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  1. Article ; Online: Comparative analysis of

    Basu, Babu V / Brown, Olen R

    Frontiers in bioscience (Landmark edition)

    2020  Volume 25, Issue 10, Page(s) 1894–1900

    Abstract: We analyzed the nucleocapsid and surface proteins from several Coronaviridae viruses using an alignment-free computer program. Three isolates of novel, human coronavirus (SARS0CoV-2) (2019) that are responsible for the current pandemic and older SARS ... ...

    Abstract We analyzed the nucleocapsid and surface proteins from several Coronaviridae viruses using an alignment-free computer program. Three isolates of novel, human coronavirus (SARS0CoV-2) (2019) that are responsible for the current pandemic and older SARS strains of human and animal coronaviruses were examined. The nucleocapsid and glycoprotein sequences are identical for the three novel 2019 human isolates and they are closely related to these sequences in six bat and human SARS coronaviruses. This strongly supports the bat origin of the pandemic, novel coronavirus. One surface glycoprotein fragment of 111 amino acids is the largest, conserved, common permutation in the examined bat SARS-like and human SARS viruses, including the Covid-19 virus. BLAST analysis confirmed that this fragment is conserved only in the human and bat SARS strains. This fragment likely is involved in infectivity and is of interest for vaccine development. Surface glycoprotein and nucleocapsid protein sequence homologies of 58.9% and 82.5%, respectively, between the novel SARS0CoV-2 strains and the human SARS (2018) virus suggest that existing anti-SARS vaccines may provide some protection against the novel coronavirus.
    MeSH term(s) Algorithms ; Amino Acid Sequence ; Animals ; Betacoronavirus/genetics ; COVID-19 ; Chiroptera/virology ; Coronaviridae/classification ; Coronaviridae/genetics ; Coronavirus Infections ; Coronavirus Nucleocapsid Proteins ; Genome, Viral/genetics ; Humans ; Nucleocapsid Proteins/genetics ; Pandemics ; Phosphoproteins ; Pneumonia, Viral ; SARS-CoV-2 ; Software ; Species Specificity ; Spike Glycoprotein, Coronavirus/genetics ; Viral Envelope Proteins/genetics
    Chemical Substances Coronavirus Nucleocapsid Proteins ; Nucleocapsid Proteins ; Phosphoproteins ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; nucleocapsid phosphoprotein, SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country Singapore
    Document type Comparative Study ; Journal Article
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 1093-9946
    ISSN (online) 2768-6698
    ISSN 1093-9946
    DOI 10.2741/4883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparative analysis of Coronaviridae nucleocapsid and surface glycoprotein sequences

    Basu, Babu V / Brown, Olen R

    Front Biosci (Landmark Ed)

    Abstract: We analyzed the nucleocapsid and surface proteins from several Coronaviridae viruses using an alignment-free computer program. Three isolates of novel, human coronavirus (SARS0CoV-2) (2019) that are responsible for the current pandemic and older SARS ... ...

    Abstract We analyzed the nucleocapsid and surface proteins from several Coronaviridae viruses using an alignment-free computer program. Three isolates of novel, human coronavirus (SARS0CoV-2) (2019) that are responsible for the current pandemic and older SARS strains of human and animal coronaviruses were examined. The nucleocapsid and glycoprotein sequences are identical for the three novel 2019 human isolates and they are closely related to these sequences in six bat and human SARS coronaviruses. This strongly supports the bat origin of the pandemic, novel coronavirus. One surface glycoprotein fragment of 111 amino acids is the largest, conserved, common permutation in the examined bat SARS-like and human SARS viruses, including the Covid-19 virus. BLAST analysis confirmed that this fragment is conserved only in the human and bat SARS strains. This fragment likely is involved in infectivity and is of interest for vaccine development. Surface glycoprotein and nucleocapsid protein sequence homologies of 58.9% and 82.5%, respectively, between the novel SARS0CoV-2 strains and the human SARS (2018) virus suggest that existing anti-SARS vaccines may provide some protection against the novel coronavirus.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32472763
    Database COVID19

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  3. Article ; Online: Oral Anticancer Heterobimetallic Pt

    Babu, Tomer / Ghareeb, Hiba / Basu, Uttara / Schueffl, Hemma / Theiner, Sarah / Heffeter, Petra / Koellensperger, Gunda / Metanis, Norman / Gandin, Valentina / Ott, Ingo / Schmidt, Claudia / Gibson, Dan

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 10, Page(s) e202217233

    Abstract: ... ...

    Abstract Au
    MeSH term(s) Antineoplastic Agents/chemistry ; Phenylbutyrates ; Prodrugs/chemistry ; Cell Line, Tumor ; Cisplatin/chemistry
    Chemical Substances Antineoplastic Agents ; 4-phenylbutyric acid (7WY7YBI87E) ; Phenylbutyrates ; Prodrugs ; carbene (2465-56-7) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2023-01-31
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202217233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?

    Schmidt, Claudia / Babu, Tomer / Kostrhunova, Hana / Timm, Annika / Basu, Uttara / Ott, Ingo / Gandin, Valentina / Brabec, Viktor / Gibson, Dan

    Journal of medicinal chemistry

    2021  Volume 64, Issue 15, Page(s) 11364–11378

    Abstract: Multi-action" Pt(IV) derivatives of cisplatin with combretastatin A4 (CA4) bioactive ligands that are conjugated to Pt(IV) by carbonate are unique because the ligand ( ... ...

    Abstract "Multi-action" Pt(IV) derivatives of cisplatin with combretastatin A4 (CA4) bioactive ligands that are conjugated to Pt(IV) by carbonate are unique because the ligand (IC
    MeSH term(s) Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Carbonic Anhydrase IV/chemistry ; Carbonic Anhydrase IV/metabolism ; Cell Line ; Cell Proliferation/drug effects ; Cricetulus ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Ligands ; Molecular Structure ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Organoplatinum Compounds/pharmacology ; Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Prodrugs/pharmacology ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents ; Ligands ; Organoplatinum Compounds ; Prodrugs ; Carbonic Anhydrase IV (EC 4.2.1.-) ; CA4 protein, human (EC 4.2.1.1)
    Language English
    Publishing date 2021-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c00706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Displacive-type ferroelectricity from magnetic correlations within spin-chain.

    Basu, Tathamay / Kishore, V V Ravi / Gohil, Smita / Singh, Kiran / Mohapatra, N / Bhattacharjee, S / Gonde, Babu / Lalla, N P / Mahadevan, Priya / Ghosh, Shankar / Sampathkumaran, E V

    Scientific reports

    2014  Volume 4, Page(s) 5636

    Abstract: Observation of ferroelectricity among non-d(0) systems, which was believed for a long time an unrealistic concept, led to various proposals for the mechanisms to explain the same (i.e. magnetically induced ferroelectricity) during last decade. Here, we ... ...

    Abstract Observation of ferroelectricity among non-d(0) systems, which was believed for a long time an unrealistic concept, led to various proposals for the mechanisms to explain the same (i.e. magnetically induced ferroelectricity) during last decade. Here, we provide support for ferroelectricity of a displacive-type possibly involving magnetic ions due to short-range magnetic correlations within a spin-chain, through the demonstration of magnetoelectric coupling in a Haldane spin-chain compound Er2BaNiO5 well above its Néel temperature of (TN = ) 32 K. There is a distinct evidence for electric polarization setting in near 60 K around which there is an evidence for short-range magnetic correlations from other experimental methods. Raman studies also establish a softening of phonon modes in the same temperature (T) range and T-dependent x-ray diffraction (XRD) patterns also reveal lattice parameters anomalies. Density-functional theory based calculations establish a displacive component (similar to d(0)-ness) as the root-cause of ferroelectricity from (magnetic) NiO6 chain, thereby offering a new route to search for similar materials near room temperature to enable applications.
    Language English
    Publishing date 2014-07-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep05636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dose escalation in image-guided, intensity-modulated radiotherapy of carcinoma prostate: initial experience in India.

    Swamy, Kumara / Sathiya Narayanan, V K / Basu, Sumeet / Maiya, Vikram / Achari, Rimpa / Deshpande, Shrikant / Bhangle, Janhavi / Gupta, Kamlesh Kumar / Babu, Nirmal / Pawar, Surendra / Atre, Ashish / Balachandra, Kashyapi / Koppiker, C B

    Journal of cancer research and therapeutics

    2009  Volume 5, Issue 4, Page(s) 277–283

    Abstract: Background: Increasing incidence and significant stage migration from distant metastases to a localized disease, due to screening application of PSA, is taking place in carcinoma prostate. Also, role of radiotherapy is increasing in carcinoma prostate ... ...

    Abstract Background: Increasing incidence and significant stage migration from distant metastases to a localized disease, due to screening application of PSA, is taking place in carcinoma prostate. Also, role of radiotherapy is increasing in carcinoma prostate due to rapid strides in technology.
    Aim: The present retrospective study, evaluates escalating the dose in the treatment of localized carcinoma prostate using integration of multiple advanced techniques.
    Settings and design: The settings designed are: a) use of gold seed internal fiducial markers: b) clinical application of emerging Megavoltage Cone Beam Computed Tomography (MVCBCT) technology for Image Guided Radiotherapy (IGRT); c) Intensity Modulated Radiotherapy (IMRT); d) adopting biochemical method for follow-up.
    Methods and material: Twelve consecutive, biopsy proven localized cancer of prostate patients, treated with dose escalation IMRT & IGRT protocol between August 2006 and January 2008, were analyzed. Gold seed markers in prostate were used for daily localization with MVCBCT or Electronic Portal Imaging (EPI). All patients underwent clinical and biochemical follow-up. STATISTICAL ANALYSIS & RESULTS: Planned dose of 7740 cGy was delivered in 10 out of 12 patients (83%). While one patient had migration of maximum of 3 mm, two others had 1 mm migration of one seed during course of treatment. One patient (8%) developed Grade II proctitis at 12th month. During the mean follow-up duration of 12.2 months, 92% (11/12) had biochemical control within 3 months of treatment.
    Conclusions: IGRT technique using MVCBCT for implanted fiducial gold seed localization was feasible for IMRT dose escalation in carcinoma prostate with excellent results.
    MeSH term(s) Aged ; Aged, 80 and over ; Carcinoma/pathology ; Carcinoma/radiotherapy ; Humans ; India ; Male ; Middle Aged ; Neoplasm Staging ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiotherapy/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; Retrospective Studies ; Surgery, Computer-Assisted
    Language English
    Publishing date 2009-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/0973-1482.59909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafish.

    Babu, Aswini / Kamaraj, Mageshi / Basu, Moumita / Mukherjee, Debanjan / Kapoor, Shruti / Ranjan, Shashi / Swamy, Mahadeva M / Kaypee, Stephanie / Scaria, Vinod / Kundu, Tapas K / Sachidanandan, Chetana

    Biochimica et biophysica acta. Molecular basis of disease

    2018  Volume 1864, Issue 4 Pt A, Page(s) 1203–1215

    Abstract: EP300 is a member of the EP300/CBP family of lysine acetyltransferases (KATs) with multiple roles in development and physiology. Loss of EP300/CBP activity in humans causes a very rare congenital disorder called Rubinstein Taybi Syndrome (RSTS). The ... ...

    Abstract EP300 is a member of the EP300/CBP family of lysine acetyltransferases (KATs) with multiple roles in development and physiology. Loss of EP300/CBP activity in humans causes a very rare congenital disorder called Rubinstein Taybi Syndrome (RSTS). The zebrafish genome has two co-orthologs of lysine acetyltransferase EP300 (KAT3B) in zebrafish viz. ep300a and ep300b. Chemical inhibition of Ep300 with C646, a competitive inhibitor and morpholino-based genetic knockdown of ep300a and ep300b cause defects in embryonic development reminiscent of the human RSTS syndrome. Remarkably, overexpression of Ep300a KAT domain results in near complete rescue of the jaw development defects, a characteristic feature of RSTS in human suggesting the dispensability of the protein-interaction and DNA-binding domains for at least some developmental roles of Ep300. We also perform a chemical screen and identify two inhibitors of deacetylases, CHIC35 and HDACi III, that can partially rescue the RSTS-like phenotypes. Thus, modeling rare human genetic disorders in zebrafish allows for functional understanding of the genes involved and can also yield small molecule candidates towards therapeutic goals.
    MeSH term(s) Animals ; Disease Models, Animal ; E1A-Associated p300 Protein/genetics ; E1A-Associated p300 Protein/metabolism ; Embryo, Nonmammalian/embryology ; Embryonic Development/genetics ; Gene Knockdown Techniques ; Humans ; Rubinstein-Taybi Syndrome/embryology ; Rubinstein-Taybi Syndrome/genetics ; Rubinstein-Taybi Syndrome/pathology ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Zebrafish Proteins ; E1A-Associated p300 Protein (EC 2.3.1.48)
    Language English
    Publishing date 2018-01-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0925-4439 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0925-4439 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 1874-9399
    DOI 10.1016/j.bbadis.2018.01.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dose escalation in image-guided, intensity-modulated radiotherapy of carcinoma prostate

    Swamy Kumara / Sathiya Narayanan V / Basu Sumeet / Maiya Vikram / Achari Rimpa / Deshpande Shrikant / Bhangle Janhavi / Gupta Kamlesh / Babu Nirmal / Pawar Surendra / Atre Ashish / Balachandra Kashyapi / Koppiker C

    Journal of Cancer Research and Therapeutics, Vol 5, Iss 4, Pp 277-

    Initial experience in India

    2009  Volume 283

    Abstract: Background : Increasing incidence and significant stage migration from distant metastases to a localized disease, due to screening application of PSA, is taking place in carcinoma prostate. Also, role of radiotherapy is increasing in carcinoma prostate ... ...

    Abstract Background : Increasing incidence and significant stage migration from distant metastases to a localized disease, due to screening application of PSA, is taking place in carcinoma prostate. Also, role of radiotherapy is increasing in carcinoma prostate due to rapid strides in technology. Aim : The present retrospective study, evaluates escalating the dose in the treatment of localized carcinoma prostate using integration of multiple advanced techniques. Settings and Design : The settings designed are: a) use of gold seed internal fiducial markers: b) clinical application of emerging Megavoltage Cone Beam Computed Tomography (MVCBCT) technology for Image Guided Radiotherapy (IGRT); c) Intensity Modulated Radiotherapy (IMRT); d) adopting biochemical method for follow-up. Methods and Material : Twelve consecutive, biopsy proven localized cancer of prostate patients, treated with dose escalation IMRT& IGRT protocol between August 2006 and January 2008, were analyzed. Gold seed markers in prostate were used for daily localization with MVCBCT or Electronic Portal Imaging (EPI). All patients underwent clinical and biochemical follow-up. Statistical Analysis& Results : Planned dose of 7740 cGy was delivered in 10 out of 12 patients (83%). While one patient had migration of maximum of 3 mm, two others had 1 mm migration of one seed during course of treatment. One patient (8%) developed Grade II proctitis at 12th month. During the mean follow-up duration of 12.2 months, 92% (11/12) had biochemical control within 3 months of treatment. Conclusions : IGRT technique using MVCBCT for implanted fiducial gold seed localization was feasible for IMRT dose escalation in carcinoma prostate with excellent results.
    Keywords Dose escalation ; gold seed markers ; image guided intensity modulated radiotherapy ; PSA. ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 616
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis.

    Agrawal, Rupesh / Betzler, Bjorn Kaijun / Testi, Ilaria / Mahajan, Sarakshi / Agarwal, Aniruddha / Gunasekeran, Dinesh Visva / Raje, Dhananjay / Aggarwal, Kanika / Murthy, Somasheila I / Westcott, Mark / Chee, Soon-Phaik / McCluskey, Peter / Ho, Su Ling / Teoh, Stephen / Cimino, Luca / Biswas, Jyotirmay / Narain, Shishir / Agarwal, Manisha / Mahendradas, Padmamalini /
    Khairallah, Moncef / Jones, Nicholas / Tugal-Tutkun, Ilknur / Babu, Kalpana / Basu, Soumayava / Carreño, Ester / Lee, Richard / Al-Dhibi, Hassan / Bodaghi, Bahram / Invernizzi, Alessandro / Goldstein, Debra A / Barisani-Asenbauer, Talin / González-López, Julio J / Androudi, Sofia / Bansal, Reema / Moharana, Bruttendu / Esposti, Simona Degli / Tasiopoulou, Anastasia / Nadarajah, Sengal / Agarwal, Mamta / Abraham, Sharanaya / Vala, Ruchi / Singh, Ramandeep / Sharma, Aman / Sharma, Kusum / Zierhut, Manfred / Kon, Onn Min / Cunningham, Emmett T / Kempen, John H / Nguyen, Quan Dong / Pavesio, Carlos / Gupta, Vishali

    Ocular immunology and inflammation

    2020  Volume 28, Issue sup1, Page(s) 27–37

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2020.1808226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population.

    Testi, Ilaria / Agrawal, Rupesh / Mahajan, Sarakshi / Agarwal, Aniruddha / Gunasekeran, Dinesh Visva / Raje, Dhananjay / Aggarwal, Kanika / Murthy, Somasheila I / Westcott, Mark / Chee, Soon-Phaik / Mccluskey, Peter / Ho, Su Ling / Teoh, Stephen / Cimino, Luca / Biswas, Jyotirmay / Narain, Shishir / Agarwal, Manisha / Mahendradas, Padmamalini / Khairallah, Moncef /
    Jones, Nicholas / Tugal-Tutkun, Ilknur / Babu, Kalpana / Basu, Soumayava / Carreño, Ester / Lee, Richard / Al-Dhibi, Hassan / Bodaghi, Bahram / Invernizzi, Alessandro / Goldstein, Debra A / Herbort, Carl P / Barisani-Asenbauer, Talin / González-López, Julio J / Androudi, Sofia / Bansal, Reema / Moharana, Bruttendu / Esposti, Simona Degli / Tasiopoulou, Anastasia / Nadarajah, Sengal / Agarwal, Mamta / Abraham, Sharanaya / Vala, Ruchi / Singh, Ramandeep / Sharma, Aman / Sharma, Kusum / Zierhut, Manfred / Kon, Onn Min / Cunningham, Emmett T / Kempen, John H / Nguyen, Quan Dong / Pavesio, Carlos / Gupta, Vishali

    Ocular immunology and inflammation

    2020  Volume 28, Issue sup1, Page(s) 58–64

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2020-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2020.1781197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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