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Article: [A multicenter randomized controlled study of bismuth-containing quadruple therapy followed by Jing-Hua-Wei-Kang in the treatment of patients newly diagnosed with

Ma, P P / Meng, L N / Wang, M T / Jin, H F / Fan, Y H / Zha, A S / Huo, X H / Chen, D F / Cao, Z Q / Tang, X F / Yang, P / Shi, Z H / Li, T W / Meng, J / Gan, C / Chen, G X / Sha, W H / Du, Q / Li, Y /

Lyu, B

Zhonghua yi xue za zhi

2021 Volume 101, Issue 26, Page(s) 2060–2065

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Bismuth/therapeutic use ; China ; Drug Therapy, Combination ; Dyspepsia/drug therapy ; Female ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Amoxicillin (804826J2HU) ; Bismuth (U015TT5I8H)
Language	Chinese
Publishing date	2021-07-18
Publishing country	China
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20210305-00563
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Article ; Online: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia.

Su, Qing / Chen, Sheng-Liang / Wang, Hua-Hong / Liang, Lie-Xin / Dai, Ning / Lyu, Bin / Zhang, Jun / Wang, Rong-Quan / Zhang, Ya-Li / Yu, Yue / Liu, Jin-Song / Hou, Xiao-Hua

Chinese medical journal

2018 Volume 131, Issue 13, Page(s) 1549–1556

Abstract: ... the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS ... treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or ... depression symptoms were also scored and compared.: Results: (1) The total effective rates in the Qi-Zhi-Wei-Tong ...

Abstract	Background: Functional dyspepsia (FD) is a common upper gastrointestinal disorder worldwide, but the current treatments for FD are still unsatisfactory. The aims of this study were to investigate the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS)-predominant FD. Methods: The study was conducted as a randomized, double-blinded, multicenter, placebo-controlled design in 197 patients with PDS. All participants received placebo treatment for 1 week. Patients whose total symptom score decreased by <50% after the placebo treatment were recruited into the 4-week treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or placebo. The patients were then followed for 2 weeks without any treatment. Dyspeptic symptoms were scored at weeks 2 and 4 during the random treatment period and 2 weeks after the treatment. Anxiety and depression symptoms were also scored and compared. Results: (1) The total effective rates in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 during the random treatment period and 2 weeks after treatment were all significantly higher than those in the placebo group (38.82% vs. 8.75%, P < 0.001; 69.14% vs. 16.25%, P < 0.001; 77.65% vs. 21.25%, P < 0.001). (2) The total dyspeptic symptoms scores in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 and 2 weeks after treatment were significantly lower than those in the placebo group. (3) The severity and frequency of each dyspeptic symptom at weeks 2 and 4 and the follow-up period were all significantly lower than those in the placebo group. (4) The anxiety scores in the Qi-Zhi-Wei-Tong granules group were significantly lower than those in the placebo group. (5) Qi-Zhi-Wei-Tong granules did not have more adverse effects than the placebo. Conclusion: Qi-Zhi-Wei-Tong granules offer significant symptomatic improvement in PDS with no more adverse effects than placebo. Trial registration: https://clinicaltrials.gov/, NCT02460601.
MeSH term(s)	Adult ; Double-Blind Method ; Drugs, Chinese Herbal ; Dyspepsia/therapy ; Female ; Humans ; Male ; Middle Aged ; Qi ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2018-08-01
Publishing country	China
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.4103/0366-6999.235118
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Article ; Online: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia

Qing Su / Sheng-Liang Chen / Hua-Hong Wang / Lie-Xin Liang / Ning Dai / Bin Lyu / Jun Zhang / Rong-Quan Wang / Ya-Li Zhang / Yue Yu / Jin-Song Liu / Xiao-Hua Hou

Chinese Medical Journal, Vol 131, Iss 13, Pp 1549-

2018 Volume 1556

Abstract: ... the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS ... treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or ... depression symptoms were also scored and compared. Results: (1) The total effective rates in the Qi-Zhi-Wei-Tong ...

Abstract	Background: Functional dyspepsia (FD) is a common upper gastrointestinal disorder worldwide, but the current treatments for FD are still unsatisfactory. The aims of this study were to investigate the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS)-predominant FD. Methods: The study was conducted as a randomized, double-blinded, multicenter, placebo-controlled design in 197 patients with PDS. All participants received placebo treatment for 1 week. Patients whose total symptom score decreased by <50% after the placebo treatment were recruited into the 4-week treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or placebo. The patients were then followed for 2 weeks without any treatment. Dyspeptic symptoms were scored at weeks 2 and 4 during the random treatment period and 2 weeks after the treatment. Anxiety and depression symptoms were also scored and compared. Results: (1) The total effective rates in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 during the random treatment period and 2 weeks after treatment were all significantly higher than those in the placebo group (38.82% vs. 8.75%, P < 0.001; 69.14% vs. 16.25%, P < 0.001; 77.65% vs. 21.25%, P < 0.001). (2) The total dyspeptic symptoms scores in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 and 2 weeks after treatment were significantly lower than those in the placebo group. (3) The severity and frequency of each dyspeptic symptom at weeks 2 and 4 and the follow-up period were all significantly lower than those in the placebo group. (4) The anxiety scores in the Qi-Zhi-Wei-Tong granules group were significantly lower than those in the placebo group. (5) Qi-Zhi-Wei-Tong granules did not have more adverse effects than the placebo. Conclusion: Qi-Zhi-Wei-Tong granules offer significant symptomatic improvement in PDS with no more adverse effects than placebo. Trial Registration: https://clinicaltrials.gov/, NCT02460601.
Keywords	Clinical Trial ; Functional Dyspepsia ; Postprandial Distress Syndrome ; Qi-Zhi-Wei-Tong Granules ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
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Article: Immunomodulatory effects of exercise in cancer prevention and adjuvant therapy: a narrative review.

Lyu, Da-Wei

Frontiers in physiology

2024 Volume 14, Page(s) 1292580

Abstract: Successful application of cancer immunotherapy has rekindled hope in cancer patients. However, a number of patients are unresponsive to immunotherapy and related treatments. This unresponsiveness in cancer patients toward different treatment regimens can ...

Abstract	Successful application of cancer immunotherapy has rekindled hope in cancer patients. However, a number of patients are unresponsive to immunotherapy and related treatments. This unresponsiveness in cancer patients toward different treatment regimens can be mainly attributed to severe immune dysfunction in such patients. Several reports indicate that physical exercise can significantly lead to improved cancer patient outcomes. Since exercise gets immense response from the immune system, it can be utilized to improve immune function. Leukocytes with enhanced functions are substantially mobilized into the circulation by a single bout of intense physical exercise. Chronic physical exercise results in greater muscle endurance and strength and improved cardiorespiratory function. This exercise regime is also useful in improving T-cell abundance and reducing dysfunctional T cells. The current available data strongly justify for future clinical trials to investigate physical exercise use as an adjuvant in cancer therapy; however, optimal parameters using exercise for a defined outcome are yet to be established. The components of the immune system associate with almost every tumorigenesis step. The inter-relationship between inflammation, cancer, and innate immunity has recently gained acceptance; however, the underlying cellular and molecular mechanisms behind this relationship are yet to be solved. Several studies suggest physical exercise-mediated induction of immune cells to elicit anti-tumorigenic effects. This indicates the potential of exercising in modulating the behavior of immune cells to inhibit tumor progression. However, further mechanistic details behind physical exercise-driven immunomodulation and anticancer effects have to be determined. This review aims to summarize and discuss the association between physical exercise and immune function modulation and the potential of exercise as an adjuvant therapy in cancer prevention and treatment.
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1292580
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Article ; Online: Determining hyperelastic properties of the constituents of the mussel byssus system.

Lyu, Yulan / Pang, Yong / Liu, Tao / Sun, Wei

Soft matter

2024 Volume 20, Issue 11, Page(s) 2442–2454

Abstract: The mussel byssus system, comprising the adhesive plaque, distal thread, and proximal thread, plays a crucial role in the survival of marine mussels amongst ocean waves. Whilst recent research has explored the stress-strain behaviour of the distal thread ...

Abstract	The mussel byssus system, comprising the adhesive plaque, distal thread, and proximal thread, plays a crucial role in the survival of marine mussels amongst ocean waves. Whilst recent research has explored the stress-strain behaviour of the distal thread and proximal thread through experimental approaches, little attention has been paid to the potential analytical or modelling methods within the current literature. In this work, analytical and finite element (FE) inverse methods were employed for the first time to identify the hyperelastic mechanical properties of both the plaque portion and the proximal thread. The results have demonstrated the feasibility of applied inverse methods in determining the mechanical properties of the constituents of the mussel byssus system, with the residual sum of squares of 0.0004 (N
MeSH term(s)	Animals ; Bivalvia
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d3sm01677c
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Article ; Online: Changes in Children's Health Care Access and Utilization in the United States in the First 2 Years of the COVID-19 Pandemic.

Lyu, Wei / Wehby, George L

Academic pediatrics

2023 Volume 23, Issue 8, Page(s) 1572–1578

Abstract: Objective: To compare children's access to and utilization of health care services in the United States during the first 2 years of the pandemic to prepandemic levels.: Methods: This cross-sectional study used data from the 2017 to 2021 National ... ...

Abstract	Objective: To compare children's access to and utilization of health care services in the United States during the first 2 years of the pandemic to prepandemic levels. Methods: This cross-sectional study used data from the 2017 to 2021 National Survey of Children's Health. Access to care was measured by having a usual place for sick and preventive care, having a personal doctor or nurse, and unmet care needs. Utilization measures included preventive, mental health, specialist, and emergency department (ED) visits, and hospital admissions in the past 12months. Outcomes were reported by parents or other caregivers. Multivariate logistic regressions were employed adjusting for sociodemographic factors and state of residence. The study sample included 163,353 children aged 0 to 17years. Results: Compared to 2019, there were declines in the probability of having a usual place for sick care in 2020 (-1.5 percentage-points) and a usual place for preventive care in 2021 (-2.1 percentage-points), and greater probability of unmet care needs in 2020 (+1.2 percentage-points) and 2021 (+0.8 percentage-points). The probability of having any preventive, specialist, and ED visits and hospitalizations remained lower in 2021 than 2019 (-7.5, 2.2, 5.4 and 0.9 percentage-points, respectively). These differences were not explained by prepandemic trends and were observed across a range of sociodemographic subgroups. Conclusions: Children's health care access and utilization declined noticeably over the first 2years of the pandemic. Evaluating these outcomes in subsequent years and addressing barriers to care continue to be critical to reduce unmet needs.
MeSH term(s)	Child ; United States/epidemiology ; Humans ; Pandemics ; COVID-19 ; Cross-Sectional Studies ; Health Services ; Health Services Accessibility
Language	English
Publishing date	2023-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483385-X
ISSN	1876-2867 ; 1876-2859
ISSN (online)	1876-2867
ISSN	1876-2859
DOI	10.1016/j.acap.2023.07.007
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Article ; Online: The effects of Medicaid expansions on dental services at federally qualified health centers.

Lyu, Wei / Wehby, George L

Journal of the American Dental Association (1939)

2023 Volume 154, Issue 3, Page(s) 215–224.e10

Abstract: Background: Federally qualified health centers (FQHCs) have become safety-net providers of dental services for low-income patients. The authors examined the effects of the Patient Protection and Affordable Care Act Medicaid expansions, according to ... ...

Abstract	Background: Federally qualified health centers (FQHCs) have become safety-net providers of dental services for low-income patients. The authors examined the effects of the Patient Protection and Affordable Care Act Medicaid expansions, according to level of dental benefits, on the number of visits for dental services at FQHCs. Methods: The authors used publicly available facility-level data on 1,400 FQHCs across the United States from the 2011 through 2019 Uniform Data System. The authors used an event-study difference-in-difference design to examine the effects of expanding Medicaid in 2014, according to the level of dental benefits, compared with nonexpansion states. Outcomes included the number of dental visits for any dental service and separately for preventive and other services. Regression models adjusted for the demographic characteristics of the FQHC's patient population, county-level factors, and center and year fixed effects. Results: Expanding Medicaid with extensive dental benefits has increased the number of dental visits provided at FQHCs in 2014 through 2019 from 2013 by 1,329 to 7,647 visits per FQHC on average compared with FQHCs in nonexpansion states. There was an increase in visits for both preventive and other dental services. In contrast, there was no evidence of such an increase from expanding Medicaid with limited or emergency-only dental benefits. Conclusions: Expanding Medicaid eligibility with extensive dental benefits has increased the number of dental visits at FQHCs, including for both preventive and other dental services. Practical implications: As safety-net providers, FQHCs might be able to provide more oral health care for low-income patients after Medicaid expansions that offer extensive dental benefits.
MeSH term(s)	Humans ; United States ; Medicaid ; Patient Protection and Affordable Care Act ; Health Services Accessibility ; Safety-net Providers ; Dental Care
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2022.11.005
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Article ; Online: Children's oral health and oral health care use during the first 2 years of the COVID-19 pandemic.

Lyu, Wei / Wehby, George L

Journal of the American Dental Association (1939)

2023 Volume 154, Issue 10, Page(s) 930–936.e7

Abstract: Background: The COVID-19 pandemic has been associated with declines in children's oral health and oral health care use in 2020. The authors examined the pandemic effects on these outcomes into 2021.: Methods: This cross-sectional study used data from ...

Abstract	Background: The COVID-19 pandemic has been associated with declines in children's oral health and oral health care use in 2020. The authors examined the pandemic effects on these outcomes into 2021. Methods: This cross-sectional study used data from the National Survey of Children's Health from 2017 through 2021. The authors compared parent's or caregiver's perceptions of the child's oral health and reported dental problems and dental visits across years, adjusting for child and household covariates and state of residence. The authors evaluated potential heterogeneity across demographic and socioeconomic subgroups. Results: In 2021, parents and caregivers were still more likely to perceive children's oral health as poor (odds ratio [OR], 1.90; 95% CI, 1.28 to 2.82) and less likely to report very good or excellent oral health (OR, 0.83; 95% CI, 0.76 to 0.92) than in 2019, similar to differences between 2020 and 2019. Dental visits were also less likely in 2021 than 2019 (OR, 0.74; 95% CI, 0.66 to 0.83). These differences between 2021 and 2019 were not explained by prepandemic trends and were observed across a range of demographic and socioeconomic subgroups. Conclusions: Children's oral health as perceived by parents and caregivers and oral health care use were still worse in 2021 than before the pandemic both overall and across demographic and socioeconomic subgroups. Practical implications: The persistent adverse effects of the COVID-19 pandemic on children's oral health as perceived by parents and caregivers and shown through dental visits highlight the need to improve oral health care access and use and to evaluate the long-term effects of the pandemic on children's oral health.
MeSH term(s)	Child ; Humans ; Oral Health ; Pandemics ; Child Health ; Cross-Sectional Studies ; COVID-19/epidemiology ; Parents ; Delivery of Health Care
Language	English
Publishing date	2023-08-28
Publishing country	England
Document type	Journal Article
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2023.07.011
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Article ; Online: Child Flourishing, School Engagement, Physical Activity, and Screen Time During the Coronavirus Disease 2019 Pandemic in 2020.

Lyu, Wei / Wehby, George L

Academic pediatrics

2023 Volume 23, Issue 3, Page(s) 659–666

Abstract: Objective: To examine changes in flourishing, school engagement, physical activity, and recreational screen time among school-aged children in the United States during the Coronavirus Disease 2019 (COVID-19) pandemic in 2020.: Methods: In this cross- ... ...

Abstract	Objective: To examine changes in flourishing, school engagement, physical activity, and recreational screen time among school-aged children in the United States during the Coronavirus Disease 2019 (COVID-19) pandemic in 2020. Methods: In this cross-sectional study, data come from the 2018-2020 National Survey of Children's Health for 68,203 children aged 6 to 17 years. Flourishing is always/usually curious to learn, resilient and having self-regulation. School engagement is always/usually completing homework and having interest in doing well in school. Other outcomes are daily 60+ minutes physical activity or number of such days, and daily recreational screen time or 2+ hours/day. Weighted regression models compare 2020 to 2019 and 2019 to 2018 adjusting for child/household covariates and state indicators. Results: Among children age 6 to 17 years in 2020, there was a decline in flourishing (OR = 0.69; 95% CI, 0.63, 0.75), school engagement (OR = 0.71; 95% CI, 0.64, 0.79), physically active days (0.26 days, 95% CI, 35, 0.17), and daily 60+ minutes activity (OR = 0.91; 95% CI, 0.83, 1.00), and increase in daily recreational screen time (0.29 hours; 95% CI, 0.25, 0.34) and 2+ hours/day (OR = 1.65; 95% CI, 1.49-1.83) compared to 2019. These differences were observed across all evaluated demographic and socioeconomics subgroups. There were no significant differences between 2019 and 2018, indicating that the 2020-2019 differences were related to the pandemic rather than a continuation of prepandemic trends. Conclusions: Children's flourishing, school engagement, and physical activity declined while recreational screen time increased during the COVID-19 pandemic in 2020. Monitoring these outcomes in the long-run is important to assessing needs and promoting children's learning and development.
MeSH term(s)	Humans ; Child ; United States/epidemiology ; Pandemics ; Cross-Sectional Studies ; Screen Time ; COVID-19 ; Exercise
Language	English
Publishing date	2023-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483385-X
ISSN	1876-2867 ; 1876-2859
ISSN (online)	1876-2867
ISSN	1876-2859
DOI	10.1016/j.acap.2022.12.016
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Article: Cardiac Magnetic Resonance Imaging Contributes to the Accurate Diagnosis of Lupus Myocarditis.

Wei, Chia-Ling Helen / Lyu, Sin-Yi / Lu, Chun-Chi

The Journal of rheumatology

2023 Volume 50, Issue 3, Page(s) 456–457

MeSH term(s)	Humans ; Myocarditis ; Heart ; Magnetic Resonance Imaging ; Contrast Media ; Predictive Value of Tests
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-02-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.210647
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