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Article ; Online: Determining the most recent common ancestor in a finite linear habitat with asymmetric dispersal.

Teller, Kyle G / Pringle, James M

2023 Volume 153, Page(s) 91–101

Abstract: ... location to the upstream edge, the effective population size (N ...

Abstract	Many species that are birthed in one location and become reproductive in another location can be treated as if in a one-dimensional habitat where dispersal is biased downstream. One example of such is planktonic larvae that disperse in coastal oceans, rivers, and streams. In these habitats, the dynamics of the dispersal are dominated by the movement of offspring in one direction and the distance between parents and offspring in the other direction does not matter. We study an idealized species with non-overlapping generations in a finite linear habitat that has no larval input from outside of the habitat and is therefore isolated from other populations. The most non-realistic assumption that we make is that there are non-overlapping generations, and this is an assumption to be considered in future work. We find that a biased dispersal in the habitat reduces the average time to the most recent common ancestor and causes the average location of the most recent common ancestor to move from the center of the habitat to the upstream edge of the habitat. Due to the decrease in the time to the most recent common ancestor and the shift of the average location to the upstream edge, the effective population size (N
MeSH term(s)	Animals ; Ecosystem ; Larva ; Population Density ; Oceans and Seas
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3948-2
ISSN	1096-0325 ; 0040-5809
ISSN (online)	1096-0325
ISSN	0040-5809
DOI	10.1016/j.tpb.2023.06.003
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Zs.A 1097: Show issues

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Article ; Online: Entanglement of Trapped-Ion Qubits Separated by 230 Meters.

Krutyanskiy, V / Galli, M / Krcmarsky, V / Baier, S / Fioretto, D A / Pu, Y / Mazloom, A / Sekatski, P / Canteri, M / Teller, M / Schupp, J / Bate, J / Meraner, M / Sangouard, N / Lanyon, B P / Northup, T E

Physical review letters

2023 Volume 130, Issue 5, Page(s) 50803

Abstract: We report on an elementary quantum network of two atomic ions separated by 230 m. The ions are ... trapped in different buildings and connected with 520(2) m of optical fiber. At each network node ...

Abstract	We report on an elementary quantum network of two atomic ions separated by 230 m. The ions are trapped in different buildings and connected with 520(2) m of optical fiber. At each network node, the electronic state of an ion is entangled with the polarization state of a single cavity photon; subsequent to interference of the photons at a beam splitter, photon detection heralds entanglement between the two ions. Fidelities of up to (88.0+2.2-4.7)% are achieved with respect to a maximally entangled Bell state, with a success probability of 4×10^{-5}. We analyze the routes to improve these metrics, paving the way for long-distance networks of entangled quantum processors.
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.050803
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Article ; Online: First in Literature Intraneuronal Sacral Nerve Stimulation for Fecal Incontinence After Robotic-Assisted En-Bloc Sacrectomy with Transection of Nerve Roots.

Melling, Nathaniel / Scognamiglio, Pasquale / Teller, Sven / Izbicki, Jakob Robert / Dreimann, Marc / Perez, Daniel

World neurosurgery

2020 Volume 136, Page(s) 208–212

Abstract: Background: En-bloc sacrectomy is the treatment of choice for patients affected by sacral chordoma. It is a radical surgical procedure, which has to face the problem of handling fragile anatomic structures, such as the internal iliac vessels and the ... ...

Abstract	Background: En-bloc sacrectomy is the treatment of choice for patients affected by sacral chordoma. It is a radical surgical procedure, which has to face the problem of handling fragile anatomic structures, such as the internal iliac vessels and the sacral nerve roots, with the risk of causing bowel, bladder, and sexual dysfunction. The combined anterior-posterior approach allows for a safer dissection of the tumor from the mesorectal fascia than the mere posterior approach, especially for tumors extending proximally to S3. Robotic surgery can improve the safety of the procedure. Sacral nerve stimulation is an accepted therapeutic option for fecal incontinence and may be used to treat postoperative incontinence. Case presentation: We report on a patient affected by sacral chordoma with en-bloc sacrectomy preceded by a robotic-assisted dissection of the mesorectal fascia and on managing the postoperative fecal incontinence by implanting a sacral nerve stimulator on the first postoperative day. To our knowledge this is the first such procedure in the literature. Conclusions: From our experience, a robotic anterior approach increases safety for the organs in the pelvis when performing a sacrectomy. Moreover, a sacral nerve stimulator should be considered to manage neurologic complications following transection of nerve roots after sacrectomy.
MeSH term(s)	Chordoma/surgery ; Electric Stimulation Therapy ; Fecal Incontinence/etiology ; Fecal Incontinence/therapy ; Humans ; Middle Aged ; Postoperative Complications/therapy ; Robotic Surgical Procedures/methods ; Sacrum/innervation ; Spinal Neoplasms/surgery
Language	English
Publishing date	2020-01-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2019.12.173
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Zs.A 1159: Show issues

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Article ; Online: A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: The Hipomenes study.

Silva, José Tiago / Montoro, Juan / Pérez-Jacoiste Asín, María Asunción / Fernández-Ruiz, Mario / Polanco, Natalia / González, Esther / Caro-Teller, José Manuel / Andrés, Amado / Aguado, José María / López-Medrano, Francisco

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2023 Volume 23, Issue 12, Page(s) 1949–1960

Abstract: Infection is a common complication in kidney transplant recipients (KTRs). The usefulness of antimicrobial stewardship programs (ASP) and hospital-acquired infection control (HAIC) initiatives in the general inpatient population is well established. We ... ...

Abstract	Infection is a common complication in kidney transplant recipients (KTRs). The usefulness of antimicrobial stewardship programs (ASP) and hospital-acquired infection control (HAIC) initiatives in the general inpatient population is well established. We performed a quasi-experimental study to evaluate a joint ASP/HAIC initiative focused on KTRs. A dedicated ASP team optimized antimicrobial prescriptions in consecutive KTRs during the intervention period (June 2015-March 2016). A multifaceted, evidence-based HAIC program was concurrently implemented. Results were compared with the preceding period (June 2014-March 2015). We included 96 and 100 KTRs in the intervention and preintervention periods, respectively. There was a reduction in the consumption of meropenem (rate ratio [RR]: 0.63; 95% confidence interval [CI]: 0.53-0.75; P <.0001), ceftazidime (RR: 0.31; 95% CI: 0.21-0.45; P <.0001), vancomycin (RR: 0.65; 95% CI: 0.53-0.8; P <.0001), and ciprofloxacin (RR: 0.66; 95% CI: 0.55-0.81; P <.0001) and an increase of fosfomycin (RR: 1.80; 95% CI: 1.17-2.76; P =.008) during the intervention period. The incidence of cystitis (RR: 0.30; 95% CI: 0.28-0.33; P <.001) and upper urinary tract infection (RR: 0.56; 95% CI: 0.33-0.95; P =.04) decreased. A specific ASP/HAIC initiative was effective in optimizing antimicrobial use and reducing the incidence of common bacterial infections among KTRs.
MeSH term(s)	Humans ; Antimicrobial Stewardship/methods ; Kidney Transplantation/adverse effects ; Anti-Infective Agents ; Cross Infection/drug therapy ; Cross Infection/etiology ; Cross Infection/prevention & control ; Hospitals ; Infection Control ; Delivery of Health Care ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1016/j.ajt.2023.07.009
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Zs.A 5542: Show issues

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Article ; Online: A qualitative systematic review of governance principles for mangrove conservation.

Golebie, Elizabeth J / Aczel, Miriam / Bukoski, Jacob J / Chau, Sophia / Ramirez-Bullon, Natali / Gong, Mimi / Teller, Noah

Conservation biology : the journal of the Society for Conservation Biology

2021 Volume 36, Issue 1, Page(s) e13850

Abstract: Management of mangrove ecosystems is complex, given that mangroves are both terrestrial and marine, often cross regional or national boundaries, and are valued by local stakeholders in different ways than they are valued on national and international ... ...

Abstract	Management of mangrove ecosystems is complex, given that mangroves are both terrestrial and marine, often cross regional or national boundaries, and are valued by local stakeholders in different ways than they are valued on national and international scales. Thus, mangrove governance has had varying levels of success, analyzed through concepts such as principles of good governance and procedural justice in decision-making. Although there is substantial research on case studies of mangrove management, global comparisons of mangrove governance are lacking. This research aims to fill this gap by comparing relationships among qualities of governance across mangrove social-ecological systems worldwide. Through a systematic literature search and screening process, we identified 65 articles that discussed mangrove governance and conservation. Case studies in these articles, drawn from 39 countries, were categorized as top-down, bottom-up, or comanaged and thematically coded to assess the influence of eight principles of good governance in mangrove conservation success. Across all three governance systems, the principles of legitimacy, fairness, and integration were most important in determining conservation success or failure. These principles are closely related to the concept of procedural justice, highlighting the importance of stakeholder inclusion throughout all stages of mangrove management. Thus, we recommend clearly defined roles for all governance actors, transparent communication of policy development to stakeholders, fairness in both process and outcome, and careful consideration of sustainable access to conservation resources.
MeSH term(s)	Conservation of Natural Resources ; Data Accuracy ; Ecosystem ; Policy Making ; Social Justice
Language	English
Publishing date	2021-11-29
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review ; Systematic Review
ZDB-ID	58735-7
ISSN	1523-1739 ; 0888-8892
ISSN (online)	1523-1739
ISSN	0888-8892
DOI	10.1111/cobi.13850
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Article: Antibiotics in experimental cancer chemotherapy.

TELLER, M N

Transactions of the New York Academy of Sciences

2003 Volume 24, Page(s) 158–166

MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Antibiotics, Antitubercular ; Dermatologic Agents ; Neoplasms, Experimental
Chemical Substances	Anti-Bacterial Agents ; Antibiotics, Antitubercular ; Dermatologic Agents
Language	English
Publishing date	2003-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1082967-2
ISSN	0028-7113 ; 0892-4503
ISSN	0028-7113 ; 0892-4503
DOI	10.1111/j.2164-0947.1961.tb00759.x
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Article ; Online: Parent Perceptions on a Walking School Bus Program Among Low-Income Families: A Qualitative Study.

Teller, Katie / Abbey-Lambertz, Mark / Sharma, Nasira / Waite, Alan / Ickes, Scott / Mendoza, Jason A

Journal of physical activity & health

2019 Volume 16, Issue 11, Page(s) 1047–1053

Abstract: Background: The walking school bus (WSB) is a promising intervention to increase walking to school and physical activity in school-age children. The aim of this qualitative study was to assess parent perceptions of a WSB program that was part of a ... ...

Abstract	Background: The walking school bus (WSB) is a promising intervention to increase walking to school and physical activity in school-age children. The aim of this qualitative study was to assess parent perceptions of a WSB program that was part of a randomized controlled trial to inform future programs. Methods: The authors interviewed 45 parents whose children had participated in a WSB program in the Seattle area, in which third- and fifth-grade students walked to/from school with adult chaperones along a set route. The authors performed a qualitative analysis of the interview transcripts and coded interview segments into 4 broad categories as follows: facilitators, barriers, general positive sentiments, and proposals. Results: Most parents spoke of the benefits of the WSB program; in particular, parents frequently applauded exercise/physical health benefits. Of the barriers, the most frequently cited was time, with work schedule and commute changes leading some families to walk less frequently. Conclusions: Most parents voiced support for the WSB program as a means to improve child health, to learn pedestrian safety, and to interact with positive adult role models. Parents made several suggestions to improve the program, including better recruitment methods, logistical improvements, and a platform for communicating with other parents.
MeSH term(s)	Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Middle Aged ; Parents/psychology ; Perception ; Poverty/psychology ; Qualitative Research ; Transportation/methods ; Walking
Language	English
Publishing date	2019-09-24
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ISSN	1543-5474
ISSN (online)	1543-5474
DOI	10.1123/jpah.2018-0637
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Article ; Online: Healthcare outcomes in patients with HIV infection at a tertiary hospital during the COVID-19 pandemic.

Quirós-González, Víctor / Rubio, Rafael / Pulido, Federico / Rial-Crestelo, David / Martín-Jurado, Carlos / Hernández-Ros, María Ángeles / López-Jiménez, Elena Ana / Ferrari, José Miguel / Caro-Teller, José Manuel / Pinar, Óscar / Pedrera-Jiménez, Miguel / García-Barrio, Noelia / Serrano, Pablo / Bernal, José Luis

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 3, Page(s) 149–154

Abstract: Background: The COVID-19 pandemic has affected the care of patients with other diseases. Difficulty in access to healthcare during these months has been especially relevant for persons with HIV infection (PWH). This study therefore sought to ascertain ... ...

Abstract	Background: The COVID-19 pandemic has affected the care of patients with other diseases. Difficulty in access to healthcare during these months has been especially relevant for persons with HIV infection (PWH). This study therefore sought to ascertain the clinical outcomes and effectiveness of the measures implemented among PWH in a region with one of the highest incidence rates in Europe. Methods: Retrospective, observational, pre-post intervention study to compare the outcomes of PWH attended at a high-complexity healthcare hospital from March to October 2020 and during the same months across the period 2016-2019. The intervention consisted of home drug deliveries and preferential use of non face-to-face consultations. The effectiveness of the measures implemented was determined by reference to the number of emergency visits, hospitalisations, mortality rate, and percentage of PWH with viral load >50copies, before and after the two pandemic waves. Results: A total of 2760 PWH were attended from January 2016 to October 2020. During the pandemic, there was a monthly mean of 106.87 telephone consultations and 2075 home deliveries of medical drugs dispensed to ambulatory patients. No statistically significant differences were found between the rate of admission of patients with COVID-HIV co-infection and that of the remaining patients (1172.76 admissions/100,000 population vs. 1424.29, p=0.401) or in mortality (11.54% vs. 12.96%, p=0.939). The percentage of PWH with viral load >50copies was similar before and after the pandemic (1.20% pre-pandemic vs. 0.51% in 2020, p=0.078). Conclusion: Our results show that the strategies implemented during the first 8 months of the pandemic prevented any deterioration in the control and follow-up parameters routinely used on PWH. Furthermore, they contribute to the debate about how telemedicine and telepharmacy can fit into future healthcare models.
MeSH term(s)	Humans ; COVID-19 ; Delivery of Health Care ; HIV Infections ; Pandemics ; Retrospective Studies ; Tertiary Care Centers
Language	English
Publishing date	2023-03-01
Publishing country	Spain
Document type	Journal Article ; Observational Study
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2021.07.011
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Article ; Online: Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia.

Teller, Johannes / Jung, Carolin / Wilke, Justus B H / Schimmelpfennig, Svea-Dorothée / Hindermann, Martin / Hinken, Lukas / Gabriel, Maria M / Fegbeutel, Christine / Schäfer, Andreas / Laser, Hans / Lichtinghagen, Ralf / Worthmann, Hans / Weissenborn, Karin / Ehrenreich, Hannelore

Brain, behavior, & immunity - health

2022 Volume 24, Page(s) 100494

Abstract: ... that upon BBB dysfunction, the brain acts as 'immunoprecipitator' of autoantibodies against N-methyl-D-aspartate ... will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery ... for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No ...

Abstract	Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically - transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as 'immunoprecipitator' of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2022.100494
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Article ; Online: Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion.

Wang, Xiaobo / Istvanffy, Rouzanna / Ye, Linhan / Teller, Steffen / Laschinger, Melanie / Diakopoulos, Kalliope N / Görgülü, Kıvanç / Li, Qiaolin / Ren, Lei / Jäger, Carsten / Steiger, Katja / Muckenhuber, Alexander / Vilne, Baiba / Çifcibaşı, Kaan / Reyes, Carmen Mota / Yurteri, Ümmügülsüm / Kießler, Maximilian / Gürçınar, Ibrahim Halil / Sugden, Maya /

Yıldızhan, Saliha Elif / Sezerman, Osman Uğur / Çilingir, Sümeyye / Süyen, Güldal / Reichert, Maximilian / Schmid, Roland M / Bärthel, Stefanie / Oellinger, Rupert / Krüger, Achim / Rad, Roland / Saur, Dieter / Algül, Hana / Friess, Helmut / Lesina, Marina / Ceyhan, Güralp Onur / Demir, Ihsan Ekin

The Journal of clinical investigation

2023 Volume 133, Issue 21

Abstract: Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetically ... ...

Abstract	Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetically engineered mouse models (GEMM) of PDAC. Here, we systematically screened for human-like NI in Europe's largest repository of GEMM of PDAC, comprising 295 different genotypes. This phenotype screen uncovered 2 GEMMs of PDAC with human-like NI, which are both characterized by pancreas-specific overexpression of transforming growth factor α (TGF-α) and conditional depletion of p53. Mechanistically, cancer-cell-derived TGF-α upregulated CCL2 secretion from sensory neurons, which induced hyperphosphorylation of the cytoskeletal protein paxillin via CCR4 on cancer cells. This activated the cancer migration machinery and filopodia formation toward neurons. Disrupting CCR4 or paxillin activity limited NI and dampened tumor size and tumor innervation. In human PDAC, phospho-paxillin and TGF-α-expression constituted strong prognostic factors. Therefore, we believe that the TGF-α-CCL2-CCR4-p-paxillin axis is a clinically actionable target for constraining NI and tumor progression in PDAC.
MeSH term(s)	Humans ; Animals ; Mice ; Transforming Growth Factor alpha/genetics ; Transforming Growth Factor alpha/metabolism ; Paxillin/genetics ; Paxillin/metabolism ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/metabolism ; Phenotype ; Cell Line, Tumor ; Pancreatic Neoplasms
Chemical Substances	Transforming Growth Factor alpha ; Paxillin
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI166333
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