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Article ; Online: Probiotics for Inflammatory Bowel Disease; A Deep Dive into Their Impact on Disease Course and Associated Health Risks.

Hassan, Wassan Nori Mohammed / Al-Kaabi, Methaq Mueen / Akram, Nabeeha Najatee / Kassim, Mustafa Ali Kassim / Pantazi, Alexandru Cosmin

Current medicinal chemistry

2024

Abstract: To date, the underlying pathology of inflammatory bowel disease (IBD) is undetermined. Disturbance of intestinal gut microbiota was implicated in many health diseases, including IBD. Increasing evidence suggests that probiotics play a beneficial role in ... ...

Abstract	To date, the underlying pathology of inflammatory bowel disease (IBD) is undetermined. Disturbance of intestinal gut microbiota was implicated in many health diseases, including IBD. Increasing evidence suggests that probiotics play a beneficial role in restoring the balance of the gut ecosystem. This review searched multiple databases for relevant works that examined probiotics' possible benefits in adults with IBD. Probiotic mode of action in ulcerative colitis patients and Crohn's disease were examined with respect to probiotic strain, their benefits, and their advantages in adult cases. Eligible studies for inclusion were assessed and analyzed. They were effective in reducing IBD disease course, inducing and maintaining remission, particularly for ulcerative colitis patients, with good efficacy and safety profile. However, the evidence for Crohn's disease was lacking. Probiotics positively affect IBD-related risks, reducing the risk of gastrointestinal malignancy and optimizing treating them. Additionally, they improved reduced fertility odds for both genders. The osteoporosis risk among IBD patients was also reduced, although the duration of use and dose were still not established. There was an encouraging role for them in reducing IBD -cardiovascular risks among cases with acute myocardial infarction and those with chronic heart failure. Finally, they had novel use in reducing IBD-related depression and improved overall mental health. In conclusion, we recommend probiotics as an adjuvant therapeutic option for IBD therapy for ulcerative colitis; however, their role in Crohn's disease needs further research.
Language	English
Publishing date	2024-04-30
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673314861240429072352
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Article ; Online: Is Adoptive Cellular Therapy With Non-T-Cell Immune Effectors the Future?

Ali, Alaa Kassim / Tarannum, Mubin / Romee, Rizwan

Cancer journal (Sudbury, Mass.)

2021 Volume 27, Issue 2, Page(s) 168–175

Abstract: Abstract: Success from checkpoint blockade and adoptive cell therapy has brought a new hope in cancer immunotherapy. Adoptive cell therapy involves the isolation of immune cells, ex vivo activation and/or expansion, and reinfusion into the patients, and ...

Abstract	Abstract: Success from checkpoint blockade and adoptive cell therapy has brought a new hope in cancer immunotherapy. Adoptive cell therapy involves the isolation of immune cells, ex vivo activation and/or expansion, and reinfusion into the patients, and their effect can be dramatically increased by the incorporation of chimeric antigen receptors specific to molecules expressed on tumor cells. Chimeric antigen receptor T cells have shown exciting results in the treatment of liquid malignancies; nevertheless, they suffer from limitations including severe adverse effects such as cytokine release syndrome and neurotoxicity seen in patients as well as a potential for causing graft-versus-host disease in an allogeneic setting. It is thus imperial to explore innate immune cells including natural killer cells, macrophages, natural killer T cells, and γδ T cells. Here, we provide a broad overview of the major innate immune cells and their potential for adoptive cell therapy and chimeric antigen receptor engineering.
MeSH term(s)	Humans ; Immunotherapy, Adoptive/trends ; Killer Cells, Natural ; Macrophages ; Natural Killer T-Cells ; Neoplasms/therapy ; Receptors, Chimeric Antigen/genetics ; T-Lymphocytes
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2021-03-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2018400-1
ISSN	1540-336X ; 1528-9117 ; 1081-4442
ISSN (online)	1540-336X
ISSN	1528-9117 ; 1081-4442
DOI	10.1097/PPO.0000000000000517
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Article ; Online: Dietary Fructose and Sodium Consumed during Early Mid-Life Are Associated with Hypertensive End-Organ Damage by Late Mid-Life in the CARDIA Cohort.

Komnenov, Dragana / Al-Hadidi, Mohammad / Ali, Hamza / Al-Jamal, Malik / Salami, Kassim / Shelbaya, Samy / Tayeb, Kareem / Domin, Daniel / Elhamzawy, Rana

Nutrients

2024 Volume 16, Issue 7

Abstract: We aimed to investigate how dietary fructose and sodium impact blood pressure and risk of hypertensive target organ damage 10 years later. Data ... ...

Abstract	We aimed to investigate how dietary fructose and sodium impact blood pressure and risk of hypertensive target organ damage 10 years later. Data from
MeSH term(s)	Middle Aged ; Young Adult ; Female ; Humans ; Coronary Vessels ; Sodium ; Albuminuria ; Hypertension/epidemiology ; Hypertension/etiology ; Diet, Sodium-Restricted ; Calcinosis ; Fructose/adverse effects
Chemical Substances	Sodium (9NEZ333N27) ; Fructose (30237-26-4)
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16070913
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Article: Non-Pharmacological Pain Management in Labor: A Systematic Review.

Nori, Wassan / Kassim, Mustafa Ali Kassim / Helmi, Zeena Raad / Pantazi, Alexandru Cosmin / Brezeanu, Dragos / Brezeanu, Ana Maria / Penciu, Roxana Cleopatra / Serbanescu, Lucian

Journal of clinical medicine

2023 Volume 12, Issue 23

Abstract: Childbirth is a remarkable, life-changing process and is frequently regarded as an excruciating, physically and emotionally demanding experience that women endure. Labor pain management poses a significant challenge for obstetricians and expectant ... ...

Abstract	Childbirth is a remarkable, life-changing process and is frequently regarded as an excruciating, physically and emotionally demanding experience that women endure. Labor pain management poses a significant challenge for obstetricians and expectant mothers. Although pharmacological pain management is the gold standard, it still imposes risks on the mother and baby. Recently, non-pharmacological pain management (NPPM) has emerged as a safe, effective option. Six databases were searched for articles published up to 2023 using specific related keywords and defined inclusion and exclusion criteria. The extraction and gathering of data was made so as to be categorized into physical, psychological, and complementary NPPM techniques. In light of the enormous development and diversity of NPPM techniques, the present review aims to examine contemporary NPPM knowledge and application, discussing efficacy, advantages, limitations, and potential adverse effects, with a specific focus on women's individual requirements, to strengthen obstetricians' knowledge in guiding decision-making for women in childbirth.
Language	English
Publishing date	2023-11-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12237203
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Article ; Online: Enhancing The Role of Zakat and Waqf on Social Forestry Program in Indonesia

Khalifah Muhamad Ali / Salina Kassim / Miftahul Jannah / Zulkarnain Muhammad Ali

Economica: Jurnal Ekonomi Islam, Vol 12, Iss 1, Pp 1-

2021 Volume 26

Abstract: Abstract: This research aims to initiate the integration model of zakat-waqf with Social Forestry Program. The study is a conceptual paper and qualitative using secondary data and descriptively analyzed. It reviews several existing models related to ... ...

Abstract	Abstract: This research aims to initiate the integration model of zakat-waqf with Social Forestry Program. The study is a conceptual paper and qualitative using secondary data and descriptively analyzed. It reviews several existing models related to Zakat and Waqf's role in financing the agriculture and forestry sectors to formulating a novel model for poverty alleviation from communities in and around forests expected to reduce forest destructions in Indonesia. The study concluded that zakat-waqf could finance the Social Forestry program to overcome poverty, inequality and increase the welfare of people living in and around forests. It will provide economic and ecological benefits, especially in reducing forest damage. This research can encourage other researchers to explore the potential of zakat-waqf for financing forestry sectors. Abstrak: Penelitian ini bertujuan untuk menginisasi model integrasi zakat dan wakaf dengan program Perhutanan Sosial. Penelitian adalah riset konseptual yang menggunakan data sekunder dan analisis deskriptif. Penelitian ini mengulas beberapa model eksisting mengenai peran zakat dan wakaf dalam membiayai sektor pertanian dan kehutanan untuk menyusun formula baru yang diharapkan mampu menjadi solusi kemiskinan masyarakat di dalam dan sekitar hutan, yang kemudian diharapkan menurunkan tingkat kebakaran dan kerusakan hutan di Indonesia. Hasil penelitian menunjukkan bahwa zakat dan wakaf dapat menjadi sumber pembiayaan program Perhutanan Sosial untuk mengatasi kemiskinan, kesenjangan, dan meningkatkan kesejahteraan masyarakat di dalam dan sekitar hutan. Program ini dapat memberikan manfaat ekonomi dan ekologi, spesifiknya untuk mengurangi kerusakan hutan. Penelitian ini diharapkan dapat mendorong peneliti-peneliti lain untuk menganalisis lebih lanjut mengenai potensi zakat dan wakaf untuk membiayai sektor kehutanan.
Keywords	islamic finance ; social forestry ; waqf ; zakat ; Islam ; BP1-253 ; Economics as a science ; HB71-74
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Universitas Islam Negeri (UIN) Walisongo Semarang
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Cytotoxicity and

Hussein, Hanaa Ali / Kassim, Murni Nur Islamiah / Maulidiani, M / Abas, Faridah / Abdullah, Mohd Azmuddin

Heliyon

2022 Volume 8, Issue 3, Page(s) e09192

Abstract: This study evaluated the cytotoxic activity of Tamoxifen (TMX), an anti-estrogen drug, with microalgal crude extracts (MCEs) in single and synergistic application (TMX-MCEs) on MCF-7 and 4T1 breast cancer cells, and non-cancerous Vero cells. The MCEs ... ...

Abstract	This study evaluated the cytotoxic activity of Tamoxifen (TMX), an anti-estrogen drug, with microalgal crude extracts (MCEs) in single and synergistic application (TMX-MCEs) on MCF-7 and 4T1 breast cancer cells, and non-cancerous Vero cells. The MCEs of
Language	English
Publishing date	2022-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e09192
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Article ; Online: Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment.

Nachef, Marianna / Ali, Alaa Kassim / Almutairi, Saeedah Musaed / Lee, Seung-Hwan

Frontiers in immunology

2021 Volume 12, Page(s) 624324

Abstract: Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the release of the tumor microenvironment (TME)-specific metabolites. They create an acidic, hypoxic, and nutrient-depleted TME that makes it difficult for the ... ...

Abstract	Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the release of the tumor microenvironment (TME)-specific metabolites. They create an acidic, hypoxic, and nutrient-depleted TME that makes it difficult for the cytotoxic immune cells to adapt to the metabolically hostile environment. Since a robust metabolism in immune cells is required for optimal anti-tumor effector functions, the challenges caused by the TME result in severe defects in the invasion and destruction of the established tumors. There have been many recent developments in NK and T cell-mediated immunotherapy, such as engineering them to express chimeric antigen receptors (CARs) to enhance tumor-recognition and infiltration. However, to defeat the tumor and overcome the limitations of the TME, it is essential to fortify these novel therapies by improving the metabolism of the immune cells. One potential strategy to enhance the metabolic fitness of immune cells is to upregulate the expression of nutrient transporters, specifically glucose and amino acid transporters. In particular, the amino acid transporters SLC1A5 and SLC7A5 as well as the ancillary subunit SLC3A2, which are required for efficient uptake of glutamine and leucine respectively, could strengthen the metabolic capabilities and effector functions of tumor-directed CAR-NK and T cells. In addition to enabling the influx and efflux of essential amino acids through the plasma membrane and within subcellular compartments such as the lysosome and the mitochondria, accumulating evidence has demonstrated that the amino acid transporters participate in sensing amino acid levels and thereby activate mTORC1, a master metabolic regulator that promotes cell metabolism, and induce the expression of c-Myc, a transcription factor essential for cell growth and proliferation. In this review, we discuss the regulatory pathways of these amino acid transporters and how we can take advantage of these processes to strengthen immunotherapy against cancer.
MeSH term(s)	Amino Acid Transport System ASC/antagonists & inhibitors ; Amino Acid Transport System ASC/metabolism ; Amino Acids/metabolism ; Animals ; Antineoplastic Agents/therapeutic use ; Energy Metabolism/drug effects ; Fusion Regulatory Protein 1, Heavy Chain/antagonists & inhibitors ; Fusion Regulatory Protein 1, Heavy Chain/metabolism ; Humans ; Immunotherapy, Adoptive ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Killer Cells, Natural/transplantation ; Large Neutral Amino Acid-Transporter 1/drug effects ; Large Neutral Amino Acid-Transporter 1/metabolism ; Minor Histocompatibility Antigens/metabolism ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation ; Tumor Microenvironment
Chemical Substances	Amino Acid Transport System ASC ; Amino Acids ; Antineoplastic Agents ; Fusion Regulatory Protein 1, Heavy Chain ; Large Neutral Amino Acid-Transporter 1 ; Minor Histocompatibility Antigens ; Receptors, Chimeric Antigen ; SLC1A5 protein, human ; SLC3A2 protein, human ; SLC7A5 protein, human
Language	English
Publishing date	2021-04-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.624324
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Article ; Online: Evaluation of production cross-sections for

Ali, Samer K I / Khandaker, Mayeen Uddin / Kassim, H A

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2018 Volume 135, Page(s) 239–250

Abstract: ... ...

Abstract	186
Language	English
Publishing date	2018-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2018.01.035
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Ue I Zs.279: Show issues

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Article ; Online: Spatial epidemiology of bacterial meningitis in the Upper West Region of Ghana: Analysis of disease surveillance data 2018-2020.

Ali, Musah / Moses, Asori / Nakua, Emmanuel Kweku / Punguyire, Damien / Cheabu, Benjamin Spears Ngmekpele / Avevor, Patrick Mawupemor / Basit, Kassim Abdul

Clinical infection in practice

2023 Volume 16, Page(s) 100160

Abstract: Background: The use of a Geographic Information System in identifying meningitis hotspots in the Upper West Region (UWR) remains underutilized, making spatial targeting of meningitis hotspots difficult. We therefore utilized surveillance data enabled ... ...

Abstract	Background: The use of a Geographic Information System in identifying meningitis hotspots in the Upper West Region (UWR) remains underutilized, making spatial targeting of meningitis hotspots difficult. We therefore utilized surveillance data enabled with GIS technology to target meningitis outbreaks in the UWR. Methods: Secondary data analysis was conducted in the study. The dynamics of bacterial meningitis in space and time were studied using epidemiological data from 2018 to 2020. Spot map and choropleths were used to depict the distribution of cases in the region. Moran's I statistics were used to assess spatial autocorrelation. Getis-Ord Gi(d) and Anselin Local Moran's statistics were used to identify hotspots and spatial outliers within the study area. A Geographic Weighted Regression model was also used to examine how socio bio-climatic conditions influence the spread of meningitis. Results:* There were 1176 cases of bacterial meningitis, 118 deaths, and 1058 survivors between 2018 and 2020. Nandom municipality had the highest Attack Rate (AR) at 492/100,000 persons, followed by Nadowli-Kaleo district at 314/100,000 persons. Jirapa had the highest case fatality rate (CFR) at 17%. The spatio-temporal analysis showed spatial diffusion of meningitis prevalence from the western half of the UWR to the east with a significant number of hotpots and cluster outliers. Conclusion: Bacterial meningitis does not occur at random. Populations (10.9%) under sub-districts identified as hotspots are exceptionally at higher risk of outbreaks. Targeted interventions should be directed towards clustered hotspots, focusing on zones with low prevalence fenced off by high prevalence zones.
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Journal Article
ISSN	2590-1702
ISSN (online)	2590-1702
DOI	10.1016/j.clinpr.2022.100160
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Article ; Online: The Traditional Practices of Mothers in Caring of Neonates Affected by Hyperbilirubinemia

Nuhad Mohammed Kassim / Ali Fadhil Obaid / Zainab Abdulameer Abdulrasol

Iranian Rehabilitation Journal, Vol 19, Iss 4, Pp 433-

2021 Volume 440

Abstract: Objectives: The current study aimed to identify the mothers’ traditional practice in caring for newborns with jaundice; we want to determine the association between mothers’ practices and their demographic characteristics. Methods: This cross-sectional ... ...

Abstract	Objectives: The current study aimed to identify the mothers’ traditional practice in caring for newborns with jaundice; we want to determine the association between mothers’ practices and their demographic characteristics. Methods: This cross-sectional study was conducted on 100 mothers from inpatient pediatric wards of Babylon Teaching Hospital for maternal and pediatric care. They were selected by non-probability, purposive sampling method. The study data were collected by a three-part tool: demographic data sheet related to mothers and children, mothers’ knowledge concerning neonatal jaundice, and the mother’s knowledge and home practices concerning neonatal jaundice. The obtained data were analyzed using the SPSS version 22. Results: Most mothers (67%) were younger than 30 years, and 10% had college or institute educational level. Also, 87% of mothers knew that jaundice is a common problem for neonates; 25% did not know that jaundice is abnormal if it occurs within the first 36 hours. About 17% of mothers did not agree that maternal and fetal blood group differences lead to jaundice. Besides, 47% of mothers were uncertain that severe jaundice could lead to deafness, and 78% knew that phototherapy is the treatment for jaundice. Discussion: The majority of respondents in the study were aged 29 years or less. Most of them adopted breast and formula as the type of feeding. The most recognizable outcome of this study was the adequate knowledge and practices of mothers concerning traditional caring for neonates with jaundice.
Keywords	traditional practices ; neonate ; hyperbilirubinemia ; Medicine ; R ; Vocational rehabilitation. Employment of people with disabilities ; HD7255-7256
Subject code	360
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Negah Institute for Scientific Communication
Document type	Article ; Online
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