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  1. Article ; Online: Platelets at the heart of therapy.

    Lordkipanidzé, Marie

    Platelets

    2018  Volume 29, Issue 2, Page(s) 103–104

    MeSH term(s) Blood Platelets ; Humans
    Language English
    Publishing date 2018-03-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/10864415.2018.1446274
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    Zs.A 2888: Show issues Location:
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  2. Article: Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

    Jourdi, Georges / Fleury, Samuel / Boukhatem, Imane / Lordkipanidzé, Marie

    Neural regeneration research

    2023  Volume 19, Issue 3, Page(s) 536–541

    Abstract: Neurodegenerative diseases are often misdiagnosed, especially when the diagnosis is based solely on clinical symptoms. The p75 neurotrophic receptor ( ... ...

    Abstract Neurodegenerative diseases are often misdiagnosed, especially when the diagnosis is based solely on clinical symptoms. The p75 neurotrophic receptor (p75
    Language English
    Publishing date 2023-09-27
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.380873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Assessment of Platelet Function by High-Throughput Screening Light Transmission Aggregometry: Optimul Assay.

    Chan, Melissa V / Lordkipanidzé, Marie / Warner, Timothy D

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2663, Page(s) 627–636

    Abstract: Platelet function testing is critical in the diagnosis of bleeding disorders and allows monitoring of antiplatelet therapy. The gold standard assay, light transmission aggregometry (LTA), was developed 60 years ago and remains widely used worldwide. It ... ...

    Abstract Platelet function testing is critical in the diagnosis of bleeding disorders and allows monitoring of antiplatelet therapy. The gold standard assay, light transmission aggregometry (LTA), was developed 60 years ago and remains widely used worldwide. It requires, however, access to expensive equipment and is time-consuming, and the interpretation of results requires evaluation by an experienced investigator. It also suffers from a lack of standardization, resulting in widely variable results between laboratories. 96-well plate-based Optimul aggregometry utilizes the same principles of LTA and aims to standardize agonist concentrations with the development of 96-well plates which are precoated with 7 concentrations of each lyophilized agonist (arachidonic acid, adenosine diphosphate, collagen, epinephrine, TRAP-6 amide, and U46619) and stored at ambient room temperature (20-25 °C) for up to 12 weeks. For platelet function testing, 40 μL of platelet-rich plasma is added to each well, and the plate is placed onto a plate shaker, after which platelet aggregation is determined by changes in light absorbance. This method reduces the blood volume required and allows for in-depth platelet function analysis without specialist training, or the need to purchase expensive, dedicated equipment.
    MeSH term(s) Humans ; High-Throughput Screening Assays ; Platelet Aggregation ; Platelet Function Tests/methods ; Platelet Aggregation Inhibitors/pharmacology ; Blood Coagulation Disorders ; Blood Platelets
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3175-1_41
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Established and Novel Roles of Platelets in Health and Disease.

    Jurasz, Paul / Ignjatovic, Vera / Lordkipanidzé, Marie

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 835615

    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.835615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Platelet Function Tests.

    Lordkipanidzé, Marie

    Seminars in thrombosis and hemostasis

    2016  Volume 42, Issue 3, Page(s) 258–267

    Abstract: Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate ... ...

    Abstract Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate endpoints of efficacy of new antiplatelet therapy, and to an extent, in the monitoring of antiplatelet therapy in clinical practice to predict thrombotic and bleeding risk. A multiplicity of platelet function assays is available to measure the level of platelet activity in various settings. These include assays that are restricted to a specialized laboratory as well as point-of-care instruments meant to investigate platelet function at patient bedside. Unlike tests that determine a defined quantity or measurement of a clinical biomarker (e.g., cholesterol or blood pressure), platelet function testing assesses the dynamics of living cells, which immediately presents a series of unique problems to any laboratory or clinic. This article presents currently used platelet function assays and discusses important variables to take into account when performing these assays, including preanalytical issues and difficulties in interpreting platelet function test results.
    MeSH term(s) Blood Platelets/physiology ; Drug Monitoring/instrumentation ; Drug Monitoring/methods ; Hemorrhage/diagnosis ; Hemorrhage/physiopathology ; Humans ; Platelet Activation/physiology ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Function Tests/instrumentation ; Platelet Function Tests/methods ; Platelet Function Tests/trends ; Point-of-Care Systems ; Sensitivity and Specificity ; Thrombosis/diagnosis ; Thrombosis/physiopathology
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0035-1564834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Consensus report on flow cytometry for platelet function testing in thrombocytopenic patients: communication from the SSC of the ISTH.

    Jourdi, Georges / Ramström, Sofia / Sharma, Ruchika / Bakchoul, Tamam / Lordkipanidzé, Marie

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 10, Page(s) 2941–2952

    Abstract: Background: Platelet count alone does not reliably predict bleeding risk, suggesting platelet function is important to monitor in patients with thrombocytopenia. There is still an unmet need for improved platelet function diagnostics in patients with ... ...

    Abstract Background: Platelet count alone does not reliably predict bleeding risk, suggesting platelet function is important to monitor in patients with thrombocytopenia. There is still an unmet need for improved platelet function diagnostics in patients with low platelet count in many clinical situations. Flow cytometry is a promising tool allowing reliable platelet function study in this setting.
    Objectives: The goal of this joint project between the International Society on Thrombosis and Haemostasis (ISTH) Scientific Standardization Committee (SSC) Subcommittees on Platelet Physiology and Platelet Immunology is to provide expert consensus guidance on the use of flow cytometry for the evaluation of platelet function, particularly activation, in patients with low platelet counts.
    Methods: A literature review was performed to identify relevant questions and areas of interest. An electronic expression of interest form was thereafter announced on the ISTH webpage, followed by a survey encompassing 37 issues regarding preanalytical, analytical, postanalytical, and performance aspects. Areas of disagreement or uncertainty were identified and formed the basis for 2 focus group discussions.
    Results: Consensus recommendations relative to patient sample collection, preanalytical variables, sample type, platelet-count cutoff, any potential specific modification of the standard flow cytometry protocol, and results expression and reporting are proposed based on the current practices of experts in the field as well as on literature review.
    Conclusion: The proposed consensus recommendations would allow standardization of protocols in upcoming clinical studies. The clinical utility of platelet function testing using flow cytometry to predict bleeding risk still needs rigorous multicenter outcome studies in patients with thrombocytopenia.
    MeSH term(s) Humans ; Flow Cytometry ; Consensus ; Blood Platelets/metabolism ; Thrombocytopenia/diagnosis ; Thrombocytopenia/metabolism ; Hemostasis ; Thrombosis/metabolism ; Communication ; Multicenter Studies as Topic
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.07.006
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    Zs.MO 295: Show issues

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  7. Article ; Online: Consensus report on markers to distinguish procoagulant platelets from apoptotic platelets: communication from the Scientific and Standardization Committee of the ISTH.

    Josefsson, Emma C / Ramström, Sofia / Thaler, Johannes / Lordkipanidzé, Marie

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 8, Page(s) 2291–2299

    Abstract: Background: Procoagulant platelets are a subpopulation of highly activated platelets that promote coagulation through surface-exposed, negatively charged phospholipids, especially phosphatidylserine. Procoagulant platelets are important for clot ... ...

    Abstract Background: Procoagulant platelets are a subpopulation of highly activated platelets that promote coagulation through surface-exposed, negatively charged phospholipids, especially phosphatidylserine. Procoagulant platelets are important for clot stabilization during hemostasis, and an increased number of these platelets is associated with thrombotic risk. There is a need for harmonization in this area since many of the markers and methods used to assess procoagulant platelets are not specific when used in isolation but are also associated with platelet apoptosis.
    Objectives: We initiated this project to identify a minimum set of markers and/or methods that can detect and distinguish procoagulant platelets from apoptotic platelets.
    Methods: The study design involved a primary panel with 27 international experts who participated in an online survey and moderated virtual focus group meetings. Primary and secondary panel members were then invited to provide input on themes and statements generated from the focus groups.
    Results: This led to a recommendation to use flow cytometry and a combination of the following 3 surface markers to differentiate procoagulant platelets from apoptotic platelets: P-selectin (CD62P), phosphatidylserine (recognized by annexin V), and the platelet-specific receptor GPIX (CD42a) or α
    Conclusion: Procoagulant platelets are expected to be positive for all 3 markers, while apoptotic platelets are positive for annexin V and the platelet-specific surface receptor(s) but negative for P-selectin.
    MeSH term(s) Humans ; Blood Platelets/metabolism ; P-Selectin/metabolism ; Phosphatidylserines ; Annexin A5 ; Consensus ; Platelet Glycoprotein GPIb-IX Complex ; Communication ; Platelet Activation
    Chemical Substances P-Selectin ; Phosphatidylserines ; Annexin A5 ; Platelet Glycoprotein GPIb-IX Complex
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Is platelet transfusion the solution to reverse platelet inhibition in patients on triple antiplatelet therapy?

    Lordkipanidzé, Marie

    Thrombosis research

    2015  Volume 136, Issue 6, Page(s) 1057–1058

    MeSH term(s) Aspirin/therapeutic use ; Blood Platelets/drug effects ; Drug Therapy, Combination ; Humans ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Transfusion ; Ticlopidine/therapeutic use
    Chemical Substances Platelet Aggregation Inhibitors ; Ticlopidine (OM90ZUW7M1) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2015.10.040
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    Zs.A 863: Show issues Location:
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  9. Article: Platelet Function in Aging.

    Le Blanc, Jessica / Lordkipanidzé, Marie

    Frontiers in cardiovascular medicine

    2019  Volume 6, Page(s) 109

    Abstract: Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that ... ...

    Abstract Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease.
    Language English
    Publishing date 2019-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2019.00109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Platelet Function Tests

    Lordkipanidzé, Marie

    Seminars in Thrombosis and Hemostasis

    (Platelet Function in Thrombosis and Hemostasis)

    2016  Volume 42, Issue 03, Page(s) 258–267

    Abstract: Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype–genotype associations in bleeding disorders, in drug development as surrogate ... ...

    Series title Platelet Function in Thrombosis and Hemostasis
    Abstract Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype–genotype associations in bleeding disorders, in drug development as surrogate endpoints of efficacy of new antiplatelet therapy, and to an extent, in the monitoring of antiplatelet therapy in clinical practice to predict thrombotic and bleeding risk. A multiplicity of platelet function assays is available to measure the level of platelet activity in various settings. These include assays that are restricted to a specialized laboratory as well as point-of-care instruments meant to investigate platelet function at patient bedside. Unlike tests that determine a defined quantity or measurement of a clinical biomarker (e.g., cholesterol or blood pressure), platelet function testing assesses the dynamics of living cells, which immediately presents a series of unique problems to any laboratory or clinic. This article presents currently used platelet function assays and discusses important variables to take into account when performing these assays, including preanalytical issues and difficulties in interpreting platelet function test results.
    Keywords antiplatelet therapy ; bleeding disorders ; platelet function testing
    Language English
    Publishing date 2016-02-29
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0035-1564834
    Database Thieme publisher's database

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