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  1. Article: Role of hematological parameters in the stratification of COVID-19 disease severity.

    Taj, Sadia / Kashif, Ambreen / Arzinda Fatima, Syeda / Imran, Sheharbano / Lone, Ayaz / Ahmed, Qasim

    Annals of medicine and surgery (2012)

    2021  Volume 62, Page(s) 68–72

    Abstract: Objective: COVID-19 virus involves respiratory as well as other body systems including cardiovascular, gastrointestinal, neurological, immunological and hematopoietic system. Patient of covid-19 pneumonia presents with wide range of hemostatic ... ...

    Abstract Objective: COVID-19 virus involves respiratory as well as other body systems including cardiovascular, gastrointestinal, neurological, immunological and hematopoietic system. Patient of covid-19 pneumonia presents with wide range of hemostatic abnormalities. These hemostatic abnormalities in COVID-19 are related with disease progression, severity and mortality. The Objective of our study is to evaluate the role of hematological parameters in determination of COVID-19 disease severity.
    Material and method: This was a retrospective study, conducted in Department of Pathology and Department of medicine, FMH college of Medicine and Dentistry from May 2020 to July 2020. Total of 101, confirmed cases of covid-19 disease, both genders between 17 and 75-year age were included. Hematological parameters were compared in mild, moderate, severe and critical disease group. Continuous variables were analyzed by using non parametric, Kruskal Wallis test while categorical variables were analyzed by chi-square test.
    Results: Out of 101 patients, 20.8%, 51.8%,19.8% and 7.9% were in mild, moderate, severe and critical group respectively. Median (IQR) values of WBCs (
    Conclusion: The study concluded that Leukocytosis, neutrophilia, elevated Neutrophil to lymphocyte ratio, APTT, D-dimer, LDH and serum ferritin and CRP are associated with severity of covid-19 disease.
    Language English
    Publishing date 2021-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2020.12.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease

    Fatima, Syeda Arzinda / Asif, Mohsin / Khan, Khurshid A. / Siddique, Nasir / Khan, Aijaz Zeeshan

    Annals of Medicine and Surgery

    2020  Volume 60, Page(s) 413–416

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2020.11.027
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease.

    Fatima, Syeda Arzinda / Asif, Mohsin / Khan, Khurshid A / Siddique, Nasir / Khan, Aijaz Zeeshan

    Annals of medicine and surgery (2012)

    2020  Volume 60, Page(s) 413–416

    Abstract: ... settings: Fatima Memorial Hospital, Lahore and Ganga Ram hospital, Lahore.: Study design: Quasi ...

    Abstract Background: The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019. In the first half of 2020 this disease has already converted into a global pandemic. Various treatment options were being tried all over the world. Some studies showed beneficial effects of corticosteroids in covid 19. Hence, we designed this study to compare the effect of two steroids in moderate to severe covid 19 disease.
    Objectives: To compare the efficacy and safety of dexamethasone and methylprednisolone in moderate to severe covid 19 disease.
    Study settings: Fatima Memorial Hospital, Lahore and Ganga Ram hospital, Lahore.
    Study design: Quasi experimental, interventional study.
    Duration of study: From 1st June 2020 to 30th June 2020.
    Methodology: Sample size and technique
    Results: The mean age of patients was 57.91 years in dexamethasone group and 54.86 years in methylprednisolone group. In dexamethasone group, there were 15 (42.8%) critically ill patients who were shifted to Intensive care unit (ICU) and seven (20%) of them needed ventilatory support, whereas in methylprednisolone group 22 (33.8%) had to be admitted in ICU with eight (12.3%) patient needing ventilator. As outcome measure, patients in both the groups showed marked improvement in temperature, oxygen requirement and C-reactive protein (CRP) on day 5. Only six (17.1%) patient died who received dexamethasone while 10 (15.3%) patients died among those receiving methylprednisolone.
    Conclusion: Dexamethasone and methylprednisolone both are equally effective in treating moderate to severe covid 19 disease.
    Keywords covid19
    Language English
    Publishing date 2020-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2020.11.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: "Tocilizumab-an option for patients with COVID-19 associated cytokine release syndrome: A single center experience", a retrospective study-original article.

    Chachar, Aijaz Zeeshan Khan / Khan, Khurshid Ahmed / Iqbal, Javeid / Shahid, Adnan Hussain / Asif, Mohsin / Fatima, Syeda Arzinda / Khan, Asma Afzal / Younis, Bilal Bin

    Annals of medicine and surgery (2012)

    2021  Volume 63, Page(s) 102165

    Abstract: Background: The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China in 2019. In the first half of 2020, this disease has already converted into a global pandemic. This study aimed to ... ...

    Abstract Background: The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China in 2019. In the first half of 2020, this disease has already converted into a global pandemic. This study aimed to find that treatment of patients with COVID-19 pneumonia with Tocilizumab or steroids was associated with better outcomes.
    Study design: Quasi-experimental.
    Duration of study: From May 12, 2020 to June 12, 2020.
    Patients & methods sample size and technique: Sample size was 93; 33 patients were kept in the experimental group, given Tocilizumab, 8 mg/kg intravenously or 162 mg subcutaneously, and the rest of the 60 patients were given corticosteroids, methylprednisolone 80 mg/day. Consecutive sampling. Failure of therapy was labeled when patients were intubated or died, and the endpoints were failure-free survival which was the primary endpoint, and overall survival secondary at the time of discharge.
    Results: A total of 93 patients were enrolled, the Tocilizumab (TCZ) group (case) and Corticosteroid (CS) group (Control). The median age was 58 years (IQR-21), 37 (39.8%) patients with diabetes mellitus, 11 (11.8%) in the TCZ group, and 26 (28%) in the CS group. On the whole, the total median hospital stay in days was 7 with IQR (4), a total of 83 (89.2%) patients recovered successfully and discharged, 27 (29%) in the TCZ group and 56 (60.2%) in the CS group. Total 10 (10.8%) patients died, out of which 6 (6.5%) belonged to the TCZ group and 4 (4.3%) belonged to the CS group The median Oxygen requirement with IQR was 8 (9) in both the groups and in total as well, p-value (0.714).
    Conclusions: Tocilizumab is a quite effective treatment option for critically sick patients of Covid-19 by reducing their oxygen requirement drastically and so the ICU stay, median hospital stay and so the mortality as well.
    Clinicals trials registration: UIN # NCT04730323.
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2021.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Online: Association of Plasma CRP Level with the Severity of COVID-19

    Shehrbano Imran, Syeda Arzinda Fatima, Namra Yunus, Sadia Taj

    International Journal of Sciences

    2020  

    Abstract: ... of Pathology, Fatima Memorial Hospital from February to June 2020. After approval from institution’s review ...

    Abstract Objective: To assess the usefulness of plasma CRP level in categorizing the patients in severity group of COVID-19 and its correlation with severity. Material and methods: A retrospective study was conducted at the Department of Medicine and Sections of Chemical Pathology and Microbiology, Department of Pathology, Fatima Memorial Hospital from February to June 2020. After approval from institution’s review board, confirmed cases of Covid-19 by PCR were selected. Their CRP levels were obtained from medical record. CRP levels were compared in the following groups of patients: mild group, moderate group, severe group. Data was analyzed using the SPSS version 25.0. Results: Out of 115 patients of covid 19 disease included in our study, 11 were in mild group, 19 in moderate and 85 in severe group. Mean CRP of patients in mild group was 3.6±1.0 mg/L, while mean CRP was 117.9±58.1 mg/L in moderate and 134±71.9 mg/L in severe group (p<0.001). Out of 85 (73.9%) severe group patients,15(17.6%) were shifted to mechanical ventilation and out of them 4(26.6%) expired. Mean CRP of ICU patients was 148±82.1 (p-value= 0.008) and 124.2±60.2 in expired patients. Conclusion: We conclude that higher level of CRP at presentation is an independent predictor of Covid 19 disease severity.
    Keywords Covid-19 ; CRP ; Severity ; covid19
    Subject code 610
    Language English
    Publisher Alkhaer Publications
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease

    Fatima, Syeda Arzinda Asif Mohsin Khan Khurshid A. / Siddique, Nasir Khan Aijaz Zeeshan

    Annals of Medicine and Surgery

    Abstract: ... Fatima Memorial Hospital, Lahore and Ganga Ram hospital, Lahore Study Design Quasi experimental ...

    Abstract Background The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019 In the first half of 2020 this disease has already converted into a global pandemic Various treatment options were being tried all over the world Some studies showed beneficial effects of corticosteroids in covid 19 Hence, we designed this study to compare the effect of two steroids in moderate to severe covid 19 disease Objectives To compare the efficacy and safety of dexamethasone and methylprednisolone in moderate to severe covid 19 disease Study Settings Fatima Memorial Hospital, Lahore and Ganga Ram hospital, Lahore Study Design Quasi experimental, interventional study Duration of Study From 1st June 2020 to 30th June 2020 Methodology Sample size and technique: there were total 100 patients;35 patients received dexamethasone and 65 were kept in methylprednisolone receiving group Results The mean age of patients was 57 91 years in dexamethasone group and 54 86 years in methylprednisolone group In dexamethasone group, there were 15 (42 8%) critically ill patients who were shifted to Intensive care unit (ICU) and seven (20%) of them needed ventilatory support, whereas in methylprednisolone group 22 (33 8%) had to be admitted in ICU with eight (12 3%) patient needing ventilator As outcome measure, patients in both the groups showed marked improvement in temperature, oxygen requirement and C-reactive protein (CRP) on day 5 Only six (17 1%) patient died who received dexamethasone while 10 (15 3%) patients died among those receiving methylprednisolone Conclusion Dexamethasone and methylprednisolone both are equally effective in treating moderate to severe covid 19 disease
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #917205
    Database COVID19

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