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  1. Article: Prediction of habitat suitability of Morina persica L. species using artificial intelligence techniques

    Ghareghan, Fateme / Ghanbarian, Gholamabbas / Pourghasemi, Hamid Reza / Safaeian, Roja

    Ecological indicators. 2020 May, v. 112

    2020  

    Abstract: The Morina genus has 13 species in the world, out of which only M. persica L. is found to be ...

    Abstract The Morina genus has 13 species in the world, out of which only M. persica L. is found to be growing wild in Iran. The aim of this research is to predict the spatial distribution and model the habitat suitability for M. persica species using four data mining models: maximum entropy (MaxEnt), support vector machine (SVM), generalized linear model (GLM), and boosted regression trees (BRT). A total of 404 M. persica locations were identified during extensive field surveys, and their geographical locations were recorded using a global positioning system (GPS) device. Furthermore, seventeen environmental predictors including topographical, geological, climatic, and edaphic factors were selected, and their thematic layers were mapped in ArcGIS. Lastly, habitat suitability was modeled using data mining techniques. The validity of the results was assessed using the area under the receiver operating characteristic curve (AUROC). Moreover, three cutoff-dependent metrics, Cohen’s kappa, sensitivity, and specificity, were used for more scrutinized performance assessment. The results revealed that the highest effects on M. persica distribution were mostly associated with edaphic factors, followed by climatic, lithological, and topographical factors. The results showed that MaxEnt with an AUROC value of 95% showed an outstanding performance in terms of prediction power and generalization capacity, followed by SVM (94.1%), GLM (87.4%), and BRT (84.7%). Comparing the AUROC values, MaxEnt was selected as the premier model with the best performance for M. persica distribution modelling across the study area. Cutoff-dependent metrics were also in line with AUROC values; however, the latter made a more discernible distinction between the performance of SVM and MaxEnt. The GLM, BRT, SVM, and MaxEnt models classified 37.37%, 27.28%, 23.31%, and 6.51% of the study area as high and very high suitable habitats for M. persica, respectively. The inferences of this research would be of interest to authorities in the natural resources sector, the research community, local stakeholders, and biodiversity conservation agencies for use in conserving and reclaiming M. persica habitats in the study area.
    Keywords Morina persica ; biodiversity conservation ; habitats ; linear models ; prediction ; stakeholders ; support vector machines ; Iran
    Language English
    Dates of publication 2020-05
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2036774-0
    ISSN 1872-7034 ; 1470-160X
    ISSN (online) 1872-7034
    ISSN 1470-160X
    DOI 10.1016/j.ecolind.2020.106096
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Protective effects of protocatechuic acid against doxorubicin- and arsenic trioxide-induced toxicity in cardiomyocytes.

    Shafiee, Fatemeh / Safaeian, Leila / Gorbani, Fatemeh

    Research in pharmaceutical sciences

    2023  Volume 18, Issue 2, Page(s) 149–158

    Abstract: Background and purpose: Some chemotherapeutic drugs are associated with an increased risk of cardiotoxicity in patients. Protocatechuic acid (PCA) is a phenolic acid with valuable cardiovascular, chemo-preventive, and anticancer activities. Recent ... ...

    Abstract Background and purpose: Some chemotherapeutic drugs are associated with an increased risk of cardiotoxicity in patients. Protocatechuic acid (PCA) is a phenolic acid with valuable cardiovascular, chemo-preventive, and anticancer activities. Recent studies have shown the cardioprotective effects of PCA in several pathological conditions. This investigation aimed to assess the possible protective effects of PCA on cardiomyocytes against toxicities caused by anti-neoplastic agents, doxorubicin (DOX), and arsenic trioxide (ATO).
    Experimental approach: H9C2 cells were exposed to DOX (1 μM) or ATO (35 μM) after 24 h pretreatment with PCA (1-100 μM). MTT and lactate dehydrogenase (LDH) tests were used to define cell viability or cytotoxicity. Total oxidant and antioxidant capacities were evaluated by measuring hydroperoxides and ferric-reducing antioxidant power (FRAP) levels. Expression of the TLR4 gene was also quantitatively estimated by real-time polymerase chain reaction.
    Findings/results: PCA showed a proliferative effect on cardiomyocytes and significantly enhanced cell viability and reduced cytotoxicity of DOX and ATO during MTT and LDH assays. Pretreatment of cardiomyocytes with PCA significantly decreased hydroperoxide levels and elevated FRAP value. Moreover, PCA meaningfully decreased TLR4 expression in DOX-and ATO-treated cardiomyocytes.
    Conclusions and implications: In conclusion, antioxidant and cytoprotective activities were found for PCA versus toxicities caused by DOX and ATO in cardiomyocytes. However, further
    Language English
    Publishing date 2023-01-19
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2400156-9
    ISSN 1735-9414 ; 1735-5362
    ISSN (online) 1735-9414
    ISSN 1735-5362
    DOI 10.4103/1735-5362.367794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Andrographolide protects against doxorubicin-and arsenic trioxide-induced toxicity in cardiomyocytes

    Safaeian, Leila / Shafiee, Fatemeh / Haghighatnazar, Samira

    Mol Biol Rep. 2023 Jan., v. 50, no. 1 p.389-397

    2023  

    Abstract: BACKGROUND: Andrographolide (AG) is a lactone diterpene with valuable biological activities. This in vitro study evaluated whether AG can protect cardiomyocytes under toxicities triggered with anti-cancer chemotherapeutic agents, doxorubicin (DOX) and ... ...

    Abstract BACKGROUND: Andrographolide (AG) is a lactone diterpene with valuable biological activities. This in vitro study evaluated whether AG can protect cardiomyocytes under toxicities triggered with anti-cancer chemotherapeutic agents, doxorubicin (DOX) and arsenic trioxide (ATO). METHODS AND RESULTS: H9C2 cells were pretreated with AG (0.5–10 µM) for 24 h and then exposed to DOX (1 μM) or ATO (35 μM) for another 24 h period. For determination of cell viability or cytotoxicity, MTT and lactate dehydrogenase (LDH) assay were used. Total oxidant and antioxidant capacities were estimated by determining hydroperoxides and ferric reducing antioxidant power (FRAP) levels. Real time-polymerase chain reaction was also used for quantitative evaluation of TLR4 gene expression. AG inhibited cardiomyocytes proliferation at the concentrations of more than 20 μM. However, it considerably enhanced cell viability and decreased cytotoxicity of DOX and ATO at the concentration range of 2.5–10 μM in MTT and LDH assays. AG significantly declined hydroperoxides concentration in ATO-treated cardiomyocytes and raised FRAP value in DOX- and ATO-treated cells. Furthermore, AG notably lessened TLR4 expression in H9C2 cells after exposure to DOX- and ATO. CONCLUSION: In conclusion, these data presented that AG was able to reverse DOX- and ATO-induced cardiotoxicity in vitro. The cardiomyocyte protective activities of AG may be due to the decrease in TLR4 expression and total oxidant capacity and increase in total antioxidant capacity.
    Keywords andrographolide ; antioxidant activity ; arsenic ; arsenic oxide ; cardiomyocytes ; cardiotoxicity ; cell viability ; cytotoxicity ; doxorubicin ; drug therapy ; gene expression ; hydroperoxides ; lactate dehydrogenase ; oxidants ; quantitative analysis
    Language English
    Dates of publication 2023-01
    Size p. 389-397.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-08042-4
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Pramlintide: An Amylin Analogue Protects Endothelial Cells against Oxidative Stress through Regulating Oxidative Markers and NF-κb Expression.

    Safaeian, Leila / Shafiee, Fatemeh / Naderi, Marzieh

    International journal of preventive medicine

    2022  Volume 13, Page(s) 20

    Abstract: Background: Oxidative stress has a prominent role in the pathogenesis of diabetes complications. Pramlintide is an injectional amylin analogue used for the treatment of type 1 and type 2 diabetic patients. The present investigation evaluated the effect ... ...

    Abstract Background: Oxidative stress has a prominent role in the pathogenesis of diabetes complications. Pramlintide is an injectional amylin analogue used for the treatment of type 1 and type 2 diabetic patients. The present investigation evaluated the effect of pramlintide against oxidative damage induced by hydrogen peroxide (H
    Methods: Cell viability was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Hydroperoxides level, ferric reducing antioxidant power (FRAP), and expression of transcription factor NF-κB were measured in HUVECs that pretreated with pramlintide and, then exposed to H
    Results: Pramlintide significantly decreased the cytotoxicity caused by H
    Conclusions: Findings of the current investigation displayed that pramlintide may act as a protective against oxidative conditions in endothelial cells through modulation of oxidative markers and transcription factor NF-κB.
    Language English
    Publishing date 2022-02-08
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2574680-7
    ISSN 2008-8213 ; 2008-7802
    ISSN (online) 2008-8213
    ISSN 2008-7802
    DOI 10.4103/ijpvm.IJPVM_425_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Andrographolide protects against doxorubicin-and arsenic trioxide-induced toxicity in cardiomyocytes.

    Safaeian, Leila / Shafiee, Fatemeh / Haghighatnazar, Samira

    Molecular biology reports

    2022  Volume 50, Issue 1, Page(s) 389–397

    Abstract: Background: Andrographolide (AG) is a lactone diterpene with valuable biological activities. This in vitro study evaluated whether AG can protect cardiomyocytes under toxicities triggered with anti-cancer chemotherapeutic agents, doxorubicin (DOX) and ... ...

    Abstract Background: Andrographolide (AG) is a lactone diterpene with valuable biological activities. This in vitro study evaluated whether AG can protect cardiomyocytes under toxicities triggered with anti-cancer chemotherapeutic agents, doxorubicin (DOX) and arsenic trioxide (ATO).
    Methods and results: H9C2 cells were pretreated with AG (0.5-10 µM) for 24 h and then exposed to DOX (1 μM) or ATO (35 μM) for another 24 h period. For determination of cell viability or cytotoxicity, MTT and lactate dehydrogenase (LDH) assay were used. Total oxidant and antioxidant capacities were estimated by determining hydroperoxides and ferric reducing antioxidant power (FRAP) levels. Real time-polymerase chain reaction was also used for quantitative evaluation of TLR4 gene expression. AG inhibited cardiomyocytes proliferation at the concentrations of more than 20 μM. However, it considerably enhanced cell viability and decreased cytotoxicity of DOX and ATO at the concentration range of 2.5-10 μM in MTT and LDH assays. AG significantly declined hydroperoxides concentration in ATO-treated cardiomyocytes and raised FRAP value in DOX- and ATO-treated cells. Furthermore, AG notably lessened TLR4 expression in H9C2 cells after exposure to DOX- and ATO.
    Conclusion: In conclusion, these data presented that AG was able to reverse DOX- and ATO-induced cardiotoxicity in vitro. The cardiomyocyte protective activities of AG may be due to the decrease in TLR4 expression and total oxidant capacity and increase in total antioxidant capacity.
    MeSH term(s) Arsenic Trioxide/pharmacology ; Myocytes, Cardiac/metabolism ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Toll-Like Receptor 4/metabolism ; Cell Line ; Doxorubicin/toxicity ; Diterpenes/pharmacology ; Diterpenes/metabolism ; Oxidants/metabolism ; Apoptosis ; Reactive Oxygen Species/metabolism ; Oxidative Stress
    Chemical Substances Arsenic Trioxide (S7V92P67HO) ; andrographolide (410105JHGR) ; Antioxidants ; Toll-Like Receptor 4 ; Doxorubicin (80168379AG) ; Diterpenes ; Oxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2022-11-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-08042-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Study of chemical compositions of the essential oils of aerial parts of Prangos ferulacea (L.) lindly in growing stage in the North of Fars Province

    Safaeian, R / Amin, G / Azarnivand, H

    Acta horticulturae. 2012 Oct., , no. 964

    2012  

    Abstract: There is a direct relation between the essential oils, that are produced and restored by the different plant species, and the biosynthesis, metabolism and biological activities of the plant, which depend on the ecological-climatic conditions of the plant` ...

    Abstract There is a direct relation between the essential oils, that are produced and restored by the different plant species, and the biosynthesis, metabolism and biological activities of the plant, which depend on the ecological-climatic conditions of the plant`s environment. The differences between chemical compositions of the essential oils caused a specific function of the plants in ethno-botany. Prangos (Umbelliferae family) is one of these plants. In Zagros Mountain, the livestock avoided grazing Prangos ferulacea in the growing stage while ethno-botany realizes the dried form of the plant is the best feed for livestock. The goal of the present research is to realize the changes that occur in the chemical compositions of Prangos ferulacea essential oils in green and dried forms in Eghlid Mountain, north of Fars province. The aerial parts of Prangos ferulacea were collected and dried in the growing stage (April). The collected green and dried samples were extracted by hydro-distillation method. The yield of essential oils in growing stage was 1.9% for green form and 2.1% for dried form. The chemical compositions of essential oils were analyzed by GC and GC/MS and recognized by reliable references. 47 compounds constituting 92.3% of dried form oil and 38 compounds constituting 95.76% of green form oil in the growing stage were identified. The main and common components of essential aerial oils of the plant in green and dried form were as follows: terpinolene (56.3-38.1%), α-terpinene (2.25-1.6%), caryophyllene < (E)- > (4.7-3.6%), bornyl acetate (2.96-1.8%). As it was predicted the results showed that some harmful components such as alpha- and beta-pinnene, myrcen and δ-3-carene were absent and the amount of terpinolene, β-phellandrene, isopentyl isovalerate and bornyl acetate were decreased in dried form.
    Keywords Prangos ; aerial parts ; beta-phellandrene ; biosynthesis ; bornyl acetate ; carene ; chemical composition ; essential oils ; grazing ; livestock ; livestock feeds ; plant fats and oils ; terpinolene
    Language English
    Size p. 71-76.
    Publishing place International Society for Horticultural Science
    Document type Article
    Note Paper presented at the International Symposium on Medicinal and Aromatics Plants IMAPS 2010, held June 21-24, 2010, Shiraz, Iran and "History of Mayan Ethnopharmacology" IMAPS 2011, held November 20-23, 2011, Antigua Guatemala, Guatemala.
    ISSN 0567-7572
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Water Extract of Juglans Regia L. And Diabetes Mellitus in Iranian Traditional Medicine

    Sarahroodi S. / Rasekh H.R. / Kamali-Nejad M. / Safaeian L.

    Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 3, Iss 3, Pp 19-

    2009  Volume 24

    Abstract: ... effect of septum water extract of Juglans Regia L. In the present study, effect of aqueous extract ... of the septum of Juglans Regia L. on plasma glucose is assessed. Methods: After preparing the water extract ... of Juglans Regia L. and concentrating of it the lyophilized extract, was tested in diabetic (ip injection ...

    Abstract AbstractBackground and Objectives: There are many reports about the glucose lowering effects of medicinal plants in animal models. There are a some reports in Iranian traditional medicine about glucose lowering effect of septum water extract of Juglans Regia L. In the present study, effect of aqueous extract of the septum of Juglans Regia L. on plasma glucose is assessed. Methods: After preparing the water extract of Juglans Regia L. and concentrating of it the lyophilized extract, was tested in diabetic (ip injection of streptozocin) and normal rats. Comparison between groups was made by analysis of variance (ANOVA) and the differences between the means assessed using student’s t test. Results: In an oral glucose tolerance test (OGGT), a single oral administration of the water extract at doses of 50, 250 and 750 mg/kg body weight didn’t lowered the plasma glucose level in the normal rats. Although that insulin administration (5IU/kg) caused a reduction of serum glucose(P<0.001), none of the extract doses (1000, 750, 500, 250mg/Kg) could cause a significant reduction in such level (P>0.005). Conclusion: These results demonstrated that the water extract of the septum of Juglans regia's fruit didn’t have a significant hypoglycemic effect in rats.Keywords: Diabetes Mellitus; Juglans Regia L.; Rat.
    Keywords Diabetes Mellitus ; Juglans Regia L ; Rat ; Medicine (General) ; R5-920
    Language Persian
    Publishing date 2009-11-01T00:00:00Z
    Publisher Qom University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Utility of Urine N-acetyl-β-D-glucosaminidase for Prediction of Renal Damage in Obese Children.

    Safaeian, Baranak / Nickavar, Azar / Zaeri, Hossein / Lahootian, Lida / Behnampour, Nasser

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2022  Volume 32, Issue 3, Page(s) 699–702

    Abstract: The incidence of obesity has increased globally in children and adults. In addition, renal dysfunction is an important complication of childhood obesity. This study was performed to identify the diagnostic value of N-acetyl-β-D-glucosaminidase (NAG), a ... ...

    Abstract The incidence of obesity has increased globally in children and adults. In addition, renal dysfunction is an important complication of childhood obesity. This study was performed to identify the diagnostic value of N-acetyl-β-D-glucosaminidase (NAG), a renal injury marker, for the early determination of renal damage in childhood obesity. Totally, 115 obese children and 115 healthy normal weight controls were enrolled in a cross-sectional case-control study. Urine NAG was measured in sample urine and normalized by urine creatinine (CR). In addition, correlation of urine NAG with other variables such as blood pressure (BP), blood glucose, and urine albumin was evaluated. Mean systolic BP (P <0.001), serum glucose (P = 0.047), urine albumin/Cr (P = 0.049), and urine NAG/Cr (P = 0.037) were significantly higher in obese children, compared with normal healthy controls. There was no correlation between urine NAG and urine albumin excretion. Urinary NAG/Cr was a simple and safe screening test for early determination of renal damage in children with obesity.
    MeSH term(s) Acetylglucosaminidase/urine ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/urine ; Adolescent ; Albuminuria/urine ; Biomarkers/urine ; Body Weight/physiology ; Case-Control Studies ; Child ; Child, Preschool ; Creatinine/urine ; Cross-Sectional Studies ; Humans ; Pediatric Obesity/complications ; Pediatric Obesity/diagnosis
    Chemical Substances Biomarkers ; Creatinine (AYI8EX34EU) ; Acetylglucosaminidase (EC 3.2.1.52)
    Language English
    Publishing date 2022-02-10
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    DOI 10.4103/1319-2442.336764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: In vivo

    Ahmadipour, Saeedeh / Varshosaz, Jaleh / Hashemibeni, Batool / Manshaei, Maziar / Safaeian, Leila

    Drug development and industrial pharmacy

    2022  Volume 48, Issue 3, Page(s) 98–108

    Abstract: Background: Gellan gum is obtained from the bacterium : Methods: The femur of rats was defected by creating a 2 × 5 mm: Results: Healing of the bone defects and bone densitometry in the treated group by calcitonin-loaded scaffold was significantly ...

    Abstract Background: Gellan gum is obtained from the bacterium
    Methods: The femur of rats was defected by creating a 2 × 5 mm
    Results: Healing of the bone defects and bone densitometry in the treated group by calcitonin-loaded scaffold was significantly higher (
    Conclusions: Gellan gum-based scaffold loaded with calcitonin may be considered a promising local treatment to progress bone formation in repairing skeletal injuries.
    MeSH term(s) Animals ; Bone Regeneration ; Calcitonin/pharmacology ; Calcium/pharmacology ; Durapatite ; Nanocomposites ; Platelet-Rich Plasma ; Rats ; Tissue Engineering/methods ; Tissue Scaffolds
    Chemical Substances Calcitonin (9007-12-9) ; Durapatite (91D9GV0Z28) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 751874-2
    ISSN 1520-5762 ; 0363-9045
    ISSN (online) 1520-5762
    ISSN 0363-9045
    DOI 10.1080/03639045.2022.2087080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: New cut-off point for D-dimer in the diagnosis of pulmonary embolism during pregnancy.

    Sadeghi, Somayeh / Golshani, Marjan / Safaeian, Bahareh

    Blood research

    2021  Volume 56, Issue 3, Page(s) 150–155

    Abstract: ... scans.: Results: D-dimer cut-off point in PE diagnosis was higher than 1,447 µg/L [sensitivity, 87.5 ... 962 µg/L were determined for D-dimer in pregnant women with likely and unlikely PE, respectively ... Moreover, the new cut-off points in the first and second trimesters of pregnancy were 1,701 µg/L and 1,451 ...

    Abstract Background: Considering that pulmonary embolism (PE) is one of the leading causes of mortality among pregnant women and that the D-dimer level in pregnancy can be highly fluctuating, a new and reliable D-dimer reference value is essential to identifying PE in this group of patients. Hence, the present study aimed to evaluate the diagnostic effect of D-dimer testing in pregnant women with suspected PE.
    Methods: This study recruited 100 women with confirmed pregnancy or six weeks after delivery or abortion with suspected PE symptoms. Wells criteria, D-dimer values, and pregnancy trimesters were recorded. Definitive PE results were obtained using multidetector computed tomography (MDCT) or pulmonary ventilation/perfusion scans.
    Results: D-dimer cut-off point in PE diagnosis was higher than 1,447 µg/L [sensitivity, 87.5%; specificity, 63.04%; area under the curve (AUC)=0.735;
    Conclusion: The new cut-off points of 1,447 and 1,962 µg/L were determined for D-dimer in pregnant women with likely and unlikely PE, respectively. Moreover, the new cut-off points in the first and second trimesters of pregnancy were 1,701 µg/L and 1,451 µg/L, respectively, which indicated no statistically acceptable diagnostic value.
    Language English
    Publishing date 2021-08-16
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2021.2021069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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