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Article: Characterization of Bacteria in Nigerian Yogurt as Promising Alternative to Antibiotics in Gastrointestinal Infections

Ayeni, Anthony Opeyemi / Ruppitsch, Werner / Ayeni, Funmilola Abidemi

Journal of dietary supplements. 2019 Mar. 4, v. 16, no. 2

2019

Abstract: Gastrointestinal infections are endemic in Nigeria and several factors contribute to their continual survival, including bacterial resistance to commonly used antibiotics. Nigerian yogurts do not include probiotics, and limited information is available ... ...

Abstract	Gastrointestinal infections are endemic in Nigeria and several factors contribute to their continual survival, including bacterial resistance to commonly used antibiotics. Nigerian yogurts do not include probiotics, and limited information is available about the antimicrobial properties of the fermenters in the yogurt against gastrointestinal pathogens. Therefore, the antimicrobial potentials of bacteria in Nigeria-produced yogurts against intestinal pathogens were investigated in this study. Viable counts of lactic acid bacteria (LAB) in 15 brands of yogurt were enumerated and the bacteria identified by partial sequencing of 16S rRNA gene. Susceptibility of the gastrointestinal pathogens (Salmonella, Shigella and E. coli) to antibiotics by disc diffusion method, to viable LAB by the agar overlay method, and to the cell-free culture supernatant (CFCS) of the LAB were investigated. Co-culture analysis of LAB and pathogens were also done. Viable counts of 1.5 × 10¹¹ cfu/ml were observed in some yogurt samples. Two genera were identified: Lactobacillus (70.7%) and Acetobacter (29.3%). The Lactobacillus species reduced multidrug-resistant gastrointestinal pathogens by 4 to 5 log while the zones of inhibition ranged between 11 and 23. The Lactobacillus and Acetobacter strains examined displayed good activities against the multidrug-resistant tested pathogens. This is the first report of antimicrobial activities of acetic acid bacteria isolated from yogurt in Nigeria.
Keywords	Acetobacter ; Escherichia coli ; Lactobacillus ; Salmonella ; Shigella ; acetic acid ; agar ; cell free system ; coculture ; genes ; intestines ; lactic acid ; multiple drug resistance ; probiotics ; yogurt ; Nigeria
Language	English
Dates of publication	2019-0304
Size	p. 141-151.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2018.1440684
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Characterization of Bacteria in Nigerian Yogurt as Promising Alternative to Antibiotics in Gastrointestinal Infections.

Ayeni, Anthony Opeyemi / Ruppitsch, Werner / Ayeni, Funmilola Abidemi

Journal of dietary supplements

2018 Volume 16, Issue 2, Page(s) 141–151

Abstract	Gastrointestinal infections are endemic in Nigeria and several factors contribute to their continual survival, including bacterial resistance to commonly used antibiotics. Nigerian yogurts do not include probiotics, and limited information is available about the antimicrobial properties of the fermenters in the yogurt against gastrointestinal pathogens. Therefore, the antimicrobial potentials of bacteria in Nigeria-produced yogurts against intestinal pathogens were investigated in this study. Viable counts of lactic acid bacteria (LAB) in 15 brands of yogurt were enumerated and the bacteria identified by partial sequencing of 16S rRNA gene. Susceptibility of the gastrointestinal pathogens (Salmonella, Shigella and E. coli ) to antibiotics by disc diffusion method, to viable LAB by the agar overlay method, and to the cell-free culture supernatant (CFCS) of the LAB were investigated. Co-culture analysis of LAB and pathogens were also done. Viable counts of 1.5 × 10
MeSH term(s)	Acetobacter/isolation & purification ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/administration & dosage ; Bacteria/classification ; Bacteria/cytology ; Bacteria/isolation & purification ; Bacterial Infections/microbiology ; Bacterial Infections/therapy ; Bacterial Load ; Coculture Techniques ; Escherichia coli/drug effects ; Fermentation ; Gastrointestinal Diseases/microbiology ; Gastrointestinal Diseases/therapy ; Lactobacillales/isolation & purification ; Lactobacillus/isolation & purification ; Nigeria ; Probiotics ; Salmonella/drug effects ; Shigella/drug effects ; Yogurt/microbiology
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2018-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2018.1440684
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Article ; Online: Antagonistic and Quantitative Assessment of Indigenous Lactic acid Bacteria in Different Varieties of

Afolayan, Ayorinde Oluwatobiloba / Ayeni, Funmilola Abidemi / Ruppitsch, Werner

The Pan African medical journal

2017 Volume 27, Page(s) 22

Abstract: Introduction: Ogi: Methods: The : Results: Omidun: Conclusion: ... ...

Abstract	Introduction: Ogi Methods: The Results: Omidun Conclusion: Ogi
MeSH term(s)	Bacteria/growth & development ; Bacteria/isolation & purification ; Bacteria/metabolism ; Bacterial Infections/microbiology ; Coculture Techniques ; Edible Grain/microbiology ; Fermentation ; Food Microbiology ; Gastrointestinal Diseases/microbiology ; Humans ; Lactic Acid/metabolism ; Nigeria ; RNA, Ribosomal, 16S
Chemical Substances	RNA, Ribosomal, 16S ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2017
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2017.27.22.9707
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Article ; Online: Prevalence and Antimicrobial Properties of Lactic Acid Bacteria in Nigerian Women During the Menstrual Cycle.

Adeoshun, Folashade Grace / Ruppitsch, Werner / Allerberger, Franz / Ayeni, Funmilola Abidemi

Polish journal of microbiology

2019 Volume 68, Issue 2, Page(s) 203–209

Abstract: The composition of vagina lactic acid bacteria (LAB) differs within the different ethnic group. This study is aimed at determining the prevalence of LAB with their antimicrobial properties in Nigerian women's vagina during different stages of the ... ...

Abstract	The composition of vagina lactic acid bacteria (LAB) differs within the different ethnic group. This study is aimed at determining the prevalence of LAB with their antimicrobial properties in Nigerian women's vagina during different stages of the menstrual cycle. Microorganisms were isolated from vaginal swabs of ten Nigerian women during different stages of the menstrual cycle and identified by partial sequencing of the 16S rRNA gene. The antimicrobial properties of the LAB were tested against the multidrug-resistant uropathogens. The prevalence of LAB was higher during ovulation period while during menstruation period, it declined. Twenty-five LAB isolates were identified as three species, namely: The composition of vagina lactic acid bacteria (LAB) differs within the different ethnic group. This study is aimed at determining the prevalence of LAB with their antimicrobial properties in Nigerian women’s vagina during different stages of the menstrual cycle. Microorganisms were isolated from vaginal swabs of ten Nigerian women during different stages of the menstrual cycle and identified by partial sequencing of the 16S rRNA gene. The antimicrobial properties of the LAB were tested against the multidrug-resistant uropathogens. The prevalence of LAB was higher during ovulation period while during menstruation period, it declined. Twenty-five LAB isolates were identified as three species, namely:
MeSH term(s)	Acetobacter/classification ; Acetobacter/genetics ; Acetobacter/isolation & purification ; Acetobacter/physiology ; Adult ; Antibiosis ; Cluster Analysis ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; DNA, Ribosomal/chemistry ; DNA, Ribosomal/genetics ; Female ; Humans ; Lactobacillales/classification ; Lactobacillales/genetics ; Lactobacillales/isolation & purification ; Lactobacillales/physiology ; Menstrual Cycle ; Nigeria ; Phylogeny ; Prevalence ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Staphylococcus/growth & development ; Vagina/microbiology ; Young Adult
Chemical Substances	DNA, Bacterial ; DNA, Ribosomal ; RNA, Ribosomal, 16S
Language	English
Publishing date	2019-06-12
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2234080-4
ISSN	2544-4646 ; 1733-1331
ISSN (online)	2544-4646
ISSN	1733-1331
DOI	10.33073/pjm-2019-020
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Article ; Online: Antagonistic and Quantitative Assessment of Indigenous Lactic Acid Bacteria in Different Varieties of Ogi against Gastrointestinal Pathogens

Ayorinde Oluwatobiloba Afolayan / Funmilola Abidemi Ayeni / Werner Ruppitsch

The Pan African Medical Journal, Vol 27, Iss

2017 Volume 22

Abstract: BACKGROUND: ogi is a popular fermented cereal gruel consumed mainly in the western part of Nigeria. Traditionally, uncooked ogi is normally administered to diarrhoea patients to reduce the frequency of stooling. This study was therefore undertaken to ... ...

Abstract	BACKGROUND: ogi is a popular fermented cereal gruel consumed mainly in the western part of Nigeria. Traditionally, uncooked ogi is normally administered to diarrhoea patients to reduce the frequency of stooling. This study was therefore undertaken to identify, quantify and determine the antimicrobial properties of lactic acid bacteria (LAB) isolated from Ogi. METHODS: the ogi samples (Yellow, white, sorghum) were obtained from different market in Ibadan, Nigeria and Ogi control (cooked, uncooked and Omidun) were prepared with the viable counts of bacteria monitored over 5 days period. LAB were isolated from the varieties and identified by partial sequencing of 16S rRNA gene. The antimicrobial activities of the cell free supernatant (CFS) and the viable cells of the isolated LAB against Escherichia coli EC004, Salmonella sp. SS11, Shigella sp. SS10 were investigated by agar diffusion assay, agar overlay method, and coculture growth studies. RESULTS: omidun had the highest LAB count while cooked ogi has the lowest LAB count. Weissella paramesenteroides , L. brevis, L. rossiae, L. fermentum, L. plantarum, Acetobacter pasteurianus, Paenibacillus sp. and Bacillus sp. were isolated from Ogi in this study. Large zone of inhibition (11?x?20) was observed with CFS against Salmonella sp. SS11 and Shigella sp. SS10 and also the overlay method. Coculture studies of Weissella paramesenteroides, Lactobacillus fermentum, and L. plantarum with Salmonella sp. SS11 showed a 5-8 log reduction of the pathogens growth after 24 hours as compared with the control. CONCLUSION: ogi and its contents have antimicrobial properties against pathogenic organisms.
Keywords	ogi ; omidun ; salmonella ; coculture ; fermentation ; acetobacter ; Medicine ; R
Subject code	630
Language	English
Publishing date	2017-05-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High resistance to tetracycline and ciprofloxacin in bacteria isolated from poultry farms in Ibadan, Nigeria.

Ayandiran, Tunmise O / Falgenhauer, Linda / Schmiedel, Judith / Chakraborty, Trinad / Ayeni, Funmilola Abidemi

Journal of infection in developing countries

2018 Volume 12, Issue 6, Page(s) 462–470

Abstract: Introduction: Resistance to ciprofloxacin and tetracycline is increasing in the food chain especially in E. coli strains and more worrisome will be occurrence of extended-spectrum beta-lactamase (ESBL) producers among ciprofloxacin- and tetracycline- ... ...

Abstract	Introduction: Resistance to ciprofloxacin and tetracycline is increasing in the food chain especially in E. coli strains and more worrisome will be occurrence of extended-spectrum beta-lactamase (ESBL) producers among ciprofloxacin- and tetracycline-resistant isolates. This study was undertaken to investigate the occurrence and mechanism of ciprofloxacin-, tetracycline- and ESBL-resistant bacteria in poultry in Ibadan, Nigeria. Methodology: Bacteria were isolated from poultry feces in two farms in Ibadan and identified by MALDI-TOF. Antibiotic susceptibility patterns of the isolates were determined by disc diffusion and Minimum Inhibitory Concentration (MIC) using Vitek-2 apparatus. Four tetracycline genes and six plasmids mediated quinolone resistance genes (PMQR) were investigated by PCR. Whole genome sequencing was done for strains that were ESBL producers. Results: Bacterial strains (≥ 105 cfu/mL) were counted on ciprofloxacin and tetracycline supplemented plates. 106 bacteria from 14 different species were identified with high resistance to quinolones, tetracycline and trimethoprim. 49% of the strains were E. coli with 90% resistance for nalidixic acid, moxifloxacin (94%), ciprofloxacin (88%) levofloxacin (78%) and tetracycline (77%). The genes tetA, tetB, qnrB, qnrS and qepA were detected with 37%, 4%, 35%, 4% and 2% prevalence in E. coli respectively. Three ESBL-producing E. coli of the sequence type ST-6359 were found and harboured blaCTX-M-15 located in the chromosome, at the same insertion site. All the ESBL producers harboured mutations in gyrA (S83L/D87N/D678E) and parC (S80I). Conclusion: The observed high quinolones and tetracycline resistance with ESBL producers in this study calls for caution in the use of these antibiotics in poultry feeds.
Language	English
Publishing date	2018-06-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.9862
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Article: Antiviral potentials of Lactobacillus plantarum, Lactobacillus amylovorus, and Enterococcus hirae against selected Enterovirus

Sunmola, Abidemi Anota / Adeniji, Johnson A / Adetoye, Adewale / Ayeni, Funmilola A / Faleye, Temitope O. C / Ogbole, Omonike O

Folia microbiologica. 2019 Mar., v. 64, no. 2

2019

Abstract: Enteroviruses have been associated with a host of clinical presentations including acute flaccid paralysis (AFP). The site of primary replication for most enteroviruses is the gastrointestinal tract (GIT) and lactic acid bacteria (LAB) may confer ... ...

Abstract	Enteroviruses have been associated with a host of clinical presentations including acute flaccid paralysis (AFP). The site of primary replication for most enteroviruses is the gastrointestinal tract (GIT) and lactic acid bacteria (LAB) may confer protection in the GIT against them. This study therefore investigates the antiviral potential of some selected lactic acid bacteria against enterovirus isolates recovered from AFP cases. The antiviral activities of Lactobacillus plantarum, Lactobacillus amylovorus, and Enterococcus hirae in broth culture, their cell-free supernatant (CFS), and bacterial cell pellets were assayed against Echovirus 7 (E7), E13, and E19 in a pre- and post-treatment approach using cytopathic effect (CPE) and cell viability (MTT) assay. The tested Lactobacillus plantarum, Lactobacillus amylovorus, and Enterococcus hirae strains have good antiviral properties against E7 and E19 but not against E13. Lactobacillus amylovorus AA099 shows the highest activity against E19. The pre-treatment approach displays better antiviral activities compared to post-treatment approach. The LAB in broth suspension have better antiviral activities than their corresponding CFS and bacterial pellet. Lactic acid bacteria used in this study have the potential as antiviral agents.
Keywords	antiviral agents ; antiviral properties ; cell viability ; culture media ; cytopathogenicity ; Enterococcus hirae ; Enterovirus ; gastrointestinal system ; lactic acid bacteria ; Lactobacillus amylovorus ; Lactobacillus plantarum ; paralysis ; pellets
Language	English
Dates of publication	2019-03
Size	p. 257-264.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-018-0648-6
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Article ; Online: Antimicrobial Potentials of Lactic Acid Bacteria Isolated From a Nigerian Menstruating Woman

Funmilola Abidemi Ayeni / Bolanle A Adeniyi

TAF Preventive Medicine Bulletin, Vol 12, Iss 3, Pp 283-

2013 Volume 290

Abstract: ABSTRACT Background: Racial differences affect the composition of lactic acid bacteria (LAB) in women’s vagina. However, the bacteria present in women’s vagina exert protective effect against invading uropathogens through production of several inhibitory ...

Abstract	ABSTRACT Background: Racial differences affect the composition of lactic acid bacteria (LAB) in women’s vagina. However, the bacteria present in women’s vagina exert protective effect against invading uropathogens through production of several inhibitory compounds. The LAB composition of the vagina of a menstruating Nigerian woman was examined to detect any difference between the subject’s vaginal LAB flora and reported cases of women from western world and to investigate the antimicrobial activities of these lactic acid bacteria against potential uropathogens and enteropathogens with analysis of possible compounds that may be responsible for inhibition. Methods: Informed consent was obtained from the subject. LAB were identified by partially sequencing the 16S rRNA gene. The organic acids were detected through High Performance Liquid Chromatography (HPLC) while the volatile compounds were detected by gas chromatography. The hydrogen peroxide production was assayed through enzymatic reactions. Results: Enterococcus faecalis FAA025 and Streptococcus equines FAA026 were the only bacterial strains isolated. The two LAB strains inhibited the growth of all tested uropathogens and enteropathogens to remarkable degree. Both strains produced high quantities of lactic acid while high quantities of hydrogen peroxide, acetic acid and ethanol were only observed in Streptococcus equines FAA026. Conclusions: The results of this study suggest that in spite of absence of lactobacilli during menstruation in the subject, other LAB present (Enterococcus faecalis FAA025 and Streptococcus equines FAA026) can exert protective effects against invading uropathogens. Also, the LAB composition of the Nigerian woman is similar to her counterparts in the West. [TAF Prev Med Bull 2013; 12(3.000): 283-290]
Keywords	Antimicrobial ; beneficial bacteria ; pathogens ; Public aspects of medicine ; RA1-1270 ; Medicine ; R ; DOAJ:Public Health ; DOAJ:Health Sciences ; Medicine (General) ; R5-920 ; DOAJ:Medicine (General)
Subject code	540
Language	Turkish
Publishing date	2013-06-01T00:00:00Z
Publisher	GMMA Department of Public health
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of identification and antimicrobial resistance pattern of Staphylococcus aureus isolated from Amassoma, Bayelsa state, Nigeria.

Ayeni, Funmilola Abidemi / Gbarabon, Tombari / Andersen, Camilla / Norskov-Lauritsen, Niels

African health sciences

2015 Volume 15, Issue 4, Page(s) 1282–1288

Abstract: Background: Staphylococcus aureus is often responsible for fatal infections and recent upsurge of resistant strains has resulted in therapeutic failure. The identification of this microorganism is a major challenge to medical microbiologists in ... ...

Abstract	Background: Staphylococcus aureus is often responsible for fatal infections and recent upsurge of resistant strains has resulted in therapeutic failure. The identification of this microorganism is a major challenge to medical microbiologists in developing countries. Methods: One hundred and eighty five isolates which had been previously isolated from the nares of 185 healthy college students' volunteers in Amassoma, Bayelsa State, South Nigeria were identified by MALDI TOF mass spectrometry, and PCR amplification of the spa gene. The identified isolates were compared with presumptive identities obtained by growth on MSA, tube coagulation and slide agglutination tests. Antimicrobial susceptibility testing of S. aureus isolates was performed by Kirby Bauer technique while MRSA was screened for by growth on chromlDTM MRSA plate and confirmed by PCR-amplification of mecA/mecC genes. Results: From the 185 staphylococci that grew with yellow colonies on MSA, 24 were positive in the slide coagulase test, while 17 were positive in the tube coagulase test; MALDI TOF mass spectrometry and PCR amplification of the spa gene showed excellent concordance with the tube test, as all tube coagulase-positive strains were identified as S. aureus, while tube coagulase-test negative isolates in all cases were designated as other staphylococcal species by MALDI-TOF mass spectrometry and were spa PCR test negative. All S. aureus isolates were susceptible to clindamycin, vancomycin, fusidic acid, rifampicin and linezolid, while observed resistance to penicillin and trimethoprim were high. Only one MRSA strain was detected. Conclusion: The study confirms that the tube coagulase test is an accurate diagnostic method for identification of S. aureus, while growths on MSA and slide agglutination tests are inaccurate. We found a low prevalence of MRSA and a high rate of trimethroprim-resistance in the studied population.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Coagulase/genetics ; Drug Resistance, Multiple, Bacterial ; Humans ; Microbial Sensitivity Tests ; Nigeria/epidemiology ; Polymerase Chain Reaction ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/genetics ; Staphylococcus aureus/isolation & purification
Chemical Substances	Anti-Bacterial Agents ; Coagulase
Language	English
Publishing date	2015-12
Publishing country	Uganda
Document type	Comparative Study ; Journal Article
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v15i4.30
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Article ; Online: Antiviral potentials of Lactobacillus plantarum, Lactobacillus amylovorus, and Enterococcus hirae against selected Enterovirus.

Sunmola, Abidemi Anota / Ogbole, Omonike O / Faleye, Temitope O C / Adetoye, Adewale / Adeniji, Johnson A / Ayeni, Funmilola A

Folia microbiologica

2018 Volume 64, Issue 2, Page(s) 257–264

Abstract	Enteroviruses have been associated with a host of clinical presentations including acute flaccid paralysis (AFP). The site of primary replication for most enteroviruses is the gastrointestinal tract (GIT) and lactic acid bacteria (LAB) may confer protection in the GIT against them. This study therefore investigates the antiviral potential of some selected lactic acid bacteria against enterovirus isolates recovered from AFP cases. The antiviral activities of Lactobacillus plantarum, Lactobacillus amylovorus, and Enterococcus hirae in broth culture, their cell-free supernatant (CFS), and bacterial cell pellets were assayed against Echovirus 7 (E7), E13, and E19 in a pre- and post-treatment approach using cytopathic effect (CPE) and cell viability (MTT) assay. The tested Lactobacillus plantarum, Lactobacillus amylovorus, and Enterococcus hirae strains have good antiviral properties against E7 and E19 but not against E13. Lactobacillus amylovorus AA099 shows the highest activity against E19. The pre-treatment approach displays better antiviral activities compared to post-treatment approach. The LAB in broth suspension have better antiviral activities than their corresponding CFS and bacterial pellet. Lactic acid bacteria used in this study have the potential as antiviral agents.
MeSH term(s)	Antiviral Agents/pharmacology ; Cell Line, Tumor ; Cell Survival ; Enterococcus hirae/physiology ; Enterovirus/classification ; Enterovirus/drug effects ; Enterovirus Infections/prevention & control ; Enterovirus Infections/virology ; Humans ; Lactobacillales/physiology ; Lactobacillus acidophilus/physiology ; Lactobacillus plantarum/physiology ; Probiotics/pharmacology ; Species Specificity
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2018-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-018-0648-6
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