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  1. Article ; Online: Correction: Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation.

    Jackson, Laura E / Kulkarni, Sucheta / Wang, Huabo / Lu, Jie / Dolezal, James M / Bharathi, Sivakama S / Ranganathan, Sarangarajan / Patel, Mulchand S / Deshpande, Rahul / Alencastro, Frances / Wendell, Stacy G / Goetzman, Eric S / Duncan, Andrew W / Prochownik, Edward V

    Cancer research

    2022  Volume 82, Issue 5, Page(s) 944

    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-21-4295
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  2. Article: Safety of Lutetium-177 prostate-specific membrane antigen-617 (PSMA-617) radioligand therapy in the setting of severe renal impairment: a case report and literature review.

    Sutherland, Duncan E K / Kashyap, Raghava / Jackson, Price / Buteau, James P / Murphy, Declan G / Kelly, Brian / Spain, Lavinia / Sandhu, Shahneen / Azad, Arun A / Medhurst, Elizabeth / Kong, Grace / Hofman, Michael S

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231177018

    Abstract: Reported here is a case of rapidly progressive metastatic castration-resistant prostate cancer treated with [ ...

    Abstract Reported here is a case of rapidly progressive metastatic castration-resistant prostate cancer treated with [
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231177018
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  3. Article ; Online: Increased fibrinaloid microclot counts in platelet-poor plasma are associated with Long COVID

    Dalton, Caroline F. / de Oliveira, Madalena IR / Stafford, Prachi / Peake, Nicholas / Kane, Binita / Higham, Andrew / Singh, Dave / Jackson, Natalie / Davies, Helen E. / Price, David A. / Duncan, Rae / Tattersall, Nicola / Barnes, Amanda / Smith, David P.

    medRxiv

    Abstract: Outcomes following SARS-CoV-2 infection are variable; whilst the majority of patients recover without serious complications, a subset of patients develop prolonged illness termed Long COVID or post-acute sequelae of SARS-CoV-2 infection (PASC). The ... ...

    Abstract Outcomes following SARS-CoV-2 infection are variable; whilst the majority of patients recover without serious complications, a subset of patients develop prolonged illness termed Long COVID or post-acute sequelae of SARS-CoV-2 infection (PASC). The pathophysiology underlying Long COVID remains unclear but appears to involve multiple mechanisms including persistent inflammation, coagulopathy, autoimmunity, and organ damage. Studies suggest that microclots, also known as fibrinaloids, play a role in Long COVID. In this context, we developed a method to quantify microclots and investigated the relationship between microclot counts and Long COVID. We show that as a cohort, platelet-poor plasma from Long COVID samples had a higher microclot count compared to control groups but retained a wide distribution of counts. Recent COVID-19 infections were also seen to be associated with microclot counts higher than the control groups and equivalent to the Long COVID cohort, with a subsequent time-dependent reduction of counts. Our findings suggest that microclots could be a potential biomarker of disease and/or a treatment target in some Long COVID patients.
    Keywords covid19
    Language English
    Publishing date 2024-04-05
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2024.04.04.24305318
    Database COVID19

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  4. Article ; Online: Fibronectin has multifunctional roles in posterior capsular opacification (PCO).

    Shihan, Mahbubul H / Kanwar, Mallika / Wang, Yan / Jackson, Erin E / Faranda, Adam P / Duncan, Melinda K

    Matrix biology : journal of the International Society for Matrix Biology

    2020  Volume 90, Page(s) 79–108

    Abstract: ... signaling and elevation of the epithelial cell marker E cadherin. Although the initial fibrotic response ...

    Abstract Fibrotic posterior capsular opacification (PCO), one of the major complications of cataract surgery, occurs when lens epithelial cells (LCs) left behind post cataract surgery (PCS) undergo epithelial to mesenchymal transition, migrate into the optical axis and produce opaque scar tissue. LCs left behind PCS robustly produce fibronectin, although its roles in fibrotic PCO are not known. In order to determine the function of fibronectin in PCO pathogenesis, we created mice lacking the fibronectin gene (FN conditional knock out -FNcKO) from the lens. While animals from this line have normal lenses, upon lens fiber cell removal which models cataract surgery, FNcKO LCs exhibit a greatly attenuated fibrotic response from 3 days PCS onward as assessed by a reduction in surgery-induced cell proliferation, and fibrotic extracellular matrix (ECM) production and deposition. This is correlated with less upregulation of Transforming Growth Factor β (TGFβ) and integrin signaling in FNcKO LCs PCS concomitant with sustained Bone Morphogenetic Protein (BMP) signaling and elevation of the epithelial cell marker E cadherin. Although the initial fibrotic response of FNcKO LCs was qualitatively normal at 48 h PCS as measured by the upregulation of fibrotic marker protein αSMA, RNA sequencing revealed that the fibrotic response was already quantitatively attenuated at this time, as measured by the upregulation of mRNAs encoding molecules that control, and are controlled by, TGFβ signaling, including many known markers of fibrosis. Most notably, gremlin-1, a known regulator of TGFβ superfamily signaling, was upregulated sharply in WT LCs PCS, while this response was attenuated in FNcKO LCs. As exogenous administration of either active TGFβ1 or gremlin-1 to FNcKO lens capsular bags rescued the attenuated fibrotic response of fibronectin null LCs PCS including the loss of SMAD2/3 phosphorylation, this suggests that fibronectin plays multifunctional roles in fibrotic PCO development.
    MeSH term(s) Animals ; Bone Morphogenetic Proteins/metabolism ; Capsule Opacification/etiology ; Capsule Opacification/genetics ; Capsule Opacification/metabolism ; Capsule Opacification/pathology ; Cataract Extraction/adverse effects ; Disease Models, Animal ; Extracellular Matrix/metabolism ; Fibronectins/genetics ; Fibronectins/metabolism ; Fibrosis ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Knockout Techniques ; Mice ; Sequence Analysis, RNA ; Signal Transduction ; Transforming Growth Factor beta/metabolism
    Chemical Substances Bone Morphogenetic Proteins ; Fibronectins ; Transforming Growth Factor beta
    Language English
    Publishing date 2020-03-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2020.02.004
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    Zs.A 1694: Show issues Location:
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  5. Article ; Online: Adopting human factors in early phase and experimental medicine research: A nested pilot study observing controlled human infection with SARS-CoV-2.

    Higham, Helen E / Morgan, Lauren / Cooper, Cushla / Marshall, Julia / Mawer, Andrew / Jackson, Susan / Lopez-Ramon, Raquel / Hughes, Eileen / Richards, Duncan / McShane, Helen / Fullerton, James N

    British journal of clinical pharmacology

    2023  

    Abstract: Aims: The influence of human factors on safety in healthcare settings is well established, with targeted interventions reducing risk and enhancing team performance. In experimental and early phase clinical research participant safety is paramount and ... ...

    Abstract Aims: The influence of human factors on safety in healthcare settings is well established, with targeted interventions reducing risk and enhancing team performance. In experimental and early phase clinical research participant safety is paramount and safeguarded by guidelines, protocolized care and staff training; however, the real-world interaction and implementation of these risk-mitigating measures has never been subjected to formal system-based assessment.
    Methods: Independent structured observations, systematic review of study documents, and interviews and focus groups were used to collate data on three key tasks undertaken in a clinical research facility (CRF) during a SARS CoV-2 controlled human infection model (CHIM) study. The Systems Engineering Initiative for Patient Safety (SEIPS) was employed to analyse and categorize findings, and develop recommendations for safety interventions.
    Results: High levels of team functioning and a clear focus on participant safety were evident throughout the study. Despite this, latent risks in both study-specific and CRF work systems were identified in all four SEIPS domains (people, environment, tasks and tools). Fourteen actionable recommendations were generated collaboratively. These included inter-organization and inter-study standardization, optimized checklists for safety critical tasks, and use of simulation for team training and exploration of work systems.
    Conclusions: This pioneering application of human factors techniques to analyse work systems during the conduct of research in a CRF revealed risks unidentified by routine review and appraisal, and despite international guideline adherence. SEIPS may aid categorization of system problems and the formulation of recommendations that reduce risk and mitigate potential harm applicable across a trials portfolio.
    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15949
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    Zs.A 1118: Show issues Location:
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  6. Article ; Online: Common guillemot (

    Jackson, Duncan / Thompson, Jamie E / Hemmings, Nicola / Birkhead, Timothy R

    The Journal of experimental biology

    2018  Volume 221, Issue Pt 23

    Abstract: Birds are arguably the most evolutionarily successful extant vertebrate taxon, in part because of their ability to reproduce in virtually all terrestrial habitats. Common guillemots, ...

    Abstract Birds are arguably the most evolutionarily successful extant vertebrate taxon, in part because of their ability to reproduce in virtually all terrestrial habitats. Common guillemots,
    MeSH term(s) Animals ; Carbon Dioxide/metabolism ; Charadriiformes/embryology ; Egg Shell/anatomy & histology ; Egg Shell/physiology ; Gases/metabolism ; Nesting Behavior ; Water
    Chemical Substances Gases ; Water (059QF0KO0R) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2018-11-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.188466
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    Zs.A 2629: Show issues Location:
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  7. Article ; Online: The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X

    Jackson, Verity / Hermann, Julia / Tynan, Christopher J / Rolfe, Daniel J / Corey, Robin A / Duncan, Anna L / Noriega, Maxime / Chu, Amy / Kalli, Antreas C / Jones, E Yvonne / Sansom, Mark S P / Martin-Fernandez, Marisa L / Seiradake, Elena / Chavent, Matthieu

    Structure (London, England : 1993)

    2022  Volume 30, Issue 9, Page(s) 1354–1365.e5

    Abstract: Fibronectin Leucine-rich Repeat Transmembrane (FLRT 1-3) proteins are a family of broadly expressed single-spanning transmembrane receptors that play key roles in development. Their extracellular domains mediate homotypic cell-cell adhesion and ... ...

    Abstract Fibronectin Leucine-rich Repeat Transmembrane (FLRT 1-3) proteins are a family of broadly expressed single-spanning transmembrane receptors that play key roles in development. Their extracellular domains mediate homotypic cell-cell adhesion and heterotypic protein interactions with other receptors to regulate cell adhesion and guidance. These in trans FLRT interactions determine the formation of signaling complexes of varying complexity and function. Whether FLRTs also interact at the surface of the same cell, in cis, remains unknown. Here, molecular dynamics simulations reveal two dimerization motifs in the FLRT2 transmembrane helix. Single particle tracking experiments show that these Small-X
    MeSH term(s) Cell Adhesion/physiology ; Cell Adhesion Molecules/metabolism ; Dimerization ; Membrane Glycoproteins/chemistry ; Signal Transduction
    Chemical Substances Cell Adhesion Molecules ; Membrane Glycoproteins
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1213087-4
    ISSN 1878-4186 ; 0969-2126
    ISSN (online) 1878-4186
    ISSN 0969-2126
    DOI 10.1016/j.str.2022.05.014
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    Zs.A 4141: Show issues Location:
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  8. Article ; Online: Complete Genome Sequences of Chop, DelRio, and GrandSlam, Three

    Mathes, Heidi N / Christenson, Elijah I / Crum, John H / Edmondson, Emme M / Gray, Kassidy E / Lawson, Luke W / Lee, Lauren E / Lee, Michael P / Lipscomb, Jackson A / Masengale, Morgan E / Matthews, Hannah G / McClain, Charles M / Melton, Tuesday N / Morrow, Trace H / Perry, Alexis M / Rainwater, David R / Renois, Grace E / Rettig, Maryann F / Troup, Duncan C /
    Wilson, Allie J / Reyna, Nathan S / Plymale, Ruth

    Microbiology resource announcements

    2023  Volume 12, Issue 5, Page(s) e0002323

    Abstract: Chop, DelRio, and GrandSlam are phage with ... ...

    Abstract Chop, DelRio, and GrandSlam are phage with a
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00023-23
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  9. Article ; Online: Nutritional ecology: a first vegetarian spider.

    Jackson, Duncan E

    Current biology : CB

    2009  Volume 19, Issue 19, Page(s) R894–5

    Abstract: Mutualisms are ubiquitous in nature and equally commonplace is their exploitation. A well-known mutualism has been found to be exploited from a surprising source: the first described vegetarian spider dines on trophic structures produced by acacia trees ... ...

    Abstract Mutualisms are ubiquitous in nature and equally commonplace is their exploitation. A well-known mutualism has been found to be exploited from a surprising source: the first described vegetarian spider dines on trophic structures produced by acacia trees to reward their mutualistic protective ants.
    MeSH term(s) Animals ; Ants ; Costa Rica ; Fabaceae ; Feeding Behavior/physiology ; Isotope Labeling ; Mexico ; Observation ; Social Behavior ; Spiders/physiology ; Symbiosis
    Language English
    Publishing date 2009-10-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2009.08.043
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    Zs.A 3208: Show issues Location:
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  10. Article: Social spiders.

    Jackson, Duncan E

    Current biology : CB

    2007  Volume 17, Issue 16, Page(s) R650–2

    MeSH term(s) Animals ; Behavior, Animal ; Ecosystem ; Social Behavior ; Spiders/physiology
    Language English
    Publishing date 2007-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2007.06.003
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