LIVIVO - Search results -

Search results

Result 1 - 10 of total 11938

Search options

Book ; Online: Advanced Coal, Petroleum and Nature Gas Exploration Technology

Feng, Gan / Meng, Qingxiang / Wu, Fei / Li, Gan / Wu, Fei

2023

Keywords	Research & information: general ; Physics ; intelligent mine ; smart mining ; intelligent working face ; intelligent control ; adaptive ; robotic technology ; seismic rock physics ; sandstone and mudstone ; P-wave and S-wave velocity ; pressure ; temperature ; sandy conglomerate ; Huanghekou Sag ; stratigraphic correlation ; calcite U-Pb dating ; detrital zircon ; pressure-controlled pyrolysis ; oil-water separation ; centrifugal force ; two-phase vapor separation ; cyclone separation ; Tarim Basin ; mixed platform ; delta ; coal-measure distribution ; coal-measure logging response ; axial flow ; swirling flow ; pickup behavior ; coefficient of variation ; tight sandstone gas reservoir ; nuclear magnetic resonance ; fracture ; water blocking ; n/a ; rock mechanical properties ; MMTS ; geothermal development ; geothermal reservoir ; different depth of occurrence ; gas storage ; injection production simulation ; effective permeability ; seepage law ; two-dimensional simulation experiment ; fracture evolution law ; fractured seepage zone ; gradient failure support ; hierarchical control mechanism
Language	English
Size	1 electronic resource (164 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030377378
ISBN	9783036566832 ; 303656683X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Structural Genomic Analysis of SARS-CoV-2 and Other Coronaviruses.

Zhang, Qiong / Guo, Huai-Lan / Wang, Jing / Zhang, Yao / Deng, Ping-Ji / Li, Fei-Feng

Frontiers in genetics

2022 Volume 13, Page(s) 801902

Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. In this study, we conducted a comparative analysis of the structural genes of SARS-CoV-2 and other CoVs. We found ... ...

Abstract	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. In this study, we conducted a comparative analysis of the structural genes of SARS-CoV-2 and other CoVs. We found that the sequence of the E gene was the most evolutionarily conserved across 200 SARS-CoV-2 isolates. The E gene and M gene sequences of SARS-CoV-2 and NC014470 CoV were closely related and fell within the same branch of a phylogenetic tree. The absolute diversity of E gene and M gene sequences of SARS-CoV-2 isolates was similar to that of common CoVs (C-CoVs) infecting other organisms. The absolute diversity of the M gene sequence of the KJ481931 CoV that can infect humans was similar to that of SARS-CoV-2 and C-CoVs infecting other organisms. The M gene sequence of KJ481931 CoV (infecting humans), SARS-CoV-2 and NC014470 CoV (infecting other organisms) were closely related, falling within the same branch of a phylogenetic tree. Patterns of variation and evolutionary characteristics of the N gene and S gene were very similar. These data may be of value for understanding the origins and intermediate hosts of SARS-CoV-2.
Language	English
Publishing date	2022-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.801902
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression

Fei-Feng Tang / Long Liu / Xiao-Ting Tian / Ning Li / Ying-Xiu Peng / Chun-Mei Qian / Ting-Ting Jia / Jing-Jin Liu / Wen-Hui Gao / Yan-Feng Xu

BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Background Corosolic acid is a pentacyclic triterpene acid with hypoglycemic, anti-inflammatory, and anti-cancer effects. However, its potential targets in hepatocellular carcinoma (HCC) are unknown, hindering clinical utilization. Methods ... ...

Abstract	Abstract Background Corosolic acid is a pentacyclic triterpene acid with hypoglycemic, anti-inflammatory, and anti-cancer effects. However, its potential targets in hepatocellular carcinoma (HCC) are unknown, hindering clinical utilization. Methods Differentially expressed proteins of the Bel-7404 cell line were identified with tandem mass tag analysis and differentially expressed genes (DEGs) of an HCC TCGA dataset using bioinformatics. Gene functions and pathways were inferred using the DAVID database. Online databases were used to establish P4HA2 expression in HCC (GEPIA2) and its relationship with patient survival (UALCAN and The Human Protein Atlas), the association between P4HA2 expression and immune cell infiltration (TIMER2), and DNA methylation of the P4HA2 gene (MethSurv). Cell proliferation, cell cycle, and cell death were assessed with PI and SYTOX-Green staining, CCK-8, and colony formation assays. Protein expression levels were detected by Western blotting. Results A total of 44 differentially expressed proteins and 4498 DEGs were identified. Four genes whose proteins were also found in the differential protein profile but with opposing expressions were selected as candidate targets. The candidate gene prolyl 4-hydroxylase subunit alpha 2 (P4HA2) was recognized as the only potential target due to its high expression in public datasets, association with poor patient survival, and relation to immune cell infiltration in HCC tissues. Moreover, the DNA methylation status in 4 CpG islands of the P4HA2 gene correlated with a poor prognosis. Furthermore, corosolic acid treatment inhibited the proliferation of HCC cell lines Bel-7404 and HepG2 in a dose-dependent manner, caused G2/M phase cell cycle arrest, and promoted cell death. In addition, the treatment reduced P4HA2 protein levels. Conclusion Our results indicate that P4HA2 is a potential target of corosolic acid. Thus, they contribute to understanding molecular changes in HCC after corosolic acid treatment and facilitate finding new treatment ...
Keywords	Corosolic acid ; Hepatocellular carcinoma ; Network pharmacology ; Proteomics ; P4HA2 ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses.

Li, Fei-Feng / Zhang, Qiong / Wang, Gui-Yu / Liu, Shu-Lin

Aging

2020 Volume 12, Issue 21, Page(s) 20938–20945

Abstract: The pandemic COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is spreading very rapidly worldwide. To date, the origin and intermediate hosts of SARS-CoV-2 remain unclear. In this study, we conducted ... ...

Abstract	The pandemic COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is spreading very rapidly worldwide. To date, the origin and intermediate hosts of SARS-CoV-2 remain unclear. In this study, we conducted comparative analysis among SARS-CoV-2 and non-SARS-CoV-2 coronavirus strains to elucidate their phylogenetic relationships. We found: 1, the SARS-CoV-2 strains analyzed could be divided into 3 clades with regional aggregation; 2, the non-SARS-CoV-2 common coronaviruses that infect humans or other organisms to cause respiratory syndrome and epizootic catarrhal gastroenteritis could also be divided into 3 clades; 3, the hosts of the common coronaviruses closest to SARS-CoV-2 were
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; COVID-19/physiopathology ; COVID-19/virology ; Coronavirus/classification ; Coronavirus/pathogenicity ; Coronavirus/physiology ; Disease Reservoirs/classification ; Disease Reservoirs/virology ; Gastrointestinal Diseases/virology ; Humans ; Phylogeny ; Respiratory Tract Infections/virology ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology
Chemical Substances	Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-11-07
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.104024
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Study on the methodology of emergency decision-making for water transfer project contingencies: A case-based reasoning and regret theory approach.

Li, Feng / Du, Xuewan / Huang, Xin / Fei, Xiaoxia

PloS one

2024 Volume 19, Issue 3, Page(s) e0300272

Abstract: To tackle the global water imbalance problem, a multitude of inter-basin water transfer projects have been built worldwide in recent decades. Nevertheless, given the complexity and safety challenges associated with project operation, effective emergency ... ...

Abstract	To tackle the global water imbalance problem, a multitude of inter-basin water transfer projects have been built worldwide in recent decades. Nevertheless, given the complexity and safety challenges associated with project operation, effective emergency decision-making is crucial for addressing unforeseen incidents. Hence, this research has developed a two-stage emergency decision-making framework to tackle the uncertainty in the development trends of emergencies in inter-basin water transfer projects. (1) The first stage mainly utilizes case-based reasoning techniques to extract historical case information and disposal plans for inter-basin water transfer projects. Subsequently, a holistic similarity model is built by employing structural similarity and local attribute similarity algorithms to identify highly similar historical cases. (2) The second stage involves the optimization and adjustment of decision-making plans based on the dynamic evolution characteristics of emergencies. It utilizes the theory of decision-makers regret psychology and combines it with practical case studies to verify the scientific rationality of the method. This enables it to achieve effective multidimensional expression and rapid matching of scenarios, satisfying the decision-making requirements of "scenario response". Finally, this study compares the results obtained from this method with those computed using the traditional TOPSIS method and fuzzy comprehensive evaluation method, further validating its feasibility and effectiveness. In practice, this method can provide effective support for decision-makers work.
MeSH term(s)	Humans ; Emergencies ; Water ; Problem Solving ; Uncertainty ; Emotions ; Decision Making
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300272
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Perceptions towards online learning among medical students during the COVID-19 pandemic

Qiong Zhang / Qing-zhi Yuan / Peng-qiang Ma / Yue Li / Meng-hui Zhao / Rong-xia Chen / Zhen-gang Tang / Bei Zhang / Bing Liu / Xiang Liu / Fei-feng Li

Heliyon, Vol 9, Iss 2, Pp e13119- (2023)

2023

Abstract: Social distancing has been essential during the COVID-19 pandemic to slow the spread of the disease. Online learning ensures students can participate in learning activities while also maintaining a physical distance from other students. Although online ... ...

Abstract	Social distancing has been essential during the COVID-19 pandemic to slow the spread of the disease. Online learning ensures students can participate in learning activities while also maintaining a physical distance from other students. Although online learning was used to prevent the spread of COVID-19, the development of online learning has also been promoted. Here, we sought to explore the perceptions and responses of students to online learning during the pandemic using a cross-sectional study. Electronic questionnaire was used for data collection. Statistical analyses were performed for 1614 valid questionnaires and P < 0.05 was considered statistically significant. Overall, COVID-19 had more effect on female students, such as fear of COVID-19 (2.4 times higher than the number of male students) and length of time spent learning (H = 42.449, P < 0.05). However, the higher the students’ grades were, the less the impact of COVID-19. For the style of lessons, all students would prefer shorter lessons (P < 0.05). Female and fifth-grade students were more prefer combined online and face-to-face learning, and male and freshmen students were more likely to prefer face-to-face learning after the pandemic. More than 50% of students thought the main advantage of online learning was convenience, with low efficiency being a disadvantage. The main factors negatively influencing online learning were eyestrain, poor network connections, and poor learning environments at home. In conclusion, synchronous online and face-to-face learning may become more common in future curricula, however the efficiency of online learning and the female students more attentions.
Keywords	COVID-19 ; Online learning ; Face-to-face learning ; Perceptions ; Efficiency of study ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	370
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Blue light stimulates light stress and phototactic behavior when received in the brain of Diaphorina citri

Fei-Feng Wang / Ming-Hui Wang / Meng-Ke Zhang / Peng Qin / Andrew G.S. Cuthbertson / Chao-Liang Lei / Bao-Li Qiu / Lin Yu / Wen Sang

Ecotoxicology and Environmental Safety, Vol 251, Iss , Pp 114519- (2023)

2023

Abstract: Blue light with a wavelength of 400–470 nm is the composition of the visible light. However, in recent years, blue light contributed the most significance to light pollution due to the artificial light at night. Previously, we have demonstrated that the ... ...

Abstract	Blue light with a wavelength of 400–470 nm is the composition of the visible light. However, in recent years, blue light contributed the most significance to light pollution due to the artificial light at night. Previously, we have demonstrated that the Asian citrus psyllid (ACP), Diaphorina citri, an important pest in citrus production, has significant positive phototaxis with a light-emitting diode light of 400 nm. In this study, ACP with positive phototactic behavior to 400 nm light (PH) and non-phototactic behavior to 400 nm light (NP) were collected, individually. Transcriptome dynamics of head tissues of PH and NP groups were captured by using RNA-sequencing technology, respectively. Forty-three to 46 million clean reads with high-quality values were obtained, and 1773 differential expressed genes (DEGs) were detected. Compared with the NP group, there were 841 up-regulated DEGs and 932 down-regulated DEGs in the PH group. Eight pathways were significantly enriched in the PH group in the KEGG database, while 43 up-regulated pathways and 25 down-regulated pathways were significantly enriched in the PH group in the GO database. The DGE approach was reliable validated by real time quantitative PCR. Results indicated that the blue light acted as an abiotic stress causing physiological and biochemical responses such as oxidative stress, protein denaturation, inflammation and tumor development in ACPs. Additionally, the light was absorbed by photoreceptors of ACPs, and converted into electrical signal to regulate neuromodulation. This study provides basic information for understanding the molecular mechanisms of ACP in response to blue light and provides a reference for further studies to elucidate phototactic behavior.
Keywords	Asian citrus psyllid ; Light stress ; Transcriptome ; Oxidative stress ; Protein denaturation ; Neuromodulation ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression.

Tang, Fei-Feng / Liu, Long / Tian, Xiao-Ting / Li, Ning / Peng, Ying-Xiu / Qian, Chun-Mei / Jia, Ting-Ting / Liu, Jing-Jin / Gao, Wen-Hui / Xu, Yan-Feng

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 171

Abstract: Background: Corosolic acid is a pentacyclic triterpene acid with hypoglycemic, anti-inflammatory, and anti-cancer effects. However, its potential targets in hepatocellular carcinoma (HCC) are unknown, hindering clinical utilization.: Methods: ... ...

Abstract	Background: Corosolic acid is a pentacyclic triterpene acid with hypoglycemic, anti-inflammatory, and anti-cancer effects. However, its potential targets in hepatocellular carcinoma (HCC) are unknown, hindering clinical utilization. Methods: Differentially expressed proteins of the Bel-7404 cell line were identified with tandem mass tag analysis and differentially expressed genes (DEGs) of an HCC TCGA dataset using bioinformatics. Gene functions and pathways were inferred using the DAVID database. Online databases were used to establish P4HA2 expression in HCC (GEPIA2) and its relationship with patient survival (UALCAN and The Human Protein Atlas), the association between P4HA2 expression and immune cell infiltration (TIMER2), and DNA methylation of the P4HA2 gene (MethSurv). Cell proliferation, cell cycle, and cell death were assessed with PI and SYTOX-Green staining, CCK-8, and colony formation assays. Protein expression levels were detected by Western blotting. Results: A total of 44 differentially expressed proteins and 4498 DEGs were identified. Four genes whose proteins were also found in the differential protein profile but with opposing expressions were selected as candidate targets. The candidate gene prolyl 4-hydroxylase subunit alpha 2 (P4HA2) was recognized as the only potential target due to its high expression in public datasets, association with poor patient survival, and relation to immune cell infiltration in HCC tissues. Moreover, the DNA methylation status in 4 CpG islands of the P4HA2 gene correlated with a poor prognosis. Furthermore, corosolic acid treatment inhibited the proliferation of HCC cell lines Bel-7404 and HepG2 in a dose-dependent manner, caused G2/M phase cell cycle arrest, and promoted cell death. In addition, the treatment reduced P4HA2 protein levels. Conclusion: Our results indicate that P4HA2 is a potential target of corosolic acid. Thus, they contribute to understanding molecular changes in HCC after corosolic acid treatment and facilitate finding new treatment regimens.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Cell Line ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Triterpenes/pharmacology ; Network Pharmacology
Chemical Substances	corosolic acid (AMX2I57A98) ; Triterpenes ; P4HA2 protein, human (EC 1.14.11.-)
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-04008-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM

Guo, Huaqi / Fei, Luo / Yu, Hengyi / Li, Yan / Feng, Yan / Wu, Shaowei / Wang, Yan

Science China. Life sciences

2024

Abstract: Emphysema, myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution, especially fine particulate matter ( ... ...

Abstract	Emphysema, myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution, especially fine particulate matter (PM
Language	English
Publishing date	2024-02-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2546732-3
ISSN	1869-1889 ; 1674-7305
ISSN (online)	1869-1889
ISSN	1674-7305
DOI	10.1007/s11427-022-2392-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Perceptions towards online learning among medical students during the COVID-19 pandemic.

Zhang, Qiong / Yuan, Qing-Zhi / Ma, Peng-Qiang / Li, Yue / Zhao, Meng-Hui / Chen, Rong-Xia / Tang, Zhen-Gang / Zhang, Bei / Liu, Bing / Liu, Xiang / Li, Fei-Feng

Heliyon

2023 Volume 9, Issue 2, Page(s) e13119

Abstract	Social distancing has been essential during the COVID-19 pandemic to slow the spread of the disease. Online learning ensures students can participate in learning activities while also maintaining a physical distance from other students. Although online learning was used to prevent the spread of COVID-19, the development of online learning has also been promoted. Here, we sought to explore the perceptions and responses of students to online learning during the pandemic using a cross-sectional study. Electronic questionnaire was used for data collection. Statistical analyses were performed for 1614 valid questionnaires and P < 0.05 was considered statistically significant. Overall, COVID-19 had more effect on female students, such as fear of COVID-19 (2.4 times higher than the number of male students) and length of time spent learning (
Language	English
Publishing date	2023-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13119
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito