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  1. Article: The Value of Mentorship.

    Almond, Alisha

    Nursing economic$

    2018  Volume 35, Issue 1, Page(s) 49

    Language English
    Publishing date 2018-07-07
    Publishing country United States
    Document type Letter
    ZDB-ID 639341-x
    ISSN 0746-1739
    ISSN 0746-1739
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Multiscale modeling of glycosaminoglycan structure and dynamics: current methods and challenges.

    Almond, Andrew

    Current opinion in structural biology

    2017  Volume 50, Page(s) 58–64

    Abstract: Glycosaminoglycans are long unbranched and complex polysaccharides that are an essential component of mammalian extracellular matrices. Characterization of their molecular structure, dynamics and interactions are essential to understand important ... ...

    Abstract Glycosaminoglycans are long unbranched and complex polysaccharides that are an essential component of mammalian extracellular matrices. Characterization of their molecular structure, dynamics and interactions are essential to understand important biological phenomena in health and disease, and will lead to novel therapeutics and medical devices. However, this has proven to be a challenge experimentally and theoretical techniques are needed to develop new hypotheses, and interpret experiments. This review aims to examine the current theoretical (rather than experimental) methods used by researchers to investigate glycosaminoglycan structure, dynamics and interactions, from the monosaccharide to the macromolecular scale. It will consider techniques such as quantum mechanics, molecular mechanics, molecular dynamics, coarse graining and docking.
    MeSH term(s) Glycosaminoglycans/chemistry ; Glycosaminoglycans/metabolism ; Molecular Dynamics Simulation ; Molecular Structure ; Protein Binding ; Proteins/chemistry ; Proteins/metabolism ; Quantitative Structure-Activity Relationship ; Quantum Theory ; Water/chemistry
    Chemical Substances Glycosaminoglycans ; Proteins ; Water (059QF0KO0R)
    Language English
    Publishing date 2017-12-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2017.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: It takes guts to be a rebel!

    Zheng, Xia / Lang, Annie / Almond, Anthony / Yan, Harry Yaojun

    Politics and the life sciences : the journal of the Association for Politics and the Life Sciences

    2023  Volume 41, Issue 1, Page(s) 28–37

    Abstract: This study tests two sets of competing hypotheses about the relationship between trait reactivity to positive and negative stimuli (i.e., motivational reactivity), moral stances on social principles (i.e., social morality), and political ideology. ... ...

    Abstract This study tests two sets of competing hypotheses about the relationship between trait reactivity to positive and negative stimuli (i.e., motivational reactivity), moral stances on social principles (i.e., social morality), and political ideology. The
    MeSH term(s) Humans ; Motivation ; Morals ; Phenotype ; Social Environment
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2040372-0
    ISSN 1471-5457 ; 0730-9384
    ISSN (online) 1471-5457
    ISSN 0730-9384
    DOI 10.1017/pls.2022.5
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  4. Article: Cylindrical Multimode Waveguides as Focusing Interferometric Systems.

    Michailow, Wladislaw / Almond, Nikita W / Beere, Harvey E / Ritchie, David A

    ACS photonics

    2023  Volume 10, Issue 6, Page(s) 1756–1768

    Abstract: Delivery and focusing of radiation requires a variety of optical elements such as waveguides and mirrors or lenses. Heretofore, they were used separately, the former for radiation delivery, the latter for focusing. Here, we show that cylindrical ... ...

    Abstract Delivery and focusing of radiation requires a variety of optical elements such as waveguides and mirrors or lenses. Heretofore, they were used separately, the former for radiation delivery, the latter for focusing. Here, we show that cylindrical multimode waveguides can both deliver and simultaneously focus radiation, without any external lenses or parabolic mirrors. We develop an analytical, ray-optical model to describe radiation propagation within and after the end of cylindrical multimode waveguides and demonstrate the focusing effect theoretically and experimentally at terahertz frequencies. In the focused spot, located at a distance of several millimeters to a few centimeters away from the waveguide end, typical for focal lengths in optical setups, we achieve a more than 8.4× higher intensity than the cross-sectional average intensity and compress the half-maximum spot area of the incident beam by a factor of >15. Our results represent the first practical realization of a focusing system consisting of only a single cylindrical multimode waveguide, that delivers radiation from one focused spot into another focused spot in free space, with focal distances that are much larger than both the radiation wavelength and the waveguide radius. The results enable design and optimization of cylindrical waveguide-containing systems and demonstrate a precise optical characterization method for cylindrical structures and objects.
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article
    ISSN 2330-4022
    ISSN 2330-4022
    DOI 10.1021/acsphotonics.2c02030
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  5. Article ; Online: Reduced trolling on Russian holidays and daily US Presidential election odds.

    Almond, Douglas / Du, Xinming / Vogel, Alana

    PloS one

    2022  Volume 17, Issue 3, Page(s) e0264507

    Abstract: Russian trolls generally supported the Trump campaign and were particularly active on Twitter 2015-2017. We find that trolling fell 35% on Russian holidays and to a lesser extent, when temperatures were cold in St. Petersburg. Exogenous variation in ... ...

    Abstract Russian trolls generally supported the Trump campaign and were particularly active on Twitter 2015-2017. We find that trolling fell 35% on Russian holidays and to a lesser extent, when temperatures were cold in St. Petersburg. Exogenous variation in trolling by day allows us to consider indirectly-affected political behaviors in the US-outcomes that are less traceable via tweet sharing but potentially more important to policymakers than the direct dissemination previously studied. As a case in point, we describe reduced form evidence that Russian holidays affected daily trading prices in 2016 election betting markets. This response is consistent with successful Russian interference in support of Trump.
    MeSH term(s) Gambling ; Holidays ; Humans ; Politics ; Russia
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0264507
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  6. Article ; Online: Evaluation of outcomes in the management of primary sporadic desmoid-type fibromatosis at a specialist soft tissue sarcoma unit.

    Khan, Misbah / Almond, Max / Ford, Samuel / Desai, Anant

    European journal of medical research

    2022  Volume 27, Issue 1, Page(s) 123

    Abstract: Background: Desmoids are rare fibroblastic tumours whose treatment in any individual case presents a persistent challenge. We endeavoured to evaluate various clinicopathological factors contributing to tumour behaviour.: Methods: This is a ... ...

    Abstract Background: Desmoids are rare fibroblastic tumours whose treatment in any individual case presents a persistent challenge. We endeavoured to evaluate various clinicopathological factors contributing to tumour behaviour.
    Methods: This is a retrospective review of 95 primary truncal sporadic fibromatosis managed between 2011 and 2020. We studied progression rate for wait and watch (WW) and recurrence rate for the surgically treated group as adverse events. Relevant event-free survivals and potential risk factors were analysed over a median follow-up of 27 months.
    Results: 66 patients (69.5%) received watchful surveillance and 28 upfront surgery. 2-year progression-free survival in WW group (88.9%) was higher than RFS in the surgical group (77.1%) p = 0.02. Adverse event rate compared favourably, 28.8% in WW and 28.6% in surgical group. At final follow-up, rate of stable disease for WW was 47%, and the regression rate was 24.2%. On Cox regression analysis, meantime to progress was 14 ± 2.0 months, with larger tumour size as a significant prognostic indicator (p = 0.05). Surgical group's mean time to recurrence was 13.8 ± 2.76 months, with tumour location a significant contributing factor (p = 0.05).
    Conclusions: This study confirms to the safety of both treatment approaches. Adverse event rates remained comparable, but event-free survival was longer for the watchful surveillance group.
    MeSH term(s) Fibromatosis, Aggressive/pathology ; Fibromatosis, Aggressive/surgery ; Humans ; Neoplasm Recurrence, Local ; Prognosis ; Retrospective Studies ; Sarcoma
    Language English
    Publishing date 2022-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-022-00751-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4636: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: CME: Renal medicine (130893): self-assessment questionnaire.

    Almond, Michael / Chowdhury, Tahseen A

    Clinical medicine (London, England)

    2020  Volume 20, Issue 2, Page(s) 161–162

    MeSH term(s) Education, Medical, Continuing ; Humans ; Self-Assessment ; Surveys and Questionnaires
    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.SAQ.20.2
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    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Systematic review of the results of fenestrated endovascular aortic repair in octogenarians.

    Elahwal, M / Richards, T / Imsirovic, A / Bagga, R / Almond, G / Yusuf, S W

    Annals of the Royal College of Surgeons of England

    2023  Volume 106, Issue 2, Page(s) 106–117

    Abstract: Introduction: With the increasing life expectancy of Western populations, more octogenarians are presenting with large abdominal aortic aneurysm (AAA). Endovascular repair offers a less invasive alternative and older patients who may not have been ... ...

    Abstract Introduction: With the increasing life expectancy of Western populations, more octogenarians are presenting with large abdominal aortic aneurysm (AAA). Endovascular repair offers a less invasive alternative and older patients who may not have been offered open repair in the past are now being considered for elective repair with this approach. Age in isolation may not be the only consideration in recommending elective aneurysm repair. We aimed to review the literature on complex endovascular AAA repairs (mainly fenestrated endovascular aortic repair [FEVAR]) in octogenarians.
    Methods: A literature search was conducted using the Ovid Medline
    Methods: The literature search identified 134 potential articles. Following qualitative assessment by two independent appraisers, this was refined to 11 studies, in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement.
    Results: The primary outcome measure was 30-day mortality, which was highly variable, ranging from 0% to 9% in octogenarians and from 0% to 5% in non-octogenarians. However, these differences were only found to be statistically significant in two studies. The secondary outcome measures included technical success rates, major adverse events, reintervention rates, freedom from reintervention, target vessel patency, freedom from target branch instability, and length of hospital and intensive care unit stay. No statistically significant differences were found between octogenarians and non-octogenarians. Long-term survival was significantly lower for octogenarians in two studies.
    Conclusions: The perioperative outcomes of FEVAR in octogenarians are comparable with those of younger patients. FEVAR therefore appears to be an acceptable option for complex endovascular aneurysm repairs in carefully selected octogenarians. Nevertheless, this review highlights the paucity of published data on the outcomes of endovascular repair of complex aneurysms in octogenarians.
    MeSH term(s) Aged, 80 and over ; Humans ; Endovascular Aneurysm Repair ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/methods ; Aortic Aneurysm, Abdominal/surgery ; Octogenarians ; Risk Factors ; Treatment Outcome ; Postoperative Complications/etiology ; Endovascular Procedures/methods ; Time Factors ; Prosthesis Design ; Retrospective Studies
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2023.0032
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    Uk I Zs.234: Show issues Location:
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  9. Article ; Online: Supplementing clinical lactation studies with PBPK modeling to inform drug therapy in lactating mothers: Prediction of primaquine exposure as a case example.

    Pan, Xian / Abduljalil, Khaled / Almond, Lisa M / Pansari, Amita / Yeo, Karen Rowland

    CPT: pharmacometrics & systems pharmacology

    2023  Volume 13, Issue 3, Page(s) 386–395

    Abstract: Evaluating the safety of primaquine (PQ) during breastfeeding requires an understanding of its pharmacokinetics (PKs) in breast milk and its exposure in the breastfed infant. Physiologically-based PK (PBPK) modeling is primed to assess the complex ... ...

    Abstract Evaluating the safety of primaquine (PQ) during breastfeeding requires an understanding of its pharmacokinetics (PKs) in breast milk and its exposure in the breastfed infant. Physiologically-based PK (PBPK) modeling is primed to assess the complex interplay of factors affecting the exposure of PQ in both the mother and the nursing infant. A published PBPK model for PQ describing the metabolism by monoamine oxidase A (MAO-A; 90% contribution) and cytochrome P450 2D6 (CYP2D6; 10%) in adults was applied to predict the exposure of PQ in mothers and their breastfeeding infants. Plasma exposures following oral daily dosing of 0.5 mg/kg in the nursing mothers in a clinical lactation study were accurately captured, including the observed ranges. Reported infant daily doses based on milk data from the clinical study were used to predict the exposure of PQ in breastfeeding infants greater than or equal to 28 days. On average, the predicted exposures were less than or equal to 0.13% of the mothers. Furthermore, in simulations involving neonates less than 28 days, PQ exposures remain less than 0.16% of the mothers. Assuming that MAO-A increases slowly with age, the predicted relative exposure of PQ remains low in neonates (<0.46%). Thus, the findings of our study support the recommendation made by the authors who reported the results of the clinical lactation study, that is, that when put into context of safety data currently available in children, PQ should not be withheld in lactating women as it is unlikely to cause adverse events in breastfeeding infants greater than or equal to 28 days old.
    MeSH term(s) Infant ; Infant, Newborn ; Adult ; Child ; Female ; Humans ; Lactation/metabolism ; Primaquine/metabolism ; Mothers ; Breast Feeding ; Cytochrome P-450 CYP2D6/metabolism ; Monoamine Oxidase
    Chemical Substances Primaquine (MVR3634GX1) ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Monoamine Oxidase (EC 1.4.3.4)
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.13090
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  10. Article ; Online: Pilot Research to Develop a Nursing Digital Health Capability Framework in Chile.

    Benavente, Antonia / Urra, Eugenia / Hullin, Carol / Almond, Helen

    Studies in health technology and informatics

    2021  Volume 284, Page(s) 186–188

    Abstract: The Global Digital Health Strategy emphasizes digital health workforce development to reach a sustainable health system. In Chile, a digital health capability framework to support the transition towards digital health and workforce development is still ... ...

    Abstract The Global Digital Health Strategy emphasizes digital health workforce development to reach a sustainable health system. In Chile, a digital health capability framework to support the transition towards digital health and workforce development is still missing. A survey will be applied at a national level. The Development of a Chilean Nursing Digital Health Capability Framework will identify the capabilities of nurses in digital health innovation and improve the quality and safety of healthcare nationwide.
    MeSH term(s) Chile ; Humans ; Staff Development
    Language English
    Publishing date 2021-07-31
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI210700
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