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Book ; Online: (Table 2) Facies and grain-size description for Mississippi Fan sediments of DSDP Leg 96, supplementary data to: Stow, Dorrik A V; Cremer, Michel; Droz, Laurence; Meyer, Audrey W; Normark, William R; O'Connell, Suzanne B; Pickering, Kevin T; Stelting, Charles E; Angell, S A; Chaplin, C (1986): Facies, composition, and texture of Mississippi Fan sediments, Deep Sea Drilling Project Leg 96, Gulf of Mexico. In: Bouma, AH; Coleman, JM; Meyer, AW; et al. (eds.), Initial Reports of the Deep Sea Drilling Project (U.S. Govt. Printing Office), 96, 475-487

Stow, Dorrik A V / Angell, S A / Chaplin, C / Cremer, Michel / Droz, Laurence / Meyer, Audrey W / Normark, William R / O'Connell, Suzanne B / Pickering, Kevin T / Stelting, Charles E

2012

Abstract: Eight lithologic facies recognized in the Mississippi Fan sediments drilled during DSDP Leg 96 are defined on the basis of lithology, sedimentary structures, composition, and texture. Of these, the calcareous biogenic sediments are of minor importance, ... ...

Abstract	Eight lithologic facies recognized in the Mississippi Fan sediments drilled during DSDP Leg 96 are defined on the basis of lithology, sedimentary structures, composition, and texture. Of these, the calcareous biogenic sediments are of minor importance, volumetrically, as compared with the dominant resedimented terrigenous facies. Clay, mud, and silt are the most abundant sediments at all the sites drilled, with some sand and gravel in the midfan channel fill and an abundance of sand on the lower fan. Facies distribution and vertical sequences reflect the importance of sediment type and supply in controlling fan development. Sea-level changes and diapiric activity have also played an important role. Clay and sand fraction mineralogy closely mirror the dominant sediment source, namely, the Mississippi River system and adjacent continental shelf. Local and regional variation in composition on the fan mostly reflects facies differences.
Language	English
Dates of publication	2012-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.2973/dsdp.proc.96.121.1986
DOI	10.1594/PANGAEA.788135
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells.

Pickering, Suzanne / Sumner, Jonathan / Kerridge, Claire / Perera, Marianne / Neil, Stuart

mBio

2023 Volume 14, Issue 4, Page(s) e0329322

Abstract: The HIV-1 Vpu protein is expressed late in the virus lifecycle to promote infectious virus production and avoid innate and adaptive immunity. This includes the inhibition of the NF-κB pathway which, when activated, leads to the induction of inflammatory ... ...

Abstract	The HIV-1 Vpu protein is expressed late in the virus lifecycle to promote infectious virus production and avoid innate and adaptive immunity. This includes the inhibition of the NF-κB pathway which, when activated, leads to the induction of inflammatory responses and the promotion of antiviral immunity. Here we demonstrate that Vpu can inhibit both canonical and non-canonical NF-κB pathways, through the direct inhibition of the F-box protein β-TrCP, the substrate recognition portion of the Skp1-Cul1-F-box (SCF)
MeSH term(s)	Humans ; NF-kappa B/metabolism ; HIV-1/genetics ; beta-Transducin Repeat-Containing Proteins/genetics ; beta-Transducin Repeat-Containing Proteins/metabolism ; I-kappa B Proteins/metabolism ; HeLa Cells ; HIV Infections ; Ligases/metabolism ; Ubiquitins/metabolism
Chemical Substances	NF-kappa B ; beta-Transducin Repeat-Containing Proteins ; I-kappa B Proteins ; Ligases (EC 6.-) ; Ubiquitins
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.03293-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessing Workplace Factors That Influence Burnout and Identifying Recommendations to Support Well-being in Pharmacy Faculty.

Zeeman, Jacqueline M / Pickering, Emily S / Nana, Akina A / Harris, Suzanne C

American journal of pharmaceutical education

2023 Volume 88, Issue 1, Page(s) 100628

Abstract: Objective: Creating environments that promote well-being is critical as studies have shown that burnout, and thus poor well-being, results in poor health outcomes and declining workplace retention. While studies have measured the prevalence of burnout ... ...

Abstract	Objective: Creating environments that promote well-being is critical as studies have shown that burnout, and thus poor well-being, results in poor health outcomes and declining workplace retention. While studies have measured the prevalence of burnout in pharmacy faculty, a gap exists regarding workplace factors that impact faculty well-being. The purpose of this study was to assess factors influencing pharmacy faculty burnout and identify recommendations to improve faculty well-being. Methods: Full-time pharmacy faculty were invited to participate in this exploratory study. Focus groups were divided by faculty rank (ie, assistant, associate, full professor). A semistructured interview format was used to identify factors contributing to faculty burnout and fulfillment as well as solicit suggestions for strategies to improve well-being. Inductive coding was used to identify themes. Results: Eleven faculty participated in 4 focus groups: 6 assistant professors in 2 focus groups (n = 3 faculty/focus group), 3 associate professors in 1 focus group, and 2 full professors in 1 focus group. Common factors influencing faculty burnout included overwhelming workload, workplace inefficiencies, and unexpected factors. Factors contributing to faculty fulfillment included impact, having a passion for work, and connecting with others. Recommendations for improving well-being included school-level well-being initiatives from leadership, encouraging work-life balance, and implementing intentional well-being initiatives and resources. Conclusion: Participants identified several workplace factors that contribute to burnout and faculty fulfillment. This study fills a critical gap in the literature regarding factors that influence pharmacy faculty well-being and burnout and can inform strategies for fostering faculty well-being in pharmacy education.
MeSH term(s)	Humans ; Faculty, Pharmacy ; Job Satisfaction ; Education, Pharmacy ; Burnout, Professional/epidemiology ; Workplace ; Surveys and Questionnaires
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.1016/j.ajpe.2023.100628
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Article ; Online: Medical student use of Facebook to support preparation for anatomy assessments.

Pickering, James D / Bickerdike, Suzanne R

Anatomical sciences education

2017 Volume 10, Issue 3, Page(s) 205–214

Abstract: The use of Facebook to support students is an emerging area of educational research. This study explored how a Facebook Page could support Year 2 medical (MBChB) students in preparation for summative anatomy assessments and alleviate test anxiety. ... ...

Abstract	The use of Facebook to support students is an emerging area of educational research. This study explored how a Facebook Page could support Year 2 medical (MBChB) students in preparation for summative anatomy assessments and alleviate test anxiety. Overall, Facebook analytics revealed that in total 49 (19.8% of entire cohort) students posted a comment in preparation for either the first (33 students) or second (34) summative anatomy assessments. 18 students commented in preparation for both. In total, 155 comments were posted, with 83 for the first and 72 for the second. Of the 83 comments, 45 related to checking anatomical information, 30 were requiring assessment information and 8 wanted general course information. For the second assessment this was 52, 14 and 6, respectively. Student perceptions on usage, and impact on learning and assessment preparation were obtained via a five-point Likert-style questionnaire, with 119 students confirming they accessed the Page. Generally, students believed the Page was an effective way to support their learning, and provided information which supported their preparation with increases in perceived confidence and reductions in anxiety. There was no difference between gender, except for males who appeared to be significantly less likely to ask a question as they may be perceived to lack knowledge (P < 0.05). This study suggests that Facebook can play an important role in supporting students in preparation for anatomy assessments. Anat Sci Educ 10: 205-214. © 2016 American Association of Anatomists.
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483491-9
ISSN	1935-9780 ; 1935-9772
ISSN (online)	1935-9780
ISSN	1935-9772
DOI	10.1002/ase.1663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Development of a Multi-Modal Cancer Rehabilitation (Including Prehabilitation) Service in Sheffield, UK: Designing the Active Together Service.

Humphreys, Liam / Myers, Anna / Frith, Gabriella / Thelwell, Michael / Pickering, Katie / Mills, Gary H / Kerr, Karen / Fisher, Patricia / Kidder, John / Keen, Carol / Hodson, Suzanne / Phillips, Gail / Smith, Rachel / Evans, Laura / Thornton, Sarah / Dale, Emma / Maxwell, Louise / Greenfield, Diana M / Copeland, Robert

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 7

Abstract: Cancer patients undergoing major interventions face numerous challenges, including the adverse effects of cancer and the side effects of treatment. Cancer rehabilitation is vital in ensuring cancer patients have the support they need to maximise ... ...

Abstract	Cancer patients undergoing major interventions face numerous challenges, including the adverse effects of cancer and the side effects of treatment. Cancer rehabilitation is vital in ensuring cancer patients have the support they need to maximise treatment outcomes and minimise treatment-related side effects and symptoms. The Active Together service is a multi-modal rehabilitation service designed to address critical support gaps for cancer patients. The service is located and provided in Sheffield, UK, an area with higher cancer incidence and mortality rates than the national average. The service aligns with local and regional cancer care objectives and aims to improve the clinical and quality-of-life outcomes of cancer patients by using lifestyle behaviour-change techniques to address their physical, nutritional, and psychological needs. This paper describes the design and initial implementation of the Active Together service, highlighting its potential to support and benefit cancer patients.
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12070742
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Inhibiting the Ins and Outs of HIV Replication: Cell-Intrinsic Antiretroviral Restrictions at the Plasma Membrane.

Foster, Toshana L / Pickering, Suzanne / Neil, Stuart J D

Frontiers in immunology

2018 Volume 8, Page(s) 1853

Abstract: Like all viruses, human immunodeficiency viruses (HIVs) and their primate lentivirus relatives must enter cells in order to replicate and, once produced, new virions need to exit to spread to new targets. These processes require the virus to cross the ... ...

Abstract	Like all viruses, human immunodeficiency viruses (HIVs) and their primate lentivirus relatives must enter cells in order to replicate and, once produced, new virions need to exit to spread to new targets. These processes require the virus to cross the plasma membrane of the cell twice: once via fusion mediated by the envelope glycoprotein to deliver the viral core into the cytosol; and secondly by ESCRT-mediated scission of budding virions during release. This physical barrier thus presents a perfect location for host antiviral restrictions that target enveloped viruses in general. In this review we will examine the current understanding of innate host antiviral defences that inhibit these essential replicative steps of primate lentiviruses associated with the plasma membrane, the mechanism by which these viruses have adapted to evade such defences, and the role that this virus/host battleground plays in the transmission and pathogenesis of HIV/AIDS.
Keywords	covid19
Language	English
Publishing date	2018-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.01853
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Disrupted Peyer's Patch Microanatomy in COVID-19 Including Germinal Centre Atrophy Independent of Local Virus.

Trevelin, Silvia C / Pickering, Suzanne / Todd, Katrina / Bishop, Cynthia / Pitcher, Michael / Garrido Mesa, Jose / Montorsi, Lucia / Spada, Filomena / Petrov, Nedyalko / Green, Anna / Shankar-Hari, Manu / Neil, Stuart J D / Spencer, Jo

Frontiers in immunology

2022 Volume 13, Page(s) 838328

Abstract: Confirmed SARS-coronavirus-2 infection with gastrointestinal symptoms and changes in microbiota associated with coronavirus disease 2019 (COVID-19) severity have been previously reported, but the disease impact on the architecture and cellularity of ... ...

Abstract	Confirmed SARS-coronavirus-2 infection with gastrointestinal symptoms and changes in microbiota associated with coronavirus disease 2019 (COVID-19) severity have been previously reported, but the disease impact on the architecture and cellularity of ileal Peyer's patches (PP) remains unknown. Here we analysed
MeSH term(s)	Atrophy/immunology ; B-Lymphocytes/immunology ; COVID-19/immunology ; Germinal Center/immunology ; Humans ; Intestinal Mucosa/immunology ; Lymphoid Tissue/immunology ; Macrophages/immunology ; Peyer's Patches/immunology ; SARS-CoV-2/immunology ; T-Lymphocytes/immunology
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.838328
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination.

Seow, Jeffrey / Khan, Hataf / Rosa, Annachiara / Calvaresi, Valeria / Graham, Carl / Pickering, Suzanne / Pye, Valerie E / Cronin, Nora B / Huettner, Isabella / Malim, Michael H / Politis, Argyris / Cherepanov, Peter / Doores, Katie J

Cell reports

2022 Volume 40, Issue 8, Page(s) 111276

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the target for neutralizing antibodies elicited following both infection and vaccination. While extensive research has shown that the receptor binding domain (RBD) and, to a lesser ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the target for neutralizing antibodies elicited following both infection and vaccination. While extensive research has shown that the receptor binding domain (RBD) and, to a lesser extent, the N-terminal domain (NTD) are the predominant targets for neutralizing antibodies, identification of neutralizing epitopes beyond these regions is important for informing vaccine development and understanding antibody-mediated immune escape. Here, we identify a class of broadly neutralizing antibodies that bind an epitope on the spike subdomain 1 (SD1) and that have arisen from infection or vaccination. Using cryo-electron microscopy (cryo-EM) and hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS), we show that SD1-specific antibody P008_60 binds an epitope that is not accessible within the canonical prefusion states of the SARS-CoV-2 spike, suggesting a transient conformation of the viral glycoprotein that is vulnerable to neutralization.
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Cryoelectron Microscopy ; Epitopes ; Humans ; Neutralization Tests ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Syndactyly ; Vaccination
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Epitopes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-08-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.111276
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of breeding for reduced methane emissions in New Zealand sheep on maternal and health traits.

Hickey, Sharon M / Bain, Wendy E / Bilton, Timothy P / Greer, Gordon J / Elmes, Sara / Bryson, Brooke / Pinares-Patiño, Cesar S / Wing, Janine / Jonker, Arjan / Young, Emily A / Knowler, Kevin / Pickering, Natalie K / Dodds, Ken G / Janssen, Peter H / McEwan, John C / Rowe, Suzanne J

Frontiers in genetics

2022 Volume 13, Page(s) 910413

Abstract: Enteric methane emissions from ruminants account for ∼35% of New Zealand's greenhouse gas emissions. This poses a significant threat to the pastoral sector. Breeding has been shown to successfully lower methane emissions, and genomic prediction for ... ...

Abstract	Enteric methane emissions from ruminants account for ∼35% of New Zealand's greenhouse gas emissions. This poses a significant threat to the pastoral sector. Breeding has been shown to successfully lower methane emissions, and genomic prediction for lowered methane emissions has been introduced at the national level. The long-term genetic impacts of including low methane in ruminant breeding programs, however, are unknown. The success of the New Zealand sheep industry is currently heavily reliant on the prolificacy, fecundity and survival of adult ewes. The objective of this study was to determine genetic and phenotypic correlations between adult maternal ewe traits (live weight, body condition score, number of lambs born, litter survival to weaning, pregnancy scanning and fleece weight), faecal and
Language	English
Publishing date	2022-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.910413
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants.

Seow, Jeffrey / Graham, Carl / Hallett, Sadie R / Lechmere, Thomas / Maguire, Thomas J A / Huettner, Isabella / Cox, Daniel / Khan, Hataf / Pickering, Suzanne / Roberts, Rebekah / Waters, Anele / Ward, Christopher C / Mant, Christine / Pitcher, Michael J / Spencer, Jo / Fox, Julie / Malim, Michael H / Doores, Katie J

Cell reports

2022 Volume 39, Issue 5, Page(s) 110757

Abstract: Although the antibody response to COVID-19 vaccination has been studied extensively at the polyclonal level using immune sera, little has been reported on the antibody response at the monoclonal level. Here, we isolate a panel of 44 anti-SARS-CoV-2 ... ...

Abstract	Although the antibody response to COVID-19 vaccination has been studied extensively at the polyclonal level using immune sera, little has been reported on the antibody response at the monoclonal level. Here, we isolate a panel of 44 anti-SARS-CoV-2 monoclonal antibodies (mAbs) from an individual who received two doses of the ChAdOx1 nCoV-19 (AZD1222) vaccine at a 12-week interval. We show that, despite a relatively low serum neutralization titer, Spike-reactive IgG+ B cells are still detectable 9 months post-boost. Furthermore, mAbs with potent neutralizing activity against the current SARS-CoV-2 variants of concern (Alpha, Gamma, Beta, Delta, and Omicron) are present. The vaccine-elicited neutralizing mAbs form eight distinct competition groups and bind epitopes overlapping with neutralizing mAbs elicited following SARS-CoV-2 infection. AZD1222-elicited mAbs are more mutated than mAbs isolated from convalescent donors 1-2 months post-infection. These findings provide molecular insights into the AZD1222 vaccine-elicited antibody response.
MeSH term(s)	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; Humans ; SARS-CoV-2 ; Vaccination
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
Language	English
Publishing date	2022-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.110757
Database	MEDical Literature Analysis and Retrieval System OnLINE

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