices were also analyzed. Direct and dietary glyphosate-based formulation exposure altered the redox homeostasis in the gills and digestive gland throughout the experimental time, inducing the detoxification response (GST), the antioxidant defenses (SOD, CAT, GSH), and causing lipid peroxidation. After 14 days of exposure, the HSI and BSI increased significantly (43% and 157%, respectively) only in the bivalves under direct exposure. Greater changes in the biochemical parameters were induced by the dietary exposure than by the direct exposure. Furthermore, the gills presented an earlier response compared to the digestive gland. These results suggested that direct and dietary exposure to a glyphosate-based formulation induced oxidative stress in the gills and digestive glands of D. chilensis. Thus, the presence of glyphosate-based formulations in aquatic ecosystems could represent a risk for filter-feeding organisms like bivalves.
MeSH term(s)	Animals ; Glyphosate ; Dietary Exposure ; Ecosystem ; Oxidative Stress ; Bivalvia ; Catalase/metabolism ; Superoxide Dismutase/metabolism ; Lipid Peroxidation ; Gills/metabolism ; Glutathione Transferase/metabolism ; Water Pollutants, Chemical/metabolism ; Biomarkers/metabolism
Chemical Substances	Glyphosate (4632WW1X5A) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Transferase (EC 2.5.1.18) ; Water Pollutants, Chemical ; Biomarkers
Language	English
Publishing date	2024-02-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32639-w
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Article ; Online: Commentary on Animal Care in Radiation Medical Countermeasures Studies.

Satyamitra, Merriline M / Taliaferro, Lanyn P / Rios, Carmen I

Radiation research

2022 Volume 198, Issue 5, Page(s) 508–513

MeSH term(s)	Animals ; Medical Countermeasures ; Acute Radiation Syndrome ; Radiation-Protective Agents
Chemical Substances	Radiation-Protective Agents
Language	English
Publishing date	2022-10-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80322-4
ISSN	1938-5404 ; 0033-7587
ISSN (online)	1938-5404
ISSN	0033-7587
DOI	10.1667/RADE-22-00009.1
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Article ; Online: Individual and joint effects of glyphosate and cypermethrin formulations on two human cell lines.

Coalova, Isis / March, Hugo / Ríos de Molina, María Del Carmen / Chaufan, Gabriela

Toxicology and applied pharmacology

2023 Volume 461, Page(s) 116398

Abstract: The final effect of pesticides and their mixtures on living organisms is determined by the particular toxicodynamics of the system. Oxidative stress is one of the most studied molecular mechanisms of toxicity due to increasing evidence supporting its ... ...

Abstract	The final effect of pesticides and their mixtures on living organisms is determined by the particular toxicodynamics of the system. Oxidative stress is one of the most studied molecular mechanisms of toxicity due to increasing evidence supporting its association with the toxic effects of different agrochemicals. In the present study we evaluated the presence of redox balance alterations in the cell lines HEp-2 and A549 exposed to formulations of glyphosate (March®) and cypermethrin (Superfina®) used separately or in combination (in a proportion equivalent to that used in soybean fields). We determined the activity of catalase, superoxide dismutase, glutathione S-transferase, intracellular GSH content, content of oxidized proteins (as measure of damage) and intracellular ROS content in both cell lines at two different mixture concentrations. Additionally, we evaluated the presence of statistical interaction to determine if the effect of the mixture on the parameters evaluated was additive, synergistic, or antagonistic. For this purpose, we used the Combination Subthresholding, Cooperative Effect and Statistical Linear Interaction approaches. We found that the interaction between pesticides depended on their concentration and the cellular models studied.
MeSH term(s)	Humans ; Pyrethrins/toxicity ; Pesticides/toxicity ; Oxidative Stress ; Cell Line ; Glyphosate
Chemical Substances	cypermethrin (1TR49121NP) ; Pyrethrins ; Pesticides
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2023.116398
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Article ; Online: Resistance to fosfomycin is increasing and is significantly associated with extended-spectrum β-lactamase-production in urinary isolates of Escherichia coli.

Ríos, Esther / Del Carmen López Diaz, María / Culebras, Esther / Rodríguez-Avial, Iciar / Rodríguez-Avial, Carmen

Medical microbiology and immunology

2022 Volume 211, Issue 5-6, Page(s) 269–272

Abstract: Fosfomycin has become a therapeutic option in urinary tract infections. Our objective was to evaluate the in vitro activity of fosfomycin against Escherichia coli isolated from urine samples in 2013, 2018 and 2021. We also determined a putative ... ...

Abstract	Fosfomycin has become a therapeutic option in urinary tract infections. Our objective was to evaluate the in vitro activity of fosfomycin against Escherichia coli isolated from urine samples in 2013, 2018 and 2021. We also determined a putative association between fosfomycin resistance and extended-spectrum β-lactamases (ESBL) production. Fosfomycin activity was evaluated against 7367, 8128 and 5072 Escherichia coli urinary isolates in 2013, 2018 and 2021, respectively. We compare the prevalence of fosfomycin-resistant strains among the ESBL- and non-ESBL-producing isolates. MICs of fosfomycin, cefotaxime, and cefotaxime-clavulanate were determined by a microdilution method. 302 ESBL-producers were selected to determine MICs of fosfomycin by agar dilution and genes encoding ESBLs were detected by PCR. Among the total of ESBL-producing strains, 14.3%, 20.8% and 20% were resistant to fosfomycin in 2013, 2018 and 2021, respectively, whereas fosfomycin resistance in non-ESBL producers was 3.5%, 4.05% and 5.53% for each year (P ≤ 0.001). In the 302 selected ESBL-producing isolates, CTX-M was the main ESBL (228 isolates), being 50.7% CTX-M-15. Resistance to fosfomycin among these ESBL-producing strains was associated (P = 0.049) with isolates that produced the CTX-M type. Our data show that fosfomycin resistance is increasing in Escherichia coli urinary isolates and it is related to ESBL-production. A follow-up of fosfomycin resistance is required.
MeSH term(s)	Humans ; Fosfomycin/pharmacology ; Fosfomycin/therapeutic use ; Escherichia coli/genetics ; beta-Lactamases/genetics ; beta-Lactamases/therapeutic use ; Escherichia coli Infections ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/epidemiology ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cefotaxime/therapeutic use
Chemical Substances	Fosfomycin (2N81MY12TE) ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; Cefotaxime (N2GI8B1GK7)
Language	English
Publishing date	2022-09-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120933-4
ISSN	1432-1831 ; 0300-8584
ISSN (online)	1432-1831
ISSN	0300-8584
DOI	10.1007/s00430-022-00749-2
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Article ; Online: Individual and joint effects of glyphosate and cypermethrin formulations on two human cell lines

Coalova, Isis / March, Hugo / Ríos de Molina, María del Carmen / Chaufan, Gabriela

Toxicology and Applied Pharmacology. 2023 Feb., v. 461, p. 116398

2023 , Page(s) 116398

Abstract	The final effect of pesticides and their mixtures on living organisms is determined by the particular toxicodynamics of the system. Oxidative stress is one of the most studied molecular mechanisms of toxicity due to increasing evidence supporting its association with the toxic effects of different agrochemicals. In the present study we evaluated the presence of redox balance alterations in the cell lines HEp-2 and A549 exposed to formulations of glyphosate (March®) and cypermethrin (Superfina®) used separately or in combination (in a proportion equivalent to that used in soybean fields). We determined the activity of catalase, superoxide dismutase, glutathione S-transferase, intracellular GSH content, content of oxidized proteins (as measure of damage) and intracellular ROS content in both cell lines at two different mixture concentrations. Additionally, we evaluated the presence of statistical interaction to determine if the effect of the mixture on the parameters evaluated was additive, synergistic, or antagonistic. For this purpose, we used the Combination Subthresholding, Cooperative Effect and Statistical Linear Interaction approaches. We found that the interaction between pesticides depended on their concentration and the cellular models studied.
Keywords	agrochemicals ; catalase ; cypermethrin ; glutathione transferase ; glyphosate ; humans ; oxidation ; oxidative stress ; pharmacology ; soybeans ; superoxide dismutase ; toxicity ; toxicology ; Joint toxicity ; Cell line
Language	English
Dates of publication	2023-02
Size	p. 116398
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2023.116398
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Article ; Online: Changes in pulmonary mechanics from supine to prone position measured through esophageal manometry in critically ill patients with COVID-19 severe acute respiratory distress syndrome.

Maldonado-Beltrán, Ismael / Ríos-Ayala, Martín Armando / Osuna-Padilla, Iván Armando / Rodríguez-Moguel, Nadia Carolina / Lugo-Goytia, Gustavo / Hernández-Cárdenas, Carmen Margarita

Medicina intensiva

2023

Abstract: Objective: To describe changes in pulmonary mechanics when changing from supine position (SP) to prone position (PP) in mechanically ventilated (MV) patients with Acute Respiratory Distress Syndrome (ARDS) due to severe COVID-19.: Design: ... ...

Abstract	Objective: To describe changes in pulmonary mechanics when changing from supine position (SP) to prone position (PP) in mechanically ventilated (MV) patients with Acute Respiratory Distress Syndrome (ARDS) due to severe COVID-19. Design: Retrospective cohort. Setting: Intensive Care Unit of the National Institute of Respiratory Diseases (Mexico City). Patients: COVID-19 patients on MV due to ARDS, with criteria for PP. Intervention: Measurement of pulmonary mechanics in patients on SP to PP, using esophageal manometry. Main variables of interest: Changes in lung and thoracic wall mechanics in SP and PP RESULTS: Nineteen patients were included. Changes during first prone positioning were reported. Reductions in lung stress (10.6 vs 7.7, p=0.02), lung strain (0.74 vs 0.57, p=0.02), lung elastance (p=0.01), chest wall elastance (p=0.003) and relation of respiratory system elastances (p=0.001) were observed between patients when changing from SP to PP. No differences were observed in driving pressure (p=0.19) and transpulmonary pressure during inspiration (p=0.70). Conclusions: Changes in pulmonary mechanics were observed when patients were comparing values of supine position with measurements obtained 24h after prone positioning. Esophageal pressure monitoring may facilitate ventilator management despite patient positioning.
Language	English
Publishing date	2023-08-12
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medine.2023.07.013
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