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  1. Article ; Online: Prognostic value of pretreatment serum fibrinogen in young patients with small cell lung cancer: A cross-sectional study.

    Tian, Juncai / Tian, Huohuan / Yang, Mengzhu / Yang, Linhui / Liu, Dan

    Health science reports

    2023  Volume 6, Issue 8, Page(s) e1507

    Abstract: Objective: To explored the prognostic value of pretreatment serum fibrinogen level in young patients with small cell lung cancer (SCLC).: Methods: The concentrations of serum fibrinogen of 183 young (<50 years old) SCLC patients were measured. The ... ...

    Abstract Objective: To explored the prognostic value of pretreatment serum fibrinogen level in young patients with small cell lung cancer (SCLC).
    Methods: The concentrations of serum fibrinogen of 183 young (<50 years old) SCLC patients were measured. The association of baseline serum fibrinogen level and clinical outcome was analyzed by survival analysis.
    Results: Hyperfibrinogenemia was significantly associated with American Veterans Administration Lung Study Group stage and surgery treatment. The survival analysis indicated that patients with hypefibrinogenemia had worse outcome than patients with normal fibrinogen. Pretreatment serum fibrinogen level was identified as a worse independent survival predictor in young SCLC. The hazard ratio was 1.420 (95% confidence interval: 1.035-1.947).
    Conclusions: Pretreatment serum fibrinogen is independent associated with overall survival in patients with young SCLC.
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparative transcriptomics and proteomics analysis of the symbiotic germination of

    Tian, Fan / Wang, Juncai / Ding, Fangjun / Wang, Lianhui / Yang, Yanbing / Bai, Xinxiang / Tan, Chengjiang / Liao, Xiaofeng

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1358137

    Abstract: Introduction: Paphiopedilum barbigerum: Methods: Herein, transcriptomics and proteomics were used to explore the changes in the : Results: Transcriptome sequencing revealed that a total of 10,961 differentially expressed genes (DEGs; 2,599 ... ...

    Abstract Introduction: Paphiopedilum barbigerum
    Methods: Herein, transcriptomics and proteomics were used to explore the changes in the
    Results: Transcriptome sequencing revealed that a total of 10,961 differentially expressed genes (DEGs; 2,599 upregulated and 8,402 downregulated) were identified in the control and FQXY019 treatment groups. These DEGs were mainly involved in carbohydrate, fatty acid, and amino acid metabolism. Furthermore, the expression levels of candidate DEGs related to nodulin, Ca
    Discussion: This study provides novel insight on the mechanisms underlying the
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1358137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Structural, functional, and physicochemical characterization of fermented whey protein concentrates recovered from various fermented-distilled whey

    Gantumur, Munkh-Amgalan / Sukhbaatar, Narantuya / Shi, Ruijie / Hu, Jialun / Bilawal, Akhunzada / Qayum, Abdul / Tian, Bo / Jiang, Zhanmei / Hou, Juncai

    Food hydrocolloids

    2023  Volume 135, Issue -, Page(s) 108130

    Language English
    Document type Article
    ZDB-ID 742742-6
    ISSN 0268-005X
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  4. Article: Spatial Heterogeneity of Soil Bacterial Community Structure and Enzyme Activity along an Altitude Gradient in the Fanjingshan Area, Northeastern Guizhou Province, China.

    Xie, Yuangui / Zhang, Lanyue / Wang, Juncai / Chen, Meng / Liu, Jiming / Xiao, Shengyang / Tian, Xiu / Wu, Tingting

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 11

    Abstract: Changes in altitude can cause regional microclimate changes, leading to the spatial heterogeneity of environmental factors and soil bacteria. However, the internal driving process and mechanism remain unclear. Here, we selected Fanjingshan, a typical ... ...

    Abstract Changes in altitude can cause regional microclimate changes, leading to the spatial heterogeneity of environmental factors and soil bacteria. However, the internal driving process and mechanism remain unclear. Here, we selected Fanjingshan, a typical nature reserve in the subtropical region of south China with a clear altitudinal belt, to reveal the response mechanisms of microbial populations with altitude changes. We examined the physiochemical and biological properties (pH and soil enzyme activities) of 0~10 cm soil layers, soil bacterial diversity, and community structure across the 2.1 km belt (consisting of six altitude ranges). Our results showed that soil pH was highest at the altitude range below 900 m and decreased with altitude thereafter. Soil enzyme activities showed an overall decreasing trend with altitude rising. The soil sucrase and catalase activity was highest (48.35 mg.g
    Language English
    Publishing date 2022-11-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12111862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corrigendum to "Citric acid promotes disulfide bond formation of whey protein isolate in non-acidic aqueous system" [Food Chemistry 338 (2020) 127819].

    Li, Tong / Hu, Jialun / Tian, Ran / Wang, Kaili / Li, Jinpeng / Qayum, Abdul / Bilawal, Akhunzada / Gantumur, Munkh-Amgalan / Jiang, Zhanmei / Hou, Juncai

    Food chemistry

    2022  Volume 406, Page(s) 134719

    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Published Erratum
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2022.134719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Structural, functional, and physicochemical characterization of fermented whey protein concentrates recovered from various fermented-distilled whey

    Gantumur, Munkh-Amgalan / Sukhbaatar, Narantuya / Shi, Ruijie / Hu, Jialun / Bilawal, Akhunzada / Qayum, Abdul / Tian, Bo / Jiang, Zhanmei / Hou, Juncai

    Food hydrocolloids. 2023 Feb., v. 135

    2023  

    Abstract: The utilization of whey has become a challenge with the significant growth in the production of cheese and coagulated milk products. Consequently, we have developed cost-effective and waste-free production technologies for processing whey disposal into a ...

    Abstract The utilization of whey has become a challenge with the significant growth in the production of cheese and coagulated milk products. Consequently, we have developed cost-effective and waste-free production technologies for processing whey disposal into a variety of high-quality, value-added food products at the industrial level. This work constitutes a research on the impact of various alcoholic fermentations on functional, structural, and physicochemical properties of fermented whey proteins recovered from whey-based spirit production effluent. The results showed that surface hydrophobicity and sulfhydryl groups of fermented whey protein concentrates (FWPC) increased significantly in comparison with native whey protein concentrate, while the zeta-potential and particle size of non-supplemented FWPC and low-supplemented FWPC were not substantially affected by fermentation. Furthermore, the outcomes indicated that the non-and low-supplemented whey fermentation led to the improvement in the solubility of FWPCs dispersions, and enhancement in the emulsifying activity and stability of FWPCs. Size exclusion chromatography and SDS-Page results also demonstrated significantly increased β-Lg content in FWPCs, which might be attributed to the reinforcement of the β-Lg intramolecular and noncovalent bonds. The enhancement in functionality was probably due to the partially unfolded whey protein molecules, exposing more hydrophobic amino acid residues, thus making the protein more amphiphilic and capable. Nevertheless, high-yield alcoholic fermentation led to critical changes in the structural properties of whey proteins as evidenced by SEM results. Therefore, our findings suggested that the application of recovering FWPCs after producing premium quality potable whey-based spirit from the presence of non-and low-lactose supplemented whey is fully proposed as an industrially recommended alternative for food-grade protein production.
    Keywords alcoholic fermentation ; amino acids ; cheesemaking ; cost effectiveness ; gel chromatography ; hydrocolloids ; hydrophobicity ; milk ; particle size ; polyacrylamide gel electrophoresis ; protein synthesis ; solubility ; value added ; whey ; whey protein concentrate ; zeta potential
    Language English
    Dates of publication 2023-02
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 742742-6
    ISSN 1873-7137 ; 0268-005X
    ISSN (online) 1873-7137
    ISSN 0268-005X
    DOI 10.1016/j.foodhyd.2022.108130
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Anlotinib exerts anti-cancer efficiency on lung cancer stem cells in vitro and in vivo through reducing NF-κB activity.

    Li, Zhuohong / Tian, Juncai / Du, Lei / Gao, Ying / Wang, Yao / You, Fengming / Wang, Li

    Journal of cellular and molecular medicine

    2021  Volume 25, Issue 12, Page(s) 5547–5559

    Abstract: Anlotinib is a multi-target tyrosine kinase inhibitor. Previous studies confirmed that anlotinib exerts anti-cancer efficiency. However, the functional roles of anlotinib on cancer stem cells (CSCs) are yet to be elucidated. In this study, lung CSCs were ...

    Abstract Anlotinib is a multi-target tyrosine kinase inhibitor. Previous studies confirmed that anlotinib exerts anti-cancer efficiency. However, the functional roles of anlotinib on cancer stem cells (CSCs) are yet to be elucidated. In this study, lung CSCs were isolated and identified in vitro, and mouse xenografts were established in vivo. MTT assays, tumour sphere formation assays, TdT-mediated dUTP nick-end labelling (TUNEL) staining, Annexin V-FITC/PI staining, immunofluorescence analysis and Western blot were performed to investigate the anti-cancer effects of anlotinib on lung CSCs. The results showed that anlotinib inhibits the growth of lung CSCs in vitro and in vivo. In addition, anlotinib induced apoptosis of these cells along with down-regulated expression level of Bcl-2 whereas up-regulated Bax and cleaved caspase-3 expression. It also sensitized lung CSCs to the cytotoxicity of cisplatin and paclitaxel; the tumour sphere formation and expression levels of multiple stemness-associated markers, such as ALDH1 and CD133, were also decreased. Furthermore, the underlying mechanism indicated that anlotinib reduces the phosphorylated levels of NF-κB p65 and IκB-α in lung CSCs. Taken together, these findings suggested that anlotinib exerts potent anti-cancer effects against lung CSCs through apoptotic induction and stemness phenotypic attenuation. The mechanism could be associated with the suppression of NF-κB activity.
    MeSH term(s) Animals ; Apoptosis ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; In Vitro Techniques ; Indoles/pharmacology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Mice, Nude ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Quinolines/pharmacology ; Signal Transduction ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
    Chemical Substances Indoles ; NF-kappa B ; Quinolines ; anlotinib
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.16564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Consequences of bail milling combined with high-pressure homogenization on structure, physicochemical and rheological properties of citrus fiber

    Jiang, Zhanmei / Mu, Sinan / Ma, Chenglong / Liu, Yue / Ma, Yue / Zhang, Minghan / Li, Hongyu / Liu, Xianqi / Hou, Juncai / Tian, Bo

    Food hydrocolloids

    2022  Volume 127, Issue -, Page(s) 107515

    Language English
    Document type Article
    ZDB-ID 742742-6
    ISSN 0268-005X
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  9. Article ; Online: Efficient multicarbon formation in acidic CO

    Chen, Yuanjun / Li, Xiao-Yan / Chen, Zhu / Ozden, Adnan / Huang, Jianan Erick / Ou, Pengfei / Dong, Juncai / Zhang, Jinqiang / Tian, Cong / Lee, Byoung-Hoon / Wang, Xinyue / Liu, Shijie / Qu, Qingyun / Wang, Sasa / Xu, Yi / Miao, Rui Kai / Zhao, Yong / Liu, Yanjiang / Qiu, Chenyue /
    Abed, Jehad / Liu, Hengzhou / Shin, Heejong / Wang, Dingsheng / Li, Yadong / Sinton, David / Sargent, Edward H

    Nature nanotechnology

    2023  Volume 19, Issue 3, Page(s) 311–318

    Abstract: The electrochemical reduction of ... ...

    Abstract The electrochemical reduction of CO
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/s41565-023-01543-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Delivery of Phenolic Compounds, Peptides and β-Glucan to the Gastrointestinal Tract by Incorporating Dietary Fibre-Rich Mushrooms into Sorghum Biscuits.

    Tu, Juncai / Brennan, Margaret Anne / Wu, Gang / Bai, Weidong / Cheng, Ping / Tian, Bin / Brennan, Charles Stephen

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 8

    Abstract: Sorghum biscuits were enriched with mushroom powders ( ...

    Abstract Sorghum biscuits were enriched with mushroom powders (
    Language English
    Publishing date 2021-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10081812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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