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Article ; Online: Reply to K. Takada et al.

Ballman, Madison / Mullenix, Cristina / Szabo, Eva / Steinberg, Seth M / Rajan, Arun

JTO clinical and research reports

2021 Volume 2, Issue 12, Page(s) 100250

Language	English
Publishing date	2021-12-18
Publishing country	United States
Document type	Journal Article
ISSN	2666-3643
ISSN (online)	2666-3643
DOI	10.1016/j.jtocrr.2021.100250
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Article ; Online: Respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK): Initial clinical experience on an MRI-guided radiotherapy system.

Han, Fei / Zhou, Ziwu / Du, Dongsu / Gao, Yu / Rashid, Shams / Cao, Minsong / Shaverdian, Narek / Hegde, John V / Steinberg, Michael / Lee, Percy / Raldow, Ann / Low, Daniel A / Sheng, Ke / Yang, Yingli / Hu, Peng

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2018 Volume 127, Issue 3, Page(s) 467–473

Abstract: ... Rotating Cartesian K-space (ROCK-4D-MRI) method in a 0.35 T MRI-guided radiotherapy (MRgRT) system ...

Abstract	Purpose: To optimize and evaluate the respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK-4D-MRI) method in a 0.35 T MRI-guided radiotherapy (MRgRT) system. Methods and materials: The study included seven patients with abdominal tumors treated on the MRgRT system. ROCK-4D-MRI and 2D-CINE, was performed immediately after one of the treatment fractions. Motion quantification based on 4D-MRI was compared with those based on 2D-CINE. The image quality of 4D-MRI was evaluated against 4D-CT. The gross tumor volumes (GTV) were defined based on individual respiratory phases of both 4D-MRI and 4D-CT and compared for their variability over the respiratory cycle. Result: The motion measurements based on 4D-MRI matched well with 2D-CINE, with differences of 1.04 ± 0.52 mm in the superior-inferior and 0.54 ± 0.21 mm in the anterior-posterior directions. The image quality scores of 4D-MRI were significantly higher than 4D-CT, with better tumor contrast (3.29 ± 0.76 vs. 1.86 ± 0.90) and less motion artifacts (3.57 ± 0.53 vs. 2.29 ± 0.95). The GTVs were more consistent in 4D-MRI than in 4D-CT, with significantly smaller GTV variability (9.31 ± 4.58% vs. 34.27 ± 23.33%). Conclusion: Our study demonstrated the clinical feasibility of using the ROCK-4D-MRI to acquire high quality, respiratory motion-resolved 4D-MRI in a low-field MRgRT system. The 4D-MRI image could provide accurate dynamic information for radiotherapy treatment planning.
MeSH term(s)	Abdominal Neoplasms/diagnostic imaging ; Abdominal Neoplasms/radiotherapy ; Artifacts ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Image-Guided ; Respiratory Mechanics/physiology ; Respiratory-Gated Imaging Techniques/methods
Language	English
Publishing date	2018-05-09
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2018.04.029
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Zs.A 1926: Show issues

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Article ; Online: Frequency and Outcomes of Reduced Dose Non-Vitamin K Antagonist Anticoagulants: Results From ORBIT-AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II).

Steinberg, Benjamin A / Shrader, Peter / Pieper, Karen / Thomas, Laine / Allen, Larry A / Ansell, Jack / Chan, Paul S / Ezekowitz, Michael D / Fonarow, Gregg C / Freeman, James V / Gersh, Bernard J / Kowey, Peter R / Mahaffey, Kenneth W / Naccarelli, Gerald V / Reiffel, James A / Singer, Daniel E / Peterson, Eric D / Piccini, Jonathan P

Journal of the American Heart Association

2018 Volume 7, Issue 4

Abstract: Background: Non-vitamin K antagonist oral anticoagulants (NOACs) are indicated for stroke ...

Abstract	Background: Non-vitamin K antagonist oral anticoagulants (NOACs) are indicated for stroke prevention in atrial fibrillation (AF) but require lower doses in certain patients. We sought to describe the frequency, appropriateness (according to Food and Drug Administration labeling), and outcomes of patients prescribed reduced doses of NOACs in community practice. Methods and results: We analyzed data from the ORBIT-AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II) registry, a prospective, national, observational registry of AF patients. Among 7925 AF patients receiving NOACs, we assessed patterns of use of reduced NOAC doses and associated cardiovascular and bleeding outcomes at median follow-up of 1 year. Overall, 6636 patients (84%) received a NOAC at standard dose, which was consistent with US Food and Drug Administration labeling in 6376 (96%). Reduced NOAC dose was prescribed to 1289 (16% overall), which was consistent with Food and Drug Administration labeling in only 555 patients (43%). Compared with those whose NOAC dose was appropriately reduced, patients receiving inappropriate dose reductions were younger (median age 79 versus 84, Conclusions: The majority of dose reductions of NOACs in AF are inconsistent with US Food and Drug Administration recommendations. There appear to be opportunities to improve current NOAC dosing in community practice. Clinical trial registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01701817.
MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/mortality ; Drug Dosage Calculations ; Drug Prescriptions ; Female ; Guideline Adherence/trends ; Hemorrhage/chemically induced ; Humans ; Male ; Middle Aged ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/trends ; Prospective Studies ; Registries ; Stroke/diagnosis ; Stroke/mortality ; Stroke/prevention & control ; Time Factors ; Treatment Outcome ; United States/epidemiology
Chemical Substances	Anticoagulants
Language	English
Publishing date	2018-02-16
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.117.007633
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Conference proceedings: Messungen von biomechanischen Eigenschaften der Hornhaut nach LASIK mit dem Corvis ST Tonometer (K)

Frings, Andreas / Bauer, Eva / Steinberg, Johannes / Casagrande, Maria K. / Druchkiv, Vasyl / Katz, Toam / Linke, Stephan J.

2014 , Page(s) PO 2.2

Event/congress	27. Internationaler Kongress der Deutschen Ophthalmochirurgen; Nürnberg; 2014
Keywords	Medizin, Gesundheit
Publishing date	2014-05-05
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/14doc167
Database	German Medical Science

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Article: Health Care Consumerism: Lessons My 401(k) Plan Taught Me.

Steinberg, Allen T

Benefits quarterly

2015 Volume 31, Issue 4, Page(s) 29–32

Abstract: ... for health care--while actively employed and while retired--our experiences with 401(k) plans provide ... daunting than the 401(k) challenge we faced 20 years ago--some very different types of support are needed ...

Abstract	Changes to the U.S. health care system are here. As we think about how individuals will pay for health care--while actively employed and while retired--our experiences with 401(k) plans provide some valuable lessons. In order to support employees in this new health care world--a challenge arguably more daunting than the 401(k) challenge we faced 20 years ago--some very different types of support are needed. Employers should consider providing their employees with the resources to manage health care changes.
MeSH term(s)	Community Participation ; Delivery of Health Care ; Pensions ; Retirement/economics ; United States
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article
ISSN	8756-1263
ISSN	8756-1263
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Article ; Online: Appropriate dosing of nonvitamin K antagonist oral anticoagulants for stroke prevention in atrial fibrillation.

Steinberg, Benjamin A / Washam, Jeffrey B

Trends in cardiovascular medicine

2017 Volume 27, Issue 8, Page(s) 567–572

Abstract: The development of nonvitamin K antagonist oral anticoagulants (NOACs) has been a major advance ...

Abstract	The development of nonvitamin K antagonist oral anticoagulants (NOACs) has been a major advance in therapy for patients requiring oral anticoagulation, particularly for long-term indications such as stroke prevention in atrial fibrillation (AF). The NOACs are generally easier to dose and manage due to less heterogeneity of effect across individuals and fewer drug and food interactions, compared with warfarin. However, the treatment effect of NOACs may vary based on important patient characteristics, particularly renal function. Therefore, the package inserts for these drugs have dosing recommendations for patients with impaired kidney function, which are frequently but not always based on evidence from large-scale, randomized, clinical trials. Furthermore, there is evidence that NOAC dosing inconsistent with the regulatory labeling may be associated with adverse clinical outcomes. This review discusses the evidence supporting the current NOAC dosing, current dosing practices, associated outcomes, and gaps in knowledge regarding use of NOACs in patients with AF.
MeSH term(s)	Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/pharmacokinetics ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Drug Administration Schedule ; Drug Dosage Calculations ; Hemorrhage/chemically induced ; Humans ; Risk Factors ; Stroke/diagnosis ; Stroke/etiology ; Stroke/prevention & control ; Time Factors ; Treatment Outcome
Chemical Substances	Anticoagulants
Language	English
Publishing date	2017-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1097434-9
ISSN	1873-2615 ; 1050-1738
ISSN (online)	1873-2615
ISSN	1050-1738
DOI	10.1016/j.tcm.2017.06.012
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Zs.A 3419: Show issues

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Article ; Online: Injuries among talented young dancers: findings from the U.K. Centres for Advanced Training.

Steinberg, N / Aujla, I / Zeev, A / Redding, E

International journal of sports medicine

2014 Volume 35, Issue 3, Page(s) 238–244

Abstract: The aim of the present study was to characterize the injuries of young dancers attending Centres for Advanced Training. 806 dancers, ages 10-18 years responded to surveys regarding their biological profile, dance experience and injury history, and were ... ...

Abstract	The aim of the present study was to characterize the injuries of young dancers attending Centres for Advanced Training. 806 dancers, ages 10-18 years responded to surveys regarding their biological profile, dance experience and injury history, and were examined for their anthropometric profile. Of the 806 dancers, 347 reported an injury. Based on 4 age groups, the total hours of practice per week increased significantly with increasing age. Incidence of injuries per 1000 h of dance practice for dancers ages 11-12 were found to be significantly higher compared to the incidence for dancers ages 13-18 (p<0.05). Foot and ankle and other lower extremities were the most common injury location, and muscle injuries were the most common type of injury. Total months in CAT training (OR=1.044, 95% CI=1.014-1.075) and hours per week in creative style practice (OR=1.282, 95% CI=1.068-1.539) were found to be significantly associated with injuries. In conclusion, both young and mature dancers are exposed to extensive risk of injury. The intensity of training (such as number of months and number of hours of training per week) is important factor that should be taken into account in order to decrease future injuries among young dancers.
MeSH term(s)	Adolescent ; Age Distribution ; Anthropometry ; Athletic Injuries/epidemiology ; Child ; Dancing/injuries ; Female ; Humans ; Incidence ; Lower Extremity/injuries ; Male ; Menarche ; Muscle, Skeletal/injuries ; Physical Education and Training ; Prevalence ; Risk Factors ; Sex Distribution ; Time Factors ; United Kingdom/epidemiology
Language	English
Publishing date	2014-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	603122-5
ISSN	1439-3964 ; 0172-4622 ; 0943-917X
ISSN (online)	1439-3964
ISSN	0172-4622 ; 0943-917X
DOI	10.1055/s-0033-1349843
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Zs.A 1561: Show issues

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Conference proceedings: Behandlung von Hyperopie: Bessere refraktive Vorhersagbarkeit durch Zykloplegie? (K)

Frings, Andreas / Steinberg, Johannes / Druchkiv, Vasyl / Linke, Stephan J. / Katz, Toam

2015 , Page(s) PO 3.5

Event/congress	28. Internationaler Kongress der Deutschen Ophthalmochirurgen; Leipzig; 2015
Keywords	Medizin, Gesundheit
Publishing date	2015-06-09
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/15doc168
Database	German Medical Science

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Article ; Online: Off-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Adverse Outcomes: The ORBIT-AF II Registry.

Steinberg, Benjamin A / Shrader, Peter / Thomas, Laine / Ansell, Jack / Fonarow, Gregg C / Gersh, Bernard J / Kowey, Peter R / Mahaffey, Kenneth W / Naccarelli, Gerald / Reiffel, James / Singer, Daniel E / Peterson, Eric D / Piccini, Jonathan P

Journal of the American College of Cardiology

2017 Volume 68, Issue 24, Page(s) 2597–2604

Abstract: Background: Although non-vitamin K antagonist oral anticoagulants (NOACs) do not require frequent ...

Abstract	Background: Although non-vitamin K antagonist oral anticoagulants (NOACs) do not require frequent laboratory monitoring, each compound requires dose adjustments on the basis of certain clinical criteria. Objectives: This study assessed the frequency of off-label NOAC doses among AF patients and the associations between off-label dose therapy and clinical outcomes in community practice. Methods: We evaluated 5,738 patients treated with a NOAC at 242 ORBIT-AF II (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation phase II) sites. NOAC doses were classified as either underdosed or overdosed, consistent with Food and Drug Administration labeling. Longitudinal outcomes (median follow-up: 0.99 years) included stroke or systemic embolism, myocardial infarction, major bleeding (International Society of Thrombosis and Haemostasis criteria), cause-specific hospitalization, and all-cause mortality. Results: Overall, 541 NOAC-treated patients (9.4%) were underdosed, 197 were overdosed (3.4%), and 5,000 were dosed according to U.S. labeling (87%). Compared with patients receiving the recommended dose, those who were receiving off-label doses were older (median: 79 and 80 years of age vs. 70 years of age, respectively; p < 0.0001), more likely female (48% and 67% vs. 40%, respectively; p < 0.0001), less likely to be treated by an electrophysiologist (18% and 19% vs. 27%, respectively; p < 0.0001), and had higher CHA Conclusions: A significant minority (almost 1 in 8) of U.S. patients in the community received NOAC doses inconsistent with labeling. NOAC over- and underdosing are associated with increased risk for adverse events. (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II [ORBIT-AF II]; NCT01701817).
MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Cause of Death/trends ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Middle Aged ; Off-Label Use/statistics & numerical data ; Registries ; Retrospective Studies ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Survival Rate/trends ; United States/epidemiology ; Vitamin K
Chemical Substances	Anticoagulants ; Vitamin K (12001-79-5)
Language	English
Publishing date	2017-01-25
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2016.09.966
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Incidence and Predictors of Left Atrial Appendage Thrombus in Patients Treated With Nonvitamin K Oral Anticoagulants Versus Warfarin Before Catheter Ablation for Atrial Fibrillation.

Wyrembak, Joanne / Campbell, Kristen B / Steinberg, Benjamin A / Bahnson, Tristram D / Daubert, James P / Velazquez, Eric J / Samad, Zainab / Atwater, Brett D

The American journal of cardiology

2017 Volume 119, Issue 7, Page(s) 1017–1022

Abstract: ... thrombus before atrial fibrillation (AF) ablation in patients treated with nonvitamin K oral anticoagulant ...

Abstract	The utility of routine transesophageal echocardiography (TEE) to exclude left atrial appendage (LAA) thrombus before atrial fibrillation (AF) ablation in patients treated with nonvitamin K oral anticoagulant (NOAC) therapy is unclear. This single-center retrospective study sought to investigate the incidence of LAA thrombus in patients undergoing routine TEE before AF ablation treated with warfarin or NOAC therapy. We included 937 routine pre-AF ablation TEE procedures performed in patients treated with warfarin (n = 517) or NOAC (n = 420). Patients were anticoagulated without interruption for at least 4 consecutive weeks before the TEE. Patients treated with warfarin had lower LAA velocity and underwent TEE earlier in the study period than those treated with NOAC (p <0.05). The incidence of LAA thrombus was higher in patients treated with warfarin (1.55%, 8 of 517) compared with patients treated with NOAC (0.24%, 1 of 420, p = 0.0473 for difference). No LAA thrombus was identified in NOAC-treated patients with a CHA
MeSH term(s)	Aged ; Anticoagulants/therapeutic use ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Catheter Ablation ; Contrast Media ; Echocardiography, Transesophageal ; Factor Xa Inhibitors/therapeutic use ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment ; Thrombosis/diagnostic imaging ; Thrombosis/epidemiology ; Thrombosis/prevention & control ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Contrast Media ; Factor Xa Inhibitors ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2017-04-01
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2016.12.008
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