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Article ; Online: Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H

Chun, Heejung / Im, Hyeonjoo / Kang, You Jung / Kim, Yunha / Shin, Jin Hee / Won, Woojin / Lim, Jiwoon / Ju, Yeonha / Park, Yongmin Mason / Kim, Sunpil / Lee, Seung Eun / Lee, Jaekwang / Woo, Junsung / Hwang, Yujin / Cho, Hyesun / Jo, Seonmi / Park, Jong-Hyun / Kim, Daesoo / Kim, Doo Yeon /

Seo, Jeong-Sun / Gwag, Byoung Joo / Kim, Young Soo / Park, Ki Duk / Kaang, Bong-Kiun / Cho, Hansang / Ryu, Hoon / Lee, C Justin

Nature neuroscience

2020 Volume 23, Issue 12, Page(s) 1555–1566

Abstract: ... H ... in Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of appropriate experimental models ...

Abstract	Although the pathological contributions of reactive astrocytes have been implicated in Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of appropriate experimental models and precise molecular mechanisms. Here, we show the importance of astrocytic reactivity on the pathogenesis of AD using GiD, a newly developed animal model of reactive astrocytes, where the reactivity of astrocytes can be manipulated as mild (GiDm) or severe (GiDs). Mechanistically, excessive hydrogen peroxide (H
MeSH term(s)	Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/psychology ; Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Atrophy ; Brain/pathology ; Cell Death ; Cognitive Dysfunction/pathology ; Disease Models, Animal ; Humans ; Hydrogen Peroxide/metabolism ; Macrophage Activation ; Mice ; Mice, Neurologic Mutants ; Mice, Transgenic ; Monoamine Oxidase/metabolism ; Nerve Degeneration/pathology ; Neuroglia ; Neurons/pathology ; Spatial Memory ; Tauopathies/pathology
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Monoamine Oxidase (EC 1.4.3.4)
Language	English
Publishing date	2020-11-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/s41593-020-00735-y
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Article ; Online: ( S )-2-(Cyclobutylamino)- N -(3-(3,4-dihydroisoquinolin-2(1 H )-yl)-2-hydroxypropyl)isonicotinamide Attenuates RANKL-Induced Osteoclast Differentiation by Inhibiting NF-κB Nuclear Translocation

Mina Ding / Eunjin Cho / Zhihao Chen / Sang-Wook Park / Tae-Hoon Lee

International Journal of Molecular Sciences, Vol 24, Iss 4327, p

2023 Volume 4327

Abstract: Osteoporosis is a common skeletal disease; however, effective pharmacological treatments still need to be discovered. This study aimed to identify new drug candidates for the treatment of osteoporosis. Here, we investigated the effect of EPZ compounds, ... ...

Abstract	Osteoporosis is a common skeletal disease; however, effective pharmacological treatments still need to be discovered. This study aimed to identify new drug candidates for the treatment of osteoporosis. Here, we investigated the effect of EPZ compounds, protein arginine methyltransferase 5 (PRMT5) inhibitors, on RANKL-induced osteoclast differentiation via molecular mechanisms by in vitro experiments. EPZ015866 attenuated RANKL-induced osteoclast differentiation, and its inhibitory effect was more significant than EPZ015666. EPZ015866 suppressed the F-actin ring formation and bone resorption during osteoclastogenesis. In addition, EPZ015866 significantly decreased the protein expression of Cathepsin K, NFATc1, and PU.1 compared with the EPZ015666 group. Both EPZ compounds inhibited the nuclear translocation of NF-κB by inhibiting the dimethylation of the p65 subunit, which eventually prevented osteoclast differentiation and bone resorption. Hence, EPZ015866 may be a potential drug candidate for the treatment of osteoporosis.
Keywords	osteoporosis ; osteoclast differentiation ; PRMT5 ; NF-κB ; methylation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pilot-Scale H 2 S and Swine Odor Removal System Using Commercially Available Biochar

Kyoung S. Ro / Bryan Woodbury / Mindy Spiehs / Ariel A. Szogi / Philip J. Silva / Okhwa Hwang / Sungback Cho

Agronomy, Vol 11, Iss 1611, p

2021 Volume 1611

Abstract: Although biochars made in laboratory seem to remove H 2 S and odorous compounds effectively, very ... CBC) for removing H 2 S and odorous volatile organic compounds (VOCs). We found that the well-known ... The H 2 S breakthrough adsorption capacity of the CBC was 2.51 mg/g under humid conditions, which was ...

Abstract	Although biochars made in laboratory seem to remove H 2 S and odorous compounds effectively, very few studies are available for commercial biochars. This study evaluated the efficacy of a commercial biochar (CBC) for removing H 2 S and odorous volatile organic compounds (VOCs). We found that the well-known Ergun equation may not be adequate in predicting pressure drop for properly sizing a ventilation system. The H 2 S breakthrough adsorption capacity of the CBC was 2.51 mg/g under humid conditions, which was much higher than that for dry conditions. The breakthrough capacity increased with the influent concentration of H 2 S. The efficacy of a pilot-scale biochar odor removal system (PSBORS) for removing 15 odorous VOCs was evaluated by placing it in a swine gestation stall continually treating the inside air for 21 days. All VOCs in the PSBORS effluent were below detection limit except for acetic acid. However, due to the very high odor threshold of acetic acid, its contribution to the odor would be minimal. It appeared that the CBC could be used to reduce both H 2 S and odorous VOCs with the potential of recycling the spent CBC for soil health improvement after using it for H 2 S and odor removal.
Keywords	livestock odor ; commercial biochar ; pilot-scale ; hydrogen sulfide ; odorous volatile organic compounds ; Agriculture ; S
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Search for next-to-minimal supersymmetric Higgs bosons in the h --> aa --> micromicromicromicro, micromicrotautau channels using pp[over] collisions at sqrt[s] = 1.96 TeV.

Abazov, V M / Abbott, B / Abolins, M / Acharya, B S / Adams, M / Adams, T / Aguilo, E / Ahsan, M / Alexeev, G D / Alkhazov, G / Alton, A / Alverson, G / Alves, G A / Ancu, L S / Andeen, T / Anzelc, M S / Aoki, M / Arnoud, Y / Arov, M /

Arthaud, M / Askew, A / Asman, B / Atramentov, O / Avila, C / Backusmayes, J / Badaud, F / Bagby, L / Baldin, B / Bandurin, D V / Banerjee, S / Barberis, E / Barfuss, A-F / Bargassa, P / Baringer, P / Barreto, J / Bartlett, J F / Bassler, U / Bauer, D / Beale, S / Bean, A / Begalli, M / Begel, M / Belanger-Champagne, C / Bellantoni, L / Bellavance, A / Benitez, J A / Beri, S B / Bernardi, G / Bernhard, R / Bertram, I / Besançon, M / Beuselinck, R / Bezzubov, V A / Bhat, P C / Bhatnagar, V / Blazey, G / Blessing, S / Bloom, K / Boehnlein, A / Boline, D / Bolton, T A / Boos, E E / Borissov, G / Bose, T / Brandt, A / Brock, R / Brooijmans, G / Bross, A / Brown, D / Bu, X B / Buchholz, D / Buehler, M / Buescher, V / Bunichev, V / Burdin, S / Burnett, T H / Buszello, C P / Calfayan, P / Calpas, B / Calvet, S / Cammin, J / Carrasco-Lizarraga, M A / Carrera, E / Carvalho, W / Casey, B C K / Castilla-Valdez, H / Chakrabarti, S / Chakraborty, D / Chan, K M / Chandra, A / Cheu, E / Cho, D K / Choi, S / Choudhary, B / Christoudias, T / Cihangir, S / Claes, D / Clutter, J / Cooke, M / Cooper, W E / Corcoran, M / Couderc, F / Cousinou, M-C / Crépé-Renaudin, S / Cutts, D / Cwiok, M / Das, A / Davies, G / De, K / de Jong, S J / De La Cruz-Burelo, E / Devaughan, K / Déliot, F / Demarteau, M / Demina, R / Denisov, D / Denisov, S P / Desai, S / Diehl, H T / Diesburg, M / Dominguez, A / Dorland, T / Dubey, A / Dudko, L V / Duflot, L / Duggan, D / Duperrin, A / Dutt, S / Dyshkant, A / Eads, M / Edmunds, D / Ellison, J / Elvira, V D / Enari, Y / Eno, S / Escalier, M / Evans, H / Evdokimov, A / Evdokimov, V N / Facini, G / Ferapontov, A V / Ferbel, T / Fiedler, F / Filthaut, F / Fisher, W / Fisk, H E / Fortner, M / Fox, H / Fu, S / Fuess, S / Gadfort, T / Galea, C F / Garcia-Bellido, A / Gavrilov, V / Gay, P / Geist, W / Geng, W / Gerber, C E / Gershtein, Y / Gillberg, D / Ginther, G / Gómez, B / Goussiou, A / Grannis, P D / Greder, S / Greenlee, H / Greenwood, Z D / Gregores, E M / Grenier, G / Gris, Ph / Grivaz, J-F / Grohsjean, A / Grünendahl, S / Grünewald, M W / Guo, F / Guo, J / Gutierrez, G / Gutierrez, P / Haas, A / Haefner, P / Hagopian, S / Haley, J / Hall, I / Hall, R E / Han, L / Harder, K / Harel, A / Hauptman, J M / Hays, J / Hebbeker, T / Hedin, D / Hegeman, J G / Heinson, A P / Heintz, U / Hensel, C / Heredia-De La Cruz, I / Herner, K / Hesketh, G / Hildreth, M D / Hirosky, R / Hoang, T / Hobbs, J D / Hoeneisen, B / Hohlfeld, M / Hossain, S / Houben, P / Hu, Y / Hubacek, Z / Huske, N / Hynek, V / Iashvili, I / Illingworth, R / Ito, A S / Jabeen, S / Jaffré, M / Jain, S / Jakobs, K / Jamin, D / Jesik, R / Johns, K / Johnson, C / Johnson, M / Johnston, D / Jonckheere, A / Jonsson, P / Juste, A / Kajfasz, E / Karmanov, D / Kasper, P A / Katsanos, I / Kaushik, V / Kehoe, R / Kermiche, S / Khalatyan, N / Khanov, A / Kharchilava, A / Kharzheev, Y N / Khatidze, D / Kim, T J / Kirby, M H / Kirsch, M / Klima, B / Kohli, J M / Konrath, J-P / Kozelov, A V / Kraus, J / Kuhl, T / Kumar, A / Kupco, A / Kurca, T / Kuzmin, V A / Kvita, J / Lacroix, F / Lam, D / Lammers, S / Landsberg, G / Lebrun, P / Lee, W M / Leflat, A / Lellouch, J / Li, J / Li, L / Li, Q Z / Lietti, S M / Lim, J K / Lincoln, D / Linnemann, J / Lipaev, V V / Lipton, R / Liu, Y / Liu, Z / Lobodenko, A / Lokajicek, M / Love, P / Lubatti, H J / Luna-Garcia, R / Lyon, A L / Maciel, A K A / Mackin, D / Mättig, P / Magaña-Villalba, R / Magerkurth, A / Mal, P K / Malbouisson, H B / Malik, S / Malyshev, V L / Maravin, Y / Martin, B / McCarthy, R / McGivern, C L / Meijer, M M / Melnitchouk, A / Mendoza, L / Menezes, D / Mercadante, P G / Merkin, M / Merritt, K W / Meyer, A / Meyer, J / Mitrevski, J / Mondal, N K / Moore, R W / Moulik, T / Muanza, G S / Mulhearn, M / Mundal, O / Mundim, L / Nagy, E / Naimuddin, M / Narain, M / Neal, H A / Negret, J P / Neustroev, P / Nilsen, H / Nogima, H / Novaes, S F / Nunnemann, T / Obrant, G / Ochando, C / Onoprienko, D / Orduna, J / Oshima, N / Osman, N / Osta, J / Otec, R / Y Garzón, G J Otero / Owen, M / Padilla, M / Padley, P / Pangilinan, M / Parashar, N / Park, S-J / Park, S K / Parsons, J / Partridge, R / Parua, N / Patwa, A / Pawloski, G / Penning, B / Perfilov, M / Peters, K / Peters, Y / Pétroff, P / Piegaia, R / Piper, J / Pleier, M-A / Podesta-Lerma, P L M / Podstavkov, V M / Pogorelov, Y / Pol, M-E / Polozov, P / Popov, A V / Prado da Silva, W L / Protopopescu, S / Qian, J / Quadt, A / Quinn, B / Rakitine, A / Rangel, M S / Ranjan, K / Ratoff, P N / Renkel, P / Rich, P / Rijssenbeek, M / Ripp-Baudot, I / Rizatdinova, F / Robinson, S / Rominsky, M / Royon, C / Rubinov, P / Ruchti, R / Safronov, G / Sajot, G / Sánchez-Hernández, A / Sanders, M P / Sanghi, B / Savage, G / Sawyer, L / Scanlon, T / Schaile, D / Schamberger, R D / Scheglov, Y / Schellman, H / Schliephake, T / Schlobohm, S / Schwanenberger, C / Schwienhorst, R / Sekaric, J / Severini, H / Shabalina, E / Shamim, M / Shary, V / Shchukin, A A / Shivpuri, R K / Siccardi, V / Simak, V / Sirotenko, V / Skubic, P / Slattery, P / Smirnov, D / Snow, G R / Snow, J / Snyder, S / Söldner-Rembold, S / Sonnenschein, L / Sopczak, A / Sosebee, M / Soustruznik, K / Spurlock, B / Stark, J / Stolin, V / Stoyanova, D A / Strandberg, J / Strang, M A / Strauss, E / Strauss, M / Ströhmer, R / Strom, D / Stutte, L / Sumowidagdo, S / Svoisky, P / Takahashi, M / Tanasijczuk, A / Taylor, W / Tiller, B / Titov, M / Tokmenin, V V / Torchiani, I / Tsybychev, D / Tuchming, B / Tully, C / Tuts, P M / Unalan, R / Uvarov, L / Uvarov, S / Uzunyan, S / van den Berg, P J / Van Kooten, R / van Leeuwen, W M / Varelas, N / Varnes, E W / Vasilyev, I A / Verdier, P / Vertogradov, L S / Verzocchi, M / Vilanova, D / Vint, P / Vokac, P / Voutilainen, M / Wagner, R / Wahl, H D / Wang, M H L S / Warchol, J / Watts, G / Wayne, M / Weber, G / Weber, M / Welty-Rieger, L / Wenger, A / Wetstein, M / White, A / Wicke, D / Williams, M R J / Wilson, G W / Wimpenny, S J / Wobisch, M / Wood, D R / Wyatt, T R / Xie, Y / Xu, C / Yacoob, S / Yamada, R / Yang, W-C / Yasuda, T / Yatsunenko, Y A / Ye, Z / Yin, H / Yip, K / Yoo, H D / Youn, S W / Yu, J / Zeitnitz, C / Zelitch, S / Zhao, T / Zhou, B / Zhu, J / Zielinski, M / Zieminska, D / Zivkovic, L / Zutshi, V / Zverev, E G

Physical review letters

2009 Volume 103, Issue 6, Page(s) 61801

Abstract: We report on a first search for production of the lightest neutral CP-even Higgs boson (h ... in the next-to-minimal supersymmetric standard model, where h decays to a pair of neutral pseudoscalar Higgs ... _{a} and M_{h}. ...

Abstract	We report on a first search for production of the lightest neutral CP-even Higgs boson (h) in the next-to-minimal supersymmetric standard model, where h decays to a pair of neutral pseudoscalar Higgs bosons (a), using 4.2 fb;{-1} of data recorded with the D0 detector at Fermilab. The a bosons are required to either both decay to micro;{+}micro;{-} or one to micro;{+}micro;{-} and the other to tau;{+}tau;{-}. No significant signal is observed, and we set limits on its production as functions of M_{a} and M_{h}.
Language	English
Publishing date	2009-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.103.061801
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Article: Infrared spectra of methylidynes formed in reactions of re atoms with methane, methyl halides, methylene halides, and ethane: methylidyne C-H stretching absorptions, bond lengths, and s character.

Cho, Han-Gook / Andrews, Lester

Inorganic chemistry

2008 Volume 47, Issue 5, Page(s) 1653–1662

Abstract: ... length increases in the order of H, F, Cl, and Br, following the decreasing s character in hybridization ... for the C-H bond. The dihalo methylidynes have higher C-H stretching frequencies and s characters ... Re atoms with methane, methyl halides, methylene halides, and ethane via oxidative C-H(X) insertion ...

Abstract	Rhenium carbyne complexes (HC identical with ReH 3, HC identical with ReH 2X, HC identical with ReHX 2, [X = F, Cl, and Br] and CH 3C identical with ReH 3) are produced by reactions of laser-ablated Re atoms with methane, methyl halides, methylene halides, and ethane via oxidative C-H(X) insertion and alpha-hydrogen migration in favor of the carbon-metal triple bond. The stabilities of the carbyne complexes relative to other possible products are predicted by DFT calculations. The diagnostic methylidyne C-H stretching absorptions of HC identical with ReH 3 and its mono- and dihalo derivatives are observed on the blue sides of the precursor C-H stretching bands, and the frequency decreases and the bond length increases in the order of H, F, Cl, and Br, following the decreasing s character in hybridization for the C-H bond. The dihalo methylidynes have higher C-H stretching frequencies and s characters than the monohalo species. The rhenium methylidynes have C s structures, and as a result the HC identical with ReH 3 and CH 3C identical with ReH 3 complexes have two equivalent shorter and one longer Re-H bonds, as compared to the tungsten methylidyne HC identical with WH 3 with three equivalent W-H bonds.
Language	English
Publishing date	2008-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic701505w
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Article ; Online: ¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism.

Chowdhury, Golam M I / Behar, Kevin L / Cho, William / Thomas, Monique A / Rothman, Douglas L / Sanacora, Gerard

Biological psychiatry

2011 Volume 71, Issue 11, Page(s) 1022–1025

Abstract: ... discovered rapid antidepressant-like properties. ¹H-[¹³C]-nuclear magnetic resonance studies were employed ... following the administration of subanesthetic doses of ketamine, are related to the drug's acute effects ...

Abstract	Ketamine has recently gained significant attention owing to its psychotomimetic and more recently discovered rapid antidepressant-like properties. ¹H-[¹³C]-nuclear magnetic resonance studies were employed to explore potential physiological processes underlying these unique effects. [1-¹³C]glucose and [2-¹³C]acetate-nuclear magnetic resonance ex vivo studies were performed on the medial prefrontal cortex (mPFC) and hippocampus of rats acutely treated with 30 mg/kg or 80 mg/kg ketamine and compared with saline-treated animals to determine the effects of ketamine on amino acid neurotransmitter cycling and glial metabolism. A subanesthetic, but not anesthetic, dose of ketamine significantly increased the percentage of ¹³C-enrichments of glutamate, γ-aminobutyric acid, and glutamine in the mPFC of rats. Subanesthetic doses of ketamine increased mPFC amino acid neurotransmitter cycling, as well as neuronal and glial energy metabolism. These data add to previous reports suggesting increased mPFC levels of glutamate release, following the administration of subanesthetic doses of ketamine, are related to the drug's acute effects on cognition, perception, and mood.
MeSH term(s)	Affect/drug effects ; Animals ; Carbon Isotopes ; Cognition/drug effects ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamic Acid/drug effects ; Glutamic Acid/metabolism ; Glutamine/drug effects ; Glutamine/metabolism ; Hippocampus/diagnostic imaging ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hydrogen ; Ketamine/pharmacology ; Magnetic Resonance Spectroscopy/methods ; Male ; Neuroglia/drug effects ; Neuroglia/metabolism ; Neurotransmitter Agents/metabolism ; Perception/drug effects ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Radionuclide Imaging ; Rats ; Rats, Sprague-Dawley ; gamma-Aminobutyric Acid/drug effects ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	Carbon Isotopes ; Excitatory Amino Acid Antagonists ; Neurotransmitter Agents ; Glutamine (0RH81L854J) ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2) ; Ketamine (690G0D6V8H) ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2011-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2011.11.006
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Book ; Online ; E-Book: Oncologic imaging: Urology

Kim, Seung Hyup / Cho, Jeong Yeon

2017

Title variant	Urology
Author's details	Seung Hyup Kim, Jeong Yean Cho editors
Keywords	Urologic Neoplasms / diagnostic imaging ; Genital Neoplasms, Male / diagnostic imaging
Language	English
Size	1 Online-Ressource (x, 260 Seiten), Illustrationen
Publisher	Springer
Publishing place	Berlin, Heidelberg
Publishing country	Germany
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019215881
ISBN	978-3-662-45218-9 ; 9783662452172 ; 3-662-45218-9 ; 3662452170
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Effects of an Acidic Environment on the Strength and Chemical Changes of Resin-based Composites.

Kang, S / Cho, B-H

Operative dentistry

2023 Volume 48, Issue 4, Page(s) E81–E94

Abstract: The objective of this study was to evaluate the aging effects of long-term exposure to acidic beverages on the flexural strength (FS) and chemical reactions of two resin-based composites (RBCs) and one giomer. The FS of composite specimen bars (2 mm × 2 ... ...

Abstract	The objective of this study was to evaluate the aging effects of long-term exposure to acidic beverages on the flexural strength (FS) and chemical reactions of two resin-based composites (RBCs) and one giomer. The FS of composite specimen bars (2 mm × 2 mm × 25 mm) was measured using a universal testing machine at various levels of thermocycling (TC; 0, 10,000, 50,000, and 100,000 cycles) in two beverages with different pH values (distilled water [DW], pH 7.0; Coca-Cola, pH 2.4-2.8). The FS data were analyzed using three-way analysis of variance with the post hoc Tukey test and t-test at a significance level of a=0.05. In DW, the FS of an RBC and a giomer did not decrease until 10,000 cycles. The other RBC, Z250, decreased rapidly until 50,000 cycles (p<0.05), followed by no additional decrease until 100,000 cycles. In Coca-Cola, the FS of two RBCs and a giomer decreased more rapidly than in DW from 10,000 cycles (t-test, p<0.05). In Coca-Cola, the increased porosity observed in scanning electron microscopy (SEM) images, the changes of the hydroxyl peak at 3340 cm-1 and ester peak at 1730-1700 cm-1 in Fourier-transform infrared spectroscopy in attenuated total reflectance mode (FTIR-ATR) spectra, and the continuous increase of the Si-O/Si-C peak height ratio from 10,000 cycles to 100,000 cycles in X-ray photoelectron spectroscopy (XPS) suggested an increased loss of silane-carbon bond between the matrix and fillers of the Z250 RBC, compared to those in DW. In conclusion, when TC was performed in DW, unreacted monomers and a coupling agent were washed out, which caused porosity and reduced FS. In Coca-Cola, acidic conditions accelerated the removal of the matrix through the hydrolysis reaction at the ester groups, resulting in more porosity and a faster decrease in FS than in DW.
MeSH term(s)	Composite Resins/chemistry ; Surface Properties ; Materials Testing ; Dental Materials/chemistry ; Esters
Chemical Substances	Composite Resins ; Dental Materials ; Esters
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	752995-8
ISSN	1559-2863 ; 0361-7734
ISSN (online)	1559-2863
ISSN	0361-7734
DOI	10.2341/22-031-L
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Article ; Online: Do age, gender, and subjective health-related factors influence health-related life satisfaction in people with disabilities who are physically active?: a secondary analysis.

Cho, Hyunseok / Ahn, Sukhee

Women's health nursing (Seoul, Korea)

2024 Volume 30, Issue 1, Page(s) 56–66

Abstract: Purpose: This study explored the factors influencing the health-related life satisfaction of people with disabilities who engaged in physical activity, by age and gender.: Methods: A secondary analysis was conducted of the 2020 Third Disability and ... ...

Abstract	Purpose: This study explored the factors influencing the health-related life satisfaction of people with disabilities who engaged in physical activity, by age and gender. Methods: A secondary analysis was conducted of the 2020 Third Disability and Life Dynamics Panel (2021). The participants were 2,796 people who performed regular physical activity at least once a week. The variables selected were disability-related factors (degree of disability, multiple disabilities, and type of disability), sociodemographic factors (age, gender, living alone, and mean monthly family income), and health-related factors (amount of physical activity, self-esteem, depression, chronic disease, subjective health, and health-related life satisfaction). Descriptive statistics, the chi-square test, the t-test, two-way analysis of variance, and multiple regression analysis were conducted. Results: In total, 58.0% of participants were male, and 42.0% were female. For age groups, 14.4% were children/adolescents (0-19 years), 42.6% were adults (20-59 years), and 43.0% were seniors (≥60 years). The mean score for health-related life satisfaction was 5.0±2.15 out of 10. Adults and seniors whose level of physical activity met or exceeded recommendations had higher subjective health. Moreover, men had better subjective health than women in seniors. Health-related life satisfaction was higher among those who had higher self-esteem, were not depressed, did not have chronic diseases, and had better subjective health. Conclusion: Gender significantly influenced health-related life satisfaction in children/ adolescents and seniors. Disability-related factors were significant in adults, and health-related factors were significant in all age groups. Therefore, these factors should be considered when designing interventions to promote subjective health and health-related life satisfaction of people with disabilities.
MeSH term(s)	Humans ; Male ; Female ; Disabled Persons/psychology ; Personal Satisfaction ; Adult ; Middle Aged ; Adolescent ; Exercise/psychology ; Child ; Aged ; Quality of Life/psychology ; Sex Factors ; Age Factors ; Self Concept ; Health Status ; Child, Preschool ; Surveys and Questionnaires ; Republic of Korea/epidemiology ; Infant ; Young Adult
Language	English
Publishing date	2024-03-29
Publishing country	Korea (South)
Document type	Journal Article
ISSN	3022-8247
ISSN (online)	3022-8247
DOI	10.4069/whn.2024.03.18
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Article: Anesthesia for a Patient with Undiagnosed Myotonic Dystrophy.

Lee, M O / Lee, J H / Cho, S H / Kim, C E

Nigerian journal of clinical practice

2024 Volume 27, Issue 4, Page(s) 541–544

Abstract: ... the patient's spontaneous breathing. We then proceeded to extubate the patient. However, the patient experienced ...

Abstract	Abstract: Myotonic dystrophy (DM) is an autosomal dominant genetic disorder characterized by progressively worsening loss of muscle mass and weakness. Anesthesiologists face challenges in managing these patients due to risks such as prolonged intubation and delayed recovery associated with anesthesia in such conditions. We report a case of a 40-year-old male patient undergoing open total gastrectomy under general anesthesia. After the surgery, we administered sugammadex to reverse neuromuscular blockade and confirmed the patient's spontaneous breathing. We then proceeded to extubate the patient. However, the patient experienced complications such as apnea, desaturation, and mental changes. The patient was re-intubated and transferred to the intensive care unit for ventilator support. He was diagnosed with DM by genetic test later. Poor preoperative assessment or undiagnosed DM in surgical patients can lead to severe complications. Thus, it is important to carefully check preoperative laboratory results, patient history, and physical findings.
MeSH term(s)	Humans ; Myotonic Dystrophy/diagnosis ; Myotonic Dystrophy/complications ; Male ; Adult ; Anesthesia, General/methods ; Gastrectomy/methods ; Sugammadex ; Neuromuscular Blockade/methods
Chemical Substances	Sugammadex (361LPM2T56)
Language	English
Publishing date	2024-04-29
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_553_23
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