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Article ; Online: Lung dendritic cells induce T(H)17 cells that produce T(H)2 cytokines, express GATA-3, and promote airway inflammation.

Raymond, Marianne / Van, Vu Quang / Wakahara, Keiko / Rubio, Manuel / Sarfati, Marika

The Journal of allergy and clinical immunology

2011 Volume 128, Issue 1, Page(s) 192–201.e6

Abstract: ... in vitro manipulation reprograms T(H)2 and T(H)17 cell lines into T(H)1 cells, leading to the concept ... of CD4(+) T(H) cell subset plasticity. The conversion of memory T(H)17 cells into T(H)2 cells or vice ... versa remains to be clarified.: Objective: We examined the localization of T(H)17/T(H)2 cells in vivo ...

Abstract	Background: Dendritic cells (DCs) are crucial to shape the adaptive immune response. Extensive in vitro manipulation reprograms T(H)2 and T(H)17 cell lines into T(H)1 cells, leading to the concept of CD4(+) T(H) cell subset plasticity. The conversion of memory T(H)17 cells into T(H)2 cells or vice versa remains to be clarified. Objective: We examined the localization of T(H)17/T(H)2 cells in vivo, their cellular origin (T(H)2 vs T(H)17), and the underlying mechanisms that drive the generation of these double T(H) producers. Methods: Antigen-loaded bone marrow-derived DCs (ovalbumin-DCs) were repeatedly administered locally (intratracheally) or systemically (intravenously) to naive mice to elicit chronic airway inflammation. Inflamed lungs and mediastinal lymph nodes were examined for the presence of IL-17(+)IL-13(+)IL-4(+)CD4(+) T cells that coexpressed retinoic acid receptor-related orphan receptor γt and GATA-3 (T(H)17/T(H)2). Results: We show that repetitive administration of inflammatory ovalbumin-DCs, locally or systemically, promoted the development of antigen-specific T(H)17/T(H)2 cells in lungs and mediastinal lymph nodes. Immunized mice had IgE-independent and steroid-resistant airway inflammation with a mixed neutrophil and eosinophil infiltration of the bronchoalveolar lavage fluid. Airway inflammatory signal regulatory protein α-positive DCs reprogrammed in vitro-generated T(H)17 but not T(H)2 cells, as well as lung effector T(H) cells, into T(H)17/T(H)2 cells. Conclusion: We demonstrate the existence of T(H)17/T(H)2 cells that express GATA-3 in inflamed tissues and their T(H)17 origin. We further propose that repeated immunization with inflammatory DCs prevails on the route of DC administration to drive T(H)17/T(H)2-associated chronic lung inflammation.
MeSH term(s)	Animals ; Cell Differentiation/immunology ; Cell Lineage ; Cell Separation ; Coculture Techniques ; Cytokines/biosynthesis ; Cytokines/immunology ; Dendritic Cells/immunology ; Female ; Flow Cytometry ; GATA3 Transcription Factor/biosynthesis ; GATA3 Transcription Factor/immunology ; Lung/cytology ; Lung/immunology ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred BALB C ; Pneumonia/immunology ; Pneumonia/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Th17 Cells/cytology ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th2 Cells/cytology ; Th2 Cells/immunology ; Th2 Cells/metabolism
Chemical Substances	Cytokines ; GATA3 Transcription Factor ; Gata3 protein, mouse
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2011.04.029
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Article ; Online: Application of the sustainable system-of-systems approach and econometric analysis to address China's decarbonisation problem.

Yap, Teck Lee / Vu, Nhung T H / Yeow, Paul H P

Ergonomics

2023 Volume 67, Issue 4, Page(s) 482–497

Abstract: The Sustainable system-of-systems (SSoS) approach, complemented with econometric analysis was used to address China's decarbonisation problem, i.e. selecting fossil fuel consumption sources to be reduced in various regions to meet ... ...

Abstract	The Sustainable system-of-systems (SSoS) approach, complemented with econometric analysis was used to address China's decarbonisation problem, i.e. selecting fossil fuel consumption sources to be reduced in various regions to meet CO
MeSH term(s)	Humans ; Carbon Dioxide/analysis ; Fossil Fuels/analysis ; Coal/analysis ; China ; Systems Analysis
Chemical Substances	Carbon Dioxide (142M471B3J) ; Fossil Fuels ; Coal
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1920-3
ISSN	1366-5847 ; 0014-0139
ISSN (online)	1366-5847
ISSN	0014-0139
DOI	10.1080/00140139.2023.2216413
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Article ; Online: Anatomical variant of the superficial temporal artery in temporoparietal fascia flap for microtia reconstruction.

Nguyen, Ha H / Vu, De D / Ngo, Linh M / Tran, Huyen T T

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2024 Volume 91, Page(s) 105–110

Abstract: Background: Single-stage microtia auricular reconstruction is becoming more relevant. The determining factor is a temporoparietal fascia flap (TPF) with both branches of the superficial temporal artery (STA). There are not many studies regarding ... ...

Abstract	Background: Single-stage microtia auricular reconstruction is becoming more relevant. The determining factor is a temporoparietal fascia flap (TPF) with both branches of the superficial temporal artery (STA). There are not many studies regarding vascular branching in people with microtia. Methods: We conducted an anatomical study on the TPF flap harvested during single-stage endoscopic-assisted microtia auricular reconstruction from May 2018 to July 2021. We observed the flaps under endoscopic and surgical microscopes to determine several variables (vascular size, number of frontal/parietal branches, distance from the branching location to the estimated external ear canal, distance from the frontal artery to projected course of facial nerve's frontal branch, etc.). Results: The study included 55 flaps from 54 patients. Of the 55 flaps, 50 (90.9%) had a parietal branch, and all 55 (100%) had a frontal branch with a mean diameter of 0.98 and 0.91 mm, respectively. Regarding the frontal artery, 1.8%, 25.5%, 50.9%, 16.35% and 5.45% had 0-4 traverse frontal branch(es), respectively. The mean distance from the frontal artery to the estimated course of the frontal nerve was 10.56 mm. Parietal artery absence is more likely in patients with severe hemifacial microsomia or STA trunk go under the auricular cartilage remnants (p < 0.05). Either frontal or parietal artery absence or small diameter can cause necrosis. Frontal arteries travelling near the frontal nerve may result in post-operative nerve palsy. Conclusions: Microtia auricular reconstructive surgery is always a big challenge for plastic surgeons. Anatomical variants are common. A detailed anatomical description of the STA, with the help of microsurgery and endoscopy, allows arterial-based flap designing and harvest, which tremendously improves surgical success rate by diminishing flap necrosis and nerve damage. Clinical question/level of evidence: Therapeutic, IV.
MeSH term(s)	Humans ; Congenital Microtia/surgery ; Temporal Arteries/surgery ; Surgical Flaps/blood supply ; Fascia/transplantation ; Necrosis
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2024.01.029
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Article: Adult-to-adult right lobe graft living donor liver transplantation for acute-on-chronic liver failure: a single-centre retrospective study in Vietnam.

Vu, Quang V / Le, Thanh V / Le, Hieu T / Nguyen, Anh H N / Nguyen, Duy T

Annals of medicine and surgery (2012)

2024 Volume 86, Issue 3, Page(s) 1261–1267

Abstract: Introduction: Acute-on-chronic liver failure (ACLF) has a high mortality rate, and liver transplantation is considered a definite treatment for patients with this condition. This study aims to evaluate the outcomes of living donor liver transplantation ( ...

Abstract	Introduction: Acute-on-chronic liver failure (ACLF) has a high mortality rate, and liver transplantation is considered a definite treatment for patients with this condition. This study aims to evaluate the outcomes of living donor liver transplantation (LDLT) in ACLF patients in a single centre in a lower middle-income country, Vietnam. Materials and methods: This was a retrospective study at the 108 Military Central Hospital (Hanoi, Vietnam), enroling 51 patients diagnosed with ACLF based on Asian Pacific Association for the Study of the Liver (APASL) criteria who underwent LDLT with a right lobe graft from December 2019 to December 2022. The authors utilize the model for end-stage liver disease (MELD) and APASL ACLF Research Consortium (AARC) scores to evaluate and stratify the severity of ACLF. Results: The average age of all patients was 47.27±13.61, with 88.24% being male. The average BMI was 22.78±2.61. The most common underlying liver disease was chronic viral hepatitis B (88.2%). The average MELD score of the patients was 34.90±5.61, with 33.3% having MELD score greater than or equal to 40. In terms of ACLF severity, five patients (9.8%) had grade I ACLF, 35 patients (68.6%) had grade II ACLF, and 11 patients (21.6%) had grade III ACLF. The average AARC score was 9.43±1.68. The duration of treatment in the ICU was 8.59±7.27 days, and the length of hospital stay was 28.02±13.45 days. The most common post-transplant complication was biliary complication (19.61%). Death occurred in 7 patients (13.7%). The survival rates at 6 months, 1 year, and 3 years were 84%, 81.7%, and 81.7%, respectively. Conclusion: Living donor liver transplantation for ACLF patients is safe and has a high post-transplant survival rate. Multidisciplinary care before, during, and after surgery, and the decision to do a liver transplant early, is essential in saving the lives of ACLF patients.
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001708
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Article ; Online: Characteristics of depressive disorders in patients with rheumatoid arthritis and some related factors.

Pham, H-T / Vu-Thi, H / Le, C-T / Dau, Q-L / Nguyen, M-D / Nguyen-Van, H

European review for medical and pharmacological sciences

2024 Volume 28, Issue 1, Page(s) 255–262

Abstract: Objective: Rheumatoid arthritis (RA), a type of chronic arthritis, is common in Vietnam. It has severe consequences for patients, both physically and psychologically, including depressive disorders. Therefore, early detection of depressive disorders is ... ...

Abstract	Objective: Rheumatoid arthritis (RA), a type of chronic arthritis, is common in Vietnam. It has severe consequences for patients, both physically and psychologically, including depressive disorders. Therefore, early detection of depressive disorders is of high importance to help provide comprehensive treatment and improve RA patients' quality of life. This cross-sectional study explored the prevalence of depressive disorders and their salient characteristics and related factors in RA patients in Vietnam. Patients and methods: We enrolled 156 patients diagnosed with RA using the ACR-1987 criteria. The Patient Health Questionnaire-9 (PHQ-9) was used to screen for depressive disorders. Patients' demographic characteristics and clinical and laboratory investigation results, such as the visual analog score, complete blood count, erythrocyte sedimentation rate, Disease Activity Score 28 for RA with C-reactive protein (DAS28-CRP), and quality-of-life score (based on the SF-36 test) were analyzed. Depressive disorders assessed on the first day of admission were reevaluated by a psychiatrist if the PHQ-9 score was ≥ 5. Results: According to the PHQ-9 results, depression prevalence among RA patients was 76.3%. The majority of patients (49.4%) had moderate-to-severe depression and 91% experienced sleep disorder symptoms. Negative thoughts -- suicidal ideation or self-injury - were reported by 21.8% of patients. Depression severity had a moderately positive relationship with disease activity level and a moderately negative relationship with quality of life. Conclusions: Depression prevalence was high among RA patients. Depression severity increased with disease activity and decreased quality of life.
MeSH term(s)	Humans ; Quality of Life ; Cross-Sectional Studies ; Depression/epidemiology ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/drug therapy ; Depressive Disorder ; Severity of Illness Index
Language	English
Publishing date	2024-01-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202401_34911
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Article: Short-Chain Fatty Acid Levels after Fecal Microbiota Transplantation in a Pediatric Cohort with Recurrent

Jess, Alison T / Eskander, George Hany / Vu, My H / Michail, Sonia

Metabolites

2023 Volume 13, Issue 10

Abstract: Though antibiotics are the mainstay treatment ... ...

Abstract	Though antibiotics are the mainstay treatment for
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13101039
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Article ; Online: Variation of Benzo[

Edwards, Selvin H / Hassink, Matthew / Taylor, Kenneth M / Vu, An T

Chemical research in toxicology

2023 Volume 36, Issue 2, Page(s) 202–212

Abstract: This study examined the variation of benzo[ ...

Abstract	This study examined the variation of benzo[
MeSH term(s)	Tobacco, Smokeless ; Benzo(a)pyrene ; Nitrosamines ; Nicotiana ; Carcinogens/analysis ; Tobacco Products
Chemical Substances	N'-nitrosonornicotine (X656TZ86DX) ; Benzo(a)pyrene (3417WMA06D) ; Nitrosamines ; Carcinogens
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	639353-6
ISSN	1520-5010 ; 0893-228X
ISSN (online)	1520-5010
ISSN	0893-228X
DOI	10.1021/acs.chemrestox.2c00289
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Article ; Online: A qualitative study on stress, coping strategies and feasibility of music intervention among women with cancer receiving chemotherapy during COVID-19 pandemic in Vietnam.

Nguyen, Khanh T / Vu, Nhung T H / Tran, Mai T T / Chan, Carmen W H

Scientific reports

2023 Volume 13, Issue 1, Page(s) 542

Abstract: Breast and gynaecological cancer (BGC) patients receiving chemotherapy may experience high levels of stress during the COVID-19 pandemic. Music interventions may be effective in lowering their stress levels. This study explored stressors, coping ... ...

Abstract	Breast and gynaecological cancer (BGC) patients receiving chemotherapy may experience high levels of stress during the COVID-19 pandemic. Music interventions may be effective in lowering their stress levels. This study explored stressors, coping strategies, and the feasibility of music interventions among BGC patients in Vietnam. An exploratory qualitative study with individual face-to-face semi-structured interviews was conducted. A convenience sample of BGC patients receiving chemotherapy was recruited from the oncology centre of a public hospital in Vietnam. Twenty patients were interviewed with open-ended questions developed based on the transactional model of stress and coping to explore stress-causing factors and coping strategies and based on guidelines for music therapy practice to explore their music preferences and perceptions. Field notes and interview transcripts were analysed following the qualitative content analysis approach. Two stressor themes were identified: undesirable experiences during treatment and patients' inability to fulfil their own roles and responsibilities. Our findings revealed a new coping strategy-self-realisation of responsibilities towards the family-that is not listed in the transactional model of stress and coping. Future psychological interventions for stress management among BGC patients should focus on raising the patients' awareness of their values and responsibilities towards their families. Three categories of preferred music genres for stress reduction were identified: religious, softly melodic, and revolutionary music. The patients were aware of the positive effects of music and had different musical preferences. This study also explored the acceptance of music interventions and facilitators and barriers to implementing them among BGC patients in Vietnam. The findings suggest that before implementing music interventions, the musical preferences, religions, and beliefs of each individual should be considered to achieve desirable results. Music interventions for BGC patients receiving chemotherapy in Vietnam are feasible. Further intervention studies are needed to evaluate their effectiveness.
MeSH term(s)	Female ; Humans ; Adaptation, Psychological ; COVID-19/epidemiology ; Feasibility Studies ; Music ; Music Therapy/methods ; Neoplasms/psychology ; Pandemics ; Vietnam/epidemiology ; Stress, Physiological
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-27654-9
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Article ; Online: The Importance of Adding Discernment to the Acting Internship - A Necessary Shift in Culture Toward Competency-Based Metrics.

Garber, Adam M / Ferris, Allison H / Vu, T Robert

The American journal of medicine

2022 Volume 135, Issue 9, Page(s) 1137–1141

MeSH term(s)	Benchmarking ; Clinical Competence ; Competency-Based Education ; Educational Measurement ; Humans ; Inservice Training ; Internship and Residency
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.05.032
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Article: Unsupervised Contrastive Peak Caller for ATAC-seq.

Vu, Ha T H / Zhang, Yudi / Tuteja, Geetu / Dorman, Karin

bioRxiv : the preprint server for biology

2023

Abstract: The assay for transposase-accessible chromatin with sequencing (ATAC-seq) is a common assay to identify chromatin accessible regions by using a Tn5 transposase that can access, cut, and ligate adapters to DNA fragments for subsequent amplification and ... ...

Abstract	The assay for transposase-accessible chromatin with sequencing (ATAC-seq) is a common assay to identify chromatin accessible regions by using a Tn5 transposase that can access, cut, and ligate adapters to DNA fragments for subsequent amplification and sequencing. These sequenced regions are quantified and tested for enrichment in a process referred to as "peak calling". Most unsupervised peak calling methods are based on simple statistical models and suffer from elevated false positive rates. Newly developed supervised deep learning methods can be successful, but they rely on high quality labeled data for training, which can be difficult to obtain. Moreover, though biological replicates are recognized to be important, there are no established approaches for using replicates in the deep learning tools, and the approaches available for traditional methods either cannot be applied to ATAC-seq, where control samples may be unavailable, or are post-hoc and do not capitalize on potentially complex, but reproducible signal in the read enrichment data. Here, we propose a novel peak caller that uses unsupervised contrastive learning to extract shared signals from multiple replicates. Raw coverage data are encoded to obtain low-dimensional embeddings and optimized to minimize a contrastive loss over biological replicates. These embeddings are passed to another contrastive loss for learning and predicting peaks and decoded to denoised data under an autoencoder loss. We compared our Replicative Contrastive Learner (RCL) method with other existing methods on ATAC-seq data, using annotations from ChromHMM genome and transcription factor ChIP-seq as noisy truth. RCL consistently achieved the best performance.
Language	English
Publishing date	2023-01-08
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.07.523108
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