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Article ; Online: Necrotizing tracheobronchial aspergillosis in an immunosuppressed patient.

Serrano-Martínez, José Luis / Caballero-Vázquez, Alberto / Núñez-Talavera, María

Medicina intensiva

2023

Language	English
Publishing date	2023-06-17
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medine.2023.05.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Validation of the inventory: lockdown and its impact on the university Community.

González-Alonso, María Yolanda / Ortiz-González, Andrea Liliana / Escolar-Llamazares, María Camino / Serrano-Gómez, Diego / Serrano-Pintado, Isabel / Martínez-Martín, María Ángeles

BMC public health

2024 Volume 24, Issue 1, Page(s) 790

Abstract: Background: Significant consequences of COVID-19 within academic/professional life are, at the psychological level, related to worry, tension, stress; coping strategies and lifestyle changes. This study describes the process of design and validation of ... ...

Abstract	Background: Significant consequences of COVID-19 within academic/professional life are, at the psychological level, related to worry, tension, stress; coping strategies and lifestyle changes. This study describes the process of design and validation of an inventory (QPIC), which aims to assess the psychological impact that a situation of confinement can produce among university students and teachers. Methods: Design of the instrument and psychometric tests. A sample of 862 students and 229 professors affiliated to Spanish and Colombian universities was used. Data were collected in April 2020 with the request of the favourable Bioethics Committee IR/2020. Results: Six experts carried out the content validation. A confirmatory factor analysis of the theoretical dimensions proposed for the scales was performed and the internal consistency of each of the three initial scales was confirmed (0.866, 0.813 and 0.834). Conclusion: A rigorous and reliable instrument is achieved, consisting of two final scales: (a) Worry, tension and stress scale (b) Coping scale, which helps to measure individual psychological effects in housebound situations. It is an instrument designed, constructed ad hoc to assess the impact of confinement and subjected to validation. The factor structure and reliability of the instrument are examined and good psychometric properties are obtained. The application of this inventory will make it possible to assess the impact on people's mental health during a period of confinement.
MeSH term(s)	Humans ; Universities ; Reproducibility of Results ; Mental Health ; Anxiety ; COVID-19/epidemiology ; Psychometrics ; Surveys and Questionnaires
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-17562-y
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Article ; Online: Adipose tissue metabolic changes in chronic kidney disease.

Serrano, Eurico / Shenoy, Prashamsa / Martinez Cantarin, Maria Paula

Immunometabolism (Cobham (Surrey, England))

2023 Volume 5, Issue 2, Page(s) e00023

Abstract: Adipose tissue is a complex organ whose functions go beyond being an energy reservoir to sustain proper body energy homeostasis. Functioning as an endocrine organ, the adipose tissue has an active role in the body's metabolic balance regulation through ... ...

Abstract	Adipose tissue is a complex organ whose functions go beyond being an energy reservoir to sustain proper body energy homeostasis. Functioning as an endocrine organ, the adipose tissue has an active role in the body's metabolic balance regulation through several secreted factors generally termed as adipokines. Thus, adipose tissue dysregulation in chronic kidney disease (CKD) can have a deep impact in the pathophysiology of diseases associated with metabolic dysregulation including metabolic syndrome, insulin resistance (IR), atherosclerosis, and even cachexia. CKD is a progressive disorder linked to increased morbidity and mortality. Despite being characterized by renal function loss, CKD is accompanied by metabolic disturbances such as dyslipidemia, protein energy wasting, chronic low-grade inflammation, IR, and lipid redistribution. Thus far, the mechanisms by which these changes occur and the role of adipose tissue in CKD development and progression are unclear. Further understanding of how these factors develop could have implications for the management of CKD by helping identify pharmacological targets to improve CKD outcomes.
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article ; Review
ISSN	2633-0407
ISSN (online)	2633-0407
DOI	10.1097/IN9.0000000000000023
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Article ; Online: Trends in Faecal Zonulin Concentrations in Paediatric Patients with Celiac Disease at Baseline and on a Gluten-Free Diet: Exploring Correlations with Other Faecal Biomarkers.

Martínez Gallego, Miguel Ángel / Crespo Sánchez, María Gema / Serrano Olmedo, María Gemma / Buño Soto, Antonio / Álvarez Casasempere, Sonia / Nozal, Pilar / Martínez-Ojinaga, Eva / Molina Arias, Manuel / Losantos-García, Itsaso / Molero-Luis, Marta

Nutrients

2024 Volume 16, Issue 5

Abstract: Celiac disease (CeD) is an autoimmune condition triggered by gluten in genetically predisposed individuals, affecting all ages. Intestinal permeability (IP) is crucial in the pathogenesis of CeD and it is primarily governed by tight junctions (TJs) that ... ...

Abstract	Celiac disease (CeD) is an autoimmune condition triggered by gluten in genetically predisposed individuals, affecting all ages. Intestinal permeability (IP) is crucial in the pathogenesis of CeD and it is primarily governed by tight junctions (TJs) that uphold the intestinal barrier's integrity. The protein zonulin plays a critical role in modulating the permeability of TJs having emerged as a potential non-invasive biomarker to study IP. The importance of this study lies in providing evidence for the usefulness of a non-invasive tool in the study of IP both at baseline and in the follow-up of paediatric patients with CeD. In this single-centre prospective observational study, we explored the correlation between faecal zonulin levels and others faecal and serum biomarkers for monitoring IP in CeD within the paediatric population. We also aimed to establish reference values for faecal zonulin in the paediatric population. We found that faecal zonulin and calprotectin values are higher at the onset of CeD compared with the control population. Specifically, the zonulin levels were 347.5 ng/mL as opposed to 177.7 ng/mL in the control population (
MeSH term(s)	Humans ; Child ; Celiac Disease ; Diet, Gluten-Free ; Glutens ; Biomarkers ; Leukocyte L1 Antigen Complex ; Haptoglobins ; Protein Precursors
Chemical Substances	zonulin ; Glutens (8002-80-0) ; Biomarkers ; Leukocyte L1 Antigen Complex ; Haptoglobins ; Protein Precursors
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16050684
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Article ; Online: Opioids and fibromyalgia: frequency of use and factors associated with increased consumption in patients remitted to a tertiary care center.

Rivera, Javier / Molina-Collada, Juan / Martínez-Barrio, Julia / Serrano-Benavente, Belén / Castrejón, Isabel / Vallejo, Miguel A / Álvaro-Gracia, Jose María

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 121

Abstract: Background: Opioids are not recommended for fibromyalgia.: Objective: To investigate the frequency of opioid use in a large cohort of fibromyalgia patients and to identify factors associated with opioid consumption.: Methods: A retrospective, ... ...

Abstract	Background: Opioids are not recommended for fibromyalgia. Objective: To investigate the frequency of opioid use in a large cohort of fibromyalgia patients and to identify factors associated with opioid consumption. Methods: A retrospective, observational study of a large fibromyalgia cohort in a tertiary care center. We assessed fibromyalgia severity, functional capacity, anxiety, depression, drugs consumption and the patient's impression of change. We compared strong opioid consumers (SOC) and non-SOC. Inferential statistical and logistic regression analysis were used to identify factors associated with opioid consumption, and ANOVA for repeated measurements. Results: We found a prevalence of 9.2% of SOC (100 patients) among 1087 patients in the cohort. During the last four years there was a significant increase on the incidence of SOC up to 12.8% (p = 0.004). There were no differences in demographic variables between SOC and non-SOC. Clinical variables were significantly more severe in SOC, and they consumed more non-opioid drugs (p < 0.0001). Opioid consumption was independently associated with other non-opioid drugs (Odds ratio 1.25, CI: 1.13-1.38), but not with the fibromyalgia severity. At three months, 62% of the patients had opioid withdrawal. There were no statistical differences in the fibromyalgia severity at the initial evaluation, or the patient's impression of change compared with those patients who continued opioids. Coping strategies were better in those patients who withdrew opioids (p = 0.044). Conclusions: We observed an increase in opioid prescriptions during the last four years. Opioid consumption was associated with concomitant use of non-opioid drugs, but it was not associated with fibromyalgia severity.
MeSH term(s)	Humans ; Analgesics, Opioid/adverse effects ; Fibromyalgia/diagnosis ; Fibromyalgia/drug therapy ; Fibromyalgia/epidemiology ; Retrospective Studies ; Tertiary Care Centers ; Opioid-Related Disorders
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07263-x
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Article: Impact of Work-Life Balance on the Quality of Life of Spanish Nurses during the Sixth Wave of the COVID-19 Pandemic: A Cross-Sectional Study.

Antolí-Jover, Ana María / Álvarez-Serrano, María Adelaida / Gázquez-López, María / Martín-Salvador, Adelina / Pérez-Morente, María Ángeles / Martínez-García, Encarnación / García-García, Inmaculada

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 5

Abstract: This study addresses the health-related quality of life (HRQoL) of Spanish nurses during the sixth wave of the COVID-19 pandemic, assessed through the EQ-5D and EQ-VAS indices.: Methods: This cross-sectional 334 study used online surveys, recruiting ... ...

Abstract	This study addresses the health-related quality of life (HRQoL) of Spanish nurses during the sixth wave of the COVID-19 pandemic, assessed through the EQ-5D and EQ-VAS indices. Methods: This cross-sectional 334 study used online surveys, recruiting 305 Spanish nurses. Results: Nurses generally perceived a good HRQoL. "Negative work-family interaction" is adversely associated with the EQ-VAS (β = -0.337, 95% CI [-1.733, -0.723]) and EQ-5D (β = -0.399, 95% CI [-0.021, -0.01]) indices, while "positive work-family interaction" shows a positive relationship with the EQ-VAS (β = 0.218, 95% CI [0.381, 1.759]). The presence of a "paid supportive caregiver" is positively associated with the EQ-VAS (β = 0.18, 95% CI [1.47, 12.3]) and EQ-5D (β = 0.149, 95% CI [0.004, 0.117]) indices, but a higher "number of children" is negatively linked with the EQ-5D index (β = -0.146, 95% CI [-0.061, -0.002]). In addition, living with a partner (EQ-VAS β = 0.16, 95% CI [1.094, 14.67] and EQ-5D index β = 0.174, 95% CI [0.018, 0.163]) and working a "rotating shift" (EQ-5D index β = 0.158, 95% CI [0.005, 0.098]) are positively associated. Conclusions: These findings highlight the need to comprehensively address nurses' well-being, considering both their working conditions and their home environment, especially in crisis contexts such as the current pandemic.
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12050598
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Article ; Online: Left atrial strain in adults after the arterial switch operation for transposition of the great arteries.

Buendía-Fuentes, Francisco / Lozano-Edo, Silvia / Jover-Pastor, Pablo / Sánchez-Martínez, José C / Martínez-Sole, Julia / Rodríguez-Serrano, María / Aguero, Jaume / Arnau-Vives, Miguel A / Osa-Sáez, Ana / Martínez-Dolz, Luis V / Rueda, Joaquín

Echocardiography (Mount Kisco, N.Y.)

2024 Volume 41, Issue 1, Page(s) e15750

Abstract: Background: No study has focused on left atrial (LA) function assessed by echocardiography in adult patients with simple D-TGA after arterial switch operation (ASO). We aimed to describe LA strain parameters in these patients.: Methods: A prospective ...

Abstract	Background: No study has focused on left atrial (LA) function assessed by echocardiography in adult patients with simple D-TGA after arterial switch operation (ASO). We aimed to describe LA strain parameters in these patients. Methods: A prospective cohort study including 42 adult patients with simple D-TGA after ASO and 33 aged-matched controls. Phasic LA and LV global longitudinal strain (GLS) were obtained by transthoracic 2D-speckle tracking echocardiography (STE). Volumetric and functional analysis of LA and LV were also evaluated by 2D and 3D analysis. A multivariable model was performed to investigate the variables that best differentiate patients with D-TGA from healthy controls. Results: LA strain parameters in D-TGA patients were within the normal range described for healthy subjects. However, the three LA strain parameters (Reservoir, Conduit, and Contraction) were lower in patients (LASr: 31.13 ± 7.67 vs. 49.71 ± 8.38; LAS cd: -22.91 ± 5.69 vs. -34.55 ± 6.54; LASct: -8.14 ± 4.93 vs. -15.15 ± 6.07, p < .001 for all three comparisons). LA volumes were similar between patients and controls. LV-GLS remained significantly lower in the D-TGA group than in controls (-17.29 ± 2.68 vs. -21.98 ± 1.84, p < .001). D-TGA patients had evidence of worse LV ejection fraction measured by the Teichholz method (63.38 ± 8.23 vs. 69.28 ± 5.92, p = .001) and 3D analysis (57.97% ± 4.16 vs. 60.67 ± 3.39, p = .011) and diastolic dysfunction as compared to healthy controls. LV-GLS and conduit LAS were the variables best differentiating patients with D-TGA from healthy controls. Conclusions: LA strain is impaired in young adults with simple D-TGA late after the ASO, probably in agreement with some degree of LV dysfunction previously described.
MeSH term(s)	Young Adult ; Humans ; Aged ; Arterial Switch Operation ; Transposition of Great Vessels/diagnostic imaging ; Transposition of Great Vessels/surgery ; Prospective Studies ; Heart Atria/diagnostic imaging ; Ventricular Dysfunction, Left ; Arteries ; Ventricular Function, Left
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15750
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Article: The Simultaneous Use of 1-Methylcyclopropene and Methyl Jasmonate Vapor as an Innovative Strategy for Reducing Chilling Injury and Maintaining Pomegranate Fruit Quality at Suboptimal Temperatures.

Lorente-Mento, José Manuel / Serrano, María / Martínez-Romero, Domingo / Ruiz-Aracil, María Celeste / Valero, Daniel / Guillén, Fabián

Foods (Basel, Switzerland)

2023 Volume 13, Issue 1

Abstract: Spain is one of the main contributors to global pomegranate production. Pomegranate presents a challenge for preservation at suboptimal temperatures. Preserving this fruit for an extended period is challenging due to its susceptibility to chilling injury ...

Abstract	Spain is one of the main contributors to global pomegranate production. Pomegranate presents a challenge for preservation at suboptimal temperatures. Preserving this fruit for an extended period is challenging due to its susceptibility to chilling injury (CI). For this reason, we have examined different postharvest treatments to extend the pomegranate shelf life and their potential impact on reducing CI. For this reason, two postharvest treatments have been applied: 1-Methylcyclopropene (1000 nL L
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13010060
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Article ; Online: Transition mechanism of the coverage-dependent polymorphism of self-assembled melamine nanostructures on Au(111).

Zamalloa-Serrano, Jorge Manuel / Gómez-Fernández, José María / Sánchez-Sánchez, Carlos / López, María Francisca / Martínez, José Ignacio / Martín-Gago, José Ángel / Palacio, Irene

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 5, Page(s) 3941–3949

Abstract: Molecular self-assembled films have recently attracted increasing attention within the field of nanotechnology as they offer a route to obtain new materials. However, careful selection of the molecular precursors and substrates, as well as exhaustive ... ...

Abstract	Molecular self-assembled films have recently attracted increasing attention within the field of nanotechnology as they offer a route to obtain new materials. However, careful selection of the molecular precursors and substrates, as well as exhaustive control of the system evolution is required to obtain the best possible outcome. The three-fold rotational symmetry of melamine molecules and their capability to form hydrogen bonds make them suitable candidates to synthesize this type of self-assembled network. In this work, we have studied the polymorphism of melamine nanostructures on Au(111) at room temperature. We find two coverage-dependent phases: a honeycomb structure (α-phase) for submonolayer coverage and a close-packed structure (β-phase) for full monolayer coverage. A combined scanning tunnel microscopy and density functional theory based-calculations study of the transition regime where both phases coexist allows describing the mechanism underlying this coverage driven phase transition in terms of the changes in the molecular lateral tension.
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp05960j
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Article ; Online: Gender, smoking, and tobacco cessation with pharmacological treatment in a cluster randomized clinical trial.

Minué-Lorenzo, César / Olano-Espinosa, Eduardo / Minué-Estirado, María / Vizcaíno-Sánchez, Jose-María / Camarelles-Guillem, Francisco / Granados-Garrido, José-Antonio / Ruiz-Pacheco, Margarita / Gámez-Cabero, María Isabel / Martínez-Suberviola, Francisco Javier / Serrano-Serrano, Encarnación / Cura-González, Isabel Del

Tobacco induced diseases

2024 Volume 22

Abstract: Introduction: Whether men find it easier to quit smoking than women is still controversial. Different studies have reported that the efficacy of pharmacological treatments could be different between men and women. This study conducted a secondary ... ...

Abstract	Introduction: Whether men find it easier to quit smoking than women is still controversial. Different studies have reported that the efficacy of pharmacological treatments could be different between men and women. This study conducted a secondary analysis of 'Subsidized pharmacological treatment for smoking cessation by the Spanish public health system' (FTFT-AP study) to evaluate the effectiveness of a drug-funded intervention for smoking cessation by gender. Methods: A pragmatic randomized clinical trial by clusters was used. The population included smokers aged ≥18 years, smoking >10 cigarettes per day, randomly assigned to an intervention group receiving regular practice and financed pharmacological treatment, or to a control group receiving only regular practice. The main outcome was continued abstinence at 12 months, self-reported and validated with CO-oximetry. The percentage, with 95% confidence intervals, of continued abstinence was compared between both groups at 12 months post-intervention, by gender and the pharmacological treatment used. Multilevel logistic regression analysis was performed. Results: A total of 1154 patients from 29 healthcare centers were included. The average age was 46 years (SD=11.78) and 51.7% were men. Overall, the self-reported abstinence at 12 months was 11.1% (62) in women and 15.7% (93) in men (AOR=1.4; 95% CI: 1.0-2.0), and abstinence validated by CO-oximetry was 4.6% (26) and 5.9% (35) in women and men, respectively (OR=1.3; 95% CI: 0.7-2.2). In the group of smokers receiving nicotine replacement treatment, self-reported abstinence was higher in men compared to women (29.5% vs 13.5%, OR=2.7; 95% CI: 1.3-5.8). Conclusions: The effectiveness of a drug-financed intervention for smoking cessation was greater in men, who also showed better results in self-reported abstinence with nicotine replacement treatment.
Language	English
Publishing date	2024-02-15
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2194616-4
ISSN	1617-9625 ; 1617-9625
ISSN (online)	1617-9625
ISSN	1617-9625
DOI	10.18332/tid/177260
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