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  1. Article: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).

    Bottas, Alexandra / Richter, Margaret A

    The Pediatric infectious disease journal

    2002  Volume 21, Issue 1, Page(s) 67–71

    MeSH term(s) Age of Onset ; Autoimmune Diseases/complications ; Autoimmune Diseases/etiology ; Autoimmune Diseases/immunology ; Child ; Child, Preschool ; Chorea/diagnosis ; Chorea/immunology ; Chorea/pathology ; Humans ; Infant ; Infant, Newborn ; Obsessive-Compulsive Disorder/etiology ; Obsessive-Compulsive Disorder/microbiology ; Risk Factors ; Streptococcal Infections/complications ; Streptococcal Infections/immunology ; Streptococcal Infections/psychology ; Tourette Syndrome/etiology ; Tourette Syndrome/microbiology
    Language English
    Publishing date 2002-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/00006454-200201000-00017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
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  2. Article: Comorbidity and pathophysiology of obsessive-compulsive disorder in schizophrenia: is there evidence for a schizo-obsessive subtype of schizophrenia?

    Bottas, Alexandra / Cooke, Robert G / Richter, Margaret A

    Journal of psychiatry & neuroscience : JPN

    2005  Volume 30, Issue 3, Page(s) 187–193

    Abstract: Epidemiologic and neurobiologic evidence suggests that patients with comorbid obsessive-compulsive disorder (OCD) and schizophrenia may represent a special category among patients with schizophrenia. Efforts to examine the neurobiology of this group have ...

    Abstract Epidemiologic and neurobiologic evidence suggests that patients with comorbid obsessive-compulsive disorder (OCD) and schizophrenia may represent a special category among patients with schizophrenia. Efforts to examine the neurobiology of this group have focused on neuroimaging studies and neuropsychologic testing. Convergent evidence suggests that there may be a specific pattern of neurobiologic dysfunction in this subgroup of patients accounting for symptom co-expression. This review indicates that future studies should distinguish among (1) apparent obsessive-compulsive symptoms (OCS) that occur only in the context of psychosis and that may overlap with psychotic phenomenology, representing a forme fruste of psychosis; (2) OCS occurring only in the prodromal phase of schizophrenia; (3) neuroleptic-induced OCS or OCD; and (4) OCS or frank OCD occurring concurrently with schizophrenia. We examine the evidence for a putative schizo-obsessive disorder and outline suggestions for identifying OCS in the presence of psychosis.
    MeSH term(s) Diagnostic Imaging ; Humans ; Neuropsychological Tests ; Obsessive-Compulsive Disorder/classification ; Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/physiopathology ; Obsessive-Compulsive Disorder/psychology ; Schizophrenia/classification ; Schizophrenia/complications ; Schizophrenia/physiopathology ; Schizophrenic Psychology
    Language English
    Publishing date 2005-05
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 1077443-9
    ISSN 1180-4882
    ISSN 1180-4882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinical translation of neuroimaging research in mood disorders.

    Konarski, Jakub Z / McIntyre, Roger S / Soczynska, Joanna K / Bottas, Alexandra / Kennedy, Sidney H

    Psychiatry (Edgmont (Pa. : Township))

    2010  Volume 3, Issue 2, Page(s) 46–57

    Abstract: Background: Practitioners are increasingly presented with data procured from studies employing advanced neuroimaging techniques. The central role that neuroimaging occupies in contemporary psychiatric research highlights the need for practitioner ... ...

    Abstract Background: Practitioners are increasingly presented with data procured from studies employing advanced neuroimaging techniques. The central role that neuroimaging occupies in contemporary psychiatric research highlights the need for practitioner familiarity with the neuroimaging technology and its clinical translation.
    Methods: We conducted a PubMed search of all English-language articles published between January 1964 - October 2005. The search words were major depressive disorder, bipolar disorder, functional magnetic resonance imaging (fMRI), single-photon-emission computed tomography (SPECT), positron emission tomography (PET), voxel-based morphometry (VBM), region of interest (ROI), blood-oxygen-level-dependent (BOLD), glucose metabolism, blood flow, statistical parametric mapping (SPM), magnetic resonance spectroscopy (MRS), and diffusion-tensor imaging (DTI). The search was supplemented with a manual review of relevant references. The authors organize the review by addressing frequently asked questions on the topic of neuroimaging by mental healthcare providers.
    Results: The localization of regional brain volumetric abnormalities with CT is enhanced with MRI techniques that allow for a separate assay of white and gray matter pathology (segmentation), cellular metabolism (MRS), and neurocircuitry (DTI). Positron emission tomography permits the quantification of brain glucose metabolism, regional blood flow, and receptor/transporter localization and function. Rapid changes in regional oxygen consumption may also be quantified with fMRI.
    Conclusions: Neuroimaging technology has helped refine pathophysiological models of disease activity in mood disorders and illuminate mechanisms of drug activity. A priority research vista in mood disorders is the integration of neuroimaging investigations with other research methods (e.g., genetics, endocrinology, etc.).
    Language English
    Publishing date 2010-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2528825-8
    ISSN 1555-5194 ; 1550-5952
    ISSN (online) 1555-5194
    ISSN 1550-5952
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  4. Article: Anxiety disorders and bipolar disorder: a review.

    McIntyre, Roger S / Soczynska, Joanna K / Bottas, Alexandra / Bordbar, Kamran / Konarski, Jakub Z / Kennedy, Sidney H

    Bipolar disorders

    2006  Volume 8, Issue 6, Page(s) 665–676

    Abstract: Context: Epidemiological, clinical and familial studies indicate that anxiety disorders (ADs) are highly comorbid in persons with bipolar disorder (BPD). The phenomenological overlap between ADs and BPD is reported more frequently in individuals with ... ...

    Abstract Context: Epidemiological, clinical and familial studies indicate that anxiety disorders (ADs) are highly comorbid in persons with bipolar disorder (BPD). The phenomenological overlap between ADs and BPD is reported more frequently in individuals with female predominant bipolar presentations (e.g., bipolar II disorder). Anxiety comorbidity in the BPD population poses a serious hazard. For example, it is associated with an intensification of symptoms, non-recovery, substance use comorbidity and harmful dysfunction (e.g., suicidality).
    Objective: The evidentiary base informing treatment decisions for the anxious bipolar patient is woefully inadequate. Several expert consensus and evidence-based treatment guidelines for BPD suggest various treatment avenues, although these have been insufficiently studied. The encompassing aim of this paper is to synthesize extant studies reporting on the co-occurrence of AD and BPD. Taken together, a compelling basis emerges for prioritizing the identification and management of anxiety symptomatology in the BPD population.
    MeSH term(s) Anxiety Disorders/epidemiology ; Anxiety Disorders/psychology ; Bipolar Disorder/epidemiology ; Bipolar Disorder/psychology ; Comorbidity ; Female ; Humans ; Male ; Prevalence
    Language English
    Publishing date 2006-12
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/j.1399-5618.2006.00355.x
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    Zs.A 5604: Show issues Location:
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  5. Article: Medical comorbidity in bipolar disorder: implications for functional outcomes and health service utilization.

    McIntyre, Roger S / Konarski, Jakub Z / Soczynska, Joanna K / Wilkins, Kathryn / Panjwani, Gulshan / Bouffard, Beverley / Bottas, Alexandra / Kennedy, Sidney H

    Psychiatric services (Washington, D.C.)

    2006  Volume 57, Issue 8, Page(s) 1140–1144

    Abstract: Objective: This is the first cross-national population-based investigation exploring the prevalence and functional implications of comorbid general medical disorders in bipolar disorder.: Methods: Data were extracted from the Canadian Community ... ...

    Abstract Objective: This is the first cross-national population-based investigation exploring the prevalence and functional implications of comorbid general medical disorders in bipolar disorder.
    Methods: Data were extracted from the Canadian Community Health Survey (N = 36,984). Analyses were conducted to ascertain the prevalence and prognostic implications of predetermined comorbid general medical disorders among persons who screened positive for a lifetime manic episode (indicative of a diagnosis of bipolar disorder). Within the subpopulation of people who screened positive for a manic episode, the effect of medical comorbidity on employment, functional role, psychiatric care, and medication use was examined.
    Results: When the data were weighted to be representative of the household population of the ten provinces in 2002, an estimated 2.4 percent of respondents screened positive for a lifetime manic episode. Rates of chronic fatigue syndrome, migraine, asthma, chronic bronchitis, multiple chemical sensitivities, hypertension, and gastric ulcer were significantly higher in the bipolar disorder group (all p < .05). Chronic medical disorders were associated with a more severe course of bipolar disorder, increased household and work maladjustment, receipt of disability payments, reduced employment, and more frequent medical service utilization.
    Conclusions: Comorbid medical disorders in bipolar disorder are associated with several indices of harmful dysfunction, decrements in functional outcomes, and increased utilization of medical services.
    MeSH term(s) Adolescent ; Adult ; Aged ; Bipolar Disorder ; Canada ; Chronic Disease ; Comorbidity ; Employment ; Female ; Health Services/utilization ; Health Surveys ; Humans ; Income ; Interviews as Topic ; Male ; Middle Aged ; National Health Programs
    Language English
    Publishing date 2006-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/ps.2006.57.8.1140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 416: Show issues Location:
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  6. Article ; Online: Substance use disorders and overweight/obesity in bipolar I disorder: preliminary evidence for competing addictions.

    McIntyre, Roger S / McElroy, Susan L / Konarski, Jakub Z / Soczynska, Joanna K / Bottas, Alexandra / Castel, Saulo / Wilkins, Kathryn / Kennedy, Sidney H

    The Journal of clinical psychiatry

    2007  Volume 68, Issue 9, Page(s) 1352–1357

    Abstract: Objective: This investigation was undertaken to explore the relationship between alcohol/illicit drug dependence and overweight/obesity in individuals with bipolar I disorder.: Method: The data for this analysis were procured from the Canadian ... ...

    Abstract Objective: This investigation was undertaken to explore the relationship between alcohol/illicit drug dependence and overweight/obesity in individuals with bipolar I disorder.
    Method: The data for this analysis were procured from the Canadian Community Health Survey-Mental Health and Well-Being (CCHS) conducted by Statistics Canada in 2002. Bipolar I disorder was defined as persons screening positive for a lifetime manic episode using the World Mental Health 2000 version of the Composite International Diagnostic Interview (WMH-CIDI). Substance abuse and illicit drug dependence were determined using criteria commensurate with the DSM-IV-TR. Overweight and obesity were defined as a body mass index of 25.0 to 29.9 and greater than or equal to 30.0 kg/m(2), respectively.
    Results: The total sample comprised 36,984 individuals (>or= 15 years old) screening positive for a lifetime manic episode. Subgroup analysis indicated that overweight/obese bipolar individuals had a significantly lower rate of substance dependence than the normal weight sample (13% vs. 21%, p < .01). Conversely, bipolar individuals who screened positive for substance dependence had a lower rate of overweight/obesity when compared with non-substance-dependent bipolar respondents (39% vs. 54%, p< .01). The inverse association between the presence of these 2 co-morbid conditions in bipolar I disorder continued to be statistically significant in multivariate analysis (OR = 0.57, 95% CI = 0.34 to 0.95, p < .05).
    Conclusion: An inverse relationship between the presence of comorbid overweight/obesity and substance use disorders was observed in bipolar I disorder. These results suggest that comorbid addictive disorders (i.e., substance use and compulsive overeating) may compete for the same brain reward systems.
    MeSH term(s) Adolescent ; Adult ; Behavior, Addictive/epidemiology ; Behavior, Addictive/psychology ; Bipolar Disorder/diagnosis ; Bipolar Disorder/epidemiology ; Bipolar Disorder/psychology ; Comorbidity ; Demography ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Male ; Mass Screening ; Middle Aged ; Obesity/epidemiology ; Obesity/psychology ; Overweight ; Prevalence ; Severity of Illness Index ; Substance-Related Disorders/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2007-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/jcp.v68n0905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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