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Article ; Online: Transcriptome and Gut Microbiota Profiling Analysis of ANIT-Induced Cholestasis and the Effects of Da-Huang-Xiao-Shi Decoction Intervention.

Wang, Wang / Jiang, Shujun / Xu, Chengcheng / Tang, Lili / Liang, Yan / Zhao, Yang / Zhu, Guoxue

2022 , Page(s) e0324222

Abstract: ... in seeking diagnosis and therapy. Da-Huang-Xiao-Shi decoction (DHXSD) is an ancient classic formula that has ...

Abstract	Cholestasis is characterized by bile acid (BA) circulation disorders, which is usually related to damage of hepatocyte barrier function. Currently, patients with cholestasis face several obstacles in seeking diagnosis and therapy. Da-Huang-Xiao-Shi decoction (DHXSD) is an ancient classic formula that has been used clinically for cholestasis treatment. Nevertheless, the underlying biological activities and therapeutic mechanisms remain unclear. In this study, an alpha-naphthylisothiocyanate (ANIT)-induced cholestasis rat model was established to examine the anticholestatic effects of DHXSD using histopathological and molecular analyses. Transcriptomic analysis combined with 16S rRNA gene sequencing analysis was systematically applied to study the mechanism of action of DHXSD. Simultaneously, the effect of DHXSD on gut microbiota, short-chain fatty acids (SCFAs), and intestinal barrier function were evaluated based on the ANIT-induced cholestasis model in rats. The results showed that DHXSD effectively attenuated ANIT-induced cholestasis by reducing liver function indicators (alanine transaminase [ALT],
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03242-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: UPLC-MS/MS for the Herb-Drug Interactions of Xiao-Ai-Ping Injection on Enasidenib in Rats Based on Pharmacokinetics.

Wang, Bo-Wen / Qiu, Cheng-Zheng / Tang, Chang-Qian / Zhang, Jia-Hui / Zhang, Yi / Du, Qi-Guang / Feng, Yi / Qiu, Xiang-Jun

BioMed research international

2021 Volume 2021, Page(s) 6636266

Abstract: ... the effect of Xiao-ai-ping injection (XAPI) on the pharmacokinetics of enasidenib in rats.: Methods ...

Abstract	Objective: To develop and validate a sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of enasidenib in rat plasma and to investigate the effect of Xiao-ai-ping injection (XAPI) on the pharmacokinetics of enasidenib in rats. Methods: The rat plasma was precipitated with acetonitrile, enasidenib and internal standard (IS) were separated on an Acquity UPLC BEH C18 column, and acetonitrile and 0.1% formic acid were used as the mobile phase in gradient mode. Enasidenib and IS were monitored and detected by multiple reaction monitoring (MRM) using tandem mass spectrometry in positive ion mode. 12 Sprague-Dawley (SD) rats were randomly divided into control group (group A) and experimental group (group B), 6 rats in each group. Group B was intramuscularly injected with XAPI (0.3 mL/kg) every morning, 7 days in a row. Group A was intramuscularly injected with normal saline, 7 days in a row. On the seventh day, enasidenib (10 mg/kg) was given to both groups 30 min after injection of normal saline (group A) or XAPI (group B), and the blood was collected at different time points such as 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 9, 12, 24, and 48 h. The concentration of enasidenib was detected by UPLC-MS/MS, and the main parameters of pharmacokinetic of enasidenib were calculated using the DAS 2.0 software. Results: Under the current experimental conditions, this UPLC method showed good linearity in the detection of enasidenib. Interday and intraday precision did not exceed 10%, the range of accuracy values were from -1.43% to 2.76%. The results of matrix effect, extraction recovery, and stability met the requirements of FDA approval guidelines of bioanalytical method validation. The Conclusion: An UPLC-MS/MS method for the determination of enasidenib in rat plasma was established. XAPI can inhibit the metabolism of enasidenib and increase the concentration of enasidenib in rats. It is suggested that when XAPI was combined with enasidenib, the herb-drug interaction and adverse reactions should be paid attention to, and the dosage should be adjusted if necessary.
MeSH term(s)	Aminopyridines/pharmacokinetics ; Aminopyridines/pharmacology ; Animals ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Herb-Drug Interactions ; Male ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry ; Triazines/pharmacokinetics ; Triazines/pharmacology
Chemical Substances	Aminopyridines ; Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Triazines ; enasidenib (3T1SS4E7AG)
Language	English
Publishing date	2021-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2021/6636266
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Integrated Pharmacology-Based Analysis for Antidepressant Mechanism of Chinese Herbal Formula Xiao-Yao-San.

Yuan, Naijun / Gong, Lian / Tang, Kairui / He, Liangliang / Hao, Wenzhi / Li, Xiaojuan / Ma, Qingyu / Chen, Jiaxu

Frontiers in pharmacology

2020 Volume 11, Page(s) 284

Abstract: ... anxiolytic effects of the herbal formula Xiao-Yao-San (XYS). However, the system mechanism of these effects has not ...

Abstract	Clinical studies and basic science experiments have widely demonstrated the antidepressant and anxiolytic effects of the herbal formula Xiao-Yao-San (XYS). However, the system mechanism of these effects has not been fully characterized. The present study conducted a comprehensive network pharmacological analysis of XYS and sorted all pharmacologically active components (149) through the TCMSP webserver. Then, all potential molecular targets (449) were predicted, of which there were 99 genes clearly related to depression. To further investigate the mechanism of antidepressant effects of XYS, a compound-depression targets (C-DTs) network was constructed, and Gene Ontology (GO) functional and KEGG pathway enrichment analyses were performed for the 99 targets. Enrichment results revealed that XYS could regulate multiple aspects of depression through these targets, related to metabolism, neuroendocrine function, and neuroimmunity. Prediction and analysis of protein-protein interactions resulted in selection of three hub genes (AKT1, TP53, and VEGFA). In addition, a total of seven ingredients from XYS could act on these hub genes and they were identified through ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS), including paeoniflorin, quercetin, luteolin, acacetin, aloe-emodin, Glyasperin C, kaempferol. Hereafter, we investigated the effects of paeoniflorin and its predicted target, the results suggest that it can reverse the neurotoxicity produced by CORT and could be a neuroprotective effect by promoting the phosphorylation of Akt. Overall, our research revealed the complicated antidepressant mechanism of XYS, and also provided a rational strategy for revealing the complex composition and function of Chinese herbal formula.
Language	English
Publishing date	2020-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00284
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: UPLC-MS/MS for the Herb-Drug Interactions of Xiao-Ai-Ping Injection on Enasidenib in Rats Based on Pharmacokinetics

Bo-wen Wang / Cheng-zheng Qiu / Chang-qian Tang / Jia-hui Zhang / Yi Zhang / Qi-guang Du / Yi Feng / Xiang-jun Qiu

BioMed Research International, Vol

2021 Volume 2021

Abstract: ... the effect of Xiao-ai-ping injection (XAPI) on the pharmacokinetics of enasidenib in rats. Methods. The rat ...

Abstract	Objective. To develop and validate a sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of enasidenib in rat plasma and to investigate the effect of Xiao-ai-ping injection (XAPI) on the pharmacokinetics of enasidenib in rats. Methods. The rat plasma was precipitated with acetonitrile, enasidenib and internal standard (IS) were separated on an Acquity UPLC BEH C18 column, and acetonitrile and 0.1% formic acid were used as the mobile phase in gradient mode. Enasidenib and IS were monitored and detected by multiple reaction monitoring (MRM) using tandem mass spectrometry in positive ion mode. 12 Sprague-Dawley (SD) rats were randomly divided into control group (group A) and experimental group (group B), 6 rats in each group. Group B was intramuscularly injected with XAPI (0.3 mL/kg) every morning, 7 days in a row. Group A was intramuscularly injected with normal saline, 7 days in a row. On the seventh day, enasidenib (10 mg/kg) was given to both groups 30 min after injection of normal saline (group A) or XAPI (group B), and the blood was collected at different time points such as 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 9, 12, 24, and 48 h. The concentration of enasidenib was detected by UPLC-MS/MS, and the main parameters of pharmacokinetic of enasidenib were calculated using the DAS 2.0 software. Results. Under the current experimental conditions, this UPLC method showed good linearity in the detection of enasidenib. Interday and intraday precision did not exceed 10%, the range of accuracy values were from -1.43% to 2.76%. The results of matrix effect, extraction recovery, and stability met the requirements of FDA approval guidelines of bioanalytical method validation. The Cmax of enasidenib in the group A and the group B was (458.87±136.02) ng/mL and (661.47±107.32) ng/mL, t1/2 was (7.74±0.91) h and (8.64±0.42) h, AUC0−t was (4067.24±1214.36) ng·h/mL and (5645.40±1046.30) ng·h/mL, AUC0−∞ was (4125.79±1235.91) ng·h/mL and (5759.61±1078.59) ng·h/mL, ...
Keywords	Medicine ; R
Subject code	630
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Zhongguo nue ji de kong zhi yu xiao chu

Tang, Linhua

Malaria control and elimination in China

2013

Title variant	Malaria control and elimination in China
Author's details	zhu bian Tang Linhua, Gao Qi
MeSH term(s)	Malaria/prevention & control
Keywords	China
Language	Chinese
Size	5, 197 pages :, illustrations
Edition	Di 1 ban.
Document type	Book
ISBN	9787547818114 ; 7547818110
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Renal protective effect of xiao-chai-hu-tang on diabetic nephropathy of type 1-diabetic mice.

Lin, Chun-Ching / Lin, Liang-Tzung / Yen, Ming-Hong / Cheng, Juei-Tang / Hsing, Chung-Hsi / Yeh, Ching-Hua

Evidence-based complementary and alternative medicine : eCAM

2012 Volume 2012, Page(s) 984024

Abstract: Xiao-Chai-Hu-Tang (XCHT), a traditional Chinese medicine formula consisting of seven ...

Abstract	Xiao-Chai-Hu-Tang (XCHT), a traditional Chinese medicine formula consisting of seven medicinal plants, is used in the treatment of various diseases. We show here that XCHT could protect type-1 diabetic mice against diabetic nephropathy, using streptozotocin (STZ)-induced diabetic mice and high-glucose (HG)-exposed rat mesangial cell (RMC) as models. Following 4 weeks of oral administration with XCHT, renal functions and renal hypertrophy significantly improved in the STZ-diabetic mice, while serum glucose was only moderately reduced compared to vehicle treatment. Treatment with XCHT in the STZ-diabetic mice and HG-exposed RMC resulted in a decrease in expression levels of TGF-β1, fibronectin, and collagen IV, with concomitant increase in BMP-7 expression. Data from DPPH assay, DHE stain, and CM-H(2)DCFDA analysis indicated that XCHT could scavenge free radicals and inhibit high-glucose-induced ROS in RMCs. Taken together, these results suggest that treatment with XCHT can improve renal functions in STZ-diabetic mice, an effect that is potentially mediated through decreasing oxidative stress and production of TGF-β1, fibronectin, and collagen IV in the kidney during development of diabetic nephropathy. XCHT, therefore merits further investigation for application to improve renal functions in diabetic disorders.
Language	English
Publishing date	2012-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2012/984024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Renal Protective Effect of Xiao-Chai-Hu-Tang on Diabetic Nephropathy of Type 1-Diabetic Mice

Chun-Ching Lin / Liang-Tzung Lin / Ming-Hong Yen / Juei-Tang Cheng / Chung-Hsi Hsing / Ching-Hua Yeh

Evidence-Based Complementary and Alternative Medicine, Vol

2012 Volume 2012

Abstract: Xiao-Chai-Hu-Tang (XCHT), a traditional Chinese medicine formula consisting of seven ...

Abstract	Xiao-Chai-Hu-Tang (XCHT), a traditional Chinese medicine formula consisting of seven medicinal plants, is used in the treatment of various diseases. We show here that XCHT could protect type-1 diabetic mice against diabetic nephropathy, using streptozotocin (STZ)-induced diabetic mice and high-glucose (HG)-exposed rat mesangial cell (RMC) as models. Following 4 weeks of oral administration with XCHT, renal functions and renal hypertrophy significantly improved in the STZ-diabetic mice, while serum glucose was only moderately reduced compared to vehicle treatment. Treatment with XCHT in the STZ-diabetic mice and HG-exposed RMC resulted in a decrease in expression levels of TGF-β1, fibronectin, and collagen IV, with concomitant increase in BMP-7 expression. Data from DPPH assay, DHE stain, and CM-H2DCFDA analysis indicated that XCHT could scavenge free radicals and inhibit high-glucose-induced ROS in RMCs. Taken together, these results suggest that treatment with XCHT can improve renal functions in STZ-diabetic mice, an effect that is potentially mediated through decreasing oxidative stress and production of TGF-β1, fibronectin, and collagen IV in the kidney during development of diabetic nephropathy. XCHT, therefore merits further investigation for application to improve renal functions in diabetic disorders.
Keywords	Other systems of medicine ; RZ201-999
Subject code	616 ; 630
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Zhong guo dang dai tong su xiao shuo shi lun

Tang, Zhesheng

(21 shi ji chuang xin xi lie jiao cai)

2007

Title variant	Zhongguo dangdai tongsu xiaoshuo shilun
Author's details	Tang zhe sheng zhu bian
Series title	21 shi ji chuang xin xi lie jiao cai
Language	Chinese
Size	6, 413 p, 23 cm
Edition	Di 1 ban
Publisher	Bei jing da xue chu ban she
Publishing place	Bei jing
Document type	Book
Note	Includes bibliographical references
ISBN	7301111983 ; 9787301111987
Database	Former special subject collection: coastal and deep sea fishing

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Article: Determination and pharmacokinetic comparison of rhein in rats after oral dosed with Da-Cheng-Qi decoction and Xiao-Cheng-Qi decoction.

Tang, Wen-Fu / Huang, Xi / Yu, Qin / Qin, Feng / Wan, Mei-Hua / Wang, Yong-Gang / Liang, Mao-Zhi

Biomedical chromatography : BMC

2007 Volume 21, Issue 11, Page(s) 1186–1190

Abstract: Da-Cheng-Qi decoction (DCQD) is composed of dahuang, houpu, zhishi and mangxiao, while Xiao-Cheng ...

Abstract	Da-Cheng-Qi decoction (DCQD) is composed of dahuang, houpu, zhishi and mangxiao, while Xiao-Cheng-Qi decoction (XCQD) just contains dahuang, houpu, and zhishi. A validated high-performance liquid chromatographic (HPLC) method was developed for the determination and pharmacokinetic comparison of rhein in rats. It was performed on a reversed-phase C(18) column (150 x 4.6 mm) with a mobile phase of methanol and 0.2% acetic acid (89:11, v/v) and ultraviolet detection at 254 nm. The assay was linear over the range 30-3000 ng/mL (r(2) = 0.9991), with mean percentage recovery of 101.4%. The RSD of intra- and inter-day precision were less than 3.0%, with accuracy in the range 96.8-102.5% for each of the concentrations tested. Following oral administration, rhein plasma levels revealed curves characterized by peaks at 20.5 and 30.1 min corresponding to dosages of 15 mg/kg (XCQD) and 20 mg/kg (DCQD) at mean concentrations of 1184.67 and 1814.27 ng/mL, respectively. The half-lives of rhein from XCQD and DCQD were 45.3 and 139.6 min, respectively. AUC(0-12h) of rhein after oral dosage with XCQD and DCQD were 3435.68 and 5382.25 microg/L h, respectively. The pharmacokinetic parameters may be used to guide the clinical prescription compatibility of traditional Chinese prescriptions related to dahuang and mangxiao.
MeSH term(s)	Administration, Oral ; Animals ; Anthraquinones/administration & dosage ; Anthraquinones/blood ; Anthraquinones/chemistry ; Calibration ; Chromatography, High Pressure Liquid/methods ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacokinetics ; Male ; Molecular Structure ; Plant Extracts/administration & dosage ; Plant Extracts/blood ; Plant Extracts/chemistry ; Rats ; Rats, Sprague-Dawley ; Reference Standards ; Reproducibility of Results ; Sensitivity and Specificity ; Specimen Handling ; Spectrophotometry, Ultraviolet/methods
Chemical Substances	Anthraquinones ; Drugs, Chinese Herbal ; Plant Extracts ; rhein (YM64C2P6UX)
Language	English
Publishing date	2007-11
Publishing country	England
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.873
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2166: Show issues

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Book ; Online: 'Eyes', 'Brain', 'Feet' and 'Hands' of Efficient Harvesting Machinery

Shen, Cheng / Tang, Zhong / Xiao, Maohua

2023

Keywords	Research & information: general ; Biology, life sciences ; Technology, engineering, agriculture ; harvester, efficient harvesting, harvester chassis, intelligent agricultural equipment, smart agriculture, image recognition, navigation, decision and control algorithms
Language	English
Size	1 electronic resource (414 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030646139
ISBN	9783036592138 ; 303659213X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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