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  1. Article: Identification of ferroptosis-related genes as potential diagnostic biomarkers for diabetic nephropathy based on bioinformatics.

    Guo, Binbin / Li, Minhui / Wu, Peipei / Chen, Yan

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1183530

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1183530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor.

    Zhang, Kaining / Li, Shanshan / Wang, Yawen / Wang, Zhihao / Mulvenna, Nancy / Yang, Hang / Zhang, Peipei / Chen, Huan / Li, Yan / Wang, Hongliang / Gao, Yongxiang / Wigneshweraraj, Sivaramesh / Matthews, Steve / Zhang, Kaiming / Liu, Bing

    Cell reports

    2022  Volume 40, Issue 1, Page(s) 111026

    Abstract: ... of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP ... of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth ... We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting ...

    Abstract Enolase is a highly conserved enzyme that presents in all organisms capable of glycolysis or fermentation. Its immediate product phosphoenolpyruvate is essential for other important processes like peptidoglycan synthesis and the phosphotransferase system in bacteria. Therefore, enolase inhibitors are of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP) of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth attenuation, thinner cell walls, and safranin color in Gram staining owing to impaired peptidoglycan synthesis. We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting the basic dimer unit. The structure reveals that PEIP does not compete for substrate binding but induces a cascade of conformational changes that limit accessibility to the enolase catalytic site. This phage-inspired disassembly of enolase represents an alternative strategy for the development of anti-microbial drugs.
    MeSH term(s) Bacillus subtilis/metabolism ; Bacteriophages/metabolism ; Catalytic Domain ; Peptidoglycan/metabolism ; Phosphopyruvate Hydratase/metabolism
    Chemical Substances Peptidoglycan ; Phosphopyruvate Hydratase (EC 4.2.1.11)
    Language English
    Publishing date 2022-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111026
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  3. Article ; Online: Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor

    Kaining Zhang / Shanshan Li / Yawen Wang / Zhihao Wang / Nancy Mulvenna / Hang Yang / Peipei Zhang / Huan Chen / Yan Li / Hongliang Wang / Yongxiang Gao / Sivaramesh Wigneshweraraj / Steve Matthews / Kaiming Zhang / Bing Liu

    Cell Reports, Vol 40, Iss 1, Pp 111026- (2022)

    2022  

    Abstract: ... inhibitors are of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP ... of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth ... We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting ...

    Abstract Summary: Enolase is a highly conserved enzyme that presents in all organisms capable of glycolysis or fermentation. Its immediate product phosphoenolpyruvate is essential for other important processes like peptidoglycan synthesis and the phosphotransferase system in bacteria. Therefore, enolase inhibitors are of great interest. Here, we report that Gp60, a phage-encoded enolase inhibitor protein (PEIP) of bacteriophage SPO1 for Bacillus subtilis, is an enolase inhibitor. PEIP-expressing bacteria exhibit growth attenuation, thinner cell walls, and safranin color in Gram staining owing to impaired peptidoglycan synthesis. We solve the structure of PEIP-enolase tetramer and show that PEIP disassembles enolase by disrupting the basic dimer unit. The structure reveals that PEIP does not compete for substrate binding but induces a cascade of conformational changes that limit accessibility to the enolase catalytic site. This phage-inspired disassembly of enolase represents an alternative strategy for the development of anti-microbial drugs.
    Keywords CP: Microbiology ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Extraction, Characterization and Osteogenic Activity of a Type I Collagen from Starfish (

    Li, Lingcui / Yu, Yu / Wu, Wenhui / Wang, Peipei

    Marine drugs

    2023  Volume 21, Issue 5

    Abstract: Outbreaks of starfish ( ...

    Abstract Outbreaks of starfish (
    MeSH term(s) Mice ; Animals ; Asterias/chemistry ; Starfish/chemistry ; Collagen Type I ; Osteogenesis ; Ecosystem ; Cell Differentiation
    Chemical Substances Collagen Type I
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21050274
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  5. Article: Identification of testis development-related genes by combining Iso-Seq and RNA-Seq in

    Liu, Peipei / Li, Ziniu / Zhang, Qiuyuan / Qiao, Jiao / Zheng, Chenjun / Zheng, Wenping / Zhang, Hongyu

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1356151

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1356151
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  6. Article: Editorial: Omics data-based identification of plant specialized metabolic genes.

    Wang, Peipei / Fan, Pengxiang / Bao, Yan / Li, Wei / Wang, Li

    Frontiers in plant science

    2023  Volume 14, Page(s) 1209334

    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1209334
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  7. Article ; Online: 18F-MFBG PET/CT and MRI in Identifying Brain Metastases in a Posttreatment Neuroblastoma Patient.

    Wang, Peipei / Li, Tuo / Zhuang, Hongming / Li, Fang / Jing, Hongli

    Clinical nuclear medicine

    2024  

    Abstract: Abstract: A 7-year-old girl with known brain metastasis from neuroblastoma developed new onset of severe headache. A brain MRI confirmed known metastasis in the right frontal lobe of the brain without new abnormalities. The patient was enrolled in a ... ...

    Abstract Abstract: A 7-year-old girl with known brain metastasis from neuroblastoma developed new onset of severe headache. A brain MRI confirmed known metastasis in the right frontal lobe of the brain without new abnormalities. The patient was enrolled in a clinical trial using 18F-MFBG PET/CT to evaluate patients with neuroblastoma. The images confirmed abnormal activity in the known lesion in the right frontal lobe. In addition, the PET showed additional foci of abnormal activity in the left cerebellopontine region. A follow-up brain MRI study acquired 4 months later revealed abnormal signals in the same region.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005224
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1276: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Comparison and Analysis of Detection Methods for Typhoon-Storm Surges Based on Tide-Gauge Data-Taking Coasts of China as Examples.

    Ma, Peipei / Li, Guosheng

    International journal of environmental research and public health

    2023  Volume 20, Issue 4

    Abstract: Global warming is predicted to lead to a new geographic and spatial distribution of storm-surge events and an increase in their activity intensity. Therefore, it is necessary to detect storm-surge events in order to reveal temporal and spatial variations ...

    Abstract Global warming is predicted to lead to a new geographic and spatial distribution of storm-surge events and an increase in their activity intensity. Therefore, it is necessary to detect storm-surge events in order to reveal temporal and spatial variations in their activity intensity. This study attempted to detect storm-surge events from the perspective of detecting outliers. Four common outlier-detection methods, the Pauta criterion (PC), Chauvenet criterion (CC), Pareto distribution (PD) and kurtosis coefficient (KC), were used to detect the storm-surge events from the hourly residual water level data of 14 tide gauges along the coasts of China. This paper evaluates the comprehensive ability of the four methods to detect storm-surge events by combining historical typhoon-storm-surge events and deep-learning target-detection-evaluation indicators. The results indicate that (1) all of the four methods are feasible for detecting storm surge events; (2) the PC has the highest comprehensive detection ability for storm-surge events (F1 = 0.66), making it the most suitable for typhoon-storm-surge detection in coastal areas of China; the CC has the highest detection accuracy for typhoon-storm-surge events (precision = 0.89), although the recall of the CC is the lowest (recall = 0.42), as only severe storm surges were detected. This paper therefore evaluates four storm-surge-detection methods in coastal areas of China and provides a basis for the evaluation of storm-surge-detection methods and detection algorithms.
    MeSH term(s) Cyclonic Storms ; China
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20043253
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  9. Article: Application of Immunoassay Technology in Food Inspection.

    Li, Peipei / Jin, Maojun

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 15

    Abstract: Food safety is as important as ever, and the safeguards implemented to inspect and reduce pesticides, veterinary drugs, toxins, pathogens, illegal additives, and other deleterious contaminants in our food supply has helped improve human health and ... ...

    Abstract Food safety is as important as ever, and the safeguards implemented to inspect and reduce pesticides, veterinary drugs, toxins, pathogens, illegal additives, and other deleterious contaminants in our food supply has helped improve human health and increase the length and quality of our lives [...].
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12152923
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  10. Article ; Online: The pivotal role of bromine in FeMnKBr/Y

    Cui, Wenjie / Xia, Yudong / Zhang, Peipei / Fu, Yajie / Ye, Xue / Li, Jie / Tan, Li

    iScience

    2024  Volume 27, Issue 5, Page(s) 109621

    Abstract: Light olefins are key intermediates in the synthesis of petrochemicals, and the conversion of stabilized carbon dioxide to light olefins using catalysts containing halogenated elements such as chlorine is a major challenge. Building on previous reports ... ...

    Abstract Light olefins are key intermediates in the synthesis of petrochemicals, and the conversion of stabilized carbon dioxide to light olefins using catalysts containing halogenated elements such as chlorine is a major challenge. Building on previous reports emphasizing the toxic effects of halogen elements on catalysts, we present the synthesis of FeMnKBr/Y
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109621
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