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  1. Article ; Online: Response to Letter to the Editor: Thresholds based on bone mineral density for therapeutic decision-making in postmenopausal women and men older than 50 years old under glucocorticoid therapy.

    Brance, María Lorena / Larroudé, María Silvia / Somma, Luis Fernando / Ramirez Stieben, Luis Agustín / Brun, Lucas R

    Reumatologia clinica

    2023  Volume 20, Issue 2, Page(s) 114–115

    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Bone Density/physiology ; Glucocorticoids/therapeutic use ; Postmenopause/physiology ; Osteoporosis/drug therapy
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-12-06
    Publishing country Spain
    Document type Letter
    ISSN 2173-5743
    ISSN (online) 2173-5743
    DOI 10.1016/j.reumae.2023.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What We Do Not Know About Stretching in Healthy Athletes: A Scoping Review with Evidence Gap Map from 300 Trials.

    Afonso, José / Andrade, Renato / Rocha-Rodrigues, Sílvia / Nakamura, Fábio Yuzo / Sarmento, Hugo / Freitas, Sandro R / Silva, Ana Filipa / Laporta, Lorenzo / Abarghoueinejad, Maryam / Akyildiz, Zeki / Chen, Rongzhi / Pizarro, Andreia / Ramirez-Campillo, Rodrigo / Clemente, Filipe Manuel

    Sports medicine (Auckland, N.Z.)

    2024  

    Abstract: Background: Stretching has garnered significant attention in sports sciences, resulting in numerous studies. However, there is no comprehensive overview on investigation of stretching in healthy athletes.: Objectives: To perform a systematic scoping ... ...

    Abstract Background: Stretching has garnered significant attention in sports sciences, resulting in numerous studies. However, there is no comprehensive overview on investigation of stretching in healthy athletes.
    Objectives: To perform a systematic scoping review with an evidence gap map of stretching studies in healthy athletes, identify current gaps in the literature, and provide stakeholders with priorities for future research.
    Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 and PRISMA-ScR guidelines were followed. We included studies comprising healthy athletes exposed to acute and/or chronic stretching interventions. Six databases were searched (CINAHL, EMBASE, PubMed, Scopus, SPORTDiscus, and Web of Science) until 1 January 2023. The relevant data were narratively synthesized; quantitative data summaries were provided for key data items. An evidence gap map was developed to offer an overview of the existing research and relevant gaps.
    Results: Of ~ 220,000 screened records, we included 300 trials involving 7080 athletes [mostly males (~ 65% versus ~ 20% female, and ~ 15% unreported) under 36 years of age; tiers 2 and 3 of the Participant Classification Framework] across 43 sports. Sports requiring extreme range of motion (e.g., gymnastics) were underrepresented. Most trials assessed the acute effects of stretching, with chronic effects being scrutinized in less than 20% of trials. Chronic interventions averaged 7.4 ± 5.1 weeks and never exceeded 6 months. Most trials (~ 85%) implemented stretching within the warm-up, with other application timings (e.g., post-exercise) being under-researched. Most trials examined static active stretching (62.3%), followed by dynamic stretching (38.3%) and proprioceptive neuromuscular facilitation (PNF) stretching (12.0%), with scarce research on alternative methods (e.g., ballistic stretching). Comparators were mostly limited to passive controls, with ~ 25% of trials including active controls (e.g., strength training). The lower limbs were primarily targeted by interventions (~ 75%). Reporting of dose was heterogeneous in style (e.g., 10 repetitions versus 10 s for dynamic stretching) and completeness of information (i.e., with disparities in the comprehensiveness of the provided information). Most trials (~ 90%) reported performance-related outcomes (mainly strength/power and range of motion); sport-specific outcomes were collected in less than 15% of trials. Biomechanical, physiological, and neural/psychological outcomes were assessed sparsely and heterogeneously; only five trials investigated injury-related outcomes.
    Conclusions: There is room for improvement, with many areas of research on stretching being underexplored and others currently too heterogeneous for reliable comparisons between studies. There is limited representation of elite-level athletes (~ 5% tier 4 and no tier 5) and underpowered sample sizes (≤ 20 participants). Research was biased toward adult male athletes of sports not requiring extreme ranges of motion, and mostly assessed the acute effects of static active stretching and dynamic stretching during the warm-up. Dose-response relationships remain largely underexplored. Outcomes were mostly limited to general performance testing. Injury prevention and other effects of stretching remain poorly investigated. These relevant research gaps should be prioritized by funding policies.
    Registration: OSF project ( https://osf.io/6auyj/ ) and registration ( https://osf.io/gu8ya ).
    Language English
    Publishing date 2024-03-08
    Publishing country New Zealand
    Document type Systematic Review
    ZDB-ID 605911-9
    ISSN 1179-2035 ; 0112-1642
    ISSN (online) 1179-2035
    ISSN 0112-1642
    DOI 10.1007/s40279-024-02002-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis in pediatrics.

    Brunetto, Oscar / Cassinelli, Hamilton R / Espada, Graciela / Viterbo, Gisela L / Meiorin, Silvia M / Ahumada, María F / Brenzoni, Luciana / Maher, María C / Chavero, Ignacio / Ramírez Stieben, Luis A / Brance, María L

    Archivos argentinos de pediatria

    2023  Volume 122, Issue 2, Page(s) e202202948

    Abstract: Objective. To provide a framework for healthcare professionals managing pediatric patients who are on active glucocorticoid (GC) therapy and to develop recommendations for the prevention and treatment of GC-induced osteoporosis in the pediatric ... ...

    Title translation Lineamientos para la prevención y el tratamiento de la osteoporosis inducida por glucocorticoides en pediatría.
    Abstract Objective. To provide a framework for healthcare professionals managing pediatric patients who are on active glucocorticoid (GC) therapy and to develop recommendations for the prevention and treatment of GC-induced osteoporosis in the pediatric population. Methods. A panel of experts on bone and pediatric diseases developed a series of PICO questions that address issues related to the prevention and treatment of osteoporosis in patients on GC therapy. In accordance with the GRADE approach, we conducted a systematic review of the literature, summarized effect estimations, and classified the quality of the evidence. Then, voting and the formulation of recommendations followed. Results. Seven recommendations and six general principles were developed for GC-induced osteoporosis in the pediatric population. Conclusion. These recommendations provide guidance for clinicians who must make decisions concerning pediatric patients undergoing treatment with GC.
    MeSH term(s) Humans ; Child ; Glucocorticoids/adverse effects ; Osteoporosis/chemically induced ; Osteoporosis/drug therapy ; Osteoporosis/prevention & control
    Chemical Substances Glucocorticoids
    Language Spanish
    Publishing date 2023-07-06
    Publishing country Argentina
    Document type Systematic Review ; Journal Article
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.5546/aap.2022-02948.eng
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The gut microbiota promotes distal tissue regeneration via RORγ

    Hanna, Bola S / Wang, Gang / Galván-Peña, Silvia / Mann, Alexander O / Ramirez, Ricardo N / Muñoz-Rojas, Andrés R / Smith, Kathleen / Wan, Min / Benoist, Christophe / Mathis, Diane

    Immunity

    2023  Volume 56, Issue 4, Page(s) 829–846.e8

    Abstract: Specific microbial signals induce the differentiation of a distinct pool of ... ...

    Abstract Specific microbial signals induce the differentiation of a distinct pool of RORγ
    MeSH term(s) Animals ; Mice ; T-Lymphocytes, Regulatory ; Gastrointestinal Microbiome ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Mice, Inbred C57BL ; Microbiota
    Chemical Substances Nuclear Receptor Subfamily 1, Group F, Member 3
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.01.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Protocol for a multi-phase, multi-center, real-world, hybrid effectiveness-implementation study of a digital intervention for pediatric chronic pain co-designed with patients (Digital SPA).

    de la Vega, Rocío / Serrano-Ibáñez, Elena R / Ruiz-Párraga, Gema T / Palermo, Tonya M / Wicksell, Rikard / Fernández-Jiménez, Eduardo / Oliva, Silvia / Roldán, Susana / Monfort, Laura / Peláez, María José / Leyva Carmona, Moisés / Ramírez-Maestre, Carmen / López-Martínez, Alicia E / Miró, Jordi / Esteve, Rosa

    Digital health

    2023  Volume 9, Page(s) 20552076231219490

    Abstract: Background: Children and adolescents with chronic pain are a vulnerable population who often lack the resources to manage their condition. Due to high personal, social, and economic consequences, proper management in its early stages is key to reducing ... ...

    Abstract Background: Children and adolescents with chronic pain are a vulnerable population who often lack the resources to manage their condition. Due to high personal, social, and economic consequences, proper management in its early stages is key to reducing disability. The aim of this project is to co-develop a digital intervention for pediatric chronic pain (Digital SPA) with end-users and to evaluate its effectiveness and implementation outcomes in Spain.
    Methods: (Phase 1) Focus groups with patients, parents, and clinicians (
    Discussion: This study is expected to produce a co-created evidence-based digital intervention for pediatric chronic pain and a roadmap for successful implementation.
    Trial registration number trn and date of registration: ClinicalTrials.gov (registered on 26 June 2023: https://clinicaltrials.gov/study/NCT05917626).
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819396-9
    ISSN 2055-2076
    ISSN 2055-2076
    DOI 10.1177/20552076231219490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nonalcoholic Fatty Liver Disease Severity Is Related to Plasma Pro-Oxidative Biomarkers Rather Than Liver Tissue-Measured Nitrogen Metabolism Biomarkers in Population with Obesity and Metabolic Syndrome.

    Suárez-Cuenca, Juan Antonio / Domínguez-Pérez, Gabriela A / Hernández-Muñóz, Rolando E / Hernández-Patricio, Alejandro / Vera-Gómez, Eduardo / Gutiérrez-Buendía, Juan A / Salamanca-García, Moisés / Montoya-Ramírez, Jesús / Gaytán-Fuentes, Omar F / Aranda-Rodríguez, Carolina / Rojas-Noverón, Amy R / García, Silvia / Mondragón-Terán, Paul

    Metabolic syndrome and related disorders

    2023  Volume 21, Issue 2, Page(s) 115–121

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Metabolic Syndrome/complications ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Cross-Sectional Studies ; Obesity/epidemiology ; Biomarkers ; Hypertension/complications ; Oxidation-Reduction ; Oxidative Stress
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2022.0007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Social Support Mediates the Effect of Burnout on Health in Health Care Professionals.

    Ruisoto, Pablo / Ramírez, Marina R / García, Pedro A / Paladines-Costa, Belén / Vaca, Silvia L / Clemente-Suárez, Vicente J

    Frontiers in psychology

    2021  Volume 11, Page(s) 623587

    Abstract: Burnout is characterized by emotional exhaustion and caused by exposure to excessive and prolonged stress related to job conditions. Moreover, burnout is highly prevalent among health care professionals. The aim of this study is, first, to examine the ... ...

    Abstract Burnout is characterized by emotional exhaustion and caused by exposure to excessive and prolonged stress related to job conditions. Moreover, burnout is highly prevalent among health care professionals. The aim of this study is, first, to examine the mediating role of social support over the effect of burnout in health care professionals and, second, to explore potential gender differences. A convenience sample of 1,035 health professionals from Ecuador, including 608 physicians and 427 nurses (68% women, with and age
    Language English
    Publishing date 2021-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2020.623587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Virtual Reality Distraction for Needle-Related Pain and Distress in Children: A Multicenter Randomized Controlled Trial.

    Czub, Marcin / Serrano-Ibáñez, Elena R / Piskorz, Joanna / Esteve, Rosa / Lydon, Helena K / López-Martínez, Alicia E / Mullen, Bertille / Ramírez-Maestre, Carmen / Heary, Caroline / O'Neill, Conor / Sainero, Gloria / Ruiz Escalera, Juan Francisco / Caes, Line / Morales Murcia, Silvia / McDarby, Vincent / McGuire, Brian E

    Cyberpsychology, behavior and social networking

    2024  

    Abstract: ... outcome was self-reported pain intensity using the Faces Pain Scale-Revised (FPS-R). Secondary outcomes ...

    Abstract This international multicenter randomized controlled trial aimed to compare the effectiveness of virtual reality (VR) distraction with an identical non-VR game in reducing needle-related pain and anxiety in children undergoing venous blood draw. The study involved 304 children aged 5-9 years undergoing a blood draw procedure, randomly allocated to one of three groups: VR distraction, non-VR distraction, and control group (usual care). The distraction task was based on the Multiple Object Tracking (MOT) paradigm, and the game was identical in design and gameplay for both VR and non-VR distraction groups. The primary outcome was self-reported pain intensity using the Faces Pain Scale-Revised (FPS-R). Secondary outcomes included child distress, attention/distraction to the blood draw, and parent and medical staff satisfaction with procedure. Analyses were conducted using analysis of variance and multivariable linear regression models. The results showed that VR distraction and non-VR distraction performed similarly, showing large effect sizes compared with standard care. There was no significant difference between the two types of distraction. The study's findings suggest that VR and non-VR distraction are similarly effective in reducing needle-related pain and anxiety in children undergoing venous blood draw. This is the first well-powered study comparing modern VR distraction with an identical task displayed on a smartphone or monitor screen. The study's results have important implications for using VR in clinical settings and suggest that investing in expensive VR equipment for acute pain management may not be necessary. The study protocol was pre-registered on Open Science Framework at https://osf.io/frsyc.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2545735-4
    ISSN 2152-2723 ; 2152-2715
    ISSN (online) 2152-2723
    ISSN 2152-2715
    DOI 10.1089/cyber.2023.0454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cross-cultural adaptation and validation of two crisis resource management scales.

    Sánchez-Marco, María / Escribano, Silvia / Cabañero-Martínez, María-José / Espinosa-Ramírez, Salvador / José Muñoz-Reig, María / Juliá-Sanchis, Rocío

    International emergency nursing

    2021  Volume 57, Page(s) 101016

    Abstract: ... between the MHPTS and Ottawa GRS (r = 0.97; p < 0.001).: Conclusion: We found strong evidence ...

    Abstract Background: Simulation training programs in crisis resource management must be evaluated using valid and reliable instruments. We translated into Spanish and linguistically validate The Mayo High Performance Teamwork Scale (MHPTS) and Ottawa Crisis Resource Management Global Rating Scale (Ottawa GRS) non-technical skills assessment instruments.
    Method: We performed a standardised cross-cultural adaptation process. The psychometric properties of both instruments in their versions adapted to Spanish were subsequently evaluated in a sample of 100 students by using exploratory factor analysis and assessing internal consistency and convergent validity through a total of 94 simulation scenarios in urgent medical situations RESULTS: Our results for the MHPTS showed a one-dimensional structure containing 8 items which explained a total variance of 72.84%; the Ottawa GRS also had a one-dimensional structure, this time with 5 items, which explained a total variance of 91.79%. According to the Cronbach alpha, the internal consistency for the MHPTS was 0.94 (1-8 items) and 0.98 for the Ottawa GRS. In addition, there was a strong correlation between the MHPTS and Ottawa GRS (r = 0.97; p < 0.001).
    Conclusion: We found strong evidence for the high validity and reliability of the Spanish versions of both these tools when tested in Spanish simulated emergency contexts.
    MeSH term(s) Cross-Cultural Comparison ; Humans ; Psychometrics ; Reproducibility of Results ; Simulation Training ; Surveys and Questionnaires
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2420747-0
    ISSN 1878-013X ; 1755-599X
    ISSN (online) 1878-013X
    ISSN 1755-599X
    DOI 10.1016/j.ienj.2021.101016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Threshold based on bone mineral density for therapeutic decision-making in postmenopausal women and men over 50 years old under glucocorticoid therapy.

    Brance, María Lorena / Larroudé, María Silvia / Somma, Luis Fernando / Giacoia, Evangelina / Diehl, María / Galich, Ana María / Ramirez Stieben, Luis Agustín / Maher, María Cielo / De La Vega, María / Ringer, Ariana / Brun, Lucas R

    Reumatologia clinica

    2023  Volume 19, Issue 5, Page(s) 279–284

    Abstract: Introduction and aim: T-score bone mineral density (BMD) thresholds may influence guidance for treatment in patients under glucocorticoid (GC) therapy. Different BMD thresholds have been described but there is no international consensus. The aim of this ...

    Abstract Introduction and aim: T-score bone mineral density (BMD) thresholds may influence guidance for treatment in patients under glucocorticoid (GC) therapy. Different BMD thresholds have been described but there is no international consensus. The aim of this study was to find a threshold to help in treatment decision-making in the population under GC therapy.
    Methods: A working group representing three scientific societies from Argentina was convened. The first team was formed by specialists with expertise in glucocorticoid-induced osteoporosis (GIO) who voted according to summary of evidence. The second team was constituted by a methodology group who coordinated and supervised each stage. We conducted two systematic reviews to synthesize the evidence. The first included trials of drugs used in GIO to analyze the BMD cut-off used as inclusion criteria. In the second, we analyzed the evidence regarding the densitometric thresholds to discriminate between fractured and non-fractured patients under GC treatment.
    Results: In the first review, 31 articles were included for qualitative synthesis and more than 90% of the trials included patients regardless of their densitometric T-score or range of osteopenia. In the second review, 4 articles were included and more than 80% of the T-scores were in the range -1.6 to -2.0. The summary of findings was analyzed and put to a vote.
    Conclusions: With more than 80% agreement of the voting expert panel, a T-score≤-1.7 was considered the most appropriate for treatment in postmenopausal women and men over 50 years of age under GC therapy. This study could help in treatment decision-making in patients under GC therapy without fractures but other fracture risk factors should certainly be considered.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Bone Density ; Glucocorticoids/adverse effects ; Postmenopause ; Osteoporosis/chemically induced ; Osteoporosis/drug therapy ; Bone Density Conservation Agents/adverse effects
    Chemical Substances Glucocorticoids ; Bone Density Conservation Agents
    Language English
    Publishing date 2023-04-18
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5743
    ISSN (online) 2173-5743
    DOI 10.1016/j.reumae.2022.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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