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Article: On optimization of Spin-Forming Process Parameters for Magnesium Alloy Wheel Hub Based on Gray Relational Analysis.

Zhang, Zheng / Lan, Yongting / Ding, Haochuan / Xie, Yuanhang

2024 Volume 17, Issue 4

Abstract: To study the influencing factors of process parameters on the wall thickness deviation and internal warpage deviation of the workpiece in magnesium alloy wheel hub spin molding, a two-pass heterogeneous spin molding model is proposed. To ensure the ... ...

Abstract	To study the influencing factors of process parameters on the wall thickness deviation and internal warpage deviation of the workpiece in magnesium alloy wheel hub spin molding, a two-pass heterogeneous spin molding model is proposed. To ensure the accuracy of the simulation results, the stress-strain data of AZ31 magnesium alloy at different temperatures and different strain rates were obtained through tests. Wall thickness deviation and internal warp deviation after molding were used as evaluation indexes of workpiece molding quality. ABAQUS software facilitated the numerical simulation and analysis of the magnesium alloy wheel hub spinning process. Gray relational degree analysis optimized the first-pass process parameters, elucidating the impact of the axial offset, the thinning ratio, and the feed ratio on forming quality. The application of optimized parameters in the hub spinning simulation resulted in a substantial 28.84% reduction in wall thickness deviation and a 4.88% reduction in inner diameter deviation. This study underscores the efficacy of employing Gray Relational Analysis for comprehensive parameter optimization, ensuring wheel hub quality. Moreover, it provides a theoretical foundation for enterprises to expedite research and development cycles and minimize associated costs.
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17040959
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mott-Schottky Effect in Core-Shell W@W

Yang, Yao / Sun, Bing / Gao, Yinhong / Zhu, Hui / Chen, Yongting / Li, Xuanke / Zhang, Qin

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 36, Page(s) e2300955

Abstract: The dynamics rate of traditional metal carbides (TMCs) is relatively slow, severely limiting its fast-charging capacity for lithium-ion batteries (LIBs). Herein, the core-shell W@ ... ...

Abstract	The dynamics rate of traditional metal carbides (TMCs) is relatively slow, severely limiting its fast-charging capacity for lithium-ion batteries (LIBs). Herein, the core-shell W@W
Language	English
Publishing date	2023-05-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202300955
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Article ; Online: An EM-Tracked Approach for Calibrating the 3D Pose of Flexible Endoscopes.

Long, Zhongjie / Chi, Yongting / Zhang, Xianbo / Li, Hongbing / Yang, Dejin / Li, Diangeng / Jiang, Zhouxiang

Annals of biomedical engineering

2024 Volume 52, Issue 5, Page(s) 1435–1447

Abstract: Flexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to ... ...

Abstract	Flexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to simplify the calibration process, we propose an electromagnetic (EM)-tracked calibration approach that does not require any predefined poses of the EM sensor. A three-stage calibration protocol was presented in an extensor. First, the orientation of the endoscope tube was derived by conducting a circular rotation of the endoscope around its axis utilizing a pair of tightly bearing stands. Second, the 3D position of the endoscope tip was acquired by having the tip come into contact with a flat plane. Third, the pose model of the bending section was derived and transformed into the local coordinate system of the EM sensor attached to the endoscope handle. To assess the accuracy of the proposed calibration approach, two experiments were designed and performed. Experimental results indicate accuracies of 0.09 ± 0.06 deg and 0.03 ± 0.19 deg in the estimation of the endoscope tube orientation and 0.52 ± 0.29, 0.33 ± 0.11, and 0.29 ± 0.17 mm in the x, y, and z estimations of the endoscope tip position, respectively. The proposed approach is accurate and easy to operate, does not require the employment of custom calibration markers, and can be used not only in surgical training systems but also in the endoscopic-based tools tracking.
MeSH term(s)	Endoscopes ; Endoscopy ; Electromagnetic Phenomena ; Phantoms, Imaging ; Equipment Design
Language	English
Publishing date	2024-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	185984-5
ISSN	1573-9686 ; 0191-5649 ; 0090-6964
ISSN (online)	1573-9686
ISSN	0191-5649 ; 0090-6964
DOI	10.1007/s10439-024-03469-1
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Article: Seeing beyond words: Visualizing autism spectrum disorder biomarker insights.

Xie, Xinyue / Zhou, Rongyi / Fang, Zihan / Zhang, Yongting / Wang, Qirong / Liu, Xiaomian

Heliyon

2024 Volume 10, Issue 9, Page(s) e30420

Abstract: Objective: This study employs bibliometric and visual analysis to elucidate global research trends in Autism Spectrum Disorder (ASD) biomarkers, identify critical research focal points, and discuss the potential integration of diverse biomarker ... ...

Abstract	Objective: This study employs bibliometric and visual analysis to elucidate global research trends in Autism Spectrum Disorder (ASD) biomarkers, identify critical research focal points, and discuss the potential integration of diverse biomarker modalities for precise ASD assessment. Methods: A comprehensive bibliometric analysis was conducted using data from the Web of Science Core Collection database until December 31, 2022. Visualization tools, including R, VOSviewer, CiteSpace, and gCLUTO, were utilized to examine collaborative networks, co-citation patterns, and keyword associations among countries, institutions, authors, journals, documents, and keywords. Results: ASD biomarker research emerged in 2004, accumulating a corpus of 4348 documents by December 31, 2022. The United States, with 1574 publications and an H-index of 213, emerged as the most prolific and influential country. The University of California, Davis, contributed significantly with 346 publications and an H-index of 69, making it the leading institution. Concerning journals, the Journal of Autism and Developmental Disorders, Autism Research, and PLOS ONE were the top three publishers of ASD biomarker-related articles among a total of 1140 academic journals. Co-citation and keyword analyses revealed research hotspots in genetics, imaging, oxidative stress, neuroinflammation, gut microbiota, and eye tracking. Emerging topics included "DNA methylation," "eye tracking," "metabolomics," and "resting-state fMRI." Conclusion: The field of ASD biomarker research is dynamically evolving. Future endeavors should prioritize individual stratification, methodological standardization, the harmonious integration of biomarker modalities, and longitudinal studies to advance the precision of ASD diagnosis and treatment.
Language	English
Publishing date	2024-04-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e30420
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Article ; Online: Ameliorative Effect of Coenzyme Q10 on Phenotypic Transformation in Human Smooth Muscle Cells with

Zhang, Xu / Zhang, Zhengyang / Wan, Sitong / Qi, Jingyi / Hao, Yanling / An, Peng / Luo, Yongting / Luo, Junjie

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Mutations of ... ...

Abstract	Mutations of the
MeSH term(s)	Humans ; Marfan Syndrome/genetics ; Phenotype ; Myocytes, Smooth Muscle/metabolism ; Mitochondrial Diseases/metabolism ; Fibrillin-1/metabolism ; Adipokines/metabolism ; Ubiquinone/analogs & derivatives
Chemical Substances	coenzyme Q10 (EJ27X76M46) ; FBN1 protein, human ; Fibrillin-1 ; Adipokines ; Ubiquinone (1339-63-5)
Language	English
Publishing date	2024-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052662
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Article ; Online: Explore Key Genes and Mechanisms Involved in Colon Cancer Progression Based on Bioinformatics Analysis.

Lan, Yongting / Yang, Xiuzhen / Wei, Yulian / Tian, Zhaobing / Zhang, Lina / Zhou, Jian

Applied biochemistry and biotechnology

2024

Abstract: To explore underlying mechanisms related to the progression of colon cancer and identify hub genes associated with the prognosis of patients with colon cancer. GSE10950 and GSE62932 were downloaded from the Gene Expression Omnibus (GEO) database. GEO2R ... ...

Abstract	To explore underlying mechanisms related to the progression of colon cancer and identify hub genes associated with the prognosis of patients with colon cancer. GSE10950 and GSE62932 were downloaded from the Gene Expression Omnibus (GEO) database. GEO2R was utilized to screen out the differentially expressed genes (DEGs). Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted on DEGs. Moreover, STRING and Cytoscape software were utilized for establishing the network of protein-protein interaction (PPI) and identifying hub genes. Afterward, data from The Cancer Genome Atlas (TCGA) was utilized for identifying prognosis-related hub genes by Kaplan-Meier survival analysis. Colon cancer cell line LOVO and human normal intestinal epithelial cell line NCM-460 were exploited to demonstrate the differential expression of selected hub genes through RT-qPCR and western blot. The LOVO cells were transfected to regulate expressions of prognosis-associated genes, followed by exploring the effects of those genes on prognosis by Cell Counting Kit-8 assay and colony-forming assay for cancer cell proliferation, cell scratch test and transwell migration assay for cancer cell migration and Annexin V-PE/7-AAD double staining as well as flow cytometry for cancer cell apoptosis. In this study, 266 common DEGs were obtained from the intersection of two datasets. The GO analysis suggested the common DEGs mainly participated in the one-carbon metabolic process, cell cycle G2/M phase transition, organelle fission, cell cycle phase transition regulation, and regulation of mitotic cell cycle phase transition. The KEGG analysis demonstrated the common DEGs were related to the p53 signaling pathway, nitrogen metabolism, mineral absorption, and cell cycle. 10 hub genes including CCNB1, KIF4A, TPX2, MT1F, PRC1, PLK4, CALD1, MMP9, CLCA1, and MMP1 were identified and CCNB1, CLCA1, and PLK4 were prognosis-related. Increased expression of CCNB1, CLCA1, and PLK4 restrained proliferation as well as migration of cancer cells and induced apoptosis of cancer cells. CCNB1, KIF4A, TPX2, MT1F, PRC1, PLK4, CALD1, MMP9, CLCA1, and MMP1 were identified as hub genes and CCNB1, CLCA1, and PLK4 could inhibit the progression of colon cancer through inhibiting proliferation as well as migration of the cancer cell and promoting apoptosis of cancer cell.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-023-04812-3
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Article ; Online: Mitochondrial Homeostasis in VSMCs as a Central Hub in Vascular Remodeling.

Xia, Yi / Zhang, Xu / An, Peng / Luo, Junjie / Luo, Yongting

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Vascular remodeling is a common pathological hallmark of many cardiovascular diseases. Vascular smooth muscle cells (VSMCs) are the predominant cell type lining the tunica media and play a crucial role in maintaining aortic morphology, integrity, ... ...

Abstract	Vascular remodeling is a common pathological hallmark of many cardiovascular diseases. Vascular smooth muscle cells (VSMCs) are the predominant cell type lining the tunica media and play a crucial role in maintaining aortic morphology, integrity, contraction and elasticity. Their abnormal proliferation, migration, apoptosis and other activities are tightly associated with a spectrum of structural and functional alterations in blood vessels. Emerging evidence suggests that mitochondria, the energy center of VSMCs, participate in vascular remodeling through multiple mechanisms. For example, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)-mediated mitochondrial biogenesis prevents VSMCs from proliferation and senescence. The imbalance between mitochondrial fusion and fission controls the abnormal proliferation, migration and phenotypic transformation of VSMCs. Guanosine triphosphate-hydrolyzing enzymes, including mitofusin 1 (MFN1), mitofusin 2 (MFN2), optic atrophy protein 1 (OPA1) and dynamin-related protein 1 (DRP1), are crucial for mitochondrial fusion and fission. In addition, abnormal mitophagy accelerates the senescence and apoptosis of VSMCs. PINK/Parkin and NIX/BINP3 pathways alleviate vascular remodeling by awakening mitophagy in VSMCs. Mitochondrial DNA (mtDNA) damage destroys the respiratory chain of VSMCs, resulting in excessive ROS production and decreased ATP levels, which are related to the proliferation, migration and apoptosis of VSMCs. Thus, maintaining mitochondrial homeostasis in VSMCs is a possible way to relieve pathologic vascular remodeling. This review aims to provide an overview of the role of mitochondria homeostasis in VSMCs during vascular remodeling and potential mitochondria-targeted therapies.
MeSH term(s)	Humans ; Muscle, Smooth, Vascular/metabolism ; Vascular Remodeling ; Mitochondria/metabolism ; DNA, Mitochondrial/metabolism ; Homeostasis ; Mitochondrial Dynamics/physiology
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043483
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Article ; Online: A Novel Homoconjugated Propellane Triimide: Synthesis, Structural Analyses, and Gas Separation.

Chen, Yan / Zhao, Yongting / Zhao, Yubo / Chen, Xiangping / Liu, Xinyue / Li, Lin / Cao, Dapeng / Wang, Shitao / Zhang, Lei

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 16, Page(s) e202401706

Abstract: Rigid three-dimensional (3D) polycyclic propellanes have garnered interest due to their unique conformational spaces, which display great potential use in selectivity, separation and as models to study through-space electronic interactions. Herein we ... ...

Abstract	Rigid three-dimensional (3D) polycyclic propellanes have garnered interest due to their unique conformational spaces, which display great potential use in selectivity, separation and as models to study through-space electronic interactions. Herein we report the synthesis of a novel rigid propellane, trinaphtho[3.3.3]propellane triimide, which comprises three imide groups embedded on a trinaphtho[3.3.3]propellane. This propellane triimide exhibits large bathochromic shift, amplified molar absorptivity, enhanced fluorescence, and lower reduction potential when compared to the subunits. Computational and experimental studies reveal that the effective through-space π-orbitals interacting (homoconjugation) occurs between the subunits. Single-crystal XRD analysis reveals that the propellane triimide has a highly quasi-D
Language	English
Publishing date	2024-03-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202401706
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Article: Chromosome-scale genomes of Quercus sichourensis and Quercus rex provide insights into the evolution and adaptation of Fagaceae.

Liu, Xue / Zhang, Weixiong / Zhang, Yongting / Yang, Jing / Zeng, Peng / Tian, Zunzhe / Sun, Weibang / Cai, Jing

Journal of genetics and genomics = Yi chuan xue bao

2024

Abstract: The Fagaceae, a plant family with a wide distribution and diverse adaptability, has garnered significant interest as a subject of study in plant speciation and adaptation. Meanwhile, certain Fagaceae species are regarded as highly valuable wood resources ...

Abstract	The Fagaceae, a plant family with a wide distribution and diverse adaptability, has garnered significant interest as a subject of study in plant speciation and adaptation. Meanwhile, certain Fagaceae species are regarded as highly valuable wood resources due to the exceptional quality of their wood. In this study, we present two high-quality, chromosome-scale genome sequences for Quercus sichourensis (848.75 Mb) and Quercus rex (883.46 Mb). Comparative genomics analysis reveals that the difference in the number of plant disease resistance genes and the nonsynonymous and synonymous substitution ratio (Ka/Ks) of protein-coding genes among Fagaceae species are related to different environmental adaptations. Interestingly, most genes related to starch synthesis in the investigated Quercoideae species are located on a single chromosome, as compared to the outgroup species, Fagus sylvatica. Furthermore, resequencing and population analysis of Q. sichourensis and Q. rex reveal that Q. sichourensis has lower genetic diversity and higher deleterious mutations compared to Q. rex. The high-quality, chromosome-level genomes and the population genomic analysis of the critically endangered Q. sichourensis and Q. rex will provide an invaluable resource as well as insights for future study in these two species, even the genus Quercus, to facilitate their conservation.
Language	English
Publishing date	2024-04-02
Publishing country	China
Document type	Journal Article
ZDB-ID	2374568-X
ISSN	1873-5533 ; 1673-8527
ISSN (online)	1873-5533
ISSN	1673-8527
DOI	10.1016/j.jgg.2024.03.012
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Article ; Online: Hepatitis B virus X protein promotes tumor glycolysis by downregulating lncRNA OIP5-AS1/HKDC1 in HCC.

Shi, Fan / Jiang, Jingjing / Wang, Baohua / Hong, Liang / Zhang, Yongting / Meng, Yuting / Zhang, Xujun / Gong, Lan / Lin, Jianjun / Diao, Hongyan

Cellular signalling

2024 Volume 119, Page(s) 111183

Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, with Hepatitis B virus (HBV) infection being the leading cause. This study aims to investigate the role of HBV in HCC pathogenesis involving glucose ... ...

Abstract	Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, with Hepatitis B virus (HBV) infection being the leading cause. This study aims to investigate the role of HBV in HCC pathogenesis involving glucose metabolism. Long non-coding RNA (lncRNA) OIP5-AS1 was significantly downregulated in HBV-positive HCC patients, and its low expression indicated a poor prognosis. This lncRNA was primarily localized in the cytoplasm, acting as a tumor suppressor. HBV protein X (HBx) repressed OIP5-AS1 expression by inhibiting a ligand-activated transcriptional factor peroxisome proliferator-activated receptor α (PPARα). Furthermore, mechanistic studies revealed that OIP5-AS1 inhibited tumor growth by suppressing Hexokinase domain component 1 (HKDC1)-mediated glycolysis. The expression of HKDC1 could be enhanced by transcriptional factor sterol regulatory element-binding protein 1 (SREBP1). OIP5-AS1 facilitated the ubiquitination and degradation of SREBP1 to suppress HKDC1 transcription, which inhibited glycolysis. The results suggest that lncRNA OIP5-AS1 plays an anti-oncogenic role in HBV-positive HCC via the HBx/OIP5-AS1/HKDC1 axis, providing a promising diagnostic marker and therapeutic target for HBV-positive HCC patients.
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2024.111183
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