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  1. Book ; Online ; E-Book: Orthostatic hypotension in older adults

    Isik, Ahmet Turan / Soysal, Pinar

    2021  

    Abstract: This book provides a comprehensive and practical guide to orthostatic hypotension (OH) for doctors and nurses involved in the care of older adults, together with a state-of-the-art update on OH, covering its epidemiology, pathophysiology, assessment, ... ...

    Author's details Ahmet Turan Isik, Pinar Soysal, editors
    Abstract This book provides a comprehensive and practical guide to orthostatic hypotension (OH) for doctors and nurses involved in the care of older adults, together with a state-of-the-art update on OH, covering its epidemiology, pathophysiology, assessment, diagnosis, causes, prevention, management, and relevance for geriatric practice. In addition, it addresses mechanisms of orthostatic tolerance and other orthostasis related conditions, as well as drugs, comorbidities and geriatric syndromes related to OH. The homeostatic ability to maintain blood pressure while standing requires an adequate blood volume and the integrity of the nervous system, heart, blood vessels and muscle pump. However, in older adults, some age-related factors can contribute to the development of OH. For example, decreased baroreflex sensitivity, α-1-adrenergic vasoconstrictor response to sympathetic stimuli, parasympathetic activity, renal salt and water conservation, increased vascular stiffness and decreased ventricular diastolic filling, as well as concentrated capacities of the kidney may be associated with changes in postural blood pressure. It has also been shown that OH is associated with falls, cardiac events, heart failure, stroke, reduced quality of life, and increased risk of overall mortality in these patients. “Orthostatic Hypotension in Older Adults” will be of considerable interest to all professionals working in the fields of geriatrics, geriatric psychiatry, neurology, internal medicine, cardiology, and emergency medicine, or working with older people in hospitals or in their community.
    Keywords Cardiovascular diseases in old age. ; Geriatrics
    Subject code 618.9761
    Language English
    Size 1 online resource (VIII, 148 p. 11 illus., 10 illus. in color.)
    Edition 1st ed. 2021.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-62493-5 ; 3-030-62492-7 ; 978-3-030-62493-4 ; 978-3-030-62492-7
    DOI 10.1007/978-3-030-62493-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Comment on "Comparison of the Accuracy of Short Cognitive Screens Among Adults With Cognitive Complaints in Turkey".

    Isik, Ahmet Turan / Soysal, Pinar

    Alzheimer disease and associated disorders

    2021  Volume 35, Issue 2, Page(s) 188

    MeSH term(s) Adult ; Cognition ; Cognition Disorders ; Humans ; Neuropsychological Tests ; Turkey
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0000000000000448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Response to "India and Turkey: An underlying common genetic ancestry".

    Soysal, Pinar / Isik, Ahmet Turan

    European geriatric medicine

    2020  Volume 11, Issue 5, Page(s) 883–884

    MeSH term(s) European Continental Ancestry Group ; Humans ; India ; Turkey
    Language English
    Publishing date 2020-07-28
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 2556794-9
    ISSN 1878-7657 ; 1878-7649
    ISSN (online) 1878-7657
    ISSN 1878-7649
    DOI 10.1007/s41999-020-00372-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Different hand-grip strength cut-offs to define sarcopenia in Turkish population.

    Soysal, Pinar / Isik, Ahmet Turan

    Aging clinical and experimental research

    2020  Volume 33, Issue 1, Page(s) 209–210

    Language English
    Publishing date 2020-10-30
    Publishing country Germany
    Document type Letter
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-020-01739-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Micronutrient deficiencies may be associated with both cognitive impairment and chemotherapy toxicity in geriatric oncologic patients.

    Soysal, Pinar / Isik, Ahmet Turan

    Journal of geriatric oncology

    2020  Volume 11, Issue 5, Page(s) 902–903

    MeSH term(s) Age Factors ; Aged ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/metabolism ; Humans ; Malnutrition/metabolism ; Micronutrients/adverse effects ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/psychology
    Chemical Substances Micronutrients
    Language English
    Publishing date 2020-02-07
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2020.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prevention of invasive fungal infections in immunocompromised patients: the role of delayed-release posaconazole.

    Soysal, Ahmet

    Infection and drug resistance

    2015  Volume 8, Page(s) 321–331

    Abstract: Posaconazole is a triazole antifungal agent that has broad-spectrum activity against many yeasts and filamentous fungi, including Candida species, Cryptococcus neoformans, Aspergillus species, and Zygomycetes. This drug has been approved for the ... ...

    Abstract Posaconazole is a triazole antifungal agent that has broad-spectrum activity against many yeasts and filamentous fungi, including Candida species, Cryptococcus neoformans, Aspergillus species, and Zygomycetes. This drug has been approved for the prevention of invasive fungal infections in patients with neutropenia and for the treatment of invasive fungal infections in hematopoietic stem cell transplant recipients with graft-versus-host disease. Studies on the clinical efficacy, safety, tolerability, and cost-effectiveness of posaconazole therapy were performed using the oral suspension form of the drug. Pharmacokinetic studies have found that the oral suspension form of posaconazole has problemeatic bioavailability: its absorption is affected by concomitant medication and food. This article discusses the pharmacokinetic properties of the newly developed posaconazole delayed-release tablet formulation and reviews the efficacy, safety, and cost-effectiveness of both the oral suspension and the new tablet formulation. In conclusion, the posaconazole tablet formulation has better systemic bioavailability, thereby enabling once-daily administration and better absorption in the presence of concomitant medication and food. However, well-designed clinical studies are needed to evaluate the use of the tablet formulation in real-life settings.
    Language English
    Publishing date 2015-09-09
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S65592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: MIS-C patients who were reinfected with SARS-CoV-2. Report of 2 cases.

    Soysal, Ahmet / Topçu, Burcu / Atıcı, Serkan / Gönüllü, Erdem / Öner, Cevat N

    Archivos argentinos de pediatria

    2023  Volume 121, Issue 6, Page(s) e202202893

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a rare condition. It is still unknown if children who have recovered from MIS-C are at a risk of recurrence of MIS-C when they are reinfected with SARSCoV-2. In this study, we aimed to report 2 ... ...

    Title translation Reinfección por SARS-CoV-2 en pacientes con antecedentes de MIS-C. Presentación de dos casos.
    Abstract Multisystem inflammatory syndrome in children (MIS-C) is a rare condition. It is still unknown if children who have recovered from MIS-C are at a risk of recurrence of MIS-C when they are reinfected with SARSCoV-2. In this study, we aimed to report 2 children who recovered from MIS-C and reinfected with SARSCoV-2 without recurrence of MIS-C.
    MeSH term(s) Child ; Humans ; SARS-CoV-2 ; COVID-19/complications ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/therapy
    Language Spanish
    Publishing date 2023-03-23
    Publishing country Argentina
    Document type Case Reports ; Journal Article
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.5546/aap.2022-02893.eng
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The tolerability issue of generic imatinib in patients with chronic myeloid leukemia

    Eskazan, Ahmet Emre / Soysal, Teoman

    Haematologica

    2019  Volume 104, Issue 7, Page(s) e330

    MeSH term(s) Drugs, Generic ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Chemical Substances Drugs, Generic ; Imatinib Mesylate (8A1O1M485B)
    Language English
    Publishing date 2019-06-27
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2019.222000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comment on "nutritional status and all-cause mortality in older adults with acute coronary syndrome".

    Soysal, Pinar / Isik, Ahmet Turan

    Clinical nutrition (Edinburgh, Scotland)

    2019  Volume 38, Issue 6, Page(s) 2958–2959

    MeSH term(s) Acute Coronary Syndrome ; Aged ; Frail Elderly ; Frailty ; Humans ; Nutritional Status
    Language English
    Publishing date 2019-09-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2019.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The relationship between nutritional status and white matter integrity in older adults: A diffusion tensor imaging study.

    Atasoy, Bahar / Balsak, Serdar / Alkan, Alpay / Akcay, Ahmet / Peker, Abdusselim Adil / Toluk, Ozlem / Atila, Naz / Kaya, Ahmet / Ipar, Ozlem / Soysal, Pinar

    Clinical nutrition (Edinburgh, Scotland)

    2024  Volume 43, Issue 5, Page(s) 1065–1072

    Abstract: Objectives: The purpose of this study to determinate whether there is a relationship between the nutritional status and white matter integrity in older patients by using Diffusion Tensor Imaging (DTI).: Methods: The patients were evaluated by Mini- ... ...

    Abstract Objectives: The purpose of this study to determinate whether there is a relationship between the nutritional status and white matter integrity in older patients by using Diffusion Tensor Imaging (DTI).
    Methods: The patients were evaluated by Mini-Nutritional Assessment Scale. The patients are categorized in the groups of well-nourished, risk of malnutrition, or malnourished, depending on the overall score> 23.5, 17-23.5, or 17; respectively. All patients had brain MRI and DTI. The mean diffusivity (MD), fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD) values were calculated by ROI-based method in white matter tracts.
    Results: Total of the 224 patients; 86 patients had normal nutrition status (group 1), 107 patients were diagnosed with malnutrition risk (group 2) and 31 patients were diagnosed with malnutrition (group 3). Significantly decreased FA values of genu of corpus callosum, forceps minor and significantly increased MD values of middle cerebellar peduncle, and superior frontooccipital fasciculus were detected in group 2 in comparison to group 1 (p < 0.05). After adjusting for the folate and age, MD and RD values of cingulum remained significantly higher and the AD values of superior cerebellar peduncle remained significantly lower in group 3 (p < 0.05).
    Conclusions: Malnutrition was associated with deteriorated DTI values, especially in cingulum and superior cerebellar peduncle. Assessing the nutritional status of older individuals is crucial to avoid its negative impact on brain.
    Advances in knowledge: Early diagnosis of malnutrition-related impaired WM integrity is important for prevention and intervention, and DTI is a useful non-invasive technique to be used for this purpose.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2024.03.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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