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  1. Book: Bacteria and cancer

    Khan, Abdul Arif

    2012  

    Author's details Abdul Arif Khan ed
    Language English
    Size VI, 278 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017117364
    ISBN 978-94-007-2584-3 ; 94-007-2584-1 ; 9789400725850 ; 940072585X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 568 order for loan Magazin

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  2. Article: Editorial: Host-pathogen interactions interplay and cancer: understanding mechanisms and beyond.

    Khan, Abdul Arif / Ahmad, Ejaz

    Frontiers in oncology

    2023  Volume 13, Page(s) 1202004

    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1202004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring polyps to colon carcinoma voyage: can blocking the crossroad halt the sequence?

    Khan, Abdul Arif

    Journal of cancer research and clinical oncology

    2021  Volume 147, Issue 8, Page(s) 2199–2207

    Abstract: Colorectal cancer is an important public health concern leading to significant cancer associate mortality. A vast majority of colon cancer arises from polyp which later follows adenoma, adenocarcinoma, and carcinoma sequence. This whole process takes ... ...

    Abstract Colorectal cancer is an important public health concern leading to significant cancer associate mortality. A vast majority of colon cancer arises from polyp which later follows adenoma, adenocarcinoma, and carcinoma sequence. This whole process takes several years to complete and recent genomic and proteomic technologies are identifying several targets involved in each step of polyp to carcinoma transformation in a large number of studies. Current text presents interaction network of targets involved in polyp to carcinoma transformation. In addition, important targets involved in each step according to network biological parameters are also presented. The functional overrepresentation analysis of each step targets and common top biological processes and pathways involved in carcinoma indicate several insights about this whole mechanism. Interaction networks indicate TP53, AKT1, GAPDH, INS, EGFR, and ALB as the most important targets commonly involved in polyp to carcinoma sequence. Though several important pathways are known to be involved in CRC, the central common involvement of PI3K-AKT indicates its potential for devising CRC management strategies. The common and central targets and pathways involved in polyp to carcinoma progression can shed light on its mechanism and potential management strategies. The data-driven approach aims to add valuable inputs to the mechanism of the years-long polyp-carcinoma sequence.
    Language English
    Publishing date 2021-06-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-021-03685-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Lactobacillus

    Vidhate, Pallavi / Wakchoure, Pooja / Borole, Samiksha / Khan, Abdul Arif

    American journal of translational research

    2024  Volume 16, Issue 3, Page(s) 720–729

    Abstract: The growing interest of the scientific community in the study of probiotics has gathered valuable data about its beneficial effects for multiple clinical conditions. This data also provides evidence for the functions and properties of probiotics and how ... ...

    Abstract The growing interest of the scientific community in the study of probiotics has gathered valuable data about its beneficial effects for multiple clinical conditions. This data also provides evidence for the functions and properties of probiotics and how they contribute to health benefits by influencing normal microbiota.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    DOI 10.62347/IGWR5474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Microbiome in the growth and management of different types of cancer.

    Khan, Abdul Arif / Büsselberg, Dietrich / de Oliveira, Gislane Lelis Vilela / Khan, Shahanavaj

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1249301

    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1249301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pathogenesis of Human Immunodeficiency Virus and

    Wakchoure, Pooja / Momin, Khizra / Khan, Abdul Arif

    Omics : a journal of integrative biology

    2023  Volume 27, Issue 1, Page(s) 15–23

    Abstract: Tuberculosis (TB) among patients with human immunodeficiency virus (HIV) is a major global health burden and contributes to a high mortality rate due to HIV-mediated immunosuppression and subsequent susceptibility to TB. It is imperative to understand ... ...

    Abstract Tuberculosis (TB) among patients with human immunodeficiency virus (HIV) is a major global health burden and contributes to a high mortality rate due to HIV-mediated immunosuppression and subsequent susceptibility to TB. It is imperative to understand the pathogenesis of the association between HIV and TB for therapeutic innovation and preventive medicine. In the present study, we employed transcriptomic and bioinformatic analyses of differential gene expression data obtained from Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information. The expression data of
    MeSH term(s) Humans ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/therapeutic use ; HIV/genetics ; HIV Infections/genetics ; Mycobacterium tuberculosis/genetics ; Transcriptome/genetics ; Tuberculosis/drug therapy
    Chemical Substances Amyloid beta-Peptides ; APP protein, human
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2030312-9
    ISSN 1557-8100 ; 1536-2310
    ISSN (online) 1557-8100
    ISSN 1536-2310
    DOI 10.1089/omi.2022.0130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Host-microbiota interactions and oncogenesis: Crosstalk and its implications in etiology.

    Khan, Abdul Arif / Nema, Vijay / Ashraf, Mohd Tashfeen

    Microbial pathogenesis

    2023  Volume 178, Page(s) 106063

    Abstract: A number of articles have discussed the potential of microbiota in oncogenesis. Several of these have evaluated the modulation of microbiota and its influence on cancer development. Even in recent past, a plethora of studies have gathered in order to ... ...

    Abstract A number of articles have discussed the potential of microbiota in oncogenesis. Several of these have evaluated the modulation of microbiota and its influence on cancer development. Even in recent past, a plethora of studies have gathered in order to understand the difference in microbiota population among different cancer and normal individuals. Although in majority of studies, microbiota mediated oncogenesis has been primarily attributed to the inflammatory mechanisms, there are several other ways through which microbiota can influence oncogenesis. These relatively less discussed aspects including the hormonal modulation through estrobolome and endobolome, production of cyclomodulins, and lateral gene transfer need more attention of scientific community. We prepared this article to discuss the role of microbiota in oncogenesis in order to provide concise information on these relatively less discussed microbiota mediated oncogenesis mechanisms.
    MeSH term(s) Humans ; Carcinogenesis ; Microbiota/genetics ; Neoplasms ; Host Microbial Interactions
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2023.106063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Editorial

    Abdul Arif Khan / Dietrich Büsselberg / Gislane Lelis Vilela de Oliveira / Shahanavaj Khan

    Frontiers in Molecular Biosciences, Vol

    Microbiome in the growth and management of different types of cancer

    2023  Volume 10

    Keywords microbiome ; cancer ; growth ; diagnosis ; treatment ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Host-microbiota interactions and oncogenesis: Crosstalk and its implications in etiology

    Khan, Abdul Arif / Nema, Vijay / Ashraf, Mohd. Tashfeen

    Microbial Pathogenesis. 2023 May, v. 178 p.106063-

    2023  

    Abstract: A number of articles have discussed the potential of microbiota in oncogenesis. Several of these have evaluated the modulation of microbiota and its influence on cancer development. Even in recent past, a plethora of studies have gathered in order to ... ...

    Abstract A number of articles have discussed the potential of microbiota in oncogenesis. Several of these have evaluated the modulation of microbiota and its influence on cancer development. Even in recent past, a plethora of studies have gathered in order to understand the difference in microbiota population among different cancer and normal individuals. Although in majority of studies, microbiota mediated oncogenesis has been primarily attributed to the inflammatory mechanisms, there are several other ways through which microbiota can influence oncogenesis. These relatively less discussed aspects including the hormonal modulation through estrobolome and endobolome, production of cyclomodulins, and lateral gene transfer need more attention of scientific community. We prepared this article to discuss the role of microbiota in oncogenesis in order to provide concise information on these relatively less discussed microbiota mediated oncogenesis mechanisms.
    Keywords carcinogenesis ; etiology ; horizontal gene transfer ; microorganisms ; Cyclomodulins ; Estrobolome ; Endobolome ; Cancer microbiome ; Cell cycle
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2023.106063
    Database NAL-Catalogue (AGRICOLA)

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV-associated lipodystrophy.

    Shyamveer / Khan, Abdul Arif / Singh, HariOm

    The journal of gene medicine

    2023  Volume 25, Issue 6, Page(s) e3493

    Abstract: Adipocytes play a crucial role in the metabolism of lipids and sugars. Their response varies depending on the circumstances or other factors influenced by physiological and metabolic stresses. People living with HIV (PLWH) experience different effects of ...

    Abstract Adipocytes play a crucial role in the metabolism of lipids and sugars. Their response varies depending on the circumstances or other factors influenced by physiological and metabolic stresses. People living with HIV (PLWH) experience different effects of HIV and highly active antiretroviral therapy (HAART) on their body fat. Some patients respond well to antiretroviral therapy (ART), while others taking similar regimens do not. The genetic makeup of patients has been strongly linked to the variable responses to HAART among PLWH. The cause of HIV-associated lipodystrophy syndrome (HALS) is not well understood, but it may be influenced by genetic variations in the host. The metabolism of lipid effectively modulates plasma triglyceride and high-density lipoprotein cholesterol levels in PLWH. Genes related to drug metabolism and transport play an important role in the transportation and metabolism of ART drugs. Genetic variation in metabolizing enzyme genes of antiretroviral drugs, lipid transport and transcription factor-related genes could interfere with fat storage and metabolism, contributing to the development of HALS. Hence we examined the impact of genes associated with transport, metabolism and various transcription factors in metabolic complications, and their impact on HALS. A study using databases such as PubMed, EMBASE and Google Scholar was conducted to understand the impact of these genes on metabolic complications and HALS. The present article discuss the changes in the expression and regulation of genes and their involvement in the lipid metabolism, lipolysis and lipogenesis pathways. Moreover, alteration of the drug transporter, metabolizing enzyme and various transcription factors can lead to HALS. Single-nucleotide polymorphisms in genes that play an essential role in drug metabolism and drug and lipid transportation may also contribute to individual differences in the emergence of metabolic and morphological alterations during HAART treatment.
    MeSH term(s) Humans ; HIV-Associated Lipodystrophy Syndrome/genetics ; HIV-Associated Lipodystrophy Syndrome/complications ; HIV Infections/drug therapy ; HIV Infections/genetics ; Membrane Transport Proteins ; Lipids ; Genes, Regulator ; Transcription Factors/metabolism ; Genetic Variation
    Chemical Substances Membrane Transport Proteins ; Lipids ; Transcription Factors
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1458024-x
    ISSN 1521-2254 ; 1099-498X
    ISSN (online) 1521-2254
    ISSN 1099-498X
    DOI 10.1002/jgm.3493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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