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  1. Article ; Online: Use of granules and free salts for Fe and Zn fortification of leafy vegetables: Improvements in trace element bioaccessibility and fulfillment of Dietary Reference Intakes.

    Martínez-Castro, J / Cámara-Martos, F / Moreno-Ortega, A / Victorio-Sánchez, M / Krstova, A / Lopes, J Almeida / Pérez-Rodríguez, F

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2023  Volume 78, Page(s) 127181

    Abstract: Background: Leafy vegetables represent an excellent dietary source of trace elements such as Fe and Zn. Nevertheless, Fe and Zn bioaccessibility can lessen due to a high concentration of anti-nutritional compounds. The encapsulation of Fe and Zn salts ... ...

    Abstract Background: Leafy vegetables represent an excellent dietary source of trace elements such as Fe and Zn. Nevertheless, Fe and Zn bioaccessibility can lessen due to a high concentration of anti-nutritional compounds. The encapsulation of Fe and Zn salts as granules could be used to fortify these leafy vegetables.
    Method: Three leafy vegetables, spinach, Swiss chard and Ethiopian mustard were fortified with iron sulfate and zinc sulfate as granules and free salts in order to test the improvements in the bioaccessibility and fulfillments of DRIs. Fe and Zn granules were prepared in a fluidized bed granulator. A probabilistic analysis was performed, using experimental data, to assess bioaccessible intake and fulfillments of DRIs in European populations.
    Results: Fe contents ranged between 4.8 mg/100 g of Ethiopian mustard to 157.4 mg/100 g of spinach. Fe and Zn bioaccessibility percentages were low for Swiss chard and spinach without fortification. Fortification with granules improved Fe bioaccessibility of these latter vegetables (196 and 223 mg/100 g). Zn contents in samples without fortification ranged between 2.3 mg/100 g for Ethiopian mustard and 7.4 mg/100 g for spinach. Zn fortification as granules improved Zn bioaccessibility for the three vegetables studied. Thus, Zn bioccessible concentrations ranged between 17.4 and 108 mg/100 g for the solubility assay and between 5.9 and 31.1 mg/100 g for the dialyzability assay. Besides, the probability analysis showed that fortification had a better performance in meeting DRIs for those populations with higher consumption levels of leafy vegetables.
    Conclusions: The probability analysis demonstrated that fortification can be a suitable strategy to meet DRIs for both trace elements, which was especially remarkable for Fe. Fortification with granule was more effective in most the cases, although for Ethiopian mustard, free salt of Fe showed a better performance.
    MeSH term(s) Trace Elements/analysis ; Vegetables ; Salts ; Recommended Dietary Allowances ; Zinc/analysis
    Chemical Substances Trace Elements ; Salts ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-04-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2023.127181
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  2. Article ; Online: Increase in hospital care at the end of life: Retrospective analysis of the last 20 years of life of a cohort of patients.

    Jiménez-Puente, Alberto / Martín-Escalante, María Dolores / Martos-Pérez, Francisco / García-Alegría, Javier

    Revista espanola de geriatria y gerontologia

    2024  Volume 59, Issue 3, Page(s) 101484

    Abstract: Background: There is an increasing need for end-of-life care due to society's progressive aging. This study aimed to describe how hospitalizations evolve long-term and in the last months life of a cohort of deceased patients.: Methods: The study ... ...

    Abstract Background: There is an increasing need for end-of-life care due to society's progressive aging. This study aimed to describe how hospitalizations evolve long-term and in the last months life of a cohort of deceased patients.
    Methods: The study population were those who died in one year who lived in a district in southern Spain. The number of hospital stays over the previous 20 years and number of contacts with the emergency department, hospitalization, outpatient clinics, and medical day hospital in the last three months of life were determined. The analyses were stratified by age, sex, and pattern of functional decline.
    Results: The study population included 1773 patients (82.5% of all who died in the district). The hospital stays during the last 20 years of life were concentrated in the last five years (66%) and specially in the last six months (32%). Eighty percent had contact with the hospital during their last three months of life. The older group had the minimun of stays over the last 20 years and contacts with the hospital in the last months of life.
    Conclusions: The majority of hospitalizations occur at the end of life and these admissions represent a significant part of an acute-care hospital's activity. The progressive prolongation of life does not have to go necessarily along with a proportional increase in hospital stays.
    MeSH term(s) Humans ; Terminal Care/trends ; Male ; Female ; Retrospective Studies ; Aged ; Hospitalization/statistics & numerical data ; Aged, 80 and over ; Spain ; Middle Aged ; Cohort Studies ; Time Factors
    Language English
    Publishing date 2024-03-28
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 605609-x
    ISSN 1578-1747 ; 0211-139X
    ISSN (online) 1578-1747
    ISSN 0211-139X
    DOI 10.1016/j.regg.2024.101484
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  3. Article ; Online: Highly deformable and strongly magnetic semi-interpenetrating hydrogels based on alginate or cellulose.

    Leon-Cecilla, Alberto / Gila-Vilchez, Cristina / Vazquez-Perez, Francisco J / Capitan-Vallvey, Luis F / Martos, Vanesa / Fernandez-Ramos, María D / Álvarez de Cienfuegos, Luis / Medina-Castillo, Antonio L / Lopez-Lopez, Modesto T

    International journal of biological macromolecules

    2024  Volume 260, Issue Pt 1, Page(s) 129368

    Abstract: The effective implementation of many of the applications of magnetic hydrogels requires the development of innovative systems capable of withstanding a substantial load of magnetic particles to ensure exceptional responsiveness, without compromising ... ...

    Abstract The effective implementation of many of the applications of magnetic hydrogels requires the development of innovative systems capable of withstanding a substantial load of magnetic particles to ensure exceptional responsiveness, without compromising their reliability and stability. To address this challenge, double-network hydrogels have emerged as a promising foundation, thanks to their extraordinary mechanical deformability and toughness. Here, we report a semi-interpenetrating polymer networks (SIPNs) approach to create diverse magnetic SIPNs hydrogels based on alginate or cellulose, exhibiting remarkable deformability under certain stresses. Achieving strong responsiveness to magnetic fields is a key objective, and this characteristic is realized by the incorporation of highly magnetic iron microparticles at moderately large concentrations into the polymer network. Remarkably, the SIPNs hydrogels developed in this research accommodate high loadings of magnetic particles without significantly compromising their physical properties. This feature is essential for their use in applications that demand robust responsiveness to applied magnetic fields and overall stability, such as a hydrogel luminescent oxygen sensor controlled by magnetic fields that we designed and tested as proof-of-concept. These findings underscore the potential and versatility of magnetic SIPNs hydrogels based on carbohydrate biopolymers as fundamental components in driving the progress of advanced hydrogels for diverse practical implementations.
    MeSH term(s) Hydrogels ; Cellulose ; Alginates ; Reproducibility of Results ; Polymers ; Magnetic Phenomena
    Chemical Substances Hydrogels ; Cellulose (9004-34-6) ; Alginates ; Polymers
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129368
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  4. Article ; Online: Gains and losses of the epiphytic lifestyle in epidendroid orchids: review and new analyses of succulence traits.

    Collobert, Géromine / Perez-Lamarque, Benoît / Dubuisson, Jean-Yves / Martos, Florent

    Annals of botany

    2023  Volume 132, Issue 4, Page(s) 787–800

    Abstract: Background and aims: Epiphytism has evolved repeatedly in plants and has resulted in a considerable number of species with original characteristics. Because water supply is generally erratic compared to that in soils, succulent forms in particular are ... ...

    Abstract Background and aims: Epiphytism has evolved repeatedly in plants and has resulted in a considerable number of species with original characteristics. Because water supply is generally erratic compared to that in soils, succulent forms in particular are widespread in epiphytic species. However, succulent organs also exist in terrestrial plants, and the question of the concomitant evolution of epiphytism and succulence has received little attention, not even in the epidendroid orchids, which account for 67.6 % of vascular epiphytes.
    Methods: We built a new time-calibrated phylogenetic tree of Epidendroideae with 203 genera treated in genus Orchidacearum, from which we reconstructed the evolution of epiphytism as well as traits related to water scarcity (stem and leaf succulence and the number of velamen layers), while testing for the correlated evolution between the two. Furthermore, we estimated the ancestral geographical ranges to evaluate the palaeoclimatic context in which epiphytism evolved.
    Key results: Epiphytism evolved at least three times: 39.0 million years ago (Mya) in the common ancestor of the Malaxideae and Cymbidieae that probably ranged from the Neotropics to Southeast Asia and Australia, 11.5 Mya in the Arethuseae in Southeast Asia and Australia, and 7.1 Mya in the neotropical Sobralieae, and it was notably lost in the Malaxidiinae, Collabieae, Calypsoeae, Bletiinae and Eulophiinae. Stem succulence is inferred to have evolved once, in a terrestrial ancestor at least 4.1 Mya before the emergence of epiphytic lineages. If lost, stem succulence was almost systematically replaced by leaf succulence in epiphytic lineages.
    Conclusions: Epiphytism may have evolved in seasonally dry forests during the Eocene climatic cooling, among stem-succulent terrestrial orchids. Our results suggest that the emergence of stem succulence in early epidendroids was a key innovation in the evolution of epiphytism, facilitating the colonization of epiphytic environments that later led to the greatest diversification of epiphytic orchids.
    MeSH term(s) Phylogeny ; Phenotype ; Soil ; Forests ; Orchidaceae
    Chemical Substances Soil
    Language English
    Publishing date 2023-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1461328-1
    ISSN 1095-8290 ; 0305-7364
    ISSN (online) 1095-8290
    ISSN 0305-7364
    DOI 10.1093/aob/mcad145
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  5. Article ; Online: Analysis of patients shared in consultations of internal medicine and other medical specialties.

    Jiménez-Puente, A / Martín-Escalante, M D / Martos-Pérez, F / García-Alegría, J

    Revista clinica espanola

    2019  Volume 219, Issue 9, Page(s) 485–489

    Abstract: Background and objective: The aging population is resulting in an increasing number of patients with multiple diseases that require treatment by various specialties. We examined the evolution of consultations and of the percentage of patients treated by ...

    Title translation Análisis de pacientes compartidos en consultas de medicina interna y otras especialidades médicas.
    Abstract Background and objective: The aging population is resulting in an increasing number of patients with multiple diseases that require treatment by various specialties. We examined the evolution of consultations and of the percentage of patients treated by several medical specialties.
    Methods: We analysed internal medicine (IM) consultations and those of other medical specialties in a hospital during 1997, 2007 and 2017 for the general population and for those older than 65 years.
    Results: Over the course of 20 years, the rate of first IM consultations per 1000 inhabitants increased 44%, and that of other medical specialties increased 137%. The percentage of patients seen by more than one specialty went from 13.8% in 1997 to 32.6% in 2017 and reached 45.5% for those older than 65 years.
    Conclusions: The care for populations with growing comorbidity has a major impact on health systems and requires organisational changes for their care.
    Language Spanish
    Publishing date 2019-04-20
    Publishing country Spain
    Document type Journal Article
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2019.03.005
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  6. Article ; Online: Effects of an Eight-Week Concurrent Training Program with Different Effort Character over Physical Fitness, Health-Related Quality of Life, and Lipid Profile among Hospital Workers: Preliminary Results.

    Pérez-Bilbao, Txomin / García-González, David / Martos-Bermúdez, Álvaro / Nieto, Sandra / Del Campo, Teresa / Pérez-Ruiz, Margarita / San Juan, Alejandro F

    International journal of environmental research and public health

    2021  Volume 18, Issue 17

    Abstract: Background: The "effort character" (EC) is a resistance training method without reaching muscle failure. It was defined by González-Badillo and Gorostiaga Ayestarán (2002) as the relationship between the repetitions performed and the repetitions ... ...

    Abstract Background: The "effort character" (EC) is a resistance training method without reaching muscle failure. It was defined by González-Badillo and Gorostiaga Ayestarán (2002) as the relationship between the repetitions performed and the repetitions achievable. Then, the EC is at its maximum (i.e., 100%) when the subject realizes all the repetitions possible in a series with any load. Therefore, an EC of 50% indicates execution of 50% of the repetitions achievable in a series. This study aimed to determine the effects of two programs of eight weeks of concurrent training (CT) with different EC over muscle strength (MS), cardiorespiratory fitness (CRF), functional mobility (FM), health-related quality of life (HRQoL), and lipid profile (LP) among hospital workers.
    Methods: Fourteen hospital workers (age: 41.1 ± 10.8 years; body mass: 63.0 ± 10.8 kg; height: 165.2 ± 6.5 cm; body mass index (BMI): 23.0 ± 3.4 kg/m
    Results: The main finding was that both groups significantly improved in MS and FM levels but not HRQoL, with no statistical differences between EC 50% and EC 100% in adherence and any test despite performing half the volume of the strength workout.
    Conclusions: An eight-week CT program with different EC (i.e., EC 50% vs. EC 100%) seems to improve the MS and FM levels in hospital workers similarly. These findings could be very useful in health-training practices because of the possibility of planning training loads with half the volume of strength workouts without the loss of any training adaptation.
    MeSH term(s) Adult ; Hospitals ; Humans ; Lipids ; Middle Aged ; Muscle Strength ; Muscle, Skeletal ; Physical Fitness ; Quality of Life ; Resistance Training
    Chemical Substances Lipids
    Language English
    Publishing date 2021-09-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18179328
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  7. Article ; Online: An Intervention on Anxiety Symptoms in Moderate Alzheimer's Disease through Virtual Reality: A Feasibility Study and Lessons Learned.

    Sánchez-Nieto, Desirée / Castaño-Castaño, Sergio / Navarro-Martos, Remedios / Obrero-Gaitán, Esteban / Cortés-Pérez, Irene / Nieto-Escamez, Francisco

    International journal of environmental research and public health

    2023  Volume 20, Issue 3

    Abstract: 1) Background: Although cognitive impairment is considered the core deficit of dementia, anxiety disorders also have a negative influence on the social and daily life of the affected population. We have explored the exposure of relaxing scenarios in ... ...

    Abstract (1) Background: Although cognitive impairment is considered the core deficit of dementia, anxiety disorders also have a negative influence on the social and daily life of the affected population. We have explored the exposure of relaxing scenarios in immersive Virtual Reality (iVR) as an intervention strategy for people with moderate Alzheimer's disease. (2) Methods: Three participants were recruited from a day center to participate in a five-week study, which included a Pre- and Post-evaluation with the Montreal Cognitive Assessment (MoCA), Neuropsychiatric Inventory-Questionnaire (NPI-Q), Clinical Dementia Rating Scale (CDR), Global Deterioration Scale (GDS), Hamilton Anxiety Rating Scale (HARS), State-Trait Anxiety Inventory (STAI), and the anxiety subdomain of the Neuropsychiatric Inventory (NPI). Participants' heart rate, oxygen saturation, arterial pressure, and respiratory rate were also monitored during intervention sessions. Three virtual scenarios from Nature Treks VR were used as the intervention over three weeks (a total of nine sessions). (3) Results: Post-intervention anxiety assessment showed a light reduction in psychological anxiety in the HARS questionnaire. A light reduction in heart rate was also observed during the exposure to iVR. (4) Discussion: The use of virtual scenarios was a satisfactory experience for all the participants. Preliminary data point to a relaxing effect of iVR scenarios and a potential reduction in psychological anxiety, but further research is required to confirm the efficacy of the intervention.
    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Feasibility Studies ; Anxiety ; Cognitive Dysfunction ; Virtual Reality
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20032727
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  8. Article: Identifying subgroups of childhood obesity by using multiplatform metabotyping.

    Chamoso-Sanchez, David / Rabadán Pérez, Francisco / Argente, Jesús / Barbas, Coral / Martos-Moreno, Gabriel A / Rupérez, Francisco J

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1301996

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1301996
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  9. Article ; Online: Minimizing Selection and Classification Biases. Comment on "Clinical Characteristics and Prognostic Factors for Intensive Care Unit Admission of Patients With COVID-19: Retrospective Study Using Machine Learning and Natural Language Processing".

    Martos Pérez, Francisco / Gomez Huelgas, Ricardo / Martín Escalante, María Dolores / Casas Rojo, José Manuel

    Journal of medical Internet research

    2021  Volume 23, Issue 5, Page(s) e27142

    MeSH term(s) Bias ; COVID-19 ; Humans ; Intensive Care Units ; Machine Learning ; Natural Language Processing ; Prognosis ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-05-26
    Publishing country Canada
    Document type Journal Article ; Comment
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1439-4456
    ISSN (online) 1438-8871
    ISSN 1439-4456
    DOI 10.2196/27142
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  10. Article ; Online: Correction to: Relationship Between Gymnastic Rhythmic Practice and Body Composition, Physical Performance, and Trace Element Status in Young Girls.

    Campos-Pérez, Julián / Páscoa, Ricardo N M J / Lopes, João Almeida / Cámara-Martos, Fernando

    Biological trace element research

    2021  Volume 200, Issue 1, Page(s) 96

    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-021-02668-4
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