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  1. Article: Editorial: Breast milk and passive immunity during the COVID-19 pandemic.

    Demers-Mathieu, Veronique

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1155901

    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1155901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Optimal Selection of IFN-α-Inducible Genes to Determine Type I Interferon Signature Improves the Diagnosis of Systemic Lupus Erythematosus.

    Demers-Mathieu, Veronique

    Biomedicines

    2023  Volume 11, Issue 3

    Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies specific to self-molecules in the nucleus, cytoplasm, and cell surface. The diversity of serologic and clinical manifestations observed ... ...

    Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies specific to self-molecules in the nucleus, cytoplasm, and cell surface. The diversity of serologic and clinical manifestations observed in SLE patients challenges the development of diagnostics and tools for monitoring disease activity. Elevated type I interferon signature (IFN- I) in SLE leads to dysregulation of innate and adaptive immune function, resulting in autoantibodies production. The most common method to determine IFN-I signature is measuring the gene expression of several IFN-α-inducible genes (IFIGs) in blood samples and calculating a score. Optimal selection of IFIGs improves the sensitivity, specificity, and accuracy of the diagnosis of SLE. We describe the mechanisms of the immunopathogenesis of IFN-I signature (IFNα production) and its clinical consequences in SLE. In addition, we explore the association between IFN-I signature, the presence of autoantibodies, disease activity, medical therapy, and ethnicity. We discuss the presence of IFN-I signature in some patients with other autoimmune diseases, including rheumatoid arthritis, systemic and multiple sclerosis, Sjogren's syndrome, and dermatomyositis. Prospective studies are required to assess the role of IFIG and the best combination of IFIGs to monitor SLE disease activity and drug treatments.
    Language English
    Publishing date 2023-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11030864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimal Selection of IFN-α-Inducible Genes to Determine Type I Interferon Signature Improves the Diagnosis of Systemic Lupus Erythematosus

    Veronique Demers-Mathieu

    Biomedicines, Vol 11, Iss 864, p

    2023  Volume 864

    Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies specific to self-molecules in the nucleus, cytoplasm, and cell surface. The diversity of serologic and clinical manifestations observed ... ...

    Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies specific to self-molecules in the nucleus, cytoplasm, and cell surface. The diversity of serologic and clinical manifestations observed in SLE patients challenges the development of diagnostics and tools for monitoring disease activity. Elevated type I interferon signature (IFN- I) in SLE leads to dysregulation of innate and adaptive immune function, resulting in autoantibodies production. The most common method to determine IFN-I signature is measuring the gene expression of several IFN-α-inducible genes (IFIGs) in blood samples and calculating a score. Optimal selection of IFIGs improves the sensitivity, specificity, and accuracy of the diagnosis of SLE. We describe the mechanisms of the immunopathogenesis of IFN-I signature (IFNα production) and its clinical consequences in SLE. In addition, we explore the association between IFN-I signature, the presence of autoantibodies, disease activity, medical therapy, and ethnicity. We discuss the presence of IFN-I signature in some patients with other autoimmune diseases, including rheumatoid arthritis, systemic and multiple sclerosis, Sjogren’s syndrome, and dermatomyositis. Prospective studies are required to assess the role of IFIG and the best combination of IFIGs to monitor SLE disease activity and drug treatments.
    Keywords IFNα ; autoimmune disease ; IFN-α-inducible genes ; diagnostics ; monitoring disease activity ; autoantibodies ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Restricting Cow's Milk in the Maternal Diet Reduces the Titers of β-Lactoglobulin-Specific IgG Antibodies in Human Milk.

    Demers-Mathieu, Veronique / Lavangnananda, Sirima

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2022  Volume 17, Issue 6, Page(s) 501–505

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Allergens ; Animals ; Breast Feeding ; Cattle ; Diet ; Female ; Humans ; Immunoglobulin A/analysis ; Immunoglobulin A, Secretory ; Immunoglobulin G/analysis ; Immunoglobulin M/analysis ; Infant ; Lactoglobulins ; Milk/chemistry ; Milk Hypersensitivity ; Milk, Human/chemistry
    Chemical Substances Allergens ; Immunoglobulin A ; Immunoglobulin A, Secretory ; Immunoglobulin G ; Immunoglobulin M ; Lactoglobulins
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2021.0242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Premature delivery impacts the concentration of plasminogen activators and a plasminogen activator inhibitor and the plasmin activity in human milk.

    Demers-Mathieu, Veronique / Underwood, Mark A / Dallas, David C

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 917179

    Abstract: Background and aims: Plasmin in human milk partially hydrolyzes milk proteins within the mammary gland and may enhance the hydrolysis of milk proteins within the infant's stomach. This study examined the effects of extremely preterm (EP)-, very preterm ( ...

    Abstract Background and aims: Plasmin in human milk partially hydrolyzes milk proteins within the mammary gland and may enhance the hydrolysis of milk proteins within the infant's stomach. This study examined the effects of extremely preterm (EP)-, very preterm (VP)-, and term-delivery on plasmin activity and the concentrations of plasminogen activators [urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA)], plasminogen activator inhibitor type 1 (PAI-1) and the complexes of PAI-1/uPA and PAI-1/tPA in human milk.
    Materials and methods: Human milk samples were collected from mothers who delivered extremely preterm infants [24-27 weeks gestational age (GA),
    Results: Plasmin activity, uPA and tPA were detected in all human milk samples, PAI-1 and the PAI-1/uPA complex were present in 42.5 and 32.5% of milk samples, respectively, and the PAI-1/tPA complex was not detected. Plasmin activity was correlated negatively with postnatal age and postmenstrual age (PMA) in the VP group and positively with postnatal age in the term group. uPA and tPA concentrations decreased with increasing postnatal age in both EP and VP groups but did not correlate in the term group. uPA concentration was correlated positively with GA in the VP group and tended to be elevated with increasing GA in the combined three groups. In contrast, tPA concentrations were correlated negatively with GA and PMA in the combined three groups (
    Conclusion: Premature delivery impacted the plasmin activity and the concentrations of uPA, tPA, and PAI-1 in human milk. Whether these changes in milk plasminogen activators and inhibitors have a role in balancing the proteolytic digestion of premature infants remains to be investigated.
    Language English
    Publishing date 2022-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.917179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Influenza Vaccine Associated with the Gene Expression of T Cell Surface Markers in Human Milk.

    Demers-Mathieu, Veronique / DaPra, Ciera / Medo, Elena

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2021  Volume 17, Issue 3, Page(s) 218–225

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Breast Feeding ; Cytokines/genetics ; Cytokines/metabolism ; Female ; Gene Expression ; Humans ; Infant ; Infant, Newborn ; Influenza Vaccines ; Lactation ; Male ; Milk, Human ; Receptors, CCR7 ; T-Lymphocytes/metabolism
    Chemical Substances Cytokines ; Influenza Vaccines ; Receptors, CCR7
    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2021.0186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Influence of Vitamin D3 Levels and T Cell-Related Cytokines in Human Milk on Coronavirus Disease 2019 Infection in Lactating Women.

    Demers-Mathieu, Veronique / Lavangnananda, Sirima / Medo, Elena

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2021  Volume 16, Issue 12, Page(s) 995–1003

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Breast Feeding ; COVID-19 ; Cholecalciferol ; Cytokines ; Female ; Humans ; Infant ; Lactation ; Milk, Human ; Pregnancy ; SARS-CoV-2 ; T-Lymphocytes
    Chemical Substances Cytokines ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2021.0170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies' Binding Capacity Between Human Milk and Serum from Coronavirus Disease 2019-Recovered Women.

    Demers-Mathieu, Veronique / DaPra, Ciera / Medo, Elena

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2021  Volume 16, Issue 5, Page(s) 393–401

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Antibodies, Viral/immunology ; Breast Feeding ; COVID-19/therapy ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunization, Passive ; Immunoglobulin G ; Infant, Newborn ; Milk, Human/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2020.0381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Receptor-binding Domain Severe Acute Respiratory Syndrome Coronavirus 2-specific Antibodies in Human Milk From Mothers With Coronavirus Disease 2019 Polymerase Chain Reaction or With Symptoms Suggestive of Coronavirus Disease 2019.

    Demers-Mathieu, Veronique / DaPra, Ciera / Fels, Shawn / Medo, Elena

    Journal of pediatric gastroenterology and nutrition

    2021  Volume 73, Issue 1, Page(s) 125–128

    Abstract: Abstract: This study aims to compare the receptor-binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody titers in human milk between mothers with a confirmed coronavirus disease 2019 (COVID-19) polymerase ... ...

    Abstract Abstract: This study aims to compare the receptor-binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody titers in human milk between mothers with a confirmed coronavirus disease 2019 (COVID-19) polymerase chain reaction (PCR) test and mothers with viral symptoms suggestive of COVID-19. The area under the curve (AUC) for RBD SARS-CoV-2-specific secretory immunoglobulin A (SIgA)/immunoglobulin A (IgA), secretory immunoglobulin M (SIgM)/immunoglobulin M (IgM), immunoglobulin G (IgG), and free secretory components (fSC) in milk samples from eight mothers with a confirmed COVID-19 PCR, eight mothers with viral symptoms (no PCR testing), and six unexposed mothers (pre-pandemic 2018). AUCs of RBD SARS-CoV-2-specific SIgA/IgA, SIgM/IgM, IgG, and fSC in milk samples were comparable between mothers with confirmed COVID-19 PCR and mothers with viral symptoms of suggestive COVID-19. AUCs of RBD-specific SIgA/IgA, IgG, and fSC were higher in the COVID-19-exposed group than in the unexposed group, and SIgM/IgM tended to be higher in the exposed mothers. In conclusion, women with viral symptoms suggestive of COVID-19 could secrete antibodies and fSC specific to SARS-CoV-2 in human milk.
    MeSH term(s) Antibodies, Viral/analysis ; COVID-19 ; Female ; Humans ; Immunoglobulin M ; Milk, Human/immunology ; Mothers ; Polymerase Chain Reaction ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin M
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000003158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1728: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Cytokine Expression by Human Macrophage-Like Cells Derived from the Monocytic Cell Line THP-1 Differs Between Treatment With Milk from Preterm- and Term-Delivering Mothers and Pasteurized Donor Milk.

    Demers-Mathieu, Veronique / Huston, Robert K / Dallas, David C

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 10

    Abstract: Immunomodulatory proteins from human milk may enhance the protection and development of the infant's gut. This study compared the immunomodulatory effects of treatment with milk from preterm-(PM) and term-delivering (TM) mothers and pasteurized donor ... ...

    Abstract Immunomodulatory proteins from human milk may enhance the protection and development of the infant's gut. This study compared the immunomodulatory effects of treatment with milk from preterm-(PM) and term-delivering (TM) mothers and pasteurized donor milk (DM) on cytokine gene expression in human macrophage-like cells derived from the monocytic cell line THP-1. The gene expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-12 (p40), IL-10 and GAPDH in macrophages treated with PM, TM and DM at steady and activated (inflammatory) states were measured using real-time reverse transcription-polymerase chain reaction. TNF-α and IL-6 in macrophages (both states) with DM were higher than PM or TM. IL-10 in steady state macrophages with DM was higher than PM whereas DM increased IL-10 in activated macrophages compared with TM. TM increased IL-6 and IL-12 (p40) in steady state macrophages compared with PM. IL-12 (p40) in activated macrophages with TM was higher than PM. IL-10 in steady state macrophages with TM was higher than PM. These results suggest that DM induces higher gene expression of pro-inflammatory and anti-inflammatory cytokines in macrophages compared with PM or TM. PM reduced gene expression of pro-inflammatory cytokines compared with TM, which may decrease the development of necrotizing enterocolitis and systematic inflammation.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/immunology ; Anti-Inflammatory Agents/pharmacology ; Cytokines/genetics ; Enterocolitis/immunology ; Enterocolitis/prevention & control ; Female ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/genetics ; Humans ; Infant ; Infant, Newborn ; Infant, Premature/immunology ; Infant, Premature/metabolism ; Inflammation/immunology ; Inflammation/prevention & control ; Interleukin-10/genetics ; Interleukin-12/genetics ; Interleukin-6/genetics ; Macrophages/drug effects ; Macrophages/immunology ; Milk Proteins/immunology ; Milk Proteins/pharmacology ; Milk, Human/immunology ; Milk, Human/metabolism ; Monocytes/drug effects ; Monocytes/metabolism ; Term Birth/metabolism ; Tumor Necrosis Factor-alpha/genetics
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Interleukin-6 ; Milk Proteins ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; Interleukin-12 (187348-17-0) ; GAPDH protein, human (EC 1.2.1.12) ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) (EC 1.2.1.12)
    Language English
    Publishing date 2020-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25102376
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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